FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3

FEBS Letters

Volumn 581, Issue 16, 2007, Pages 3063-3068

  Mechtcheriakova, Diana ^a   Wlachos, Alexander ^a   Sobanov, Jury ^b   Bornancin, Frederic ^a   Zlabinger, Gerhard ^b   Baumruker, Thomas ^a   Billich, Andreas ^a  

^a Novartis Institutes for BioMedical Research Vienna   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

FTY720; Phosphatase; Sphingosine 1 phosphate

Indexed keywords

ENZYME; FINGOLIMOD; FTY720 PHOSPHATE; LIPID PHOSPHATE PHOSPHATASE 3; PHOSPHATASE; PHOSPHATE; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE PHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CONTROLLED STUDY; DEPHOSPHORYLATION; EMBRYO; ENZYME ACTIVITY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

CELLS, CULTURED; HUMANS; PHOSPHATES; PHOSPHATIDATE PHOSPHATASE; PROPYLENE GLYCOLS; SPHINGOSINE; TRANSFECTION;

EID: 34250159500     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.05.069     Document Type: Article

References (17)

1. Brinkmann V., Cyster J.G., and Hla T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am. J. Transplant. 4 (2004) 1019-1025
2. McVerry B.J., and Garcia J.G. In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell Signal 17 (2005) 131-139
3. Kharel Y., Lee S., Snyder A.H., Sheasley-O'Neill S.L., Morris M.A., Setiady Y., Zhu R., Zigler M.A., Burcin T.L., Ley K., Tung K.S.K., Engelhard V.H., Macdonald T.L., and Lynch K.R. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. J. Biol. Chem. 280 (2005) 36865-36872
4. Zemann B., Kinzel B., Muller M., Reuschel R., Mechtcheriakova D., Urtz N., Bornancin F., Baumruker T., and Billich A. Sphingosine kinase type 2 is essential for lymphodepletion induced by the immunomodulatory drug FTY720. Blood 107 (2005) 1454-1458
5. Brinkmann V., Davis M.D., Heise C.E., Albert R., Cottens S., Hof R., Bruns C., Prieschl E., Baumruker T., Hiestand P., Foster C.A., Zollinger M., and Lynch K.R. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J. Biol. Chem. 277 (2002) 21453-21457
6. Mandala S., Hajdu R., Bergstrom J., Quackenbush E., Xie J., Milligan J., Thornton R., Shei G.J., Card D., Keohane C., Rosenbach M., Hale J., Lynch C.L., Rupprecht K., Parsons W., and Rosen H. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296 (2002) 346-349
7. Ogawa C., Kihara A., Gokoh M., and Igarashi Y. Identification and characterization of a novel human sphingosine 1-phosphate phosphohydrolase, hSPP2. J. Biol. Chem. 278 (2002) 1268-1272
8. Mandala S.M., Thornton R., Galve-Roperh I., Poulton S., Peterson C., Olivera A., Bergstrom J., Kurtz M.B., and Spiegel S. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1-phosphate and induces cell death. Proc. Natl. Acad. Sci. USA 97 (2000) 7859-7864
9. Roberts R., Sciorra V.A., and Morris A.J. Human type 2a phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. J. Biol. Chem. 273 (1998) 22059-22067
10. Van Veldhoven P.P., and Mannaerts G.P. Sphingosine-phosphate lyase. Adv. Lipid Res. 26 (1993) 69-98
11. Bandhuvula P., Tam Y.Y., Oskouian B., and Saba J.D. The immune modulator FTY720 inhibits sphingosine-1-phosphate lyase activity. J. Biol. Chem. 280 (2005) 33697-33700
12. Ettmayer P., Baumruker T., Guerini D., Mechtcheriakova D., Nussbaumer P., Streiff M.B., and Billich A. NBD-labeled derivatives of the immunomodulatory drug FTY720 as tools for metabolism and mode of action studies. Bioorg. Med. Chem. Lett. 16 (2006) 84-87
13. Ettmayer P., Billich A., Baumruker T., Mechtcheriakova D., Schmid H., and Nussbaumer P. Fluorescence-labeled sphingosines as substrates of sphingosine kinases 1 and 2. Bioorg. Med. Chem. Lett. 14 (2004) 1555-1558
14. Mechtcheriakova D., Wlachos A., Sobanov J., Kopp T., Reuschel R., Bornancin F., Cai R., Zemann B., Urtz N., Stingl G., Zlabinger G., Woisetschlager M., Baumruker T., and Billich A. Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses. Cell Signal. 19 (2007) 748-760
15. Billich A., Bornancin F., Devay P., Mechtcheriakova D., Urtz N., and Baumruker T. Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J. Biol. Chem. 278 (2003) 47408-47415
16. Johnson K.R., Johnson K.Y., Becker K.P., Bielawski J., Mao C., and Obeid L.M. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J. Biol. Chem. 278 (2003) 34541-34547
17. Le Stunff H., Peterson C., Thornton R., Milstien S., Mandala S.M., and Spiegel S. Characterization of murine sphingosine-1-phosphate phosphohydrolase. J. Biol. Chem. 277 (2002) 8920-8927