Insulin-degrading enzyme antagonizes insulin-dependent tissue growth and Aβ-induced neurotoxicity in Drosophila

FEBS Letters

Volumn 584, Issue 13, 2010, Pages 2916-2920

  Tsuda, Manabu ^a   Kobayashi, Toshikazu ^a   Matsuo, Takashi ^a   Aigaki, Toshiro ^a  

^a TOKYO METROPOLITAN UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Drosophila disease model; Gene targeting; Insulin degrading enzyme; Type 2 diabetes mellitus

Indexed keywords

AMYLOID BETA PROTEIN; INSULIN; INSULINASE; TREHALOSE;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DROSOPHILA; ENZYME ACTIVITY; FEMALE; GENE INACTIVATION; GENE TARGETING; GLUCOSE BLOOD LEVEL; HEMOLYMPH; HISTOLOGY; INSULIN DEPENDENCE; MALE; NEUROTOXICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEPLETION; SIGNAL TRANSDUCTION; TISSUE GROWTH;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BODY WEIGHT; DISEASE MODELS, ANIMAL; DROSOPHILA; FEMALE; GLUCOSE; HEMOLYMPH; HUMANS; INSULYSIN; MALE; NEURONS; TREHALOSE;

HEXAPODA;

EID: 77953723289     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.05.010     Document Type: Article

References (29)

1. Saltiel A.R., Kahn C.R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001, 414:799-806.
2. Steyn N.P., Mann J., Bennett P.H., Temple N., Zimmet P., Tuomilehto J., Lindstrom J., Louheranta A. Diet, nutrition and the prevention of type 2 diabetes. Public Health Nutr. 2004, 7:147-165.
3. Balkau B. The DECODE study. Diabetes epidemiology: collaborative analysis of diagnostic criteria in Europe. Diabetes Metab. 2000, 26:282-286.
4. Leibson C.L., Rocca W.A., Hanson V.A., Cha R., Kokmen E., O'Brien P.C., Palumbo P.J. The risk of dementia among persons with diabetes mellitus: a population-based cohort study. Ann. NY Acad. Sci. 1997, 826:422-427.
5. Arvanitakis Z., Wilson R.S., Bienias J.L., Evans D.A., Bennett D.A. Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch. Neurol. 2004, 61:661-666.
6. Roher A.E., et al. Morphology and toxicity of Aβ-(1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease. J. Biol. Chem. 1996, 271:20631-20635.
7. Gong Y., Chang L., Viola K.L., Lacor P.N., Lambert M.P., Finch C.E., Krafft G.A., Klein W.L. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proc. Natl. Acad. Sci. USA 2003, 100:10417-10422.
8. Farris W., et al. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am. J. Pathol. 2007, 171:241-251.
9. Fakhrai-Rad H., Nikoshkov A., Kamel A., Fernstrom M., Zierath J.R., Norgren S., Luthman H., Galli J. Insulin-degrading enzyme identified as a candidate diabetes susceptibility gene in GK rats. Human Mol. Genet. 2000, 9:2149-2158.
10. Sladek R., et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007, 445:881-885.
11. Bertram L., et al. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. Science 2000, 290:2302-2303.
12. Zhao Z., Xiang Z., Haroutunian V., Buxbaum J.D., Stetka B., Pasinetti G.M. Insulin degrading enzyme activity selectively decreases in the hippocampal formation of cases at high risk to develop Alzheimer's disease. Neurobiol. Aging 2007, 28:824-830.
13. Farris W., et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. USA 2003, 100:4162-4167.
14. Farris W., Mansourian S., Leissring M.A., Eckman E.A., Bertram L., Eckman C.B., Tanzi R.E., Selkoe D.J. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid β-protein. Am. J. Pathol. 2004, 164:1425-1434.
15. Duckworth W.C., Bennett R.G., Hamel F.G. Insulin degradation: progress and potential. Endocr. Rev. 1998, 19:608-624.
16. Garcia J.V., Fenton B.W., Rosner M.R. Isolation and characterization of an insulin-degrading enzyme from Drosophila melanogaster. Biochemistry 1988, 27:4237-4244.
17. Rulifson E.J., Kim S.K., Nusse R. Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 2002, 296:1118-1120.
18. Brogiolo W., Stocker H., Ikeya T., Rintelen F., Fernandez R., Hafen E. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 2001, 11:213-221.
19. Rong Y.S., Golic K.G. A targeted gene knockout in Drosophila. Genetics 2001, 157:1307-1312.
20. Greeve I., Kretzschmar D., Tschape J.A., Beyn A., Brellinger C., Schweizer M., Nitsch R.M., Reifegerste R. Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic Drosophila. J. Neurosci. 2004, 24:3899-3906.
21. Gao X., Neufeld T.P., Pan D. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev. Biol. 2000, 221:404-418.
22. Rubin G.M., Spradling A.C. Genetic transformation of Drosophila with transposable element vectors. Science 1982, 218:348-353.
23. Brand A.H., Perrimon N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415.
24. Gong W.J., Golic K.G. Ends-out, or replacement, gene targeting in Drosophila. Proc. Natl. Acad. Sci. USA 2003, 100:2556-2561.
25. Takeo S., Tsuda M., Akahori S., Matsuo T., Aigaki T. The calcineurin regulator sra plays an essential role in female meiosis in Drosophila. Curr. Biol. 2006, 16:1435-1440.
26. Umeda-Kameyama Y., Tsuda M., Ohkura C., Matsuo T., Namba Y., Ohuchi Y., Aigaki T. Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila. J. Biol. Chem. 2007, 282:11180-11187.
27. Goberdhan D.C., Paricio N., Goodman E.C., Mlodzik M., Wilson C. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev. 1999, 13:3244-3258.
28. Leissring M.A., Farris W., Wu X., Christodoulou D.C., Haigis M.C., Guarente L., Selkoe D.J. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. Biochem. J. 2004, 383:439-446.
29. Haigis M.C., et al. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell 2006, 126:941-954.