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de Bont JM, Packer RJ, Michiels EM, den Boer ML, Pieters R. Biological background of pediatric medulloblastoma and ependymoma: a review from a translational research perspective. Neuro Oncol. 10, 1040-1060 (2008). Excellent perspective on newly developed array-based techniques for studying gene expression, protein expression, copy number aberrations and epigenetic events in pediatric medulloblastomas and ependymomas.
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Meta-analysis of all comparative genomic hybridization studies on primary ependymomas examining more than 300 tumors. The potential biological markers of prognosis in pediatric ependymoma are assessed and the ependymoma cancer stem cell hypothesis is highlighted with respect to tumor resistance and recurrence. A shifting paradigm for treatment modalities in ependymoma targeting molecular alterations in tumor-initiating cell populations is discussed
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Kilday JP, Rahman R, Dyer S et al. Pediatric ependymoma: biological perspectives. Mol Cancer Res. 7, 765-786 (2009). Meta-analysis of all comparative genomic hybridization studies on primary ependymomas examining more than 300 tumors. The potential biological markers of prognosis in pediatric ependymoma are assessed and the ependymoma cancer stem cell hypothesis is highlighted with respect to tumor resistance and recurrence. A shifting paradigm for treatment modalities in ependymoma targeting molecular alterations in tumor-initiating cell populations is discussed.
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188
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