Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy

Neuro-Oncology

Volumn 11, Issue 2, 2009, Pages 201-210

  Rutkowski, Stefan ^a   Gerber, Nicolas Ulrich ^a   Von Hoff, Katja ^a   Gnekow, Astrid ^b   Bode, Udo ^c   Graf, Norbert ^d   Berthold, Frank ^e   Henze, Günter ^f   Wolff, Johannes E A ^g   Warmuth Metz, Monika ^a   Soerensen, Niels ^a   Emser, Angela ^h   Ottensmeier, Holger ^a   Deinlein, Frank ^a   Schlegel, Paul Gerhardt ^a   Kortmann, Rolf Dieter ⁱ   Pietsch, Torsten ^c   Kuehl, Joachim ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b KLINIKUM AUGSBURG   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d SAARLAND UNIVERSITY   (Germany)

^e UNIVERSITY OF COLOGNE   (Germany)

^f HUMBOLDT UNIVERSITY   (Germany)

^g TEXAS CHILDREN S CANCER CENTER   (United States)

^h JOHANNES GUTENBERG UNIVERSITY   (Germany)

ⁱ UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Chemotherapy; Histology; Medulloblastoma; Prognosis; Radiotherapy

Indexed keywords

CISPLATIN; CYTARABINE; ETOPOSIDE; FOLINATE CALCIUM; IFOSFAMIDE; MESNA; METHOTREXATE; PROCARBAZINE; VINCRISTINE;

ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; INFANT; MALE; MEDULLOBLASTOMA; METASTASIS; MULTIPLE CYCLE TREATMENT; NEUROPSYCHOLOGICAL TEST; POSTOPERATIVE CARE; PRESCHOOL CHILD; PROGNOSIS; SALVAGE THERAPY; SEX DIFFERENCE; THERAPY DELAY; TUMOR GROWTH; UNSPECIFIED SIDE EFFECT;

ANTINEOPLASTIC AGENTS; CEREBELLAR NEOPLASMS; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; CRANIAL IRRADIATION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; INFANT; MALE; MEDULLOBLASTOMA; NEOPLASM RECURRENCE, LOCAL; PILOT PROJECTS; PROGNOSIS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 65949119515     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1215/15228517-2008-084     Document Type: Article

References (40)

1. Kaatsch P, Rickert CH, Kuhl J, et al. Population-based epidemiologic data on brain tumors in German children. Cancer. 2001;92:3155-3164.
2. Kellie SJ. Chemotherapy of central nervous system tumours in infants. Childs Nerv Syst. 1999;15:592-612.
3. Evans AE, Jenkin RD, Sposto R, et al. The treatment of medulloblas- toma. Results of a prospective randomized trial of radiation therapy with and without CCNU, vincristine, and prednisone. J Neurosurg. 1990;72:572-582.
4. Zeltzer PM, Boyett JM, Finlay JL, et al. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblas- toma in children: conclusions from the Children's Cancer Group 921 randomized phase III study. J Clin Oncol. 1999;17:832-845.
5. Packer RJ, Rood BR, MacDonald TJ. Medulloblastoma: present con- cepts of stratification into risk groups. Pediatr Neurosurg. 2003; 39:60-67.
6. Mulhern RK, Horowitz ME, Kovnar EH, et al. Neurodevelopmental status of infants and young children treated for brain tumors with pre- irradiation chemotherapy. J Clin Oncol. 1989;7:1660-1666.
7. Jenkin D, Danjoux C, Greenberg M. Subsequent quality of life for chil- dren irradiated for a brain tumor before age four years. Med Pediatr Oncol. 1998;31:506-511.
8. Kiltie AE, Lashford LS, Gattamaneni HR. Survival and late effects in medulloblastoma patients treated with craniospinal irradiation under three years old. Med Pediatr Oncol. 1997;28:348-354.
9. Hoppe-Hirsch E, Brunet L, Laroussinie F, et al. Intellectual outcome in children with malignant tumors of the posterior fossa: influence of the field of irradiation and quality of surgery. Childs Nerv Syst. 1995;11:340-346.
10. Mulhern RK, Palmer SL, Merchant TE, et al. Neurocognitive conse- quences of risk-adapted therapy for childhood medulloblastoma. J Clin Oncol. 2005;23:5511-5519.
11. Palmer SL, Goloubeva O, Reddick WE, et al. Patterns of intellectual development among survivors of pediatric medulloblastoma: a longi- tudinal analysis. J Clin Oncol. 2001;19:2302-2308.
12. Goldwein JW, Radcliffe J, Johnson J, et al. Updated results of a pilot study of low dose craniospinal irradiation plus chemotherapy for chil- dren under five with cerebellar primitive neuroectodermal tumors (medulloblastoma). Int J Radiat Oncol Biol Phys. 1996;34:899-904.
13. Duffner PK, Horowitz ME, Krischer JP, et al. Postoperative chemo- therapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med. 1993;328:1725-1731.
14. Saran FH, Driever PH, Thilmann C, et al. Survival of very young chil- dren with medulloblastoma (primitive neuroectodermal tumor of the posterior fossa) treated with craniospinal irradiation. Int J Radiat Oncol Biol Phys. 1998;42:959-967.
15. Geyer JR, Zeltzer PM, Boyett JM, et al. Survival of infants with primi- tive neuroectodermal tumors or malignant ependymomas of the CNS treated with eight drugs in 1 day: a report from the Children's Cancer Group. J Clin Oncol. 1994;12:1607-1615.
16. White L, Kellie S, Gray E, et al. Postoperative chemotherapy in children less than 4 years of age with malignant brain tumors: promising initial response to a VETOPEC-based regimen. A Study of the Australian and New Zealand Children's Cancer Study Group (ANZCCSG). J Pediatr Hematol Oncol. 1998;20:125-130.
17. Ater JL, van Eys J, Woo SY, et al. MOPP chemotherapy without irra- diation as primary postsurgical therapy for brain tumors in infants and young children. J Neurooncol. 1997;32:243-252.
18. Rutkowski S, Bode U, Deinlein F, et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005;352:978-986.
19. Geyer JR, Sposto R, Jennings M, et al. Multiagent chemotherapy and deferred radiotherapy in infants with malignant brain tumors: a report from the Children's Cancer Group. J Clin Oncol. 2005;23:7621-7631.
20. Grill J, Sainte-Rose C, Jouvet A, et al. Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children. Lancet Oncol. 2005;6:573-580.
21. Rutkowski S. Current treatment approaches to early childhood medulloblastoma. Expert Rev Neurother. 2006;6:1211-1221.
22. Kalifa C, Grill J. The therapy of infantile malignant brain tumors: cur- rent status? J Neurooncol. 2005;75:279-285.
23. Walker DA, Wilne S. Treatment of medulloblastoma in young chil- dren. Lancet Oncol. 2005;6:541-542.
24. Kuhl J, Beck J, Bode U, et al. Delayed radiation therapy after post- operative chemotherapy in children less than 3 years of age with medulloblastoma. Results of the trial HIT-SKK'87, and preliminary results of the pilot trial HIT-SKK'92 [abstract]. Med Pediatr Oncol. 1995;25:250.
25. Giangaspero F, Bigner SH, Kleihues P, Pietsch T, Trojanowski JQ. Medulloblastoma. In: Kleihues P, Cavenee, WK, eds. WHO Classifica- tion of Tumours of the Central Nervous System. Lyon, France: IARC Press; 2000:129-137.
26. Chang CH, Housepian EM, Herbert C Jr. An operative staging system and a megavoltage radiotherapeutic technic for cerebellar medullo- blastomas. Radiology. 1969;93:1351-1359.
27. Raven JC. Coloured Progressive Matrices. Revised Order. London: Lewis; 1956.
28. Melchers P. Preuß U. Kaufmann Assessment Battery for Children- deutschsprachige Fassung (K-ABC). Frankfurt: Swets; 1994.
29. Beery, KE. Beery Developmental Test of Visual-Motor Integration: Administration, Scoring and Teaching Manual. Cleveland: Modern Curriculum Press; 1989.
30. Timmermann B, Kortmann RD, Kuhl J, et al. Role of radiotherapy in supratentorial primitive neuroectodermal tumor in young children: results of the German HIT-SKK87 and HIT-SKK92 trials. J Clin Oncol. 2006;24:1554-1560.
31. Collett D. Strategy for model selection. In: Collett D, ed. Modelling Survival Data in Medical Research. London: CRC Press/Chapman and Hall; 1994:78-83.
32. Clarke JW, Hadziahmetovic M, Tzou K, et al. What is the best adjuvant treatment for very young patients with medulloblastoma? Expert Rev Neurother. 2007;7:373-381.
33. Duffner PK. Long-term effects of radiation therapy on cognitive and endocrine function in children with leukemia and brain tumors. Neu- rologist. 2004;10:293-310.
34. Attard-Montalto S, Plowman N, Breatnach F, et al. Is there a danger in delaying radiotherapy in childhood medulloblastoma? Br J Radiol. 1993;66:807-813.
35. Hartsell WF, Gajjar A, Heideman RL, et al. Patterns of failure in chil- dren with medulloblastoma: effects of preirradiation chemotherapy. Int J Radiat Oncol Biol Phys. 1997;39:15-24.
36. Giangaspero F, Perilongo G, Fondelli MP, et al. Medulloblastoma with extensive nodularity: a variant with favorable prognosis. J Neurosurg. 1999;91:971-977.
37. McManamy CS, Pears J, Weston CL, et al. Nodule formation and des- moplasia in medulloblastomas-defining the nodular/desmoplastic variant and its biological behavior. Brain Pathol. 2007;17:151-164.
38. Giangaspero F, Eberhart CG, Haapasalo H, Pietsch T, Wiestler OD, Ellison DW. Medulloblastoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, eds. WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC Press; 2007:132-140.
39. Cattell R. Advances in Psychology. Amsterdam: Elsevier; 1987.
40. Mulhern RK, Palmer SL, Reddick WE, et al. Risks of young age for selected neurocognitive deficits in medulloblastoma are associated with white matter loss. J Clin Oncol. 2001;19:472-479.