Activation of the ERK/MAPK pathway: A signature genetic defect in posterior fossa pilocytic astrocytomas

Journal of Pathology

Volumn 218, Issue 2, 2009, Pages 172-181

  Forshew, Tim ^a   Tatevossian, Ruth G ^a,b   Lawson, Andrew R J ^a   Ma, Jing ^c   Neale, Geoff ^c   Ogunkolade, Babatunji W ^a   Jones, Tania A ^a   Aarum, Johan ^a   Dalton, James ^c   Bailey, Simon ^d   Chaplin, Tracy ^a   Carter, Rowena L ^a   Gajjar, Amar ^c   Broniscer, Alberto ^c   Young, Bryan D ^a   Ellison, David W ^c   Sheer, Denise ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^d ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

Astrocytoma; BRAF; Cerebellum; DNA copy number; Gene fusion; Pilocytic; RAF1

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN;

ADOLESCENT; ADULT; ARTICLE; ASTROCYTOMA; CHILD; CHROMOSOME 3P; CHROMOSOME 7Q; CLINICAL ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; EXON; FEMALE; GENE FUSION; GENE MUTATION; HUMAN; HUMAN TISSUE; MALE; MUTATIONAL ANALYSIS; ONCOGENE H RAS; ONCOGENE K RAS; ONCOGENE N RAS; PILOCYTIC ASTROCYTOMA; POSTERIOR CRANIAL FOSSA TUMOR; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTO ONCOGENE; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; ASTROCYTOMA; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; DNA MUTATIONAL ANALYSIS; DNA, COMPLEMENTARY; ENZYME ACTIVATION; GTPASE-ACTIVATING PROTEINS; HUMANS; INFANT; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASES; ONCOGENE PROTEINS, FUSION; PROTO-ONCOGENE PROTEINS B-RAF; PROTO-ONCOGENE PROTEINS C-RAF; YOUNG ADULT;

EID: 66849099801     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2558     Document Type: Article

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