Pilot study of high-dose thiotepa and etoposide with autologous bone marrow rescue in children and young adults with recurrent CNS tumors

Journal of Clinical Oncology

Volumn 14, Issue 9, 1996, Pages 2495-2503

  Finlay, J L ^a   Goldman, S ^a   Wong, M C ^a   Cairo, M ^a   Garvin, J ^a   August, C ^a   Cohen, B H ^a   Stanley, P ^a   Zimmerman, R A ^a   Bostrom, B ^a   Geyer, J R ^a   Harris, R E ^a   Sanders, J ^a   Yates, A J ^a   Boyett, J M ^a   Packer, R J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETOPOSIDE; THIOTEPA;

ADULT; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CANCER SURVIVAL; CENTRAL NERVOUS SYSTEM TUMOR; CLINICAL ARTICLE; GLIOMA; GRAFT SURVIVAL; HUMAN; MEDULLOBLASTOMA; NEUROECTODERM TUMOR; PRIORITY JOURNAL;

EID: 9544237124     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.1996.14.9.2495     Document Type: Article

References (35)

1. Torres CF, Rebsamen S, Silber JH, et al: Surveillance scanning of children with medulloblastoma. N Engl J Med 330:892-895, 1994
2. Goldwein JW, Glauser TA, Packer RJ, et al: Recurrent intracranial ependymomas in children. Survival, patterns of failure, and prognostic factors. Cancer 66:553-563, 1990
3. Finlay JL, Boyett JM, Yates AJ, et al: Randomized phase III trial in childhood high-grade astrocytoma comparing vincristine, lomustine and prednisone with the eight-drugs-in-1-day regimen. J Clin Oncol 13:112-123, 1995
4. Sposto R, Ertel IJ, Jenkin RDT, et al: The effectiveness of chemotherapy for treatment of high grade astrocytoma in children. Results of a randomized trial. A report from the Childrens Cancer Study Group. J Neurooncol 7:165-177, 1989
5. Longee DC, Friedman HS, Allbright RE, et al: Treatment of patients with recurrent gliomas with cyclophosphamide and vincristine. J Neurosurg 72:583-588, 1990
6. Bertolone SJ, Baum ES, Krivit W, et al: A phase II study of cisplatin therapy in recurrent childhood brain tumors. A report from the Childrens Cancer Study Group. J Neurooncol 7:5-11, 1989
7. Gaynon PS, Ettinger LJ, Baum ES, et al: Carboplatin in childhood brain tumors. A Childrens Cancer Study Group phase II trial. Cancer 66:2465-2469, 1990
8. Schabel FM, Griswold DP, Corbett TH, et al: Increasing the therapeutic response rates to antitumor drugs by applying the basic principles of pharmacology. Cancer 54:1160-1167, 1984 (suppl)
9. Nowak CH, Steinhoff G, Arnold W: Testing ifos/mesna and VP-16 combination therapy in the P388 leukemia model. Contrib Oncol 26:105-113, 1987
10. Ayash LJ, Antman K, Chesbon, BD: A perspective on dose intensive therapy with autologous bone marrow transplantation for solid tumors. Oncology 5:25-41, 1991
11. Hochberg FH, Parker LM, Takvorian T, et al: High dose BCNU with autologous bone marrow rescue for recurrent glioblastoma multiforme. J Neurosurg 54:455-460, 1981
12. Herzig RH, Phillips GL, Lazarus HL, et al: Bone marrow transplantation for the treatment of refractory malignancies, in Dicke KA, Spitzer G, Zander AR (eds): Autologous Bone Marrow transplantation. First International Symposium. Houston, TX, University of Texas M.D. Anderson Cancer Center, 1985, pp 255-259
13. Phillips GL, Wolff SN, Fay JW, et al: Intensive l,3-bis(2-chloroethyl)-l-nitrosourea (BCNU) monochemotherapy and autologous marrow transplantation for malignant glioma. J Clin Oncol 4:639-645, 1986
14. Wolff SN, Phillips GL, Fay JW, et al: High dose chemotherapy with autologous marrow transplantation for gliomas of the central nervous system, in Dicke KA, Spitzer G, Jagannath S (eds): Autologous Bone Marrow Transplantation. Third International Symposium. Houston, TX, University of Texas M.D. Anderson Cancer Center, 1985, pp 557-563
15. Biron P, Mornex F, Colombat P, et al: High dose BCNU and ABMR, surgery and radiotherapy in gliomas, in Dicke KA, Spitzer G, Jagannath S, Eringer-Hodges MJ (eds): Autologous Bone Marrow Transplantation. Fourth International Symposium. Houston, TX, University of Texas M.D. Anderson Cancer Center, 1989, pp 437-447
16. Johnson DB, Thompson JM, Corwin JA, et al: Adjuvant high dose BCNU and autologous bone marrow transplantation for high grade malignant gliomas, in Dicke KA, Spitzer G, Jagannath S, Eringer-Hodges MJ (eds): Autologous Bone Marrow Transplantation. Fourth International Symposium. Houston, TX, University of Texas M.D. Anderson Cancer Center, 1989, pp 457-461
17. Ascencao J, Ahmed T, Feldman E, et al: High dose thiotepa with autologous bone marrow transplantation (ABMT) and localized radiotherapy (RT) for patients (PTS) with astrocytoma grade III-IV (glioma): A promising approach. Proc Am Soc Clin Oncol 8:90, 1989 (abstr)
18. Mbidde EK, Selby PJ, Perren TJ, et al: High dose BCNU chemotherapy with autologous bone marrow transplantation and full dose radiotherapy for grade IV astrocytoma. Br J Cancer 58:779-782, 1988
19. Wolff SN, Phillips GL, Herzig GP, et al: High dose carmustine with autologous bone marrow transplantation for the adjuvant treatment of high grade gliomas of the central nervous system. Cancer Treat Rep 71:183-185, 1987
20. Fingert HJ, Hochberg FH: Megadose chemotherapy with bone marrow rescue. Prog Exp Tumor Res 28:67-78, 1984
21. Finlay JL, Knipple J, Turski P, et al: Pharmacokinetic studies of thiotepa in dogs following delivery by various routes. J Neurooncol 4:110, 1986 (abstr)
22. Heidernan RL, Cole DE, Balis F, et al: Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: Evidence for dose-dependent plasma clearance of thiotepa. Cancer Res 49:736-741, 1989
23. Stewart DJ, Richard MT, Hugenholtz H, et al: Penetration of VP-16 (etoposide) into human intracerebral and extracerebral tumors. J Neurooncol 2: 133-139, 1984
24. Edwards MS, Levin VA, Seager ML, et al: Phase II evaluation of thiotepa for treatment of central nervous system tumors. Cancer Treat Rep 73:1419-1421, 1979
25. Heidernan RL, Packer RJ, Reaman GH, et al: A phase II evaluation of thiotepa in pediatric central nervous system malignancies. Cancer 72:271-275, 1993
26. Radice PA, Bunn PA Jr, Ihde DC: Therapeutic trials with VP-16-213 and VM-26:Active agents in small cell lung cancer, non-Hodgkins lymphoma and other malignancies. Cancer Treat Rep 63:1231-1239, 1979
27. Tirelli U, D'Incalci M, Canetta R, et al: Etoposide (VP-16-213) in malignant brain tumors. A phase II study. J Clin Oncol 2:432-437, 1984
28. Finlay JL, August C, Packer R, et al: High dose multiagent chemotherapy followed by bone marrow rescue for malignant astrocytomas of childhood and adolescence. J Neurooncol 9:239-248, 1990
29. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
30. Peto R, Pike MC, Armitage P, et al: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Part 1. Introduction and design. Br J Cancer 34:585-612, 1976
31. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163-170, 1966
32. Kramer E, Thompson SJ, Bayer LA, et al: Neurotoxicity associated with high dose chemotherapy and autologous marrow rescue. Sixth International Symposium of Pediatric Neuro-oncology, Houston, Texas, 1994. Pediatr Neurosurg 21:271, 1994 (abstr)
33. Finlay JL, Geyer JR, Turski PA, et al: Pre-irradiation chemotherapy in children with high-grade astrocytoma: Tumor response to two cycles of the "eight-drugs-in-one-day" regimen: A Childrens Cancer Group study CCG-945. J Neurooncol 21:255-265, 1994
34. Finlay JL, Garvin J, Alien JC, et al: High-dose chemotherapy (HDCx) with autologous marrow rescue (ABMR) in patients with recurrent medulloblastoma/PNET. Proc Am Soc Clin Oncol 13:176, 1994 (abstr)
35. Faulkner LB, Lindsley KL, Kher W, et al: High-dose chemotherapy with autologous marrow rescue for malignant brain tumors: Analysis of the impact of prior chemotherapy and craniospinal irradiation on hematopoietic recovery. Bone Marrow Transplant 17:389-394, 1996