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Volumn 2, Issue , 2009, Pages 39-49

Manifestation of renal disease in obesity: Pathophysiology of obesity-related dysfunction of the kidney

Author keywords

Adiponectin; Albuminuria; Glomerulomegaly; Insulin; Leptin; Obesity; Podocyte hypertrophy

Indexed keywords

ADIPONECTIN; FATTY ACID; INSULIN; LEPTIN; NEPHRIN; PODOCIN; RESISTIN;

EID: 77953458310     PISSN: None     EISSN: 11787058     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (17)

References (80)
  • 1
    • 1442334070 scopus 로고    scopus 로고
    • Predictors of new-onset kidney disease in a community-based population
    • Fox C, Larson M, Leip E, Culleton B, Wilson P, Levy D. Predictors of new-onset kidney disease in a community-based population. JAMA. 2004;291:844-850.
    • (2004) JAMA , vol.291 , pp. 844-850
    • Fox, C.1    Larson, M.2    Leip, E.3    Culleton, B.4    Wilson, P.5    Levy, D.6
  • 2
    • 67649855154 scopus 로고    scopus 로고
    • Does greater adiposity increase blood pressure and hypertension risk? Mendelian randomization using the FTO/MC4R genotype
    • Timpson N, Harbord R, Smith G, Zacho J, Tybjaerg-Hansen A, Nordestgaard B. Does greater adiposity increase blood pressure and hypertension risk? Mendelian randomization using the FTO/MC4R genotype. Hypertension. 2009;54:84-90.
    • (2009) Hypertension , vol.54 , pp. 84-90
    • Timpson, N.1    Harbord, R.2    Smith, G.3    Zacho, J.4    Tybjaerg-Hansen, A.5    Nordestgaard, B.6
  • 3
    • 67649863789 scopus 로고    scopus 로고
    • Low cardiorespiratory fitness levels and elevated blood pressure. What is the contribution of visceral adiposity?
    • Rheaume C, Arsenaylt, Belanger S, et al. Low cardiorespiratory fitness levels and elevated blood pressure. What is the contribution of visceral adiposity? Hypertension. 2009;54:91-97.
    • (2009) Hypertension , vol.54 , pp. 91-97
    • Rheaume, C.1    Arsenaylt, B.S.2
  • 5
    • 67651119970 scopus 로고    scopus 로고
    • Body mass index modifies the risk of cardiovascular death in proteinuric chronic kidney disease
    • Obermayr R, Temml C, Gutjahr G, et al. Body mass index modifies the risk of cardiovascular death in proteinuric chronic kidney disease. Nephrology Dialysis and Transplantation. 2009;24:2421-2428.
    • (2009) Nephrology Dialysis and Transplantation , vol.24 , pp. 2421-2428
    • Obermayr, R.1    Temml, C.2    Gutjahr, G.3
  • 6
    • 41449110029 scopus 로고    scopus 로고
    • Renal injury in extremely obese patients with normal renal function
    • Serra A, Romero R, Lopez D, et al. Renal injury in extremely obese patients with normal renal function. Kidney International. 2008;73:947-955.
    • (2008) Kidney International , vol.73 , pp. 947-955
    • Serra, A.1    Romero, R.2    Lopez, D.3
  • 7
    • 77953417609 scopus 로고    scopus 로고
    • Pathological influence of obesity on renal structural changes in chronic kidney disease
    • Kato S, Nazneen A, Nakashima Y, et al. Pathological influence of obesity on renal structural changes in chronic kidney disease. Clinical Experimental Nephrology. 2009;9:169-173.
    • (2009) Clinical Experimental Nephrology , vol.9 , pp. 169-173
    • Kato, S.1    Nazneen, A.2    Nakashima, Y.3
  • 8
    • 71049171278 scopus 로고    scopus 로고
    • Early histological changes in the kidney of people with morbid obesity
    • July 13, Epub ahead of print
    • Goumenos D, Kawar B, El Nahas M, et al. Early histological changes in the kidney of people with morbid obesity. Nephrology Dialysis and Transplantation. 2009 July 13, [Epub ahead of print].
    • (2009) Nephrology Dialysis and Transplantation
    • Goumenos, D.1    Kawar, B.2    El Nahas, M.3
  • 9
    • 2142771733 scopus 로고    scopus 로고
    • Risk factors for obstructive sleep apnea in adults
    • Young T, Skatrud J, Peppard PE. Risk factors for obstructive sleep apnea in adults. JAMA. 2004;291:2013.
    • (2004) JAMA , vol.291 , pp. 2013
    • Young, T.1    Skatrud, J.2    Peppard, P.E.3
  • 10
    • 0034636477 scopus 로고    scopus 로고
    • Prospective study of the association between sleep-disordered breathing and hypertension
    • Peppard PE, Young T, Palta M, Skatrud J. Prospective study of the association between sleep-disordered breathing and hypertension. NEJM. 2000;342:1378.
    • (2000) NEJM , vol.342 , pp. 1378
    • Peppard, P.E.1    Young, T.2    Palta, M.3    Skatrud, J.4
  • 12
    • 0023928720 scopus 로고
    • Reversible proteinuria in obstructive sleep apnea syndrome
    • Sklar A, Chaudhary B. Reversible proteinuria in obstructive sleep apnea syndrome. Archives of Internal Medicine. 1988;148:87-89.
    • (1988) Archives of Internal Medicine , vol.148 , pp. 87-89
    • Sklar, A.1    Chaudhary, B.2
  • 13
    • 0024552346 scopus 로고
    • Nocturnal urinary protein excretion rates in patients with sleep apnea
    • Sklar AH, Chaudhary BA, Harp R. Nocturnal urinary protein excretion rates in patients with sleep apnea. Nephron. 1989;51:35-38.
    • (1989) Nephron , vol.51 , pp. 35-38
    • Sklar, A.H.1    Chaudhary, B.A.2    Harp, R.3
  • 14
    • 47149094110 scopus 로고    scopus 로고
    • Association of obstructive sleep apnea with urinary albumin excretion in essential hypertension: A cross-sectional study
    • Tsioufis C, Thomopoulos C, Dimitriadis K, et al. Association of obstructive sleep apnea with urinary albumin excretion in essential hypertension: a cross-sectional study. Am J Kidney Dis. 2008;52:285-293.
    • (2008) Am J Kidney Dis , vol.52 , pp. 285-293
    • Tsioufis, C.1    Thomopoulos, C.2    Dimitriadis, K.3
  • 16
    • 0027103878 scopus 로고
    • Obesity-associated focal segmental glomerulosclerosis: Pathologic features of the lesion and relationship with cardiomegaly and hyperlipidemia
    • Verani R. Obesity-associated focal segmental glomerulosclerosis: pathologic features of the lesion and relationship with cardiomegaly and hyperlipidemia. Am J Kidney Diseases. 1992;20:629-634.
    • (1992) Am J Kidney Diseases , vol.20 , pp. 629-634
    • Verani, R.1
  • 17
    • 77953411308 scopus 로고    scopus 로고
    • Excessive body weight as a new risk factor for clinical and pathological progression in primary IgA nephritis
    • Bonnett F, Deprele C, Sassolas A, et al. Excessive body weight as a new risk factor for clinical and pathological progression in primary IgA nephritis. American J of Kidney Disease. 2001;37:1-12.
    • (2001) American J of Kidney Disease , vol.37 , pp. 1-12
    • Bonnett, F.1    Deprele, C.2    Sassolas, A.3
  • 18
    • 0034641647 scopus 로고    scopus 로고
    • Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF kappa B signaling through a cyclic AMP-dependent pathway
    • Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF kappa B signaling through a cyclic AMP-dependent pathway. Circulation. 2000;102:1296-1301.
    • (2000) Circulation , vol.102 , pp. 1296-1301
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 19
    • 77953438591 scopus 로고
    • Crescenteric glomerulonephritis
    • Chapter 3, Editor Seymour Rosen. Churchill-Livingston, New York
    • Stilmant M. Crescenteric glomerulonephritis. Chapter 3, page 40 in Pathology of Glomerular Disease, Editor Seymour Rosen. Churchill-Livingston, New York, 1983.
    • (1983) page 40 in Pathology of Glomerular Disease
    • Stilmant, M.1
  • 20
    • 0030923725 scopus 로고    scopus 로고
    • Hall J Mechanisms of abnormal renal sodium handling in obesity. Hypertension. Amer J Hypertension. 1997;10:49S-55S.
    • Hall J Mechanisms of abnormal renal sodium handling in obesity. Hypertension. Amer J Hypertension. 1997;10:49S-55S.
  • 22
    • 47549088476 scopus 로고    scopus 로고
    • Primary Aldosteronism Prevalence in hYpertension Study Investigators. Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertension patients
    • Rossi GP, Belfiore A, Bernini G, et al; Primary Aldosteronism Prevalence in hYpertension Study Investigators. Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertension patients. J Clin Endocrinol Metab. 2008;93:2566-2571.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2566-2571
    • Rossi, G.P.1    Belfiore, A.2    Bernini, G.3
  • 25
    • 0029120410 scopus 로고
    • Combined renal effects of overweight and hypertension
    • Ribstein J, du Cailar G, Mimran A. Combined renal effects of overweight and hypertension. Hypertension. 1995;26:610-615.
    • (1995) Hypertension , vol.26 , pp. 610-615
    • Ribstein, J.1    du Cailar, G.2    Mimran, A.3
  • 26
    • 0028085621 scopus 로고
    • Hemodynamic actions of insulin
    • 267: Endocrinology Metabolism
    • Baron A. Hemodynamic actions of insulin. The American Journal of Physiology. 1994;267: Endocrinology Metabolism 30:E187-E202.
    • (1994) The American Journal of Physiology , vol.30
    • Baron, A.1
  • 27
    • 65449118525 scopus 로고    scopus 로고
    • Effects of a modified low calorie diet in metabolic changes and kidney histology in young obese Zucker rats
    • Liao J, Richards R, Zhang R, Reisin E. Effects of a modified low calorie diet in metabolic changes and kidney histology in young obese Zucker rats. J Am Soc Nephrology. 2007;18:823A.
    • (2007) J Am Soc Nephrology , vol.18
    • Liao, J.1    Richards, R.2    Zhang, R.3    Reisin, E.4
  • 28
    • 0037309569 scopus 로고    scopus 로고
    • Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies
    • Morales E, Valero M, Leon M, Hernandez E, Praga M. Beneficial effects of weight loss in overweight patients with chronic proteinuric nephropathies. Am J Kidney Dis. 2003;41:319-327.
    • (2003) Am J Kidney Dis , vol.41 , pp. 319-327
    • Morales, E.1    Valero, M.2    Leon, M.3    Hernandez, E.4    Praga, M.5
  • 30
    • 66349105917 scopus 로고    scopus 로고
    • Metformin prevents progression of heart failure in dogs. Role of AMP-activated protein kinase
    • Sasaki, Asanum H, Fujita M, et al. Metformin prevents progression of heart failure in dogs. Role of AMP-activated protein kinase. Circulation. 2009;119:2568-2577.
    • (2009) Circulation , vol.119 , pp. 2568-2577
    • Sasaki1    Asanum, H.2    Fujita, M.3
  • 31
    • 34047099749 scopus 로고    scopus 로고
    • Nephrin is critical for the action of insulin on human glomerular podocytes
    • Coward RJM, Welsh GI, Kopziell A, et al. Nephrin is critical for the action of insulin on human glomerular podocytes. Diabetes. 2007;56:1127-1135.
    • (2007) Diabetes , vol.56 , pp. 1127-1135
    • Coward, R.J.M.1    Welsh, G.I.2    Kopziell, A.3
  • 32
    • 43049095682 scopus 로고    scopus 로고
    • Adiponectin regulates albuminuria and podocyte function in mice
    • Sharma K, RamachandraRao S, Qiu G, et al. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest. 2008;118:1645-1656.
    • (2008) J Clin Invest , vol.118 , pp. 1645-1656
    • Sharma, K.1    RamachandraRao, S.2    Qiu, G.3
  • 33
    • 16644363689 scopus 로고    scopus 로고
    • Obesity-initiated metabolic syndrome and the kidney: A recipe for chronic renal disease?
    • Bagby S. Obesity-initiated metabolic syndrome and the kidney: A recipe for chronic renal disease? J of the American Society of Nephrology. 2004;15:2775-2791.
    • (2004) J of the American Society of Nephrology , vol.15 , pp. 2775-2791
    • Bagby, S.1
  • 34
    • 0029962286 scopus 로고    scopus 로고
    • Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats
    • Kim J, Wi J, Youn J. Plasma free fatty acids decrease insulin-stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes. 1996;45:446-453.
    • (1996) Diabetes , vol.45 , pp. 446-453
    • Kim, J.1    Wi, J.2    Youn, J.3
  • 35
    • 34548850880 scopus 로고    scopus 로고
    • Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells
    • Hitomi H, Kiyomoto H, Nishiyama A, et al. Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells. Hypertension. 2007;50:750-755.
    • (2007) Hypertension , vol.50 , pp. 750-755
    • Hitomi, H.1    Kiyomoto, H.2    Nishiyama, A.3
  • 36
    • 15744377168 scopus 로고    scopus 로고
    • Aldosterone activates vascular p38MAP kinase and NADP oxidase via c-Src
    • Callera G, Touyz R, Tostes R, et al. Aldosterone activates vascular p38MAP kinase and NADP oxidase via c-Src. Hypertension. 2005;45:773-779.
    • (2005) Hypertension , vol.45 , pp. 773-779
    • Callera, G.1    Touyz, R.2    Tostes, R.3
  • 37
    • 65249153029 scopus 로고    scopus 로고
    • RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes
    • Apr;
    • Coughlan MT, Thorburn DR, Penfold SA, et al. RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. J Am Soc Nephrol. 2009 Apr;20(4):742-752.
    • (2009) J Am Soc Nephrol , vol.20 , Issue.4 , pp. 742-752
    • Coughlan, M.T.1    Thorburn, D.R.2    Penfold, S.A.3
  • 38
    • 0037406905 scopus 로고    scopus 로고
    • Glucose, glycation, and RAGE: Implications for amplification of cellular dysfunction in diabetic nephropathy
    • Wendt T, Tanji N, Guo J, et al. Glucose, glycation, and RAGE: Implications for amplification of cellular dysfunction in diabetic nephropathy. J American Society of Nephrology. 2003;14:1383-1395.
    • (2003) J American Society of Nephrology , vol.14 , pp. 1383-1395
    • Wendt, T.1    Tanji, N.2    Guo, J.3
  • 39
    • 67650691748 scopus 로고    scopus 로고
    • Unexpected high prevalence of cardiovascular complications in type 1 diabetes of extreme duration
    • Geltman J, Sun J, Keenan H, et al. Unexpected high prevalence of cardiovascular complications in type 1 diabetes of extreme duration. Diabetes. 2009;58:(S1)A199.
    • (2009) Diabetes , vol.58 , Issue.S1
    • Geltman, J.1    Sun, J.2    Keenan, H.3
  • 40
    • 65549105834 scopus 로고    scopus 로고
    • Specific local cardiovascular changes of N (carboxymethyl) lysine, vascular endothelial growth factor and Smad2 in the developing embryos coincide with maternal diabetes-induced congenital heart defects
    • Roest P, Molin D, Schralkwijk C, et al. Specific local cardiovascular changes of N (carboxymethyl) lysine, vascular endothelial growth factor and Smad2 in the developing embryos coincide with maternal diabetes-induced congenital heart defects. Diabetes. 2009;58:1222-1228.
    • (2009) Diabetes , vol.58 , pp. 1222-1228
    • Roest, P.1    Molin, D.2    Schralkwijk, C.3
  • 41
    • 0344286498 scopus 로고    scopus 로고
    • Activation of receptor for advanced glycation end products: A mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis
    • Schmidt AM, Yan S, Wautier J, Stern D. Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circulation Research. 1999;84:489-497.
    • (1999) Circulation Research , vol.84 , pp. 489-497
    • Schmidt, A.M.1    Yan, S.2    Wautier, J.3    Stern, D.4
  • 42
    • 36848998955 scopus 로고    scopus 로고
    • PPAR alpha protects proximal tubular cells from acute fatty acid toxicity
    • Kamijo Y, Hora K, Kono K, et al. PPAR alpha protects proximal tubular cells from acute fatty acid toxicity. J Am Soc Nephrology. 2007;18:3089-4011.
    • (2007) J Am Soc Nephrology , vol.18 , pp. 3089-4011
    • Kamijo, Y.1    Hora, K.2    Kono, K.3
  • 43
    • 70349241849 scopus 로고    scopus 로고
    • Ameliorating hypertension and insulin resistance ion subjects at increased cardiovascular risk
    • Ruggenti P, Cattaneo D, Loriga G, et al. Ameliorating hypertension and insulin resistance ion subjects at increased cardiovascular risk. Hypertension. 2009;54:567-574.
    • (2009) Hypertension , vol.54 , pp. 567-574
    • Ruggenti, P.1    Cattaneo, D.2    Loriga, G.3
  • 44
    • 0029983884 scopus 로고    scopus 로고
    • A fatty acid-induced decrease in pyruvate hydrogenase activity is an important determination of beta-cell dysfunction in the obese diabetic db/db mouse
    • Zhou Y, Berggren P, Grill V. A fatty acid-induced decrease in pyruvate hydrogenase activity is an important determination of beta-cell dysfunction in the obese diabetic db/db mouse. Diabetes. 1996;45:580-586.
    • (1996) Diabetes , vol.45 , pp. 580-586
    • Zhou, Y.1    Berggren, P.2    Grill, V.3
  • 45
    • 0030152610 scopus 로고    scopus 로고
    • Disordered expression of glyoclytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency
    • Hotta K, Kuwajima M, Ono A, et al. Disordered expression of glyoclytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency. Diabetes Research Clinical Practice. 1996;32:117-123.
    • (1996) Diabetes Research Clinical Practice , vol.32 , pp. 117-123
    • Hotta, K.1    Kuwajima, M.2    Ono, A.3
  • 47
    • 58149119483 scopus 로고    scopus 로고
    • Aldosterone induces collagen synthesis via activation of extracellular signal-regulated kinase 1 and 2 in renal proximal tubules
    • Xu G, Liu A, Liu X. Aldosterone induces collagen synthesis via activation of extracellular signal-regulated kinase 1 and 2 in renal proximal tubules. Nephrology. 2008;13:694-701.
    • (2008) Nephrology , vol.13 , pp. 694-701
    • Xu, G.1    Liu, A.2    Liu, X.3
  • 49
    • 34447318485 scopus 로고    scopus 로고
    • Adiponectin and renal function, and implication as a risk factor of cardiovascular disease
    • Iwashima Y, Horio T, Kumada M, et al. Adiponectin and renal function, and implication as a risk factor of cardiovascular disease. Am J Cardiol. 2006;98:1603-1608.
    • (2006) Am J Cardiol , vol.98 , pp. 1603-1608
    • Iwashima, Y.1    Horio, T.2    Kumada, M.3
  • 50
    • 34548529961 scopus 로고    scopus 로고
    • Adiponectin in children with chronic kidney disease: Role of adiposity and kidney dysfunction
    • Mitsnefes M, Kartal J, Khoury P, Daniels S. Adiponectin in children with chronic kidney disease: role of adiposity and kidney dysfunction. Clin J Am Soc Nephrol. 2007;2:46-50.
    • (2007) Clin J Am Soc Nephrol , vol.2 , pp. 46-50
    • Mitsnefes, M.1    Kartal, J.2    Khoury, P.3    Daniels, S.4
  • 51
    • 34548853985 scopus 로고    scopus 로고
    • Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults
    • Ellington AA, Malik AR, Klee GG, et al. Association of plasma resistin with glomerular filtration rate and albuminuria in hypertensive adults. Hypertension. 2007;50:708-714.
    • (2007) Hypertension , vol.50 , pp. 708-714
    • Ellington, A.A.1    Malik, A.R.2    Klee, G.G.3
  • 52
    • 0036091969 scopus 로고    scopus 로고
    • Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway
    • Vecchione C, Maffei A, Colella S, et al. Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes. 2002;51:168-173.
    • (2002) Diabetes , vol.51 , pp. 168-173
    • Vecchione, C.1    Maffei, A.2    Colella, S.3
  • 53
    • 65549086426 scopus 로고    scopus 로고
    • Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome
    • Straznicky N, Lambert G, McGrane M, et al. Weight loss may reverse blunted sympathetic neural responsiveness to glucose ingestion in obese subjects with metabolic syndrome. Diabetes. 2009;58:1126-1132.
    • (2009) Diabetes , vol.58 , pp. 1126-1132
    • Straznicky, N.1    Lambert, G.2    McGrane, M.3
  • 54
    • 67049100067 scopus 로고    scopus 로고
    • Free leptin is associated with masked hypertension in nonobese subjects
    • Thomopoulos C, Papadopoulos D, Papazachou O, et al. Free leptin is associated with masked hypertension in nonobese subjects. Hypertension. 2009;53:965-972.
    • (2009) Hypertension , vol.53 , pp. 965-972
    • Thomopoulos, C.1    Papadopoulos, D.2    Papazachou, O.3
  • 55
    • 58249087146 scopus 로고    scopus 로고
    • Modulation of blood pressure by central melanocortinergic pathways
    • Greenfield JR, Miller JW, Keogh JM, et al. Modulation of blood pressure by central melanocortinergic pathways. NEJM. 2009;360;44-52.
    • (2009) NEJM , vol.360 , pp. 44-52
    • Greenfield, J.R.1    Miller, J.W.2    Keogh, J.M.3
  • 56
    • 68049133174 scopus 로고    scopus 로고
    • A functional melanocortin system may be required for CNS-mediated antidiabetic and cardiovascular actions of leptin
    • da Silva A, do Carmo J, Freeman J, Tallum L, Hall J. A functional melanocortin system may be required for CNS-mediated antidiabetic and cardiovascular actions of leptin. Diabetes. 2009;58:1749-1756.
    • (2009) Diabetes , vol.58 , pp. 1749-1756
    • da Silva, A.1    do Carmo, J.2    Freeman, J.3    Tallum, L.4    Hall, J.5
  • 57
    • 0032899719 scopus 로고    scopus 로고
    • Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic
    • Haynes W, Morgan D, Djalali A, Svitz W, Mark A. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension. 1999;33:542-547.
    • (1999) Hypertension , vol.33 , pp. 542-547
    • Haynes, W.1    Morgan, D.2    Djalali, A.3    Svitz, W.4    Mark, A.5
  • 58
    • 65249102725 scopus 로고    scopus 로고
    • Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients
    • Greenstein AS, Khavandi K, Withers SB, et al. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation. 2009;119:1661-1670.
    • (2009) Circulation , vol.119 , pp. 1661-1670
    • Greenstein, A.S.1    Khavandi, K.2    Withers, S.B.3
  • 59
    • 0032964594 scopus 로고    scopus 로고
    • Evidence for a local renin angiotensin system in primary cultured human adipocytes
    • Schling P, Mallow H, Trindl A, Löffler G. Evidence for a local renin angiotensin system in primary cultured human adipocytes, J Obes Relat Metab Disord. 1999;23:336-411.
    • (1999) J Obes Relat Metab Disord , vol.23 , pp. 336-411
    • Schling, P.1    Mallow, H.2    Trindl, A.3    Löffler, G.4
  • 61
    • 10744220710 scopus 로고    scopus 로고
    • Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, et al. Human adipocytes secrete mineralocorticoid-releasing factors Proc Natl Acad Sci U S A. 2003 November 25;100(24):14211-14216.
    • Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, et al. Human adipocytes secrete mineralocorticoid-releasing factors Proc Natl Acad Sci U S A. 2003 November 25;100(24):14211-14216.
  • 62
    • 33750350450 scopus 로고    scopus 로고
    • Aldosterone blockade: An emerging strategy for abrogating progressive renal disease
    • Epstein M. Aldosterone blockade: an emerging strategy for abrogating progressive renal disease. Am J Med. 2006;119:912-919.
    • (2006) Am J Med , vol.119 , pp. 912-919
    • Epstein, M.1
  • 63
    • 33750331264 scopus 로고    scopus 로고
    • Selective aldosterone blockade with Eplerenone reduces albuminuria in patients with type 2 diabetes
    • Epstein M, Williams GH, Weinberger M, et al. Selective aldosterone blockade with Eplerenone reduces albuminuria in patients with type 2 diabetes. Clin J Am Soc Nephrol. 2006;1:940-951.
    • (2006) Clin J Am Soc Nephrol , vol.1 , pp. 940-951
    • Epstein, M.1    Williams, G.H.2    Weinberger, M.3
  • 66
    • 33644783770 scopus 로고    scopus 로고
    • Glucose - induced reactive oxygen species causes apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
    • Susztak K, Raff A, Schiffer M, Bottinger E. Glucose - induced reactive oxygen species causes apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes. 2006;55:225-233.
    • (2006) Diabetes , vol.55 , pp. 225-233
    • Susztak, K.1    Raff, A.2    Schiffer, M.3    Bottinger, E.4
  • 67
    • 34948906839 scopus 로고    scopus 로고
    • Advanced glycation end products induce podocyte apoptosis by activation of the FOXO 4 transcription factor
    • Chuang P, Yu Q, Fang W, Uribarri J, He J. Advanced glycation end products induce podocyte apoptosis by activation of the FOXO 4 transcription factor. Kid Int. 2007;72:965-976.
    • (2007) Kid Int , vol.72 , pp. 965-976
    • Chuang, P.1    Yu, Q.2    Fang, W.3    Uribarri, J.4    He, J.5
  • 68
    • 0031029379 scopus 로고    scopus 로고
    • Podocyte loss and progressive glomerular injury in type 2 diabetes
    • Pagtalunan M, Miller P, Jumping-Eagle S, et al. Podocyte loss and progressive glomerular injury in type 2 diabetes. J Clin Invest. 1997;99:m342-m348
    • (1997) J Clin Invest , vol.99
    • Pagtalunan, M.1    Miller, P.2    Jumping-Eagle, S.3
  • 69
    • 0345505674 scopus 로고    scopus 로고
    • Nephrin expression is reduced in human diabetic nephropathy: Evidence for a distinct role for glycated albumin and angiotensin 2
    • Doublier S, Salvidio G, Lupia E, et al. Nephrin expression is reduced in human diabetic nephropathy: evidence for a distinct role for glycated albumin and angiotensin 2. Diabetes. 2003;52:1023-1030.
    • (2003) Diabetes , vol.52 , pp. 1023-1030
    • Doublier, S.1    Salvidio, G.2    Lupia, E.3
  • 71
    • 65949121384 scopus 로고    scopus 로고
    • Predictors of overweight during childhood in offspring of parents with type 1 diabetes
    • Hummel S, Pfluger M, Kriechauf S, Hummel M, Ziegler A. Predictors of overweight during childhood in offspring of parents with type 1 diabetes. Diabetes Care. 2009;32:921-925.
    • (2009) Diabetes Care , vol.32 , pp. 921-925
    • Hummel, S.1    Pfluger, M.2    Kriechauf, S.3    Hummel, M.4    Ziegler, A.5
  • 72
    • 65949095219 scopus 로고    scopus 로고
    • Health Study Writing Group. Risk factors for Type 2 Diabetes in a sixth grade multiracial cohort
    • Kaufman F, Hirst K, Linder B, et al. Health Study Writing Group. Risk factors for Type 2 Diabetes in a sixth grade multiracial cohort. Diabetes Care. 2009;32:953-955.
    • (2009) Diabetes Care , vol.32 , pp. 953-955
    • Kaufman, F.1    Hirst, K.2    Linder, B.3
  • 73
    • 57049177011 scopus 로고    scopus 로고
    • Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium
    • Kong J, Qiao G, Zhang Z, Liu S, Li Y. Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium. Kidney International. 2008;74:1577-1581.
    • (2008) Kidney International , vol.74 , pp. 1577-1581
    • Kong, J.1    Qiao, G.2    Zhang, Z.3    Liu, S.4    Li, Y.5
  • 75
    • 68349094014 scopus 로고    scopus 로고
    • Mineralocorticoid receptor activation in obesity hypertension
    • Nagase M, Fujita T. Mineralocorticoid receptor activation in obesity hypertension. Hypertens Res. 2009;32:649-657.
    • (2009) Hypertens Res , vol.32 , pp. 649-657
    • Nagase, M.1    Fujita, T.2
  • 76
    • 33746491157 scopus 로고    scopus 로고
    • The central role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diagram signaling
    • Dai C, Stolz D, St. Bastacky S, et al. The central role of integrin-linked kinase in podocyte biology: bridging the integrin and slit diagram signaling. J Am Soc Nephrol. 2006;17:2164-2175.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2164-2175
    • Dai, C.1    Stolz, D.2    St. Bastacky, S.3
  • 77
    • 0033613545 scopus 로고    scopus 로고
    • Novel modulator of endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin
    • Ouchi N, Kihara S, Arita Y, et al. Novel modulator of endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin. Circulation. 1999;100:2473-2476.
    • (1999) Circulation , vol.100 , pp. 2473-2476
    • Ouchi, N.1    Kihara, S.2    Arita, Y.3
  • 78
    • 33644869129 scopus 로고    scopus 로고
    • Eicosopentanoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/TA mice: Involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylation
    • Hajiwara S, Makita Y, Gu L, et al. Eicosopentanoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/TA mice: involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylation. Nephrol Dial Transplant. 2006;21:605-615.
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 605-615
    • Hajiwara, S.1    Makita, Y.2    Gu, L.3
  • 79
    • 70349231115 scopus 로고    scopus 로고
    • The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: Role of cardiac phospholipids remodeling
    • Shah KB, Duda MK, O'Shea KM, et al. The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipids remodeling. Hypertension. 2009;54:605-611.
    • (2009) Hypertension , vol.54 , pp. 605-611
    • Shah, K.B.1    Duda, M.K.2    O'Shea, K.M.3
  • 80
    • 66849102001 scopus 로고    scopus 로고
    • The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: Meta-analysis of clinical trials
    • Miller ER 3rd, Juraschek SP, Appel LJ, et al. The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: meta-analysis of clinical trials. Am J Clin Nutr. 2009;89:1937-1945.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1937-1945
    • Miller 3rd, E.R.1    Juraschek, S.P.2    Appel, L.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.