The effect of n-3 long-chain polyunsaturated fatty acid supplementation on urine protein excretion and kidney function: Meta-analysis of clinical trials

American Journal of Clinical Nutrition

Volumn 89, Issue 6, 2009, Pages 1937-1945

  Miller III, Edgar R ^a   Juraschek, Stephen P ^d   Appel, Lawrence J ^a   Madala, Madhavi ^b   Anderson, Cheryl A M ^a   Bleys, Joachim ^a   Guallar, Eliseo ^a,c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARBOR HOSPITAL   (United States)

^c CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

5,8,11,14,17 ICOSAPENTAENOIC ACID; CERVONIC ACID; FISH OIL; N 3 LONG CHAIN POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG; OMEGA 3 FATTY ACID; PROTEIN;

ALBUMINURIA; ARTICLE; CLINICAL TRIAL; CREATININE CLEARANCE; DIABETES MELLITUS; DIET SUPPLEMENTATION; FISHY AFTERTASTE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; GLOMERULUS FILTRATION RATE; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY FAILURE; KIDNEY FUNCTION; LUPUS ERYTHEMATOSUS NEPHRITIS; NAUSEA; PROTEINURIA; TASTE DISORDER; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; KIDNEY; KIDNEY DISEASE; META ANALYSIS; METABOLISM; PATHOPHYSIOLOGY; URINE;

CONTROLLED CLINICAL TRIALS AS TOPIC; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; GLOMERULAR FILTRATION RATE; HUMANS; KIDNEY; KIDNEY DISEASES; PROTEINS; PROTEINURIA;

EID: 66849102001     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2008.26867     Document Type: Article

References (29)

1. De Caterina R, Bertolotto A, Madonna R, Schmidt EB. n-3 Fatty acids in the treatment of diabetic patients. Diabetes Care 2007;30:1012-1026
2. Brown SA, Brown CA, Crowell WA, et al. Effects of dietary poly-unsaturated fatty acid supplementation in early renal insufficiency in dogs. J Lab Clin Med 2000;135:275-286
3. Hagiwara S, Makita Y, Gu L, et al. Eicosapentaenoic acid ameliorates diabetic nephropathy of type 2 diabetic KKAy/Ta mice: involvement of MCP-1 suppression and decreased ERK1/2 and p38 phosphorylation. Nephrol Dial Transplant 2006;21:605-615 (Pubitemid 43372905)
4. Abeywardena MY, Head RJ. Longchain n-3 polyunsaturated fatty acids and blood vessel function. Cardiovasc Res 2001;52:361-371 (Pubitemid 33153099)
5. Lee CT, Adler AI, Forouhi NG, et al. Cross-sectional association between fish consumption and albuminuria: the European Prospective Investigation Of Cancer-Norfolk Study. Am J Kidney Dis 2008;52: 876-886
6. Lauretani F, Semba RD, Bandinelli S, et al. Plasma polyunsaturated fatty acids and the decline of renal function. Clin Chem 2008;54: 475-481 (Pubitemid 351348158)
7. MacLean CH, Mojica WA, Morton SC, et al. Effects of omega-3 fatty acids on lipids and glycemic control in type II diabetes and the metabolic syndrome and on inflammatory bowel disease, rheumatoid arthritis, renal disease, systemic lupus erythematosus, and osteoporosis. Evid Rep Technol Assess (Summ) 2004;89:1-4.
8. Rosenthal R. Parametric measures of effect size. In: Handbook of research synthesis. New York, NY: Russell Sage Foundation, 1994.
9. Appel LJ, Miller ER III, Seidler AJ, Whelton PK. Does supplementation of diet with 'fish oil' reduce blood pressure? A meta-analysis of controlled clinical trials. Arch Intern Med 1993;153:1429-1438
10. Dickinson HO, Mason JM, Nicolson DJ, et al. Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials. J Hypertens 2006;24:215-233
11. Clark WF, Parbtani A, Naylor CD, et al. Fish oil in lupus nephritis: clinical findings and methodological implications. Kidney Int 1993;44: 75-86. (Pubitemid 23198028)
12. Zeman M, Zak A, Vecka M, Tvrzicka E, Pisarikova A, Stankova B. n-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. J Nutr Biochem 2006;17:379-384 (Pubitemid 43729351)
13. de Zeeuw D. Targeting proteinuria as a valid surrogate for individualized kidney protective therapy. Am J Kidney Dis 2008;51:713-716 (Pubitemid 351626262)
14. Agodoa LY, Appel L, Bakris GL, et al. African American Study of Kidney Disease and Hypertension (AASK) Study Group. Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. JAMA 2001;285:2719-2728
15. Haines AP, Sanders TA, Imeson JD, et al. Effects of a fish oil supplement on platelet function, haemostatic variables and albuminuria in insulin-dependent diabetics. Thromb Res 1986;43:643-655
16. Bennett WM, Walker RG, Kincaid-Smith P. Treatment of IgA nephropathy with eicosapentanoic acid (EPA): a two-year prospective trial. Clin Nephrol 1989;31:128-131 (Pubitemid 19080448)
17. Jensen T, Stender S, Goldstein K, Holmer G, Deckert T. Partial normalization by dietary cod-liver oil of increased microvascular albumin leakage in patients with insulin-dependent diabetes and albuminuria. N Engl J Med 1989;321:1572-1577 (Pubitemid 20008236)
18. Hamazaki T, Takazakura E, Osawa K, Urakaze M, Yano S. Reduction in microalbuminuria in diabetics by eicosapentaenoic acid ethyl ester. Lipids 1990;25:541-545 (Pubitemid 20327615)
19. Gentile MG, Fellin G, Cofano F, et al. Treatment of proteinuric patients with a vegetarian soy diet and fish oil. Clin Nephrol 1993;40:315-320 (Pubitemid 24002588)
20. Pettersson EE, Rekola S, Berglund L, et al. Treatment of IgA nephropathy with omega-3-polyunsaturated fatty acids: a prospective, double-blind, randomized study. Clin Nephrol 1994;41:183-190 (Pubitemid 24104881)
21. Shimizu H, Ohtani K, Tanaka Y, Sato N, Mori M, Shimomura Y. Long-term effect of eicosapentaenoic acid ethyl (EPA-E) on albuminuria of non-insulin dependent diabetic patients. Diabetes Res Clin Pract 1995;28:35-40.
22. Rossing P, Hansen BV, Nielsen FS, Myrup B, Holmer G, Parving HH. Fish oil in diabetic nephropathy. Diabetes Care 1996;19:1214-1219
23. Cappelli P, Di Liberato L, Stuard S, Ballone E, Albertazzi A. n-3 Polyunsaturated fatty acid supplementation in chronic progressive renal disease. J Nephrol 1997;10:157-162 (Pubitemid 27297133)
24. Lungershausen YK, Howe PR, Clifton PM, et al. Evaluation of an omega-3 fatty acid supplement in diabetics with microalbuminuria. Ann N Y Acad Sci 1997;827:369-381
25. Donadio JV Jr, Grande JP, Bergstralh EJ, Dart RA, Larson TS, Spencer DC. The long-term outcome of patients with IgA nephropathy treated with fish oil in a controlled trial. Mayo Nephrology Collaborative Group. J Am Soc Nephrol 1999;10:1772-1777
26. Branten AJ, Klasen IS, Wetzels JF. Short-term effects of fish oil treatment on urinary excretion of high- and low-molecular weight proteins in patients with IgA nephropathy. Clin Nephrol 2002;58:267-274
27. Alexopoulos E, Stangou M, Pantzaki A, Kirmizis D, Memmos D. Treatment of severe IgA nephropathy with omega-3 fatty acids: The effect of a "very low dose" regimen. Ren Fail 2004;26:453-459
28. Svensson M, Christensen JH, Solling J, Schmidt EB. The effect of n-3 fatty acids on plasma lipids and lipoproteins and blood pressure in patients with CRF. Am J Kidney Dis 2004;44:77-83. (Pubitemid 38880930)
29. Theobald HE, Goodall AH, Sattar N, Talbot DC, Chowienczyk PJ, Sanders TA. Low-dose docosahexaenoic acid lowers diastolic blood pressure in middle-aged men and women. J Nutr 2007;137:973-978 (Pubitemid 46596896)