Disordered expression of glycolytic and gluconeogenic liver enzymes of juvenile visceral steatosis mice with systemic carnitine deficiency

Diabetes Research and Clinical Practice

Volumn 32, Issue 3, 1996, Pages 117-123

  Hotta, Kikuko ^a   Kuwajima, Masamichi ^a,b   Ono, Akira ^a   Nakajima, Hiromu ^a   Horikawa, Yukio ^a   Miyagawa, Jun Ichiro ^a   Namba, Mitsuyoshi ^a   Hanafusa, Toshiaki ^a   Horiuchi, Masahisa ^c   Nikaido, Hiroko ^d   Hayakawa, Jun Ichiro ^d   Saheki, Takeyori ^c   Kono, Norio ^a   Noguchi, Tamio ^a   Matsuzawa, Yuji ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d KANAZAWA UNIVERSITY   (Japan)

Author keywords

Carnitine deficiency; Gene expression; Gluconeogenic enzyme; Glycolytic enzyme; Juvenile visceral steatosis mice

Indexed keywords

6 PHOSPHOFRUCTOKINASE; CARNITINE; GLUCOKINASE; GLUCOSE; INSULIN; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PYRUVATE KINASE;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARNITINE DEFICIENCY; CONTROLLED STUDY; LIVER METABOLISM; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; STEATOSIS;

EID: 0030152610     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-8227(96)01247-8     Document Type: Article

References (32)

1. [1] Koizumi, T., Nikaido, H., Hayakawa, J., Nonomura, A. and Yoneda, T. (1988) Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2° strain of mouse with similarities to Reye's syndrome. Lab. Anim. 22, 83-87.
2. [2] Hayakawa, J., Koizumi, T. and Nikaido, H. (1990) Inheritance of juvenile visceral steatosis (jvs) found in C3H-H-2° mice. Mouse Genome 86, 261.
3. [3] Kuwajima, M., Kono, N., Horiuchi, M. et al. (1991) Animal model of systemic carnitine deficiency: analysis in C3H-H-2° strain of mouse associated with juvenile visceral steatosis. Biochem. Biophys. Res. Commun. 174, 1090-1094.
4. [4] McGarry, J.D. and Foster, D.W. (1980) Regulation of hepatic fatty acid oxidation and ketone body production. Annu. Rev. Biochem. 49, 395-420.
5. [5] Stanley, C.A. (1987) New genetic defects in mitochondrial fatty acid oxidation and carnitine deficiency. Adv. Pediatr. 34, 59-88.
6. [6] Imamura, Y., Saheki, T., Arakawa, H. et al. (1990) Urea cycle disorder in C3H-H-2° mice with juvenile steatosis of viscera. FEBS Lett. 260, 119-121.
7. [7] Tomomura, M., Imamura, Y., Horiuchi, M. et al. (1992) Abnormal expression of urea cycle enzyme genes in juvenile visceral steatosis (jvs) mice. Biochim. Biophys. Acta. 1138, 167-171.
8. [8] Horiuchi, M., Kobayashi, K., Tomomura, M. et al. (1992) Carnitine administration to juvenile visceral steatosis mice corrects the suppressed expression of urea cycle enzymes by normalizing their transcription. J. Biol. Chem. 267, 5032-5035.
9. [9] Hotta, K., Kuwajima, M., Ono, A. et al. (1996) Altered expression of carnitine palmitoyltransferase II in liver, muscle, and heart of mouse strain with juvenile visceral steatosis. Biochim. Biophys. Acta. 1289, 131-135.
10. [10] Roncero, C. and Goodridge, A.G. (1992) Regulation of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture: corticosterone and carnitine regulate responsiveness to triiodothyronine. Arch. Biochem. Biophys. 295, 258-267.
11. [11] Granner, D. and Pilkis, S. (1990) The genes of hepatic glucose metabolism. J. Biol. Chem. 265, 10173-10176.
12. [12] Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
13. [13] Maniatis, T., Fritsch, E.F. and Sambrook, J. (1989) Molecular cloning: a laboratory manual, 2nd ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
14. [14] Hotta, K., Nakajima, H., Yamasaki, T. et al. (1991) Rat-liver-type phosphofructokinase mRNA: structure, tissue distribution and regulation. Eur. J. Biochem. 202, 293-298.
15. [15] Noguchi, T., Matsuda, T., Tomari, Y. et al. (1993) The regulation of gene expression by insulin is differentially impaired in the liver of the genetically obese-hyperglycemic Wistar fatty rat. FEBS Lett. 328, 145-148.
16. 3 during monocytic differentiation. Proc. Natl. Acad. Sci. USA 85, 6904-6908.
17. [17] Nakajima, H., Kono, N., Yamasaki, T. et al. (1990) Tissue specificity in expression and alternative RNA splicing of human phosphofructokinase-M and -L genes. Biochem. Biophys. Res. Commun. 173, 1317-1321.
18. [18] Miwa, I., Okuda, J., Maeda, K. and Okuda, G. (1972) Mutarotase effect on colorimetric determination of blood glucose with D-glucose oxidase. Clin. Chim. Acta. 37, 538-540.
19. [19] Hales, C.N. (1972) Immunological techniques in diabetes research. Diabetologia 8, 229-235.
20. [20] Iynedjian, P.B., Jotterand, D., Nouspikel, T., Asfari, M. and Pilot P.-R. (1989) Transcriptional induction of glucokinase gene by insulin in cultured liver cells and its repression by the glucagon-cAMP system. J. Biol. Chem. 264, 21824-21829.
21. [21] Matsuda, T., Noguchi, T., Yamada, K., Takenaka, M. and Tanaka, T. (1990) Regulation of the gene expression of glucokinase and L-type pyruvate kinase in primary cultures of rat hepatocytes by hormones and carbohydrates. J. Biochem. (Tokyo) 108, 778-784.
22. [22] Noguchi, T., Inoue, H. and Tanaka, T. (1982) Regulation of rat liver L-type pyruvate kinase mRNA by insulin and by fructose. Eur. J. Biochem. 128, 583-588.
23. [23] Noguchi, T., Inoue, H. and Tanaka, T. (1985) Transcriptional and post-transcriptional regulation of L-type pyruvate kinase in diabetic rat liver by insulin and dietary fructose. J. Biol. Chem. 260, 14393-14397.
24. [24] Matsuda, T., Noguchi, T., Takenaka, M., Yamada, K. and Tanaka, T. (1990) Regulation of L-type pyruvate kinase gene expression by dietary fructose in normal and diabetic rats. J. Biochem. (Tokyo) 107, 655-660.
25. [25] Decaux, J.-F., Antoine, B. and Kahn, A. (1989) Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture. J. Biol. Chem. 264, 11584-11590.
26. [26] Höppner, W. and Seitz, H.-J. (1989) Effect of thyroid hormones on glucokinase gene transcription in rat liver. J. Biol. Chem. 264, 20643-20647.
27. [27] El-Maghrabi, M.R., Pilkis, J., Marker, A.J. et al. (1988) cDNA sequence of rat liver fructose-1,6-bisphosphatase and evidence for down-regulation of its mRNA by insulin. Proc. Natl. Acad. Sci. USA 85, 8430-8434.
28. [28] El-Maghrabi, M.R., Lange, A.J., Kümmel, L. and Pilkis, S.J. (1991) The rat fructose-1,6-bisphosphatase gene: structure and regulation of expression. J. Biol. Chem. 266, 2115-2120.
29. [29] Sasaki, K., Cripe, T.P., Koch, S.R. et al. (1984) Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription: the dominant role of insulin. J. Biol. Chem. 259, 15242-15251.
30. [30] Chrapkiewicz, N.B., Beale, E.G. and Granner, D.K. (1982) Induction of the messenger ribonucleic acid coding for phosphoenolpyruvate carboxykinase in H4-II-E cells: evidence for a nuclear effect of cyclic AMP. J. Biol. Chem. 257, 14428-14432.
31. [31] Lamers, W.H., Hanson, R.W. and Meisner, H.M. (1982) cAMP stimulates transcription of the gene for cytosolic phosphoenolpyruvate carboxykinase in rat liver nuclei. Proc. Natl. Acad. Sci. USA 79, 5137-5141.
32. [32] Hod, Y. and Hanson, R.W. (1988) Cyclic AMP stabilizes the mRNA for phosphoenolpyruvate carboxykinase (GTP) against degradation. J. Biol. Chem. 263, 7747-7752.