메뉴 건너뛰기




Volumn 8, Issue , 2010, Pages

Epigenetics of human cutaneous melanoma: Setting the stage for new therapeutic strategies

Author keywords

[No Author keywords available]

Indexed keywords

4 [N (2 HYDROXYETHYL) N [2 (3 INDOLYL)ETHYL]AMINOMETHYL]CINNAMOHYDROXAMIC ACID; 5 AZA 2' DEOXYCYTIDINE; ALPHA INTERFERON; AZACITIDINE; BAY 865274; BELINOSTAT; CISPLATIN; DACARBAZINE; DEPAKOTE ER; DNA METHYLTRANSFERASE INHIBITOR; DOXORUBICIN; ENTINOSTAT; EPIGALLOCATECHIN GALLATE; ETOPOSIDE; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 2; KARENITECIN; MG 98; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N PHTHALOYLTRYPTOPHAN; PANOBINOSTAT; PDX 110; PEGINTERFERON ALPHA2B; PROCAINAMIDE; PROCAINE; RECOMBINANT ALPHA2B INTERFERON; ROMIDEPSIN; S 110; SNDX 275; STAVZOR; TEMOZOLOMIDE; UNCLASSIFIED DRUG; VALPROATE SEMISODIUM; VALPROIC ACID; VORINOSTAT; ZEBULARINE; ENZYME INHIBITOR; HISTONE; MICRORNA;

EID: 77953306334     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-8-56     Document Type: Review
Times cited : (89)

References (161)
  • 2
    • 0036780566 scopus 로고    scopus 로고
    • Focus on melanoma
    • 10.1016/S1535-6108(02)00161-7, 12398891
    • Houghton AN, Polsky D. Focus on melanoma. Cancer Cell 2002, 2:275-278. 10.1016/S1535-6108(02)00161-7, 12398891.
    • (2002) Cancer Cell , vol.2 , pp. 275-278
    • Houghton, A.N.1    Polsky, D.2
  • 5
    • 37249031406 scopus 로고    scopus 로고
    • Epigenetic lesions in malignant melanoma
    • 10.2174/138920107783018372, 18289047
    • Schwabe M, Lubbert M. Epigenetic lesions in malignant melanoma. Curr Pharm Biotechnol 2007, 8:382-387. 10.2174/138920107783018372, 18289047.
    • (2007) Curr Pharm Biotechnol , vol.8 , pp. 382-387
    • Schwabe, M.1    Lubbert, M.2
  • 6
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • 10.1016/j.cell.2007.01.029, 17320506
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007, 128:683-692. 10.1016/j.cell.2007.01.029, 17320506.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 7
    • 55949134303 scopus 로고    scopus 로고
    • DNA methylomes, histone codes and miRNAs: tying it all together
    • 10.1016/j.biocel.2008.09.005, 18834952
    • Guil S, Esteller M. DNA methylomes, histone codes and miRNAs: tying it all together. Int J Biochem Cell Biol 2009, 41:87-95. 10.1016/j.biocel.2008.09.005, 18834952.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 87-95
    • Guil, S.1    Esteller, M.2
  • 8
    • 0032722062 scopus 로고    scopus 로고
    • Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation
    • 10.1074/jbc.274.46.33002, 10551868
    • Pradhan S, Bacolla A, Wells RD, Roberts RJ. Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J Biol Chem 1999, 274:33002-33010. 10.1074/jbc.274.46.33002, 10551868.
    • (1999) J Biol Chem , vol.274 , pp. 33002-33010
    • Pradhan, S.1    Bacolla, A.2    Wells, R.D.3    Roberts, R.J.4
  • 9
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • 10.1038/890, 9662389
    • Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 1998, 19:219-220. 10.1038/890, 9662389.
    • (1998) Nat Genet , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 10
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • 10.1016/S0092-8674(00)81656-6, 10555141
    • Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999, 99:247-257. 10.1016/S0092-8674(00)81656-6, 10555141.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 13
    • 0036683055 scopus 로고    scopus 로고
    • Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases
    • 10.1093/emboj/cdf401, 126147, 12145218
    • Kim GD, Ni J, Kelesoglu N, Roberts RJ, Pradhan S. Co-operation and communication between the human maintenance and de novo DNA (cytosine-5) methyltransferases. EMBO J 2002, 21:4183-4195. 10.1093/emboj/cdf401, 126147, 12145218.
    • (2002) EMBO J , vol.21 , pp. 4183-4195
    • Kim, G.D.1    Ni, J.2    Kelesoglu, N.3    Roberts, R.J.4    Pradhan, S.5
  • 14
    • 0041779528 scopus 로고    scopus 로고
    • Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases
    • 10.1093/hmg/ddg226, 12915469
    • Paz MF, Wei S, Cigudosa JC, Rodriguez-Perales S, Peinado MA, Huang TH, Esteller M. Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases. Hum Mol Genet 2003, 12:2209-2219. 10.1093/hmg/ddg226, 12915469.
    • (2003) Hum Mol Genet , vol.12 , pp. 2209-2219
    • Paz, M.F.1    Wei, S.2    Cigudosa, J.C.3    Rodriguez-Perales, S.4    Peinado, M.A.5    Huang, T.H.6    Esteller, M.7
  • 15
    • 32344450824 scopus 로고    scopus 로고
    • Genomic DNA methylation: the mark and its mediators
    • 10.1016/j.tibs.2005.12.008, 16403636
    • Klose RJ, Bird AP. Genomic DNA methylation: the mark and its mediators. Trends Biochem Sci 2006, 31:89-97. 10.1016/j.tibs.2005.12.008, 16403636.
    • (2006) Trends Biochem Sci , vol.31 , pp. 89-97
    • Klose, R.J.1    Bird, A.P.2
  • 16
    • 0012959217 scopus 로고    scopus 로고
    • Aberrant DNA methylation in cancer: potential clinical interventions
    • 10.1017/S1462399402004222, 14987388
    • Strathdee G, Brown R. Aberrant DNA methylation in cancer: potential clinical interventions. Expert Rev Mol Med 2002, 4:1-17. 10.1017/S1462399402004222, 14987388.
    • (2002) Expert Rev Mol Med , vol.4 , pp. 1-17
    • Strathdee, G.1    Brown, R.2
  • 17
    • 14844307097 scopus 로고    scopus 로고
    • Epigenetic regulation by histone methylation and histone variants
    • 10.1210/me.2004-0496, 15677708
    • Cheung P, Lau P. Epigenetic regulation by histone methylation and histone variants. Mol Endocrinol 2005, 19:563-573. 10.1210/me.2004-0496, 15677708.
    • (2005) Mol Endocrinol , vol.19 , pp. 563-573
    • Cheung, P.1    Lau, P.2
  • 18
    • 35848961668 scopus 로고    scopus 로고
    • How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
    • 10.1038/nsmb1338, 17984965
    • Taverna SD, Li H, Ruthenburg AJ, Allis CD, Patel DJ. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol 2007, 14:1025-1040. 10.1038/nsmb1338, 17984965.
    • (2007) Nat Struct Mol Biol , vol.14 , pp. 1025-1040
    • Taverna, S.D.1    Li, H.2    Ruthenburg, A.J.3    Allis, C.D.4    Patel, D.J.5
  • 19
    • 0038243168 scopus 로고    scopus 로고
    • The role of DNA methylation in setting up chromatin structure during development
    • 10.1038/ng1158, 12740577
    • Hashimshony T, Zhang J, Keshet I, Bustin M, Cedar H. The role of DNA methylation in setting up chromatin structure during development. Nat Genet 2003, 34:187-192. 10.1038/ng1158, 12740577.
    • (2003) Nat Genet , vol.34 , pp. 187-192
    • Hashimshony, T.1    Zhang, J.2    Keshet, I.3    Bustin, M.4    Cedar, H.5
  • 20
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: past, present and future
    • 10.1038/nrd1930, 16485345
    • Yoo CB, Jones PA. Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 2006, 5:37-50. 10.1038/nrd1930, 16485345.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 21
    • 33845735043 scopus 로고    scopus 로고
    • Epigenetic silencing of novel tumor suppressors in malignant melanoma
    • 10.1158/0008-5472.CAN-06-1274, 17145863
    • Muthusamy V, Duraisamy S, Bradbury CM, Hobbs C, Curley DP, Nelson B, Bosenberg M. Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res 2006, 66:11187-11193. 10.1158/0008-5472.CAN-06-1274, 17145863.
    • (2006) Cancer Res , vol.66 , pp. 11187-11193
    • Muthusamy, V.1    Duraisamy, S.2    Bradbury, C.M.3    Hobbs, C.4    Curley, D.P.5    Nelson, B.6    Bosenberg, M.7
  • 22
    • 58049188918 scopus 로고    scopus 로고
    • Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma
    • 10.1002/gcc.20615, 18803327
    • Bonazzi VF, Irwin D, Hayward NK. Identification of candidate tumor suppressor genes inactivated by promoter methylation in melanoma. Genes Chromosomes Cancer 2009, 48:10-21. 10.1002/gcc.20615, 18803327.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 10-21
    • Bonazzi, V.F.1    Irwin, D.2    Hayward, N.K.3
  • 23
    • 35248899866 scopus 로고    scopus 로고
    • DNA microarray analyses of melanoma gene expression: a decade in the mines
    • 10.1111/j.1600-0749.2007.00412.x, 17935490
    • Hoek KS. DNA microarray analyses of melanoma gene expression: a decade in the mines. Pigment Cell Res 2007, 20:466-484. 10.1111/j.1600-0749.2007.00412.x, 17935490.
    • (2007) Pigment Cell Res , vol.20 , pp. 466-484
    • Hoek, K.S.1
  • 24
    • 0019332015 scopus 로고
    • Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues
    • 10.1093/nar/8.20.4777, 324387, 7443525
    • Wang RY, Gehrke CW, Ehrlich M. Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues. Nucleic Acids Res 1980, 8:4777-4790. 10.1093/nar/8.20.4777, 324387, 7443525.
    • (1980) Nucleic Acids Res , vol.8 , pp. 4777-4790
    • Wang, R.Y.1    Gehrke, C.W.2    Ehrlich, M.3
  • 25
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • 10.1073/pnas.89.5.1827, 48546, 1542678
    • Frommer M, McDonald LE, Millar DS, Collis CM, Watt F, Grigg GW, Molloy PL, Paul CL. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 1992, 89:1827-1831. 10.1073/pnas.89.5.1827, 48546, 1542678.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3    Collis, C.M.4    Watt, F.5    Grigg, G.W.6    Molloy, P.L.7    Paul, C.L.8
  • 26
    • 0038678777 scopus 로고    scopus 로고
    • Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites
    • Colella S, Shen L, Baggerly KA, Issa JP, Krahe R. Sensitive and quantitative universal Pyrosequencing methylation analysis of CpG sites. Biotechniques 2003, 35:146-150.
    • (2003) Biotechniques , vol.35 , pp. 146-150
    • Colella, S.1    Shen, L.2    Baggerly, K.A.3    Issa, J.P.4    Krahe, R.5
  • 27
    • 33644861803 scopus 로고    scopus 로고
    • Accurate quantification of DNA methylation using combined bisulfite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform
    • 10.1093/nar/gnj017, 1361623, 16464820
    • Brena RM, Auer H, Kornacker K, Hackanson B, Raval A, Byrd JC, Plass C. Accurate quantification of DNA methylation using combined bisulfite restriction analysis coupled with the Agilent 2100 Bioanalyzer platform. Nucleic Acids Res 2006, 34:e17. 10.1093/nar/gnj017, 1361623, 16464820.
    • (2006) Nucleic Acids Res , vol.34
    • Brena, R.M.1    Auer, H.2    Kornacker, K.3    Hackanson, B.4    Raval, A.5    Byrd, J.C.6    Plass, C.7
  • 28
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
    • 10.1073/pnas.93.18.9821, 38513, 8790415
    • Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996, 93:9821-9826. 10.1073/pnas.93.18.9821, 38513, 8790415.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3    Nelkin, B.D.4    Baylin, S.B.5
  • 30
    • 2342557977 scopus 로고    scopus 로고
    • A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
    • 10.1093/nar/gnh032, 373427, 14973332
    • Yang AS, Estecio MR, Doshi K, Kondo Y, Tajara EH, Issa JP. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res 2004, 32:e38. 10.1093/nar/gnh032, 373427, 14973332.
    • (2004) Nucleic Acids Res , vol.32
    • Yang, A.S.1    Estecio, M.R.2    Doshi, K.3    Kondo, Y.4    Tajara, E.H.5    Issa, J.P.6
  • 33
    • 67349209853 scopus 로고    scopus 로고
    • Next-generation DNA sequencing techniques
    • 10.1016/j.nbt.2008.12.009, 19429539
    • Ansorge WJ. Next-generation DNA sequencing techniques. N Biotechnol 2009, 25:195-203. 10.1016/j.nbt.2008.12.009, 19429539.
    • (2009) N Biotechnol , vol.25 , pp. 195-203
    • Ansorge, W.J.1
  • 34
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • 10.1038/nrg2005, 17339880
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007, 8:286-298. 10.1038/nrg2005, 17339880.
    • (2007) Nat Rev Genet , vol.8 , pp. 286-298
    • Esteller, M.1
  • 35
    • 42449142005 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation assays: molecular analysis of chromatin modification and gene regulation
    • full_text, 18217683
    • Dasgupta P, Chellappan SP. Chromatin immunoprecipitation assays: molecular analysis of chromatin modification and gene regulation. Methods Mol Biol 2007, 383:135-152. full_text, 18217683.
    • (2007) Methods Mol Biol , vol.383 , pp. 135-152
    • Dasgupta, P.1    Chellappan, S.P.2
  • 39
    • 2542522279 scopus 로고    scopus 로고
    • Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients
    • 10.1038/sj.onc.1207505, 2856469, 15064737
    • Hoon DS, Spugnardi M, Kuo C, Huang SK, Morton DL, Taback B. Profiling epigenetic inactivation of tumor suppressor genes in tumors and plasma from cutaneous melanoma patients. Oncogene 2004, 23:4014-4022. 10.1038/sj.onc.1207505, 2856469, 15064737.
    • (2004) Oncogene , vol.23 , pp. 4014-4022
    • Hoon, D.S.1    Spugnardi, M.2    Kuo, C.3    Huang, S.K.4    Morton, D.L.5    Taback, B.6
  • 40
    • 0037380925 scopus 로고    scopus 로고
    • Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma
    • Spugnardi M, Tommasi S, Dammann R, Pfeifer GP, Hoon DS. Epigenetic inactivation of RAS association domain family protein 1 (RASSF1A) in malignant cutaneous melanoma. Cancer Res 2003, 63:1639-1643.
    • (2003) Cancer Res , vol.63 , pp. 1639-1643
    • Spugnardi, M.1    Tommasi, S.2    Dammann, R.3    Pfeifer, G.P.4    Hoon, D.S.5
  • 41
    • 33645050917 scopus 로고    scopus 로고
    • Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons
    • 10.1158/0008-5472.CAN-05-2303, 1769551, 16510600
    • Reu FJ, Leaman DW, Maitra RR, Bae SI, Cherkassky L, Fox MW, Rempinski DR, Beaulieu N, MacLeod AR, Borden EC. Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons. Cancer Res 2006, 66:2785-2793. 10.1158/0008-5472.CAN-05-2303, 1769551, 16510600.
    • (2006) Cancer Res , vol.66 , pp. 2785-2793
    • Reu, F.J.1    Leaman, D.W.2    Maitra, R.R.3    Bae, S.I.4    Cherkassky, L.5    Fox, M.W.6    Rempinski, D.R.7    Beaulieu, N.8    MacLeod, A.R.9    Borden, E.C.10
  • 42
    • 63449140854 scopus 로고    scopus 로고
    • CpG island methylator phenotype predicts progression of malignant melanoma
    • 10.1158/1078-0432.CCR-08-1361, 2703821, 19223509
    • Tanemura A, Terando AM, Sim MS, van Hoesel AQ, de Maat MF, Morton DL, Hoon DS. CpG island methylator phenotype predicts progression of malignant melanoma. Clin Cancer Res 2009, 15:1801-1807. 10.1158/1078-0432.CCR-08-1361, 2703821, 19223509.
    • (2009) Clin Cancer Res , vol.15 , pp. 1801-1807
    • Tanemura, A.1    Terando, A.M.2    Sim, M.S.3    van Hoesel, A.Q.4    de Maat, M.F.5    Morton, D.L.6    Hoon, D.S.7
  • 43
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • 10.1056/NEJMra072067, 18337604
    • Esteller M. Epigenetics in cancer. N Engl J Med 2008, 358:1148-1159. 10.1056/NEJMra072067, 18337604.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 44
    • 67849109939 scopus 로고    scopus 로고
    • CpG island methylation profiling in human melanoma cell lines
    • 10.1097/CMR.0b013e32832b274e, 19441164
    • Tellez CS, Shen L, Estecio MR, Jelinek J, Gershenwald JE, Issa JP. CpG island methylation profiling in human melanoma cell lines. Melanoma Res 2009, 19:146-155. 10.1097/CMR.0b013e32832b274e, 19441164.
    • (2009) Melanoma Res , vol.19 , pp. 146-155
    • Tellez, C.S.1    Shen, L.2    Estecio, M.R.3    Jelinek, J.4    Gershenwald, J.E.5    Issa, J.P.6
  • 45
    • 0029957792 scopus 로고    scopus 로고
    • The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation
    • 10.1073/pnas.93.14.7149, 38951, 8692960
    • De Smet C, De Backer O, Faraoni I, Lurquin C, Brasseur F, Boon T. The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation. Proc Natl Acad Sci USA 1996, 93:7149-7153. 10.1073/pnas.93.14.7149, 38951, 8692960.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7149-7153
    • De Smet, C.1    De Backer, O.2    Faraoni, I.3    Lurquin, C.4    Brasseur, F.5    Boon, T.6
  • 46
    • 0032694084 scopus 로고    scopus 로고
    • DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter
    • 84726, 10523621
    • De Smet C, Lurquin C, Lethe B, Martelange V, Boon T. DNA methylation is the primary silencing mechanism for a set of germ line- and tumor-specific genes with a CpG-rich promoter. Mol Cell Biol 1999, 19:7327-7335. 84726, 10523621.
    • (1999) Mol Cell Biol , vol.19 , pp. 7327-7335
    • De Smet, C.1    Lurquin, C.2    Lethe, B.3    Martelange, V.4    Boon, T.5
  • 48
    • 71049153709 scopus 로고    scopus 로고
    • Cancer/testis (CT) antigens: potential targets for immunotherapy
    • 10.1111/j.1349-7006.2009.01303.x, 19719775
    • Caballero OL, Chen YT. Cancer/testis (CT) antigens: potential targets for immunotherapy. Cancer Sci 2009, 100:2014-2021. 10.1111/j.1349-7006.2009.01303.x, 19719775.
    • (2009) Cancer Sci , vol.100 , pp. 2014-2021
    • Caballero, O.L.1    Chen, Y.T.2
  • 49
    • 10844289762 scopus 로고    scopus 로고
    • Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine
    • 10.1158/0008-5472.CAN-04-1442, 15604288
    • Sigalotti L, Fratta E, Coral S, Tanzarella S, Danielli R, Colizzi F, Fonsatti E, Traversari C, Altomonte M, Maio M. Intratumor heterogeneity of cancer/testis antigens expression in human cutaneous melanoma is methylation-regulated and functionally reverted by 5-aza-2'-deoxycytidine. Cancer Res 2004, 64:9167-9171. 10.1158/0008-5472.CAN-04-1442, 15604288.
    • (2004) Cancer Res , vol.64 , pp. 9167-9171
    • Sigalotti, L.1    Fratta, E.2    Coral, S.3    Tanzarella, S.4    Danielli, R.5    Colizzi, F.6    Fonsatti, E.7    Traversari, C.8    Altomonte, M.9    Maio, M.10
  • 51
    • 40949121440 scopus 로고    scopus 로고
    • Cancer testis antigens in human melanoma stem cells: expression, distribution, and methylation status
    • 10.1002/jcp.21380, 18205182
    • Sigalotti L, Covre A, Zabierowski S, Himes B, Colizzi F, Natali PG, Herlyn M, Maio M. Cancer testis antigens in human melanoma stem cells: expression, distribution, and methylation status. J Cell Physiol 2008, 215:287-291. 10.1002/jcp.21380, 18205182.
    • (2008) J Cell Physiol , vol.215 , pp. 287-291
    • Sigalotti, L.1    Covre, A.2    Zabierowski, S.3    Himes, B.4    Colizzi, F.5    Natali, P.G.6    Herlyn, M.7    Maio, M.8
  • 52
    • 73349120570 scopus 로고    scopus 로고
    • Cancer testis antigens and melanoma stem cells: new promises for therapeutic intervention
    • 10.1007/s00262-009-0785-5, 19862522
    • Sigalotti L, Covre A, Nicolay HJ, Coral S, Maio M. Cancer testis antigens and melanoma stem cells: new promises for therapeutic intervention. Cancer Immunol Immunother 2010, 59:487-488. 10.1007/s00262-009-0785-5, 19862522.
    • (2010) Cancer Immunol Immunother , vol.59 , pp. 487-488
    • Sigalotti, L.1    Covre, A.2    Nicolay, H.J.3    Coral, S.4    Maio, M.5
  • 53
    • 3042711192 scopus 로고    scopus 로고
    • Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival
    • 10.1097/01.cmr.0000129576.49313.26, 15179185
    • Florenes VA, Skrede M, Jorgensen K, Nesland JM. Deacetylase inhibition in malignant melanomas: impact on cell cycle regulation and survival. Melanoma Res 2004, 14:173-181. 10.1097/01.cmr.0000129576.49313.26, 15179185.
    • (2004) Melanoma Res , vol.14 , pp. 173-181
    • Florenes, V.A.1    Skrede, M.2    Jorgensen, K.3    Nesland, J.M.4
  • 54
    • 4444239987 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells
    • Zhang XD, Gillespie SK, Borrow JM, Hersey P. The histone deacetylase inhibitor suberic bishydroxamate regulates the expression of multiple apoptotic mediators and induces mitochondria-dependent apoptosis of melanoma cells. Mol Cancer Ther 2004, 3:425-435.
    • (2004) Mol Cancer Ther , vol.3 , pp. 425-435
    • Zhang, X.D.1    Gillespie, S.K.2    Borrow, J.M.3    Hersey, P.4
  • 56
    • 7444256739 scopus 로고    scopus 로고
    • Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway
    • 10.1158/0008-5472.CAN-03-3897, 15520174
    • Bandyopadhyay D, Mishra A, Medrano EE. Overexpression of histone deacetylase 1 confers resistance to sodium butyrate-mediated apoptosis in melanoma cells through a p53-mediated pathway. Cancer Res 2004, 64:7706-7710. 10.1158/0008-5472.CAN-03-3897, 15520174.
    • (2004) Cancer Res , vol.64 , pp. 7706-7710
    • Bandyopadhyay, D.1    Mishra, A.2    Medrano, E.E.3
  • 57
    • 52149120730 scopus 로고    scopus 로고
    • The role of p53 in pigmentation, tanning and melanoma
    • 10.1111/j.1755-148X.2008.00495.x, 18761658
    • Box NF, Terzian T. The role of p53 in pigmentation, tanning and melanoma. Pigment Cell Melanoma Res 2008, 21:525-533. 10.1111/j.1755-148X.2008.00495.x, 18761658.
    • (2008) Pigment Cell Melanoma Res , vol.21 , pp. 525-533
    • Box, N.F.1    Terzian, T.2
  • 58
    • 34447335892 scopus 로고    scopus 로고
    • Expression of polycomb group protein EZH2 in nevi and melanoma
    • 10.1111/j.1600-0560.2006.00678.x, 17640228
    • McHugh JB, Fullen DR, Ma L, Kleer CG, Su LD. Expression of polycomb group protein EZH2 in nevi and melanoma. J Cutan Pathol 2007, 34:597-600. 10.1111/j.1600-0560.2006.00678.x, 17640228.
    • (2007) J Cutan Pathol , vol.34 , pp. 597-600
    • McHugh, J.B.1    Fullen, D.R.2    Ma, L.3    Kleer, C.G.4    Su, L.D.5
  • 59
    • 58449132116 scopus 로고    scopus 로고
    • Epigenetic marks in melanoma
    • 10.1111/j.1755-148X.2008.00534.x, 19040501
    • Richards HW, Medrano EE. Epigenetic marks in melanoma. Pigment Cell Melanoma Res 2009, 22:14-29. 10.1111/j.1755-148X.2008.00534.x, 19040501.
    • (2009) Pigment Cell Melanoma Res , vol.22 , pp. 14-29
    • Richards, H.W.1    Medrano, E.E.2
  • 60
    • 33746167772 scopus 로고    scopus 로고
    • Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells
    • 10.1038/sj.jid.5700324, 16645588
    • Roesch A, Becker B, Schneider-Brachert W, Hagen I, Landthaler M, Vogt T. Re-expression of the retinoblastoma-binding protein 2-homolog 1 reveals tumor-suppressive functions in highly metastatic melanoma cells. J Invest Dermatol 2006, 126:1850-1859. 10.1038/sj.jid.5700324, 16645588.
    • (2006) J Invest Dermatol , vol.126 , pp. 1850-1859
    • Roesch, A.1    Becker, B.2    Schneider-Brachert, W.3    Hagen, I.4    Landthaler, M.5    Vogt, T.6
  • 61
    • 68749117723 scopus 로고    scopus 로고
    • Role of miRNAs in the progression of malignant melanoma
    • 10.1038/sj.bjc.6605204, 19638982
    • Mueller DW, Bosserhoff AK. Role of miRNAs in the progression of malignant melanoma. Br J Cancer 2009, 101:551-556. 10.1038/sj.bjc.6605204, 19638982.
    • (2009) Br J Cancer , vol.101 , pp. 551-556
    • Mueller, D.W.1    Bosserhoff, A.K.2
  • 62
    • 67449119421 scopus 로고    scopus 로고
    • MiRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma
    • 10.1038/jid.2008.452, 19212343
    • Mueller DW, Rehli M, Bosserhoff AK. miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma. J Invest Dermatol 2009, 129:1740-1751. 10.1038/jid.2008.452, 19212343.
    • (2009) J Invest Dermatol , vol.129 , pp. 1740-1751
    • Mueller, D.W.1    Rehli, M.2    Bosserhoff, A.K.3
  • 67
    • 56149110341 scopus 로고    scopus 로고
    • Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma
    • 10.1038/onc.2008.282, 18679415
    • Muller DW, Bosserhoff AK. Integrin beta 3 expression is regulated by let-7a miRNA in malignant melanoma. Oncogene 2008, 27:6698-6706. 10.1038/onc.2008.282, 18679415.
    • (2008) Oncogene , vol.27 , pp. 6698-6706
    • Muller, D.W.1    Bosserhoff, A.K.2
  • 68
    • 43049133807 scopus 로고    scopus 로고
    • MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth
    • 10.1038/cr.2008.45, 18379589
    • Schultz J, Lorenz P, Gross G, Ibrahim S, Kunz M. MicroRNA let-7b targets important cell cycle molecules in malignant melanoma cells and interferes with anchorage-independent growth. Cell Res 2008, 18:549-557. 10.1038/cr.2008.45, 18379589.
    • (2008) Cell Res , vol.18 , pp. 549-557
    • Schultz, J.1    Lorenz, P.2    Gross, G.3    Ibrahim, S.4    Kunz, M.5
  • 71
    • 27144509196 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors and the development of epigenetic cancer therapies
    • 10.1093/jnci/dji311, 16234563
    • Lyko F, Brown R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J Natl Cancer Inst 2005, 97:1498-1506. 10.1093/jnci/dji311, 16234563.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1498-1506
    • Lyko, F.1    Brown, R.2
  • 72
    • 34447123203 scopus 로고    scopus 로고
    • Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides
    • 10.1158/0008-5472.CAN-07-0251, 17616700
    • Yoo CB, Jeong S, Egger G, Liang G, Phiasivongsa P, Tang C, Redkar S, Jones PA. Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res 2007, 67:6400-6408. 10.1158/0008-5472.CAN-07-0251, 17616700.
    • (2007) Cancer Res , vol.67 , pp. 6400-6408
    • Yoo, C.B.1    Jeong, S.2    Egger, G.3    Liang, G.4    Phiasivongsa, P.5    Tang, C.6    Redkar, S.7    Jones, P.A.8
  • 73
    • 0000418476 scopus 로고
    • Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine
    • 10.1073/pnas.81.22.6993, 392062, 6209710
    • Santi DV, Norment A, Garrett CE. Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci USA 1984, 81:6993-6997. 10.1073/pnas.81.22.6993, 392062, 6209710.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 6993-6997
    • Santi, D.V.1    Norment, A.2    Garrett, C.E.3
  • 74
    • 27144535374 scopus 로고    scopus 로고
    • Trapped in action: direct visualization of DNA methyltransferase activity in living cells
    • 10.1038/nmeth794, 16179921
    • Schermelleh L, Spada F, Easwaran HP, Zolghadr K, Margot JB, Cardoso MC, Leonhardt H. Trapped in action: direct visualization of DNA methyltransferase activity in living cells. Nat Methods 2005, 2:751-756. 10.1038/nmeth794, 16179921.
    • (2005) Nat Methods , vol.2 , pp. 751-756
    • Schermelleh, L.1    Spada, F.2    Easwaran, H.P.3    Zolghadr, K.4    Margot, J.B.5    Cardoso, M.C.6    Leonhardt, H.7
  • 75
    • 0038142344 scopus 로고    scopus 로고
    • 5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach?
    • 10.1182/blood-2002-11-3458, 12756166
    • Sigalotti L, Altomonte M, Colizzi F, Degan M, Rupolo M, Zagonel V, Pinto A, Gattei V, Maio M. 5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach?. Blood 2003, 101:4644-4646. 10.1182/blood-2002-11-3458, 12756166.
    • (2003) Blood , vol.101 , pp. 4644-4646
    • Sigalotti, L.1    Altomonte, M.2    Colizzi, F.3    Degan, M.4    Rupolo, M.5    Zagonel, V.6    Pinto, A.7    Gattei, V.8    Maio, M.9
  • 78
    • 33646595937 scopus 로고    scopus 로고
    • Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study
    • 10.1007/s10637-006-5938-1, 16502349
    • Winquist E, Knox J, Ayoub JP, Wood L, Wainman N, Reid GK, Pearce L, Shah A, Eisenhauer E. Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study. Invest New Drugs 2006, 24:159-167. 10.1007/s10637-006-5938-1, 16502349.
    • (2006) Invest New Drugs , vol.24 , pp. 159-167
    • Winquist, E.1    Knox, J.2    Ayoub, J.P.3    Wood, L.4    Wainman, N.5    Reid, G.K.6    Pearce, L.7    Shah, A.8    Eisenhauer, E.9
  • 80
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • 10.1038/nrd2133, 16955068
    • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006, 5:769-784. 10.1038/nrd2133, 16955068.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 82
    • 73949128107 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • 10.1200/JCO.2009.22.1291, 19826124
    • Lane AA, Chabner BA. Histone deacetylase inhibitors in cancer therapy. J Clin Oncol 2009, 27:5459-5468. 10.1200/JCO.2009.22.1291, 19826124.
    • (2009) J Clin Oncol , vol.27 , pp. 5459-5468
    • Lane, A.A.1    Chabner, B.A.2
  • 83
    • 64049097640 scopus 로고    scopus 로고
    • The promises and pitfalls of epigenetic therapies in solid tumours
    • 10.1016/j.ejca.2009.01.003, 19211243
    • Graham JS, Kaye SB, Brown R. The promises and pitfalls of epigenetic therapies in solid tumours. Eur J Cancer 2009, 45:1129-1136. 10.1016/j.ejca.2009.01.003, 19211243.
    • (2009) Eur J Cancer , vol.45 , pp. 1129-1136
    • Graham, J.S.1    Kaye, S.B.2    Brown, R.3
  • 84
    • 55749110754 scopus 로고    scopus 로고
    • Demethylating agents in myeloid malignancies
    • 10.1097/CCO.0b013e328313699c, 18841054
    • Garcia-Manero G. Demethylating agents in myeloid malignancies. Curr Opin Oncol 2008, 20:705-710. 10.1097/CCO.0b013e328313699c, 18841054.
    • (2008) Curr Opin Oncol , vol.20 , pp. 705-710
    • Garcia-Manero, G.1
  • 87
    • 31544432509 scopus 로고    scopus 로고
    • De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model
    • 10.1158/0008-5472.CAN-05-3020, 2242843, 16424047
    • Guo ZS, Hong JA, Irvine KR, Chen GA, Spiess PJ, Liu Y, Zeng G, Wunderlich JR, Nguyen DM, Restifo NP, Schrump DS. De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model. Cancer Res 2006, 66:1105-1113. 10.1158/0008-5472.CAN-05-3020, 2242843, 16424047.
    • (2006) Cancer Res , vol.66 , pp. 1105-1113
    • Guo, Z.S.1    Hong, J.A.2    Irvine, K.R.3    Chen, G.A.4    Spiess, P.J.5    Liu, Y.6    Zeng, G.7    Wunderlich, J.R.8    Nguyen, D.M.9    Restifo, N.P.10    Schrump, D.S.11
  • 88
    • 11844264545 scopus 로고    scopus 로고
    • Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms
    • Schmelz K, Sattler N, Wagner M, Lubbert M, Dorken B, Tamm I. Induction of gene expression by 5-Aza-2'-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms. Leukemia 2005, 19:103-111.
    • (2005) Leukemia , vol.19 , pp. 103-111
    • Schmelz, K.1    Sattler, N.2    Wagner, M.3    Lubbert, M.4    Dorken, B.5    Tamm, I.6
  • 90
    • 0032920527 scopus 로고    scopus 로고
    • Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2'-deoxycytidine (5-AZA-CdR)
    • 10.1097/00002371-199901000-00003, 9924695
    • Coral S, Sigalotti L, Gasparollo A, Cattarossi I, Visintin A, Cattelan A, Altomonte M, Maio M. Prolonged upregulation of the expression of HLA class I antigens and costimulatory molecules on melanoma cells treated with 5-aza-2'-deoxycytidine (5-AZA-CdR). J Immunother 1999, 22:16-24. 10.1097/00002371-199901000-00003, 9924695.
    • (1999) J Immunother , vol.22 , pp. 16-24
    • Coral, S.1    Sigalotti, L.2    Gasparollo, A.3    Cattarossi, I.4    Visintin, A.5    Cattelan, A.6    Altomonte, M.7    Maio, M.8
  • 93
    • 33646709661 scopus 로고    scopus 로고
    • Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells
    • 10.1038/sj.onc.1209319, 16407841
    • Luo W, Wang X, Kageshita T, Wakasugi S, Karpf AR, Ferrone S. Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells. Oncogene 2006, 25:2873-2884. 10.1038/sj.onc.1209319, 16407841.
    • (2006) Oncogene , vol.25 , pp. 2873-2884
    • Luo, W.1    Wang, X.2    Kageshita, T.3    Wakasugi, S.4    Karpf, A.R.5    Ferrone, S.6
  • 94
    • 20144387910 scopus 로고    scopus 로고
    • Potent selection of antigen loss variants of B16 melanoma following inflammatory killing of melanocytes in vivo
    • 10.1158/0008-5472.CAN-04-3216, 15753401
    • Sanchez-Perez L, Kottke T, Diaz RM, Ahmed A, Thompson J, Chong H, Melcher A, Holmen S, Daniels G, Vile RG. Potent selection of antigen loss variants of B16 melanoma following inflammatory killing of melanocytes in vivo. Cancer Res 2005, 65:2009-2017. 10.1158/0008-5472.CAN-04-3216, 15753401.
    • (2005) Cancer Res , vol.65 , pp. 2009-2017
    • Sanchez-Perez, L.1    Kottke, T.2    Diaz, R.M.3    Ahmed, A.4    Thompson, J.5    Chong, H.6    Melcher, A.7    Holmen, S.8    Daniels, G.9    Vile, R.G.10
  • 95
    • 0037544226 scopus 로고    scopus 로고
    • Methylation-regulated expression of HLA class I antigens in melanoma
    • 10.1002/ijc.11077, 12704681
    • Fonsatti E, Sigalotti L, Coral S, Colizzi F, Altomonte M, Maio M. Methylation-regulated expression of HLA class I antigens in melanoma. Int J Cancer 2003, 105:430-431. 10.1002/ijc.11077, 12704681.
    • (2003) Int J Cancer , vol.105 , pp. 430-431
    • Fonsatti, E.1    Sigalotti, L.2    Coral, S.3    Colizzi, F.4    Altomonte, M.5    Maio, M.6
  • 96
    • 34250621776 scopus 로고    scopus 로고
    • Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications
    • 10.1158/1078-0432.CCR-06-3091, 17545540
    • Fonsatti E, Nicolay HJ, Sigalotti L, Calabro L, Pezzani L, Colizzi F, Altomonte M, Guidoboni M, Marincola FM, Maio M. Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications. Clin Cancer Res 2007, 13:3333-3338. 10.1158/1078-0432.CCR-06-3091, 17545540.
    • (2007) Clin Cancer Res , vol.13 , pp. 3333-3338
    • Fonsatti, E.1    Nicolay, H.J.2    Sigalotti, L.3    Calabro, L.4    Pezzani, L.5    Colizzi, F.6    Altomonte, M.7    Guidoboni, M.8    Marincola, F.M.9    Maio, M.10
  • 97
    • 0035886022 scopus 로고    scopus 로고
    • Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment
    • 10.1002/ijc.1452, 11668505
    • Serrano A, Tanzarella S, Lionello I, Mendez R, Traversari C, Ruiz-Cabello F, Garrido F. Rexpression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells following 5-aza-2'-deoxycytidine treatment. Int J Cancer 2001, 94:243-251. 10.1002/ijc.1452, 11668505.
    • (2001) Int J Cancer , vol.94 , pp. 243-251
    • Serrano, A.1    Tanzarella, S.2    Lionello, I.3    Mendez, R.4    Traversari, C.5    Ruiz-Cabello, F.6    Garrido, F.7
  • 98
    • 38349041706 scopus 로고    scopus 로고
    • Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL
    • 10.1038/sj.onc.1210655, 17653094
    • Bae SI, Cheriyath V, Jacobs BS, Reu FJ, Borden EC. Reversal of methylation silencing of Apo2L/TRAIL receptor 1 (DR4) expression overcomes resistance of SK-MEL-3 and SK-MEL-28 melanoma cells to interferons (IFNs) or Apo2L/TRAIL. Oncogene 2008, 27:490-498. 10.1038/sj.onc.1210655, 17653094.
    • (2008) Oncogene , vol.27 , pp. 490-498
    • Bae, S.I.1    Cheriyath, V.2    Jacobs, B.S.3    Reu, F.J.4    Borden, E.C.5
  • 99
    • 33747339752 scopus 로고    scopus 로고
    • Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation
    • 10.1200/JCO.2005.03.4074, 16801630
    • Reu FJ, Bae SI, Cherkassky L, Leaman DW, Lindner D, Beaulieu N, MacLeod AR, Borden EC. Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation. J Clin Oncol 2006, 24:3771-3779. 10.1200/JCO.2005.03.4074, 16801630.
    • (2006) J Clin Oncol , vol.24 , pp. 3771-3779
    • Reu, F.J.1    Bae, S.I.2    Cherkassky, L.3    Leaman, D.W.4    Lindner, D.5    Beaulieu, N.6    MacLeod, A.R.7    Borden, E.C.8
  • 100
    • 0035855626 scopus 로고    scopus 로고
    • Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer
    • 10.1038/sj.onc.1204750, 11593392
    • Fulda S, Kufer MU, Meyer E, van VF, Dockhorn-Dworniczak B, Debatin KM. Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene 2001, 20:5865-5877. 10.1038/sj.onc.1204750, 11593392.
    • (2001) Oncogene , vol.20 , pp. 5865-5877
    • Fulda, S.1    Kufer, M.U.2    Meyer, E.3    van, V.F.4    Dockhorn-Dworniczak, B.5    Debatin, K.M.6
  • 101
    • 49649125674 scopus 로고    scopus 로고
    • Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling
    • 10.1111/j.1755-148X.2008.00484.x, 18627528
    • Liu S, Ren S, Howell P, Fodstad O, Riker AI. Identification of novel epigenetically modified genes in human melanoma via promoter methylation gene profiling. Pigment Cell Melanoma Res 2008, 21:545-558. 10.1111/j.1755-148X.2008.00484.x, 18627528.
    • (2008) Pigment Cell Melanoma Res , vol.21 , pp. 545-558
    • Liu, S.1    Ren, S.2    Howell, P.3    Fodstad, O.4    Riker, A.I.5
  • 102
    • 3242670444 scopus 로고    scopus 로고
    • An epigenetically altered tumor cell vaccine
    • 10.1007/s00262-004-0513-0, 14997346
    • Khan AN, Magner WJ, Tomasi TB. An epigenetically altered tumor cell vaccine. Cancer Immunol Immunother 2004, 53:748-754. 10.1007/s00262-004-0513-0, 14997346.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 748-754
    • Khan, A.N.1    Magner, W.J.2    Tomasi, T.B.3
  • 103
    • 43149097365 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells
    • 10.1007/s00262-007-0402-4, 18046553
    • Khan AN, Gregorie CJ, Tomasi TB. Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. Cancer Immunol Immunother 2008, 57:647-654. 10.1007/s00262-007-0402-4, 18046553.
    • (2008) Cancer Immunol Immunother , vol.57 , pp. 647-654
    • Khan, A.N.1    Gregorie, C.J.2    Tomasi, T.B.3
  • 104
    • 39049115955 scopus 로고    scopus 로고
    • An epigenetic vaccine model active in the prevention and treatment of melanoma
    • 10.1186/1479-5876-5-64, 2231344, 18070359
    • Khan AN, Magner WJ, Tomasi TB. An epigenetic vaccine model active in the prevention and treatment of melanoma. J Transl Med 2007, 5:64. 10.1186/1479-5876-5-64, 2231344, 18070359.
    • (2007) J Transl Med , vol.5 , pp. 64
    • Khan, A.N.1    Magner, W.J.2    Tomasi, T.B.3
  • 105
    • 43749087126 scopus 로고    scopus 로고
    • Transcriptional Modulation Using HDACi Depsipeptide Promotes Immune Cell-Mediated Tumor Destruction of Murine B16 Melanoma
    • 10.1038/sj.jid.5701216, 18185535
    • Murakami T, Sato A, Chun NA, Hara M, Naito Y, Kobayashi Y, Kano Y, Ohtsuki M, Furukawa Y, Kobayashi E. Transcriptional Modulation Using HDACi Depsipeptide Promotes Immune Cell-Mediated Tumor Destruction of Murine B16 Melanoma. J Invest Dermatol 2008, 128:1506-1516. 10.1038/sj.jid.5701216, 18185535.
    • (2008) J Invest Dermatol , vol.128 , pp. 1506-1516
    • Murakami, T.1    Sato, A.2    Chun, N.A.3    Hara, M.4    Naito, Y.5    Kobayashi, Y.6    Kano, Y.7    Ohtsuki, M.8    Furukawa, Y.9    Kobayashi, E.10
  • 106
    • 33845352223 scopus 로고    scopus 로고
    • Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells
    • 10.1007/s10495-006-0283-6, 17051334
    • Gillespie S, Borrow J, Zhang XD, Hersey P. Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells. Apoptosis 2006, 11:2251-2265. 10.1007/s10495-006-0283-6, 17051334.
    • (2006) Apoptosis , vol.11 , pp. 2251-2265
    • Gillespie, S.1    Borrow, J.2    Zhang, X.D.3    Hersey, P.4
  • 107
    • 12444252093 scopus 로고    scopus 로고
    • Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice
    • Kozar K, Kaminski R, Switaj T, Oldak T, Machaj E, Wysocki PJ, Mackiewicz A, Lasek W, Jakobisiak M, Golab J. Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice. Clin Cancer Res 2003, 9:3124-3133.
    • (2003) Clin Cancer Res , vol.9 , pp. 3124-3133
    • Kozar, K.1    Kaminski, R.2    Switaj, T.3    Oldak, T.4    Machaj, E.5    Wysocki, P.J.6    Mackiewicz, A.7    Lasek, W.8    Jakobisiak, M.9    Golab, J.10
  • 109
    • 33748046812 scopus 로고    scopus 로고
    • Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma
    • 10.1158/1078-0432.CCR-06-0883, 16899610
    • Gollob JA, Sciambi CJ, Peterson BL, Richmond T, Thoreson M, Moran K, Dressman HK, Jelinek J, Issa JP. Phase I trial of sequential low-dose 5-aza-2'-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma. Clin Cancer Res 2006, 12:4619-4627. 10.1158/1078-0432.CCR-06-0883, 16899610.
    • (2006) Clin Cancer Res , vol.12 , pp. 4619-4627
    • Gollob, J.A.1    Sciambi, C.J.2    Peterson, B.L.3    Richmond, T.4    Thoreson, M.5    Moran, K.6    Dressman, H.K.7    Jelinek, J.8    Issa, J.P.9
  • 110
    • 33846804139 scopus 로고    scopus 로고
    • Antitumor effect of the histone deacetylase inhibitor LAQ824 in combination with 13-cis-retinoic acid in human malignant melanoma
    • 10.1158/1535-7163.MCT-06-0125, 17237267
    • Kato Y, Salumbides BC, Wang XF, Qian DZ, Williams S, Wei Y, Sanni TB, Atadja P, Pili R. Antitumor effect of the histone deacetylase inhibitor LAQ824 in combination with 13-cis-retinoic acid in human malignant melanoma. Mol Cancer Ther 2007, 6:70-81. 10.1158/1535-7163.MCT-06-0125, 17237267.
    • (2007) Mol Cancer Ther , vol.6 , pp. 70-81
    • Kato, Y.1    Salumbides, B.C.2    Wang, X.F.3    Qian, D.Z.4    Williams, S.5    Wei, Y.6    Sanni, T.B.7    Atadja, P.8    Pili, R.9
  • 112
    • 34548721263 scopus 로고    scopus 로고
    • A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system
    • Alvino E, Castiglia D, Caporali S, Pepponi R, Caporaso P, Lacal PM, Marra G, Fischer F, Zambruno G, Bonmassar E, Jiricny J, D'Atri S. A single cycle of treatment with temozolomide, alone or combined with O(6)-benzylguanine, induces strong chemoresistance in melanoma cell clones in vitro: role of O(6)-methylguanine-DNA methyltransferase and the mismatch repair system. Int J Oncol 2006, 29:785-797.
    • (2006) Int J Oncol , vol.29 , pp. 785-797
    • Alvino, E.1    Castiglia, D.2    Caporali, S.3    Pepponi, R.4    Caporaso, P.5    Lacal, P.M.6    Marra, G.7    Fischer, F.8    Zambruno, G.9    Bonmassar, E.10    Jiricny, J.11    D'Atri, S.12
  • 113
    • 0035313980 scopus 로고    scopus 로고
    • Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT
    • 10.1002/1097-0215(200102)9999:9999<::AID-IJC1160>3.0.CO;2-V, 11279615
    • Christmann M, Pick M, Lage H, Schadendorf D, Kaina B. Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT. Int J Cancer 2001, 92:123-129. 10.1002/1097-0215(200102)9999:9999<::AID-IJC1160>3.0.CO;2-V, 11279615.
    • (2001) Int J Cancer , vol.92 , pp. 123-129
    • Christmann, M.1    Pick, M.2    Lage, H.3    Schadendorf, D.4    Kaina, B.5
  • 114
    • 34247324355 scopus 로고    scopus 로고
    • Valproic acid induces apoptosis, p16INK4A upregulation and sensitization to chemotherapy in human melanoma cells
    • 10.4161/cbt.6.2.3578, 17218782
    • Valentini A, Gravina P, Federici G, Bernardini S. Valproic acid induces apoptosis, p16INK4A upregulation and sensitization to chemotherapy in human melanoma cells. Cancer Biol Ther 2007, 6:185-191. 10.4161/cbt.6.2.3578, 17218782.
    • (2007) Cancer Biol Ther , vol.6 , pp. 185-191
    • Valentini, A.1    Gravina, P.2    Federici, G.3    Bernardini, S.4
  • 115
    • 65249131145 scopus 로고    scopus 로고
    • Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial
    • 10.1158/1078-0432.CCR-08-1931, 19318485
    • Daud AI, Dawson J, DeConti RC, Bicaku E, Marchion D, Bastien S, Hausheer FA, Lush R, Neuger A, Sullivan DM, Munster PN. Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial. Clin Cancer Res 2009, 15:2479-2487. 10.1158/1078-0432.CCR-08-1931, 19318485.
    • (2009) Clin Cancer Res , vol.15 , pp. 2479-2487
    • Daud, A.I.1    Dawson, J.2    DeConti, R.C.3    Bicaku, E.4    Marchion, D.5    Bastien, S.6    Hausheer, F.A.7    Lush, R.8    Neuger, A.9    Sullivan, D.M.10    Munster, P.N.11
  • 118
    • 58149377828 scopus 로고    scopus 로고
    • Multicenter phase II trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2-aminophenyl)-carbamoyl]-benzyl}-carbamate in pretreated metastatic melanoma
    • 10.1097/CMR.0b013e328307c248, 18626312
    • Hauschild A, Trefzer U, Garbe C, Kaehler KC, Ugurel S, Kiecker F, Eigentler T, Krissel H, Schott A, Schadendorf D. Multicenter phase II trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2-aminophenyl)-carbamoyl]-benzyl}-carbamate in pretreated metastatic melanoma. Melanoma Res 2008, 18:274-278. 10.1097/CMR.0b013e328307c248, 18626312.
    • (2008) Melanoma Res , vol.18 , pp. 274-278
    • Hauschild, A.1    Trefzer, U.2    Garbe, C.3    Kaehler, K.C.4    Ugurel, S.5    Kiecker, F.6    Eigentler, T.7    Krissel, H.8    Schott, A.9    Schadendorf, D.10
  • 119
    • 27644586649 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity
    • 10.1158/1078-0432.CCR-04-2088, 16000590
    • Munshi A, Kurland JF, Nishikawa T, Tanaka T, Hobbs ML, Tucker SL, Ismail S, Stevens C, Meyn RE. Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Clin Cancer Res 2005, 11:4912-4922. 10.1158/1078-0432.CCR-04-2088, 16000590.
    • (2005) Clin Cancer Res , vol.11 , pp. 4912-4922
    • Munshi, A.1    Kurland, J.F.2    Nishikawa, T.3    Tanaka, T.4    Hobbs, M.L.5    Tucker, S.L.6    Ismail, S.7    Stevens, C.8    Meyn, R.E.9
  • 120
    • 33748360764 scopus 로고    scopus 로고
    • Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci
    • 10.1158/1535-7163.MCT-06-0022, 16928817
    • Munshi A, Tanaka T, Hobbs ML, Tucker SL, Richon VM, Meyn RE. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther 2006, 5:1967-1974. 10.1158/1535-7163.MCT-06-0022, 16928817.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1967-1974
    • Munshi, A.1    Tanaka, T.2    Hobbs, M.L.3    Tucker, S.L.4    Richon, V.M.5    Meyn, R.E.6
  • 121
    • 75549087174 scopus 로고    scopus 로고
    • Methylation of PTEN as a Prognostic Factor in Malignant Melanoma of the Skin
    • 10.1038/jid.2009.226, 19798057
    • Lahtz C, Stranzenbach R, Fiedler E, Helmbold P, Dammann RH. Methylation of PTEN as a Prognostic Factor in Malignant Melanoma of the Skin. J Invest Dermatol 2009, 130:620-622. 10.1038/jid.2009.226, 19798057.
    • (2009) J Invest Dermatol , vol.130 , pp. 620-622
    • Lahtz, C.1    Stranzenbach, R.2    Fiedler, E.3    Helmbold, P.4    Dammann, R.H.5
  • 122
    • 77951224561 scopus 로고    scopus 로고
    • MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma
    • Satzger I, Mattern A, Kuettler U, Weinspach D, Voelker B, Kapp A, Gutzmer R. MicroRNA-15b represents an independent prognostic parameter and is correlated with tumor cell proliferation and apoptosis in malignant melanoma. Int J Cancer 2009, 126:2553-2562.
    • (2009) Int J Cancer , vol.126 , pp. 2553-2562
    • Satzger, I.1    Mattern, A.2    Kuettler, U.3    Weinspach, D.4    Voelker, B.5    Kapp, A.6    Gutzmer, R.7
  • 125
    • 37049001640 scopus 로고    scopus 로고
    • Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel
    • 10.1158/0008-5472.CAN-07-1502, 18056460
    • Shen L, Kondo Y, Ahmed S, Boumber Y, Konishi K, Guo Y, Chen X, Vilaythong JN, Issa JP. Drug sensitivity prediction by CpG island methylation profile in the NCI-60 cancer cell line panel. Cancer Res 2007, 67:11335-11343. 10.1158/0008-5472.CAN-07-1502, 18056460.
    • (2007) Cancer Res , vol.67 , pp. 11335-11343
    • Shen, L.1    Kondo, Y.2    Ahmed, S.3    Boumber, Y.4    Konishi, K.5    Guo, Y.6    Chen, X.7    Vilaythong, J.N.8    Issa, J.P.9
  • 127
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • 10.1158/0008-5472.CAN-04-2957, 16024632
    • Brueckner B, Boy RG, Siedlecki P, Musch T, Kliem HC, Zielenkiewicz P, Suhai S, Wiessler M, Lyko F. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res 2005, 65:6305-6311. 10.1158/0008-5472.CAN-04-2957, 16024632.
    • (2005) Cancer Res , vol.65 , pp. 6305-6311
    • Brueckner, B.1    Boy, R.G.2    Siedlecki, P.3    Musch, T.4    Kliem, H.C.5    Zielenkiewicz, P.6    Suhai, S.7    Wiessler, M.8    Lyko, F.9
  • 128
    • 33750006223 scopus 로고    scopus 로고
    • Aberrant DNA methylation silences the novel heat shock protein H11 in melanoma but not benign melanocytic lesions
    • 10.1159/000095035, 17033167
    • Sharma BK, Smith CC, Laing JM, Rucker DA, Burnett JW, Aurelian L. Aberrant DNA methylation silences the novel heat shock protein H11 in melanoma but not benign melanocytic lesions. Dermatology 2006, 213:192-199. 10.1159/000095035, 17033167.
    • (2006) Dermatology , vol.213 , pp. 192-199
    • Sharma, B.K.1    Smith, C.C.2    Laing, J.M.3    Rucker, D.A.4    Burnett, J.W.5    Aurelian, L.6
  • 129
    • 11844302899 scopus 로고    scopus 로고
    • Promoter methylation profiling of 30 genes in human malignant melanoma
    • 10.1111/j.1349-7006.2004.tb03184.x, 15596045
    • Furuta J, Umebayashi Y, Miyamoto K, Kikuchi K, Otsuka F, Sugimura T, Ushijima T. Promoter methylation profiling of 30 genes in human malignant melanoma. Cancer Sci 2004, 95:962-968. 10.1111/j.1349-7006.2004.tb03184.x, 15596045.
    • (2004) Cancer Sci , vol.95 , pp. 962-968
    • Furuta, J.1    Umebayashi, Y.2    Miyamoto, K.3    Kikuchi, K.4    Otsuka, F.5    Sugimura, T.6    Ushijima, T.7
  • 130
    • 33644659012 scopus 로고    scopus 로고
    • Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma
    • 10.1038/sj.jid.5700073, 16374457
    • Marini A, Mirmohammadsadegh A, Nambiar S, Gustrau A, Ruzicka T, Hengge UR. Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma. J Invest Dermatol 2006, 126:422-431. 10.1038/sj.jid.5700073, 16374457.
    • (2006) J Invest Dermatol , vol.126 , pp. 422-431
    • Marini, A.1    Mirmohammadsadegh, A.2    Nambiar, S.3    Gustrau, A.4    Ruzicka, T.5    Hengge, U.R.6
  • 131
    • 0141857814 scopus 로고    scopus 로고
    • ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma
    • 10.1002/ijc.11376, 12949795
    • Guan X, Sagara J, Yokoyama T, Koganehira Y, Oguchi M, Saida T, Taniguchi S. ASC/TMS1, a caspase-1 activating adaptor, is downregulated by aberrant methylation in human melanoma. Int J Cancer 2003, 107:202-208. 10.1002/ijc.11376, 12949795.
    • (2003) Int J Cancer , vol.107 , pp. 202-208
    • Guan, X.1    Sagara, J.2    Yokoyama, T.3    Koganehira, Y.4    Oguchi, M.5    Saida, T.6    Taniguchi, S.7
  • 132
    • 0034687169 scopus 로고    scopus 로고
    • Aberrant p27Kip1 promoter methylation in malignant melanoma
    • 10.1038/sj.onc.1203891, 11042700
    • Worm J, Bartkova J, Kirkin AF, Straten P, Zeuthen J, Bartek J, Guldberg P. Aberrant p27Kip1 promoter methylation in malignant melanoma. Oncogene 2000, 19:5111-5115. 10.1038/sj.onc.1203891, 11042700.
    • (2000) Oncogene , vol.19 , pp. 5111-5115
    • Worm, J.1    Bartkova, J.2    Kirkin, A.F.3    Straten, P.4    Zeuthen, J.5    Bartek, J.6    Guldberg, P.7
  • 133
    • 0036313607 scopus 로고    scopus 로고
    • Significant impact of promoter hypermethylation and the 540 C > T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase
    • 1850679, 12107107
    • Straume O, Smeds J, Kumar R, Hemminki K, Akslen LA. Significant impact of promoter hypermethylation and the 540 C > T polymorphism of CDKN2A in cutaneous melanoma of the vertical growth phase. Am J Pathol 2002, 161:229-237. 1850679, 12107107.
    • (2002) Am J Pathol , vol.161 , pp. 229-237
    • Straume, O.1    Smeds, J.2    Kumar, R.3    Hemminki, K.4    Akslen, L.A.5
  • 135
    • 33750869288 scopus 로고    scopus 로고
    • A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion
    • 10.1038/sj.onc.1209688, 16715130
    • Takeuchi T, Adachi Y, Sonobe H, Furihata M, Ohtsuki Y. A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. Oncogene 2006, 25:7059-7069. 10.1038/sj.onc.1209688, 16715130.
    • (2006) Oncogene , vol.25 , pp. 7059-7069
    • Takeuchi, T.1    Adachi, Y.2    Sonobe, H.3    Furihata, M.4    Ohtsuki, Y.5
  • 136
    • 3142710392 scopus 로고    scopus 로고
    • Genetic and epigenetic alterations of the APC gene in malignant melanoma
    • 10.1038/sj.onc.1207647, 15133491
    • Worm J, Christensen C, Gronbaek K, Tulchinsky E, Guldberg P. Genetic and epigenetic alterations of the APC gene in malignant melanoma. Oncogene 2004, 23:5215-5226. 10.1038/sj.onc.1207647, 15133491.
    • (2004) Oncogene , vol.23 , pp. 5215-5226
    • Worm, J.1    Christensen, C.2    Gronbaek, K.3    Tulchinsky, E.4    Guldberg, P.5
  • 138
    • 33745728166 scopus 로고    scopus 로고
    • Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas
    • 10.1158/0008-5472.CAN-06-0157, 16778180
    • Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K, Ushijima T. Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. Cancer Res 2006, 66:6080-6086. 10.1158/0008-5472.CAN-06-0157, 16778180.
    • (2006) Cancer Res , vol.66 , pp. 6080-6086
    • Furuta, J.1    Nobeyama, Y.2    Umebayashi, Y.3    Otsuka, F.4    Kikuchi, K.5    Ushijima, T.6
  • 139
    • 33644758237 scopus 로고    scopus 로고
    • Promoter hypermethylation of the O(6)-methylguanine DNA methyltransferase gene and microsatellite instability in metastatic melanoma
    • 10.1038/sj.jid.5700005, 16417233
    • Kohonen-Corish MR, Cooper WA, Saab J, Thompson JF, Trent RJ, Millward MJ. Promoter hypermethylation of the O(6)-methylguanine DNA methyltransferase gene and microsatellite instability in metastatic melanoma. J Invest Dermatol 2006, 126:167-171. 10.1038/sj.jid.5700005, 16417233.
    • (2006) J Invest Dermatol , vol.126 , pp. 167-171
    • Kohonen-Corish, M.R.1    Cooper, W.A.2    Saab, J.3    Thompson, J.F.4    Trent, R.J.5    Millward, M.J.6
  • 141
    • 16444373352 scopus 로고    scopus 로고
    • Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells
    • 10.1158/0008-5472.CAN-04-3531, 15753377
    • Mori T, Kim J, Yamano T, Takeuchi H, Huang S, Umetani N, Koyanagi K, Hoon DS. Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells. Cancer Res 2005, 65:1800-1807. 10.1158/0008-5472.CAN-04-3531, 15753377.
    • (2005) Cancer Res , vol.65 , pp. 1800-1807
    • Mori, T.1    Kim, J.2    Yamano, T.3    Takeuchi, H.4    Huang, S.5    Umetani, N.6    Koyanagi, K.7    Hoon, D.S.8
  • 142
    • 38449112061 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV (DPPIV), a candidate tumor suppressor gene in melanomas is silenced by promoter methylation
    • 10.2741/2856, 17981724
    • McGuinness C, Wesley UV. Dipeptidyl peptidase IV (DPPIV), a candidate tumor suppressor gene in melanomas is silenced by promoter methylation. Front Biosci 2008, 13:2435-2443. 10.2741/2856, 17981724.
    • (2008) Front Biosci , vol.13 , pp. 2435-2443
    • McGuinness, C.1    Wesley, U.V.2
  • 143
    • 33947327082 scopus 로고    scopus 로고
    • Loss of maspin expression contributes to a more invasive potential in malignant melanoma
    • 10.1111/j.1600-0749.2007.00363.x, 17371437
    • Denk AE, Bettstetter M, Wild PJ, Hoek K, Bataille F, Dietmaier W, Bosserhoff AK. Loss of maspin expression contributes to a more invasive potential in malignant melanoma. Pigment Cell Res 2007, 20:112-119. 10.1111/j.1600-0749.2007.00363.x, 17371437.
    • (2007) Pigment Cell Res , vol.20 , pp. 112-119
    • Denk, A.E.1    Bettstetter, M.2    Wild, P.J.3    Hoek, K.4    Bataille, F.5    Dietmaier, W.6    Bosserhoff, A.K.7
  • 144
    • 1842740113 scopus 로고    scopus 로고
    • Aberrant expression of the maspin gene associated with epigenetic modification in melanoma cells
    • 10.1111/j.0022-202X.2004.22308.x, 15086568
    • Wada K, Maesawa C, Akasaka T, Masuda T. Aberrant expression of the maspin gene associated with epigenetic modification in melanoma cells. J Invest Dermatol 2004, 122:805-811. 10.1111/j.0022-202X.2004.22308.x, 15086568.
    • (2004) J Invest Dermatol , vol.122 , pp. 805-811
    • Wada, K.1    Maesawa, C.2    Akasaka, T.3    Masuda, T.4
  • 146
    • 14844364254 scopus 로고    scopus 로고
    • Silencing of the thrombomodulin gene in human malignant melanoma
    • 10.1097/00008390-200502000-00004, 15714116
    • Furuta J, Kaneda A, Umebayashi Y, Otsuka F, Sugimura T, Ushijima T. Silencing of the thrombomodulin gene in human malignant melanoma. Melanoma Res 2005, 15:15-20. 10.1097/00008390-200502000-00004, 15714116.
    • (2005) Melanoma Res , vol.15 , pp. 15-20
    • Furuta, J.1    Kaneda, A.2    Umebayashi, Y.3    Otsuka, F.4    Sugimura, T.5    Ushijima, T.6
  • 150
    • 65649092616 scopus 로고    scopus 로고
    • Regulation of RUNX3 tumor suppressor gene expression in cutaneous melanoma
    • 10.1158/1078-0432.CCR-08-3172, 2682369, 19336521
    • Kitago M, Martinez SR, Nakamura T, Sim MS, Hoon DS. Regulation of RUNX3 tumor suppressor gene expression in cutaneous melanoma. Clin Cancer Res 2009, 15:2988-2994. 10.1158/1078-0432.CCR-08-3172, 2682369, 19336521.
    • (2009) Clin Cancer Res , vol.15 , pp. 2988-2994
    • Kitago, M.1    Martinez, S.R.2    Nakamura, T.3    Sim, M.S.4    Hoon, D.S.5
  • 151
    • 0642345200 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor suberic bishydroxamate: a potential sensitizer of melanoma to TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis
    • 10.1016/S0006-2952(03)00509-4, 14555232
    • Zhang XD, Gillespie SK, Borrow JM, Hersey P. The histone deacetylase inhibitor suberic bishydroxamate: a potential sensitizer of melanoma to TNF-related apoptosis-inducing ligand (TRAIL) induced apoptosis. Biochem Pharmacol 2003, 66:1537-1545. 10.1016/S0006-2952(03)00509-4, 14555232.
    • (2003) Biochem Pharmacol , vol.66 , pp. 1537-1545
    • Zhang, X.D.1    Gillespie, S.K.2    Borrow, J.M.3    Hersey, P.4
  • 152
    • 4344716951 scopus 로고    scopus 로고
    • Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors
    • 10.1023/B:APPT.0000038036.31271.50, 15314285
    • Facchetti F, Previdi S, Ballarini M, Minucci S, Perego P, La Porta CA. Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors. Apoptosis 2004, 9:573-582. 10.1023/B:APPT.0000038036.31271.50, 15314285.
    • (2004) Apoptosis , vol.9 , pp. 573-582
    • Facchetti, F.1    Previdi, S.2    Ballarini, M.3    Minucci, S.4    Perego, P.5    La Porta, C.A.6
  • 153
    • 0036829085 scopus 로고    scopus 로고
    • Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes
    • Bandyopadhyay D, Okan NA, Bales E, Nascimento L, Cole PA, Medrano EE. Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes. Cancer Res 2002, 62:6231-6239.
    • (2002) Cancer Res , vol.62 , pp. 6231-6239
    • Bandyopadhyay, D.1    Okan, N.A.2    Bales, E.3    Nascimento, L.4    Cole, P.A.5    Medrano, E.E.6
  • 154
    • 33845925314 scopus 로고    scopus 로고
    • Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid
    • 10.1021/jm050214x, 17181145
    • Kahnberg P, Lucke AJ, Glenn MP, Boyle GM, Tyndall JD, Parsons PG, Fairlie DP. Design, synthesis, potency, and cytoselectivity of anticancer agents derived by parallel synthesis from alpha-aminosuberic acid. J Med Chem 2006, 49:7611-7622. 10.1021/jm050214x, 17181145.
    • (2006) J Med Chem , vol.49 , pp. 7611-7622
    • Kahnberg, P.1    Lucke, A.J.2    Glenn, M.P.3    Boyle, G.M.4    Tyndall, J.D.5    Parsons, P.G.6    Fairlie, D.P.7
  • 155
    • 37349022318 scopus 로고    scopus 로고
    • Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases
    • 10.1007/s00401-006-0082-8, 16773328
    • Holsken A, Eyupoglu IY, Lueders M, Trankle C, Dieckmann D, Buslei R, Hahnen E, Blumcke I, Siebzehnrubl FA. Ex vivo therapy of malignant melanomas transplanted into organotypic brain slice cultures using inhibitors of histone deacetylases. Acta Neuropathol 2006, 112:205-215. 10.1007/s00401-006-0082-8, 16773328.
    • (2006) Acta Neuropathol , vol.112 , pp. 205-215
    • Holsken, A.1    Eyupoglu, I.Y.2    Lueders, M.3    Trankle, C.4    Dieckmann, D.5    Buslei, R.6    Hahnen, E.7    Blumcke, I.8    Siebzehnrubl, F.A.9
  • 156
    • 0037260144 scopus 로고    scopus 로고
    • New established melanoma cell lines: genetic and biochemical characterization of cell division cycle
    • 10.1046/j.1468-3083.2003.00644.x, 12602966
    • Vozza A, Borriello A, Criniti V, Vozza G, Della RF. New established melanoma cell lines: genetic and biochemical characterization of cell division cycle. J Eur Acad Dermatol Venereol 2003, 17:37-41. 10.1046/j.1468-3083.2003.00644.x, 12602966.
    • (2003) J Eur Acad Dermatol Venereol , vol.17 , pp. 37-41
    • Vozza, A.1    Borriello, A.2    Criniti, V.3    Vozza, G.4    Della, R.F.5
  • 157
    • 0035835483 scopus 로고    scopus 로고
    • Effects of retinoic acid and sodium butyrate on gene expression, histone acetylation and inhibition of proliferation of melanoma cells
    • 10.1016/S0304-3835(00)00676-5, 11163113
    • Demary K, Wong L, Spanjaard RA. Effects of retinoic acid and sodium butyrate on gene expression, histone acetylation and inhibition of proliferation of melanoma cells. Cancer Lett 2001, 163:103-107. 10.1016/S0304-3835(00)00676-5, 11163113.
    • (2001) Cancer Lett , vol.163 , pp. 103-107
    • Demary, K.1    Wong, L.2    Spanjaard, R.A.3
  • 161


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.