Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 6, 2009, Pages 1814-1819

  Segura, Miguel F ^a   Hanniford, Douglas ^a   Menendez, Silvia ^a   Reavie, Linsey ^a   Zou, Xuanyi ^a   Alvarez Diaz, Silvia ^b   Zakrzewski, Jan ^a   Blochin, Elen ^a   Rose, Amy ^a   Bogunovic, Dusan ^a   Polsky, David ^a   Wei, Jianjun ^a   Lee, Peng ^a   Belitskaya Levy, Ilana ^a   Bhardwaj, Nina ^a   Osman, Iman ^a   Hernando, Eva ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

Cancer; Invasion; Microrna

Indexed keywords

MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MICRORNA; MIR 182; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CONTROLLED STUDY; DOWN REGULATION; GENE NUMBER; HUMAN; HUMAN CELL; IN VITRO SELECTION; IN VIVO STUDY; MELANOMA CELL; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; CELL MOVEMENT; CELL SURVIVAL; DISEASE PROGRESSION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MELANOMA; MICE; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MICRORNAS; NEOPLASM METASTASIS; TUMOR CELLS, CULTURED;

EID: 60549112361     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808263106     Document Type: Article

References (35)

1. Chin L, Garraway LA, Fisher DE (2006) Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev 20:2149-2182.
2. Jonsson G, et al. (2007) Genomic profiling of malignant melanoma using tiling-resolution array CGH. Oncogene 6:4738-4748.
3. Zhang L, et al. (2006) microRNAs exhibit high frequency genomic alterations in human cancer. Proc Natl Acad Sci USA 103:9136-9141.
4. Meister G, Landthaler M, Dorsett Y, Tuschl T (2004) Sequence-specific inhibition of microRNA-and siRNA-induced RNA silencing. Rna 10:544-550.
5. Chen CZ, Li L, Lodish HF, Bartel DP (2004) MicroRNAs modulate hematopoietic lineage differentiation. Science 303:83-86.
6. He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5:522-531.
7. Yi R, et al. (2006) Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet 38:356-362.
8. Croce CM, Calin GA (2005) miRNAs, cancer, and stem cell division. Cell 122:6-7.
9. Bastian BC, et al. (1998) Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res 58:2170-2175.
10. Lin WM, et al. (2008) Modeling genomic diversity and tumor dependency in malignant melanoma. Cancer Res 68:664-673.
11. Tavazoie SF, et al. (2008) Endogenous human microRNAs that suppress breast cancer metastasis. Nature 451:147-152.
12. Xu S, et al. (2007) MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J Biol Chem 282:25053-25066.
13. Landgraf P, et al. (2007) A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129:1401-1414.
14. MaL, Teruya-Feldstein J, Weinberg RA (2007) Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449:682-688.
15. Tanami H, et al. (2004) Involvement of overexpressed wild-type BRAF in the growth of malignant melanoma cell lines. Oncogene 23:8796-8804.
16. Willmore-Payne C, Holden JA, Hirschowitz S, Layfield LJ (2006) BRAF and c-kit gene copy number in mutation-positive malignant melanoma. Hum Pathol 37:520-527.
17. Natali PG, et al. (1993) Expression of the c-Met/HGF receptor in human melanocytic neoplasms: demonstration of the relationship to malignant melanoma tumour progression. Br J Cancer 68:746-750.
18. Trent JM, et al. (1990) Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma. N Engl J Med 322:1508-1511.
19. Garraway LA, et al. (2005) Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 436:117-122.
20. Levy C, Khaled M, Fisher DE (2006) MITF:master regulator of melanocyte development and melanoma oncogene. Trends Mol Med 12:406-414.
21. Reed JA, Medrano EE (2006) Recent advances in melanoma research. Front Biosci 11:3003-3013.
22. Hoek KS, et al. (2008) In vivo switching of human melanoma cells between proliferative and invasive states. Cancer Res 68:650-656.
23. Lekmine F, et al. (2007) Role of microphthalmia transcription factor (Mitf) in melanoma differentiation. Biochem Biophys Res Commun 354:830-835.
24. Salti GI, et al. (2000) Micropthalmia transcription factor: a new prognostic marker in intermediate-thickness cutaneous malignant melanoma. Cancer Res 60:5012-5016.
25. Selzer E, et al. (2002) The melanocyte-specific isoform of the microphthalmia transcription factor affects the phenotype of human melanoma. Cancer Res 62:2098-2103.
26. Loercher AE, Tank EM, Delston RB, Harbour JW (2005) MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J Cell Biol 168:35-40.
27. Carreira S, et al. (2005) Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 433:764-769.
28. Carreira S, et al. (2006) Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev 20:3426-3439.
29. Myatt SS, Lam EW (2007) The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 7:847-859.
30. Paik JH, et al. (2007) FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128:309-323.
31. Hilmi C, et al. (2008) Involvement of FKHRL1 in melanoma cell survival and death. Pigment Cell Melanoma Res 21:139-146.
32. Gomez-Gutierrez JG, et al. (2006) Adenovirus-mediated gene transfer of FKHRL1 triple mutant efficiently induces apoptosis in melanoma cells. Cancer Biol Ther 5:875-883.
33. Dijkers PF, et al. (2000) Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 10:1201-1204.
34. Reginato MJ, et al. (2003) Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol 5:733-740.
35. Hsu MY, Elder DE, Herlyn M (1999) Melanoma: the Wistar (WM) melanoma cell lines. Masters JRW, Palsson B, editors. Human Cell Culture. London: Kluwer Academic Publisher. pp. 259-274.