메뉴 건너뛰기




Volumn 49, Issue 23, 2010, Pages 4833-4840

Incorporation of gemcitabine and cytarabine into DNA by DNA polymerase β and ligase III/XRCC1

Author keywords

[No Author keywords available]

Indexed keywords

BASE EXCISION REPAIRS; CANCER CHEMOTHERAPEUTIC AGENTS; CHEMOTHERAPY TREATMENT; CYTARABINE; CYTIDINE; DNA POLYMERASE; DNA SUBSTRATES; DNA SYNTHESISS; GEMCITABINE; MODIFIED NUCLEOTIDES; NUCLEOSIDE TRIPHOSPHATES; NUCLEOTIDE ANALOGUES;

EID: 77953257303     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100200c     Document Type: Article
Times cited : (40)

References (68)
  • 1
    • 33947205565 scopus 로고    scopus 로고
    • A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment
    • Burnett, A. K., Milligan, D., Prentice, A. G., Goldstone, A. H., McMullin, M. F., Hills, R. K., and Wheatley, K. (2007) A comparison of low-dose cytarabine and hydroxyurea with or without all-trans retinoic acid for acute myeloid leukemia and high-risk myelodysplastic syndrome in patients not considered fit for intensive treatment Cancer 109, 1114-1124
    • (2007) Cancer , vol.109 , pp. 1114-1124
    • Burnett, A.K.1    Milligan, D.2    Prentice, A.G.3    Goldstone, A.H.4    McMullin, M.F.5    Hills, R.K.6    Wheatley, K.7
  • 3
    • 0142121290 scopus 로고    scopus 로고
    • Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero, M., Plunkett, W., Ruiz, v. H. V., Hainsworth, J., Hochster, H., Lenzi, R., and Abbruzzese, J. (2003) Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma J. Clin. Oncol. 21, 3402-3408
    • (2003) J. Clin. Oncol. , vol.21 , pp. 3402-3408
    • Tempero, M.1    Plunkett, W.2    Ruiz H. V, V.3    Hainsworth, J.4    Hochster, H.5    Lenzi, R.6    Abbruzzese, J.7
  • 5
    • 33746003335 scopus 로고    scopus 로고
    • Phase I/II study of weekly paclitaxel plus carboplatin and gemcitabine as first-line treatment of advanced-stage ovarian cancer: Pathologic complete response and longitudinal assessment of impact on cognitive functioning
    • Hensley, M. L., Correa, D. D., Thaler, H., Wilton, A., Venkatraman, E., Sabbatini, P., Chi, D. S., Dupont, J., Spriggs, D., and Aghajanian, C. (2006) Phase I/II study of weekly paclitaxel plus carboplatin and gemcitabine as first-line treatment of advanced-stage ovarian cancer: pathologic complete response and longitudinal assessment of impact on cognitive functioning Gynecol. Oncol. 102, 270-277
    • (2006) Gynecol. Oncol. , vol.102 , pp. 270-277
    • Hensley, M.L.1    Correa, D.D.2    Thaler, H.3    Wilton, A.4    Venkatraman, E.5    Sabbatini, P.6    Chi, D.S.7    Dupont, J.8    Spriggs, D.9    Aghajanian, C.10
  • 6
    • 33745624597 scopus 로고    scopus 로고
    • Biological agents and gemcitabine in the treatment of breast cancer
    • Morandi, P. (2006) Biological agents and gemcitabine in the treatment of breast cancer Ann. Oncol. 17 (Suppl. 5) v177-v180
    • (2006) Ann. Oncol. , vol.17 , Issue.SUPPL. 5
    • Morandi, P.1
  • 7
    • 0029849973 scopus 로고    scopus 로고
    • Phase II activity of gemcitabine in advanced breast cancer
    • Carmichael, J. and Walling, J. (1996) Phase II activity of gemcitabine in advanced breast cancer Semin. Oncol. 23, 77-81
    • (1996) Semin. Oncol. , vol.23 , pp. 77-81
    • Carmichael, J.1    Walling, J.2
  • 9
    • 0035014189 scopus 로고    scopus 로고
    • Treatment of refractory T-cell malignancies using gemcitabine
    • Sallah, S., Wan, J. Y., and Nguyen, N. P. (2001) Treatment of refractory T-cell malignancies using gemcitabine Br. J. Haematol. 113, 185-187
    • (2001) Br. J. Haematol. , vol.113 , pp. 185-187
    • Sallah, S.1    Wan, J.Y.2    Nguyen, N.P.3
  • 11
    • 0026324313 scopus 로고
    • Action of 2′,2′-difluorodeoxycytidine on DNA synthesis
    • Huang, P., Chubb, S., Hertel, L. W., Grindey, G. B., and Plunkett, W. (1991) Action of 2′,2′-difluorodeoxycytidine on DNA synthesis Cancer Res. 51, 6110-6117
    • (1991) Cancer Res. , vol.51 , pp. 6110-6117
    • Huang, P.1    Chubb, S.2    Hertel, L.W.3    Grindey, G.B.4    Plunkett, W.5
  • 12
    • 0030921076 scopus 로고    scopus 로고
    • Differential incorporation of ara-C, gemcitabine, and fludarabine into replicating and repairing DNA in proliferating human leukemia cells
    • Iwasaki, H., Huang, P., Keating, M. J., and Plunkett, W. (1997) Differential incorporation of ara-C, gemcitabine, and fludarabine into replicating and repairing DNA in proliferating human leukemia cells Blood 90, 270-278
    • (1997) Blood , vol.90 , pp. 270-278
    • Iwasaki, H.1    Huang, P.2    Keating, M.J.3    Plunkett, W.4
  • 13
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-beta- d -arabinofuranosylcytosine
    • Heinemann, V., Hertel, L. W., Grindey, G. B., and Plunkett, W. (1988) Comparison of the cellular pharmacokinetics and toxicity of 2′,2′- difluorodeoxycytidine and 1-beta- d -arabinofuranosylcytosine Cancer Res. 48, 4024-4031
    • (1988) Cancer Res. , vol.48 , pp. 4024-4031
    • Heinemann, V.1    Hertel, L.W.2    Grindey, G.B.3    Plunkett, W.4
  • 14
    • 33745823841 scopus 로고    scopus 로고
    • Ribonucleotide reductase inhibitors and future drug design
    • Shao, J., Zhou, B., Chu, B., and Yen, Y. (2006) Ribonucleotide reductase inhibitors and future drug design Curr. Cancer Drug Targets 6, 409-431
    • (2006) Curr. Cancer Drug Targets , vol.6 , pp. 409-431
    • Shao, J.1    Zhou, B.2    Chu, B.3    Yen, Y.4
  • 15
    • 71549157751 scopus 로고    scopus 로고
    • Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5′-diphosphate
    • Wang, J., Lohman, G. J. S., and Stubbe, J. (2009) Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5′-diphosphate Biochemistry 48, 11612-11621
    • (2009) Biochemistry , vol.48 , pp. 11612-11621
    • Wang, J.1    Lohman, G.J.S.2    Stubbe, J.3
  • 16
    • 71549129302 scopus 로고    scopus 로고
    • Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5′-diphosphate in the presence or absence of reductant
    • Artin, E., Wang, J., Lohman, G. J. S., Yokoyama, K., Yu, G., Griffin, R. G., Bar, G., and Stubbe, J. (2009) Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5′-diphosphate in the presence or absence of reductant Biochemistry 48, 11622-11629
    • (2009) Biochemistry , vol.48 , pp. 11622-11629
    • Artin, E.1    Wang, J.2    Lohman, G.J.S.3    Yokoyama, K.4    Yu, G.5    Griffin, R.G.6    Bar, G.7    Stubbe, J.8
  • 17
    • 0034652117 scopus 로고    scopus 로고
    • Induction of topoisomerase i cleavage complexes by 1-beta- d -arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells
    • Pourquier, P., Takebayashi, Y., Urasaki, Y., Gioffre, C., Kohlhagen, G., and Pommier, Y. (2000) Induction of topoisomerase I cleavage complexes by 1-beta- d -arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells Proc. Natl. Acad. Sci. U.S.A. 97, 1885-1890
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 1885-1890
    • Pourquier, P.1    Takebayashi, Y.2    Urasaki, Y.3    Gioffre, C.4    Kohlhagen, G.5    Pommier, Y.6
  • 19
    • 8844232440 scopus 로고    scopus 로고
    • Polymerization of the triphosphates of AraC, 2′,2′- difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase
    • Richardson, K. A., Vega, T. P., Richardson, F. C., Moore, C. L., Rohloff, J. C., Tomkinson, B., Bendele, R. A., and Kuchta, R. D. (2004) Polymerization of the triphosphates of AraC, 2′,2′-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase Biochem. Pharmacol. 68, 2337-2346
    • (2004) Biochem. Pharmacol. , vol.68 , pp. 2337-2346
    • Richardson, K.A.1    Vega, T.P.2    Richardson, F.C.3    Moore, C.L.4    Rohloff, J.C.5    Tomkinson, B.6    Bendele, R.A.7    Kuchta, R.D.8
  • 20
    • 0034061749 scopus 로고    scopus 로고
    • Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome
    • Jiang, H. Y., Hickey, R. J., Abdel-Aziz, W., and Malkas, L. H. (2000) Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome Cancer Chemother. Pharmacol. 45, 320-328
    • (2000) Cancer Chemother. Pharmacol. , vol.45 , pp. 320-328
    • Jiang, H.Y.1    Hickey, R.J.2    Abdel-Aziz, W.3    Malkas, L.H.4
  • 21
    • 47249108640 scopus 로고    scopus 로고
    • Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase gamma
    • Fowler, J. D., Brown, J. A., Johnson, K. A., and Suo, Z. (2008) Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase gamma J. Biol. Chem. 283, 15339-15348
    • (2008) J. Biol. Chem. , vol.283 , pp. 15339-15348
    • Fowler, J.D.1    Brown, J.A.2    Johnson, K.A.3    Suo, Z.4
  • 22
    • 0035116697 scopus 로고    scopus 로고
    • S-phase arrest by nucleoside analogues and abrogation of survival without cell cycle progression by 7-hydroxystaurosporine
    • Shi, Z., Azuma, A., Sampath, D., Li, Y. X., Huang, P., and Plunkett, W. (2001) S-phase arrest by nucleoside analogues and abrogation of survival without cell cycle progression by 7-hydroxystaurosporine Cancer Res. 61, 1065-1072
    • (2001) Cancer Res. , vol.61 , pp. 1065-1072
    • Shi, Z.1    Azuma, A.2    Sampath, D.3    Li, Y.X.4    Huang, P.5    Plunkett, W.6
  • 23
    • 34248184571 scopus 로고    scopus 로고
    • H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation
    • Ewald, B., Sampath, D., and Plunkett, W. (2007) H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation Mol. Cancer Ther. 6, 1239-1248
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1239-1248
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 24
    • 33646158472 scopus 로고    scopus 로고
    • A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents
    • Chen, Y. W., Cleaver, J. E., Hanaoka, F., Chang, C. F., and Chou, K. M. (2006) A novel role of DNA polymerase eta in modulating cellular sensitivity to chemotherapeutic agents Mol. Cancer Res. 4, 257-265
    • (2006) Mol. Cancer Res. , vol.4 , pp. 257-265
    • Chen, Y.W.1    Cleaver, J.E.2    Hanaoka, F.3    Chang, C.F.4    Chou, K.M.5
  • 25
    • 32044449228 scopus 로고    scopus 로고
    • DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation
    • Liu, G. and Chen, X. (2006) DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation Mol. Cell. Biol. 26, 1398-1413
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 1398-1413
    • Liu, G.1    Chen, X.2
  • 27
    • 2942593991 scopus 로고    scopus 로고
    • ROS stress in cancer cells and therapeutic implications
    • Pelicano, H., Carney, D., and Huang, P. (2004) ROS stress in cancer cells and therapeutic implications Drug Resist. Updates 7, 97-110
    • (2004) Drug Resist. Updates , vol.7 , pp. 97-110
    • Pelicano, H.1    Carney, D.2    Huang, P.3
  • 28
    • 0036801346 scopus 로고    scopus 로고
    • Repair of deaminated bases in DNA
    • Kow, Y. W. (2002) Repair of deaminated bases in DNA Free Radical Biol. Med. 33, 886-893
    • (2002) Free Radical Biol. Med. , vol.33 , pp. 886-893
    • Kow, Y.W.1
  • 29
    • 0032557570 scopus 로고    scopus 로고
    • Nitric oxide-induced deamination of cytosine and guanine in deoxynucleosides and oligonucleotides
    • Caulfield, J. L., Wishnok, J. S., and Tannenbaum, S. R. (1998) Nitric oxide-induced deamination of cytosine and guanine in deoxynucleosides and oligonucleotides J. Biol. Chem. 273, 12689-12695
    • (1998) J. Biol. Chem. , vol.273 , pp. 12689-12695
    • Caulfield, J.L.1    Wishnok, J.S.2    Tannenbaum, S.R.3
  • 31
    • 9244261938 scopus 로고    scopus 로고
    • Chemotherapy-associated oxidative stress: Impact on chemotherapeutic effectiveness
    • Conklin, K. A. (2004) Chemotherapy-associated oxidative stress: impact on chemotherapeutic effectiveness Integr. Cancer Ther. 3, 294-300
    • (2004) Integr. Cancer Ther. , vol.3 , pp. 294-300
    • Conklin, K.A.1
  • 32
    • 16244375578 scopus 로고    scopus 로고
    • The overexpression of specialized DNA polymerases in cancer
    • Albertella, M. R., Lau, A., and OConnor, M. J. (2005) The overexpression of specialized DNA polymerases in cancer DNA Repair 4, 583-593
    • (2005) DNA Repair , vol.4 , pp. 583-593
    • Albertella, M.R.1    Lau, A.2    Oconnor, M.J.3
  • 34
    • 33947662993 scopus 로고    scopus 로고
    • In vitro ligation of oligodeoxynucleotides containing C8-oxidized purine lesions using bacteriophage T4 DNA ligase
    • Zhao, X., Muller, J. G., Halasyam, M., David, S. S., and Burrows, C. J. (2007) In vitro ligation of oligodeoxynucleotides containing C8-oxidized purine lesions using bacteriophage T4 DNA ligase Biochemistry 46, 3734-3744
    • (2007) Biochemistry , vol.46 , pp. 3734-3744
    • Zhao, X.1    Muller, J.G.2    Halasyam, M.3    David, S.S.4    Burrows, C.J.5
  • 35
  • 36
    • 0034687093 scopus 로고    scopus 로고
    • Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis
    • Opresko, P. L., Shiman, R., and Eckert, K. A. (2000) Hydrophobic interactions in the hinge domain of DNA polymerase beta are important but not sufficient for maintaining fidelity of DNA synthesis Biochemistry 39, 11399-11407
    • (2000) Biochemistry , vol.39 , pp. 11399-11407
    • Opresko, P.L.1    Shiman, R.2    Eckert, K.A.3
  • 37
    • 33645211143 scopus 로고    scopus 로고
    • Structure of purine-purine mispairs during misincorporation and extension by E. coli DNA polymerase i
    • Kretulskie, A. M. and Spratt, T. E. (2006) Structure of purine-purine mispairs during misincorporation and extension by E. coli DNA polymerase I Biochemistry 45, 3740-3746
    • (2006) Biochemistry , vol.45 , pp. 3740-3746
    • Kretulskie, A.M.1    Spratt, T.E.2
  • 38
    • 0037379215 scopus 로고    scopus 로고
    • Polymerase mu is a DNA-directed DNA/RNA polymerase
    • Nick McElhinny, S. A. and Ramsden, D. A. (2003) Polymerase mu is a DNA-directed DNA/RNA polymerase Mol. Cell. Biol. 23, 2309-2315
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 2309-2315
    • Nick McElhinny, S.A.1    Ramsden, D.A.2
  • 40
    • 0037183526 scopus 로고    scopus 로고
    • A reexamination of the nucleotide incorporation fidelity of DNA polymerases
    • Showalter, A. K. and Tsai, M. D. (2002) A reexamination of the nucleotide incorporation fidelity of DNA polymerases Biochemistry 41, 10571-10576
    • (2002) Biochemistry , vol.41 , pp. 10571-10576
    • Showalter, A.K.1    Tsai, M.D.2
  • 41
    • 51849149950 scopus 로고    scopus 로고
    • Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways
    • Roettger, M. P., Bakhtina, M., and Tsai, M. D. (2008) Mismatched and matched dNTP incorporation by DNA polymerase beta proceed via analogous kinetic pathways Biochemistry 47, 9718-9727
    • (2008) Biochemistry , vol.47 , pp. 9718-9727
    • Roettger, M.P.1    Bakhtina, M.2    Tsai, M.D.3
  • 42
    • 44349090420 scopus 로고    scopus 로고
    • Mismatched dNTP incorporation by DNA polymerase beta does not proceed via globally different conformational pathways
    • Tang, K. H., Niebuhr, M., Tung, C. S., Chan, H. C., Chou, C. C., and Tsai, M. D. (2008) Mismatched dNTP incorporation by DNA polymerase beta does not proceed via globally different conformational pathways Nucleic Acids Res. 36, 2948-2957
    • (2008) Nucleic Acids Res. , vol.36 , pp. 2948-2957
    • Tang, K.H.1    Niebuhr, M.2    Tung, C.S.3    Chan, H.C.4    Chou, C.C.5    Tsai, M.D.6
  • 43
    • 0032055511 scopus 로고    scopus 로고
    • DNA polymerase beta: Effects of gapped substrates on dNTP specificity, fidelity, processivity and conformational changes
    • Ahn, J., Kraynov, V. S., Zhong, X., Werneburg, B. G., and Tsai, M. D. (1998) DNA polymerase beta: effects of gapped substrates on dNTP specificity, fidelity, processivity and conformational changes Biochem. J. 331, 79-87
    • (1998) Biochem. J. , vol.331 , pp. 79-87
    • Ahn, J.1    Kraynov, V.S.2    Zhong, X.3    Werneburg, B.G.4    Tsai, M.D.5
  • 44
    • 0035793560 scopus 로고    scopus 로고
    • DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change
    • Vande Berg, B. J., Beard, W. A., and Wilson, S. H. (2001) DNA structure and aspartate 276 influence nucleotide binding to human DNA polymerase beta. Implication for the identity of the rate-limiting conformational change J. Biol. Chem. 276, 3408-3416
    • (2001) J. Biol. Chem. , vol.276 , pp. 3408-3416
    • Vande Berg, B.J.1    Beard, W.A.2    Wilson, S.H.3
  • 45
    • 33748742873 scopus 로고    scopus 로고
    • The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases
    • DeLucia, A. M., Chaudhuri, S., Potapova, O., Grindley, N. D. F., and Joyce, C. M. (2006) The properties of steric gate mutants reveal different constraints within the active sites of Y-family and A-family DNA polymerases J. Biol. Chem. 281, 27286-27291
    • (2006) J. Biol. Chem. , vol.281 , pp. 27286-27291
    • Delucia, A.M.1    Chaudhuri, S.2    Potapova, O.3    Grindley, N.D.F.4    Joyce, C.M.5
  • 46
    • 0023677076 scopus 로고
    • Functional consequences of the arabinosylcytosine structural lesion in DNA
    • Mikita, T. and Beardsley, G. P. (1988) Functional consequences of the arabinosylcytosine structural lesion in DNA Biochemistry 27, 4698-4705
    • (1988) Biochemistry , vol.27 , pp. 4698-4705
    • Mikita, T.1    Beardsley, G.P.2
  • 47
    • 65249138188 scopus 로고    scopus 로고
    • Contribution of the reverse rate of the conformational step to polymerase beta fidelity
    • Bakhtina, M., Roettger, M. P., and Tsai, M. D. (2009) Contribution of the reverse rate of the conformational step to polymerase beta fidelity Biochemistry 48, 3197-3208
    • (2009) Biochemistry , vol.48 , pp. 3197-3208
    • Bakhtina, M.1    Roettger, M.P.2    Tsai, M.D.3
  • 48
    • 34248370198 scopus 로고    scopus 로고
    • A unified kinetic mechanism applicable to multiple DNA polymerases
    • Bakhtina, M., Roettger, M. P., Kumar, S., and Tsai, M. D. (2007) A unified kinetic mechanism applicable to multiple DNA polymerases Biochemistry 46, 5463-5472
    • (2007) Biochemistry , vol.46 , pp. 5463-5472
    • Bakhtina, M.1    Roettger, M.P.2    Kumar, S.3    Tsai, M.D.4
  • 49
    • 0242317682 scopus 로고    scopus 로고
    • An error-prone family y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a "steric gate" residue for discrimination against ribonucleotides
    • DeLucia, A. M., Grindley, N. D. F., and Joyce, C. M. (2003) An error-prone family Y DNA polymerase (DinB homolog from Sulfolobus solfataricus) uses a "steric gate" residue for discrimination against ribonucleotides Nucleic Acids Res. 31, 4129-4137
    • (2003) Nucleic Acids Res. , vol.31 , pp. 4129-4137
    • Delucia, A.M.1    Grindley, N.D.F.2    Joyce, C.M.3
  • 50
    • 0032584219 scopus 로고    scopus 로고
    • A single side chain prevents Escherichia coli DNA polymerase i (Klenow fragment) from incorporating ribonucleotides
    • Astatke, M., Ng, K., Grindley, N. D., and Joyce, C. M. (1998) A single side chain prevents Escherichia coli DNA polymerase I (Klenow fragment) from incorporating ribonucleotides Proc. Natl. Acad. Sci. U.S.A. 95, 3402-3407
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 3402-3407
    • Astatke, M.1    Ng, K.2    Grindley, N.D.3    Joyce, C.M.4
  • 51
    • 0037072265 scopus 로고    scopus 로고
    • A conserved Tyr residue is required for sugar selectivity in a pol alpha DNA polymerase
    • Yang, G., Franklin, M., Li, J., Lin, T. C., and Konigsberg, W. (2002) A conserved Tyr residue is required for sugar selectivity in a pol alpha DNA polymerase Biochemistry 41, 10256-10261
    • (2002) Biochemistry , vol.41 , pp. 10256-10261
    • Yang, G.1    Franklin, M.2    Li, J.3    Lin, T.C.4    Konigsberg, W.5
  • 52
    • 0345188651 scopus 로고    scopus 로고
    • A single tyrosine prevents insertion of ribonucleotides in the eukaryotic-type [phi]29 DNA polymerase
    • Bonnin, A., Lsszaro, J. M., Blanco, L., and Salas, M. (1999) A single tyrosine prevents insertion of ribonucleotides in the eukaryotic-type [phi]29 DNA polymerase J. Mol. Biol. 290, 241-251
    • (1999) J. Mol. Biol. , vol.290 , pp. 241-251
    • Bonnin, A.1    Lsszaro, J.M.2    Blanco, L.3    Salas, M.4
  • 53
    • 0033564079 scopus 로고    scopus 로고
    • Determinants of nucleotide sugar recognition in an archaeon DNA polymerase
    • Gardner, A. F. and Jack, W. E. (1999) Determinants of nucleotide sugar recognition in an archaeon DNA polymerase Nucleic Acids Res. 27, 2545-2553
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2545-2553
    • Gardner, A.F.1    Jack, W.E.2
  • 55
    • 0028566215 scopus 로고
    • Polymerase structures and mechanism
    • Pelletier, H. (1994) Polymerase structures and mechanism Science 266, 2025-2026
    • (1994) Science , vol.266 , pp. 2025-2026
    • Pelletier, H.1
  • 56
    • 0031883128 scopus 로고    scopus 로고
    • Structural insights into polymerase beta fidelity: Hold tight if you want it right
    • Beard, W. A. and Wilson, S. H. (1998) Structural insights into polymerase beta fidelity: hold tight if you want it right Chem. Biol. 5, R7-R13
    • (1998) Chem. Biol. , vol.5
    • Beard, W.A.1    Wilson, S.H.2
  • 58
    • 0032524759 scopus 로고    scopus 로고
    • Cytarabine-induced destabilization of a model Okazaki fragment
    • Gmeiner, W. H., Skradis, A., Pon, R. T., and Liu, J. (1998) Cytarabine-induced destabilization of a model Okazaki fragment Nucleic Acids Res. 26, 2359-2365
    • (1998) Nucleic Acids Res. , vol.26 , pp. 2359-2365
    • Gmeiner, W.H.1    Skradis, A.2    Pon, R.T.3    Liu, J.4
  • 59
    • 0028020868 scopus 로고
    • Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: Combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement
    • Schweitzer, B. I., Mikita, T., Kellogg, G. W., Gardner, K. H., and Beardsley, G. P. (1994) Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement Biochemistry 33, 11460-11475
    • (1994) Biochemistry , vol.33 , pp. 11460-11475
    • Schweitzer, B.I.1    Mikita, T.2    Kellogg, G.W.3    Gardner, K.H.4    Beardsley, G.P.5
  • 60
    • 0025012931 scopus 로고
    • Hairpin structures in DNA containing arabinofuranosylcytosine. A combination of nuclear magnetic resonance and molecular dynamics
    • Pieters, J. M., de Vroom, E., van der Marel, G. A., van Boom, J. H., Koning, T. M., Kaptein, R., and Altona, C. (1990) Hairpin structures in DNA containing arabinofuranosylcytosine. A combination of nuclear magnetic resonance and molecular dynamics Biochemistry 29, 788-799
    • (1990) Biochemistry , vol.29 , pp. 788-799
    • Pieters, J.M.1    De Vroom, E.2    Van Der Marel, G.A.3    Van Boom, J.H.4    Koning, T.M.5    Kaptein, R.6    Altona, C.7
  • 61
    • 0024971418 scopus 로고
    • Conformational consequences of the incorporation of arabinofuranosylcytidine in DNA. An NMR study of the DNA fragments d(CGCTAGCG) and d(CGaCTAGCG) in solution
    • Pieters, J. M., de Vroom, E., van der Marel, G. A., van Boom, J. H., and Altona, C. (1989) Conformational consequences of the incorporation of arabinofuranosylcytidine in DNA. An NMR study of the DNA fragments d(CGCTAGCG) and d(CGaCTAGCG) in solution Eur. J. Biochem. 184, 415-425
    • (1989) Eur. J. Biochem. , vol.184 , pp. 415-425
    • Pieters, J.M.1    De Vroom, E.2    Van Der Marel, G.A.3    Van Boom, J.H.4    Altona, C.5
  • 62
    • 0034926661 scopus 로고    scopus 로고
    • Fluorine substituent effects (on bioactivity)
    • Smart, B. E. (2001) Fluorine substituent effects (on bioactivity) J. Fluorine Chem. 109, 3-11
    • (2001) J. Fluorine Chem. , vol.109 , pp. 3-11
    • Smart, B.E.1
  • 64
    • 51349152032 scopus 로고    scopus 로고
    • Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine
    • Lee, S., Bowman, B. R., Ueno, Y., Wang, S., and Verdine, G. L. (2008) Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine J. Am. Chem. Soc. 130, 11570-11571
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 11570-11571
    • Lee, S.1    Bowman, B.R.2    Ueno, Y.3    Wang, S.4    Verdine, G.L.5
  • 65
    • 48149108427 scopus 로고    scopus 로고
    • Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: A system for the structure determination of lesion-containing DNA
    • Bowman, B. R., Lee, S., Wang, S., and Verdine, G. L. (2008) Structure of the E. coli DNA glycosylase AlkA bound to the ends of duplex DNA: a system for the structure determination of lesion-containing DNA Structure 16, 1166-1174
    • (2008) Structure , vol.16 , pp. 1166-1174
    • Bowman, B.R.1    Lee, S.2    Wang, S.3    Verdine, G.L.4
  • 66
    • 0344527720 scopus 로고    scopus 로고
    • The fidelity of DNA polymerase beta during distributive and processive DNA synthesis
    • Osheroff, W. P., Jung, H. K., Beard, W. A., Wilson, S. H., and Kunkel, T. A. (1999) The fidelity of DNA polymerase beta during distributive and processive DNA synthesis J. Biol. Chem. 274, 3642-3650
    • (1999) J. Biol. Chem. , vol.274 , pp. 3642-3650
    • Osheroff, W.P.1    Jung, H.K.2    Beard, W.A.3    Wilson, S.H.4    Kunkel, T.A.5
  • 67
    • 0033569841 scopus 로고    scopus 로고
    • Delayed DNA joining at 3′ mismatches by human DNA ligases
    • Bhagwat, A. S., Sanderson, R. J., and Lindahl, T. (1999) Delayed DNA joining at 3′ mismatches by human DNA ligases Nucleic Acids Res. 27, 4028-4033
    • (1999) Nucleic Acids Res. , vol.27 , pp. 4028-4033
    • Bhagwat, A.S.1    Sanderson, R.J.2    Lindahl, T.3
  • 68
    • 9644289536 scopus 로고    scopus 로고
    • Human DNA ligase i completely encircles and partially unwinds nicked DNA
    • Pascal, J. M., OBrien, P. J., Tomkinson, A. E., and Ellenberger, T. (2004) Human DNA ligase I completely encircles and partially unwinds nicked DNA Nature 432, 473-478
    • (2004) Nature , vol.432 , pp. 473-478
    • Pascal, J.M.1    Obrien, P.J.2    Tomkinson, A.E.3    Ellenberger, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.