메뉴 건너뛰기




Volumn 45, Issue 4, 2000, Pages 320-328

Effects of gemcitabine and araC on in vitro DNA synthesis mediated by the human breast cell DNA synthesome

Author keywords

AraC; DNA replication; DNA synthesome; Gemcitabine; In vitro

Indexed keywords

CYTARABINE; DNA POLYMERASE; GEMCITABINE;

EID: 0034061749     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002800050047     Document Type: Article
Times cited : (31)

References (34)
  • 4
    • 0029850608 scopus 로고    scopus 로고
    • The human cell multiprotein DNA replication complex (MRC): The effect of camptothecin on its ability to support in vitro DNA synthesis
    • Coll JM, Hickey RJ, Wei Y, Malkas LH (1996) The human cell multiprotein DNA replication complex (MRC): the effect of camptothecin on its ability to support in vitro DNA synthesis. Cancer Chemother Pharmacol 39: 97
    • (1996) Cancer Chemother Pharmacol , vol.39 , pp. 97
    • Coll, J.M.1    Hickey, R.J.2    Wei, Y.3    Malkas, L.H.4
  • 5
    • 0025295958 scopus 로고
    • Modulatory activity of 2',2'-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides
    • Gandhi V, Plunkett W (1990) Modulatory activity of 2',2'-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. Cancer Res 50: 3675
    • (1990) Cancer Res , vol.50 , pp. 3675
    • Gandhi, V.1    Plunkett, W.2
  • 6
    • 0031972535 scopus 로고    scopus 로고
    • AraC: Cellular and molecular pharmacology
    • Grant S (1998) AraC: cellular and molecular pharmacology. Adv Cancer Res 72: 197
    • (1998) Adv Cancer Res , vol.72 , pp. 197
    • Grant, S.1
  • 7
    • 0025089191 scopus 로고
    • Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (gemcitabine) administration in leukemia
    • Grunewald R, Kantarjian H, Keating MJ, Abbruzzese J, Tarassoff P, Plunkett W (1990) Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (gemcitabine) administration in leukemia. Cancer Res 50: 6823
    • (1990) Cancer Res , vol.50 , pp. 6823
    • Grunewald, R.1    Kantarjian, H.2    Keating, M.J.3    Abbruzzese, J.4    Tarassoff, P.5    Plunkett, W.6
  • 8
    • 0026101039 scopus 로고
    • Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine
    • Grunewald R, Abbruzzese JL, Tarassoff P, Plunkett W (1991) Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine. Cancer Chemother Pharmacol 27: 258
    • (1991) Cancer Chemother Pharmacol , vol.27 , pp. 258
    • Grunewald, R.1    Abbruzzese, J.L.2    Tarassoff, P.3    Plunkett, W.4
  • 9
    • 0029902591 scopus 로고    scopus 로고
    • Clinical toxicological and pharmacological aspects of gemcitabine
    • Guchelaar HJ, Richel DJ, Knapen A (1996) Clinical toxicological and pharmacological aspects of gemcitabine. Cancer Treat Rev 22: 15
    • (1996) Cancer Treat Rev , vol.22 , pp. 15
    • Guchelaar, H.J.1    Richel, D.J.2    Knapen, A.3
  • 10
    • 4243380146 scopus 로고    scopus 로고
    • Human cell DNA synthesome associated polymerases are inhibited differentially by the antimetabolite 1-β-D-arabinofuranosylcytosine triphosphate (araCTP)
    • in press
    • Han S, Hickey RJ, Timothy TD, Wills PW, Malkas LH (2000) Human cell DNA synthesome associated polymerases are inhibited differentially by the antimetabolite 1-β-D-arabinofuranosylcytosine triphosphate (araCTP). Biochem Pharmacol (in press)
    • (2000) Biochem Pharmacol
    • Han, S.1    Hickey, R.J.2    Timothy, T.D.3    Wills, P.W.4    Malkas, L.H.5
  • 11
    • 0023783698 scopus 로고
    • Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-β-D-arabinofuransylcytosine
    • Heinemann V, Hertel LW, Grindey GB, Plunkett W (1988) Comparison of the cellular pharmacokinetics and toxicity of 2',2'-difluorodeoxycytidine and 1-β-D-arabinofuransylcytosine. Cancer Res 48: 4024
    • (1988) Cancer Res , vol.48 , pp. 4024
    • Heinemann, V.1    Hertel, L.W.2    Grindey, G.B.3    Plunkett, W.4
  • 12
    • 0028832342 scopus 로고
    • Gemcitabine: A modulator of intracellular nucleotide and deoxynucleotide metabolism
    • Heinemann V, Schulz L, Issels R, Plunkett W (1995) Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism. Semin Oncol 22(4 Suppl 11): 11
    • (1995) Semin Oncol , vol.22 , Issue.4 , pp. 11
    • Heinemann, V.1    Schulz, L.2    Issels, R.3    Plunkett, W.4
  • 13
    • 0023935362 scopus 로고
    • Synthesis of 2'-deoxy-2',2'-difluro-D-ribose and 2'-deoxy-2',2'-D-ribofuranosyl nucleosides
    • Hertel LW, Kroin JS, Misner JW (1988) Synthesis of 2'-deoxy-2',2'-difluro-D-ribose and 2'-deoxy-2',2'-D-ribofuranosyl nucleosides. J Org Chem 53: 2406
    • (1988) J Org Chem , vol.53 , pp. 2406
    • Hertel, L.W.1    Kroin, J.S.2    Misner, J.W.3
  • 14
    • 0025325071 scopus 로고
    • Evaluation of the antitumor activity of gemcitabine
    • Hertel LW, Boder GB, Kroin JS (1990) Evaluation of the antitumor activity of gemcitabine. Cancer Res 50: 4417
    • (1990) Cancer Res , vol.50 , pp. 4417
    • Hertel, L.W.1    Boder, G.B.2    Kroin, J.S.3
  • 17
    • 0030921076 scopus 로고    scopus 로고
    • Differential incorporation of araC, gemcitabine, and fludarabine into replication and repair DNA in proliferating human leukemia cells
    • Iwasaki H, Huang P, Keating MJ, Plunkett W (1997) Differential incorporation of araC, gemcitabine, and fludarabine into replication and repair DNA in proliferating human leukemia cells. Blood 90: 270
    • (1997) Blood , vol.90 , pp. 270
    • Iwasaki, H.1    Huang, P.2    Keating, M.J.3    Plunkett, W.4
  • 19
    • 0030859544 scopus 로고    scopus 로고
    • Gemcitabine: A new chemotherapy agent for solid cancers
    • Klastersky J, Awada A (1997) Gemcitabine: a new chemotherapy agent for solid cancers. Rev Med Brux 18(5): 328
    • (1997) Rev Med Brux , vol.18 , Issue.5 , pp. 328
    • Klastersky, J.1    Awada, A.2
  • 20
    • 0030929389 scopus 로고    scopus 로고
    • The isolation of a DNA synthesome from human leukemia cells
    • Lin S, Hickey RJ, Malkas LH (1997) The isolation of a DNA synthesome from human leukemia cells. Leuk Res 6: 501
    • (1997) Leuk Res , vol.6 , pp. 501
    • Lin, S.1    Hickey, R.J.2    Malkas, L.H.3
  • 22
    • 0001865745 scopus 로고    scopus 로고
    • SV40 in vitro DNA replication: A potential model for studying anticancer drug action
    • Snapka RM (ed). RG Landes Company, Austin
    • Malkas LH (1996) SV40 in vitro DNA replication: A potential model for studying anticancer drug action. In: Snapka RM (ed) The SV40 replication model for analysis of anticancer drugs. RG Landes Company, Austin, p 150
    • (1996) The SV40 Replication Model for Analysis of Anticancer Drugs , pp. 150
    • Malkas, L.H.1
  • 23
    • 0032445147 scopus 로고    scopus 로고
    • DNA replication machinery of mammalian cell
    • Malkas LH (1998) DNA replication machinery of mammalian cell. J Cell Biochem 30/31: 18
    • (1998) J Cell Biochem , vol.30-31 , pp. 18
    • Malkas, L.H.1
  • 24
    • 0025346309 scopus 로고
    • A 21 S enzyme complex from HeLa cells that functions in simian virus 40 DNA replication in vitro
    • Malkas LH, Hickey RJ, Li CJ, Pederson N, Baril EF (1990) A 21 S enzyme complex from HeLa cells that functions in simian virus 40 DNA replication in vitro. Biochemistry 29: 6362
    • (1990) Biochemistry , vol.29 , pp. 6362
    • Malkas, L.H.1    Hickey, R.J.2    Li, C.J.3    Pederson, N.4    Baril, E.F.5
  • 28
    • 0028062981 scopus 로고
    • Molecular effects of 2',2'-difluorodeoxycytidine on DNA replication in intact HL-60 cells
    • Ross DD, Cuddy DP (1994) Molecular effects of 2',2'-difluorodeoxycytidine on DNA replication in intact HL-60 cells. Biochem Pharmacol 48: 1619
    • (1994) Biochem Pharmacol , vol.48 , pp. 1619
    • Ross, D.D.1    Cuddy, D.P.2
  • 29
    • 0028786646 scopus 로고
    • Consequences of 2',2'-difluorodeoxycytidine (Gemcitabine) on replicative DNA synthesis in intact HL60 cells
    • Ross DD, Cuddy DP (1995) Consequences of 2',2'-difluorodeoxycytidine (Gemcitabine) on replicative DNA synthesis in intact HL60 cells. Semin Oncol 22(4 Suppl 11): 26
    • (1995) Semin Oncol , vol.22 , Issue.4 , pp. 26
    • Ross, D.D.1    Cuddy, D.P.2
  • 30
    • 0021970530 scopus 로고
    • An immunoaffinity purification procedure for SV40 large T-antigen
    • Simanis V, Lane DP (1985) An immunoaffinity purification procedure for SV40 large T-antigen. Virology 144: 88
    • (1985) Virology , vol.144 , pp. 88
    • Simanis, V.1    Lane, D.P.2
  • 31
    • 0029805303 scopus 로고    scopus 로고
    • Identification of multiprotein complexes containing DNA replication factors by native immunoblotting of HeLa cell protein preparations with T-antigen-dependent SV40 DNA replication activity
    • Tom TD, Malkas LH, Hickey RJ (1996) Identification of multiprotein complexes containing DNA replication factors by native immunoblotting of HeLa cell protein preparations with T-antigen-dependent SV40 DNA replication activity. J Cell Biochem 63: 259
    • (1996) J Cell Biochem , vol.63 , pp. 259
    • Tom, T.D.1    Malkas, L.H.2    Hickey, R.J.3
  • 33
    • 0033803021 scopus 로고    scopus 로고
    • Ara-C differentially affects multiprotein forms of human cell DNA polymerase
    • in press
    • Wills PW, Hickey RJ, Malkas LH (2000) Ara-C differentially affects multiprotein forms of human cell DNA polymerase. Cancer Chemother Pharmacol (in press)
    • (2000) Cancer Chemother Pharmacol
    • Wills, P.W.1    Hickey, R.J.2    Malkas, L.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.