Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5′-diphosphate in the presence or absence of reductant

Biochemistry

Volumn 48, Issue 49, 2009, Pages 11622-11629

  Artin, Erin ^a,b   Wang, Jun ^a   Lohman, Gregory J S ^a   Yokoyama, Kenichi ^a   Yu, Guixue ^a   Griffin, Robert G ^a   Bar, Galit ^a   Stubbe, JoAnne ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Intelligent BioSystems   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; COVALENT LABELING; DIPHOSPHATES; DNA REPLICATIONS; ENZYME INACTIVATION; EPR SPECTROSCOPY; G-VALUES; GEMCITABINE; HYPERFINE INTERACTIONS; POTENT INHIBITOR; REDUCTANTS; RIBONUCLEOTIDE REDUCTASE; SDS-PAGE ANALYSIS; TYROSYL RADICALS;

DIFFUSERS (OPTICAL); ELECTRON RESONANCE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME ACTIVITY; ENZYMES; ESCHERICHIA COLI; FLUORINE COMPOUNDS; NUCLEIC ACIDS; NUCLEOTIDES; PARAMAGNETIC RESONANCE; POLYPEPTIDES; QUANTUM THEORY; SUGAR (SUCROSE); SUGARS;

BRIDGE BEARINGS;

CETUXIMAB; CYTOSINE; DITHIOTHREITOL; FLUORIDE; GEMCITABINE; NUCLEOTIDE; RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCING AGENT; RIBONUCLEOTIDE REDUCTASE; THIOREDOXIN; THIOREDOXIN REDUCTASE; TYROSINE;

ARTICLE; CATALYSIS; DRUG MECHANISM; ELECTRON SPIN RESONANCE; ENZYME INACTIVATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ANIMALS; CERCOPITHECUS AETHIOPS; CHOLESTEROL; COS CELLS; CYTIDINE DIPHOSPHATE; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; OXIDATION-REDUCTION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RIBONUCLEOTIDE REDUCTASES; SWINE;

ESCHERICHIA COLI;

EID: 71549129302     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901590q     Document Type: Article

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