Giant cell glioblastoma is associated with altered aurora b expression and concomitant p53 mutation

Journal of Neuropathology and Experimental Neurology

Volumn 69, Issue 6, 2010, Pages 632-642

  Temme, Achim ^a   Geiger, Kathrin D ^b   Wiedemuth, Ralf ^a   Biol, Dipl ^j   Conseur, Katharina ^a   Pietsch, Torsten ^c   Felsberg, Jörg ^d   Reifenberger, Guido ^d   Tatsuka, Masaaki ^e   Hagel, Christian ^f   Westphal, Manfred ^f,i   Berger, Hilmar ^g   Simon, Matthias ^h   Weller, Michael ^f,i   Schackert, Gabriele ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY HOSPITAL BONN   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e Faculty of Life and Environmental Sciences   (Japan)

^f UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^g UNIVERSITY OF LEIPZIG   (Germany)

^h UNIVERSITY OF BONN   (Germany)

ⁱ UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^j University Hospital Zurich ^*

more..

Author keywords

Aurora B; Giant cell glioblastoma; P53

Indexed keywords

AURORA B KINASE; DNA; MESSENGER RNA; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CHILD; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE OVEREXPRESSION; GIANT CELL TUMOR; GLIOBLASTOMA; GLIOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; LOSS OF FUNCTION MUTATION; MAJOR CLINICAL STUDY; MALE; MULTINUCLEAR CELL; MUTANT; PRIORITY JOURNAL; SCHOOL CHILD; WILD TYPE;

ADULT; AGED; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL LINE, TUMOR; CHILD; FEMALE; FLOW CYTOMETRY; GIANT CELLS; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77953130088     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181e4c06e     Document Type: Article

References (47)

1. Louis DN, Ohgaki H, Wiestler OD, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007;114: 97-109
2. Palma L, Celli P, Maleci A, et al. Malignant monstrocellular brain tumours. A study of 42 surgically treated cases. Acta Neurochir (Wien) 1989;97:17-25
3. Peraud A, Watanabe K, Plate KH, et al. p53 mutations versus EGF receptor expression in giant cell glioblastomas. J Neuropathol Exp Neurol 1997;56:1236-41
4. Homma T, Fukushima T, Vaccarella S, et al. Correlation among pathology, genotype, and patient outcomes in glioblastoma. J Neuropathol Exp Neurol 2006;65:846-54
5. Meyer-Puttlitz B, Hayashi Y, Waha A, et al. Molecular genetic analysis of giant cell glioblastomas. Am J Pathol 1997;151:853-57
6. Muller W, Slowik F, Firsching R, et al. Contribution to the problem of giant cell astrocytomas. Neurosurg Rev 1987;10:213-19
7. Li JJ, Li SA. Mitotic kinases: The key to duplication, segregation, and cytokinesis errors, chromosomal instability, and oncogenesis. Pharmacol Ther 2006;111:974-84
8. Fujita M, Mizuno M, Nagasaka T, et al. Aurora-B dysfunction of multi-nucleated giant cells in glioma detected by site-specific phosphorylated antibodies. J Neurosurg 2004;101:1012-17
9. Terada Y, Tatsuka M, Suzuki F, et al. AIM-1: A mammalian midbody-associated protein required for cytokinesis. EMBO J 1998;17:667-76
10. Tatsuka M, Katayama H, Ota T, et al. Multinuclearity and increased ploidy caused by overexpression of the Aurora-and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells. Cancer Res 1998; 58(21):4811-16
11. Qi G, Ogawa I, Kudo Y, et al. Aurora-B expression and its correlation with cell proliferation and metastasis in oral cancer. Virchows Arch 2007; 450:297-302
12. Vischioni B, Oudejans JJ, Vos W, et al. Frequent overexpression of aurora B kinase, a novel drug target, in non-small cell lung carcinoma patients. Mol Cancer Ther 2006;5:2905-13
13. Vagnarelli P, Earnshaw WC. Chromosomal passengers: The four-dimensional regulation of mitotic events. Chromosoma 2004;113:211-22
14. Zeitlin SG, Shelby RD, Sullivan KF. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. J Cell Biol 2001;155:1147-57
15. Goto H, Yasui Y, Nigg EA, Inagaki M. Aurora-B phosphorylates histone H3 at serine28 with regard to the mitotic chromosome condensation. Genes Cells 2002;7:11-17
16. Goto H, Yasui Y, Kawajiri A, et al. Aurora-B regulates the cleavage furrow-specific vimentin phosphorylation in the cytokinetic process. J Biol Chem 2003;278:8526-30
17. Kawajiri A, Yasui Y, Goto H, et al. Functional significance of the specific sites phosphorylated in desmin at cleavage furrow: Aurora-B may phos-phorylate and regulate type III intermediate filaments during cytokinesis coordinatedly with Rho-kinase. Mol Biol Cell 2003;14:1489-500
18. Minoshima Y, Kawashima T, Hirose K, et al. Phosphorylation by aurora B converts MgcRacGAP to a RhoGAP during cytokinesis. Dev Cell 2003;4:549-60
19. Yasui Y, Urano T, Kawajiri A, et al. Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem 2004;279:12997-3003
20. Wheatley SP, Carvalho A, Vagnarelli P, Earnshaw WC. INCENP is required for proper targeting of survivin to the centromeres and the ana-phase spindle during mitosis. Curr Biol 2001;11:886-90
21. Tsuno T, Natsume A, Katsumata S, et al. Inhibition of Aurora-B function increases formation of multinucleated cells in p53 geneYdeficient cells and enhances anti-tumor effect of temozolomide in human glioma cells. J Neurooncol 2007;83:249-58
22. Temme A, Rieger M, Reber F, et al. Localization, dynamics, and function of survivin revealed by expression of functional survivinDsRed fusion proteins in the living cell. Mol Biol Cell 2003;14:78-92
23. Ruchaud S, Carmena M, Earnshaw WC. The chromosomal passenger complex: One for all and all for one. Cell 2007;131:230-31
24. Martinez R, Roggendorf W, Baretton G, et al. Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations. Cancer Genet Cytogenet 2007;175:26-34
25. Yu J, Zhang L. The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 2005;331:851-58
26. Jiang P, Du W, Heese K, et al. The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis. Mol Cell Biol 2006;26: 9071-82
27. Sherr CJ, Roberts JM. CDK inhibitors: Positive and negative regulators of G1-phase progression. Genes Dev 1999;13:1501-12
28. Gizatullin F, Yao Y, Kung V, et al. The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function. Cancer Res 2006;66:7668-77
29. Kitamura Y, Ota T, Matsuoka Y, et al. Hydrogen peroxideYinduced apoptosis mediated by p53 protein in glial cells. Glia 1999;25(2):154-64
30. Shono T, Tofilon PJ, Schaefer TS, et al. Apoptosis induced by adenovirus-mediated p53 gene transfer in human glioma correlates with site-specific phosphorylation. Cancer Res 2002;62:1069-76
31. Bullock AN, Fersht AR. Rescuing the function of mutant p53. Nat Rev Cancer 2001;1:68-76
32. Krex D, Mohr B, Appelt H, et al. Genetic analysis of a multifocal glio-blastoma multiforme: A suitable tool to gain new aspects in glioma development. Neurosurgery 2003;53:1377-84
33. Temme A, Rodriguez JA, Hendruschk S, et al. Nuclear localization of survivin renders HeLa tumor cells more sensitive to apoptosis by induction of p53 and Bax. Cancer Lett 2007;250:177-93
34. Hemann MT, Fridman JS, Zilfou JT, et al. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat Genet 2003;33:396-400
35. Elbashir SM, Harborth J, Weber K, et al. Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 2002; 26:199-213
36. Soneoka Y, Cannon PM, Ramsdale EE, et al. A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res 1995;23:628-33
37. Zeng WF, Navaratne K, Prayson RA, et al. Aurora B expression correlates with aggressive behaviour in glioblastoma multiforme. J Clin Pathol 2007;60:218-21
38. Kozak KR, Moody JS. Giant cell glioblastoma: A glioblastoma subtype with distinct epidemiology and superior prognosis. Neuro Oncol 2009; 11:833-41
39. Burger PC, Vollmer RT. Histologic factors of prognostic significance in the glioblastoma multiforme. Cancer 1980;46:1179-86
40. Jellinger K. Glioblastoma multiforme: Morphology and biology. Acta Neurochir (Wien) 1978;42:5-32
41. Sabel M, Reifenberger J, Weber RG, et al. Long-term survival of a patient with giant cell glioblastoma. Case report. J Neurosurg 2001;94:605-11
42. Temme A, Herzig E, Weigle B, et al. Inhibition of malignant glioma cell growth by a survivin mutant retrovirus. Hum Gene Ther 2005;16:209-22
43. Nguyen HG, Chinnappan D, Urano T, et al. Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: Identification of an aneuploidy-promoting property. Mol Cell Biol 2005;25: 4977-92
44. Fukuda S, Mantel CR, Pelus LM. Survivin regulates hematopoietic progenitor cell proliferation through p21WAF1/Cip1-dependent and-independent pathways. Blood 2004;103:120-27
45. Murata-Hori M, Tatsuka M, Wang YL. Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis. Mol Biol Cell 2002;13:1099-108
46. Murata-Hori M, Wang YL. The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis. Curr Biol 2002;12: 894-99
47. Tanno Y, Kobayashi K, Tatsuka M, et al. Mitotic arrest caused by an X-ray microbeam in a single cell expressing EGFPYAurora kinase B. Radiat Prot Dosimetry 2006;122:301-6