Inhibition of Aurora-B function increases formation of multinucleated cells in p53 gene deficient cells and enhances anti-tumor effect of temozolomide in human glioma cells

Journal of Neuro-Oncology

Volumn 83, Issue 3, 2007, Pages 249-258

  Tsuno, Takaya ^a   Natsume, Atsushi ^a,b   Katsumata, Shun ^a   Mizuno, Masaaki ^a   Fujita, Mitsugu ^a   Osawa, Hirokatsu ^a   Nakahara, Norimoto ^a   Wakabayashi, Toshihiko ^a,b   Satoh, Yu Ichiro ^a   Inagaki, Masaki ^c   Yoshida, Jun ^a,b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY HOSPITAL   (Japan)

^c AICHI CANCER CENTER HOSPITAL   (Japan)

Author keywords

Aurora B; Glioma; Multinucleated cells; p53; siRNA; Temozolomide

Indexed keywords

AURORA B KINASE; MUTANT PROTEIN; PROTEIN P53; SMALL INTERFERING RNA; TEMOZOLOMIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER RESISTANCE; CELL COUNT; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME INHIBITION; GENE MUTATION; GENETIC TRANSDUCTION; GLIOBLASTOMA; HUMAN; HUMAN CELL; MULTINUCLEAR CELL; NUCLEOTIDE SEQUENCE; NULL ALLELE; PROTEIN DEFECT; PROTEIN DEFICIENCY; PROTEIN FUNCTION; WILD TYPE;

ANTINEOPLASTIC AGENTS, ALKYLATING; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL CYCLE; CELL SURVIVAL; DACARBAZINE; FLOW CYTOMETRY; GIANT CELLS; GLIOMA; HUMANS; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34250773487     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-007-9335-1     Document Type: Article

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