Mitotic arrest caused by an X-ray microbeam in a single cell expressing EGFP-aurora kinase B

Radiation Protection Dosimetry

Volumn 122, Issue 1-4, 2006, Pages 301-306

  Tanno, Y ^a   Kobayashi, K ^b   Tatsuka, M ^c   Gotoh, E ^d   Takakura, K ^a  

^a INTERNATIONAL CHRISTIAN UNIVERSITY   (Japan)

^b INSTITUTE OF MATERIALS STRUCTURE SCIENCE   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

^d NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA B KINASE; DNA; ENHANCED GREEN FLUORESCENT PROTEIN; HISTONE H2AX; AURKB PROTEIN, HUMAN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINESIS; DNA DAMAGE; DOSIMETRY; HELA CELL; HUMAN; HUMAN CELL; METAPHASE; MITOSIS INHIBITION; PHASE TRANSITION; PROMETAPHASE; PROPHASE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; TELOPHASE; X IRRADIATION; ELECTRONICS; GENETICS; INSTRUMENTATION; MAGNETIC AND ELECTROMAGNETIC EQUIPMENT; METABOLISM; MITOSIS; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; X RAY;

DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MINIATURIZATION; MITOSIS; PARTICLE ACCELERATORS; PROTEIN-SERINE-THREONINE KINASES; RADIATION DOSAGE; RADIATION TOLERANCE; RECOMBINANT FUSION PROTEINS; X-RAYS;

EID: 34347405326     PISSN: 01448420     EISSN: None     Source Type: Journal    
DOI: 10.1093/rpd/ncl512     Document Type: Article

References (13)

1. Iliakis, G., Krieg, T., Guan, J., Wang, Y. and Leeper, D. Evidence for an S-phase checkpoint regulating DNA replication after heat shock: A review. Int. J. Hyperthermia 20, 240-249 (2004).
2. Bulavin, D. V., Amundson, S. A. and Fornace, A. J. p38 and Chk1 kinases: Different conductors for the G(2)/M checkpoint symphony. Curr. Opin. Genet. Dev. 12, 92-97 (2002).
3. Morrison, C. and Rieder, C. L. Chromosome damage and progression into and through mitosis in vertebrates. DNA Repair (Amst.) 3, 1133-1139 (2004).
4. Smits, V. A., Klompmaker, R., Arnaud, L., Rijksen, G., Nigg, E. A. and Medema, R. H. Polo-like kinase-I is a target of the DNA damage checkpoint. Nat. Cell Biol. 2, 672-676 (2000).
5. Mikhailov, A., Cole, R. W. and Rieder, C. L. DNA damage during mitosis in human cells delays the metaphase/anaphase transition via the spindle-assembly checkpoint. Curt. Biol. 12, 1797-1806 (2002).
6. Royou, A., Macias, H. and Sullivan, W. The Drosophila Grp/Chk1 DNA damage checkpoint controls entry into anaphase. Curr. Biol. 15, 334-339 (2005).
7. Skoufias, D. A., Lacroix, F. B., Andreassen, P. R., Wilson, L. and Margolis, R. L. Inhibition of DNA decatenation, but not DNA damage, arrests cells at metaphase. Mol. Cell 15, 977-990 (2004).
8. Kobayashi, K., Usami, N., Maezawa, H., Hayashi, T., Hieda, K. and Takakura, K. Development of photon microbeam irradiation system for radiobiology. Int. Congr. Ser. 1258, 207-211 (2003).
9. Kobayashi, K., Usami, N., Maezawa, H., Hayashi, T., Hieda, K. and Takakura, K. Synchrotron X-ray microbeam irradiation system for radiobiology. J. Biomed. Nanotechnol. 2, 1-4 (2006).
10. Carmena, M. and Earnshaw, W. C. The cellular geography of aurora kinases. Nat. Rev. Mol. Cell Biol. 4, 842-854 (2003).
11. Murata-Hori, M., Tatsuka, M. and Wang, Y. L. Probing the dynamics and functions of aurora B kinase in living cells during mitosis and cytokinesis. Mol. Biol. Cell 13, 1099-1108 (2002).
12. Puck, T. T., Markus, P. I. Action of x-rays on mammalian cells. J. Exp. Med. 103, 653-666 (1956).
13. Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. and Bonner, W. M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-68 (1998).