The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

Cancer Research

Volumn 66, Issue 15, 2006, Pages 7668-7677

  Gizatullin, Farid ^a,b   Yao, Yao ^c   Kung, Victor ^a   Harding, Matthew W ^c   Loda, Massimo ^a,b   Shapiro, Geoffrey I ^a,b  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c VERTEX PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA KINASE INHIBITOR; CYCLIN DEPENDENT KINASE 2; CYCLIN E; CYCLOPROPANECARBOXYLIC ACID [4 [4 (4 METHYL 1 PIPERAZINYL) 6 (5 METHYL 2H PYRAZOL 3 YLAMINO) 2 PYRIMIDINYLTHIO]PHENYL]AMIDE; ENZYME INHIBITOR; HPV16 E6 PROTEIN; ONCOPROTEIN; PROTEIN P21; PROTEIN P53; RETINOBLASTOMA PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL LINE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; ENDOREDUPLICATION; ENZYME ACTIVITY; ENZYME REPRESSION; HUMAN; HUMAN CELL; LUNG NON SMALL CELL CANCER; MITOSIS; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING;

APOPTOSIS; CELL LINE, TUMOR; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GENE DUPLICATION; HUMANS; MITOSIS; NEOPLASMS; PHOSPHORYLATION; PIPERAZINES; PROTEIN-SERINE-THREONINE KINASES; RETINOBLASTOMA PROTEIN; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33747877023     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-3353     Document Type: Article

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