Effects of Pressure and Flow on the Pulmonary Endothelium

The Pulmonary Endothelium: Function in health and disease

Volumn , Issue , 2009, Pages 309-335

  Kuebler, Wolfgang M ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Acute pressure stress on pulmonary endothelium; Flow effects on pulmonary endothelium; High altitude pulmonary edema (HAPE) or ventilator induced lung injury (VILI); Mechanical forces acting on pulmonary endothelium; Mechanical injury to endothelium in lung disease; Mechanotransduction in ECs; Pressure effects and flow on pulmonary endothelium; VILI iatrogenic disease constituting a challenge

Indexed keywords

EID: 77953051716     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470747490.ch20     Document Type: Chapter

References (201)

1. Uhlig, S. (2002) Ventilation-induced lung injury and mechanotransduction: stretching it too far? American Journal of Physiology: Lung Cellular and Molecular Physiology, 282, L892-96.
2. Fahraeus, R. (1929) The suspension stability of the blood. Physiological Reviews, 9, 241-71.
3. Frame, M.D. and Sarelius, I.H. (1996) Endothelial cell dilatory pathways link flow and wall shear stress in an intact arteriolar network. Journal of Applied Physiology, 81, 2105-14.
4. Kuebler, W.M., Kuhnle, G.E., Groh, J., and Goetz, A.E. (1994) Leukocyte kinetics in pulmonary microcirculation: intravital fluorescence microscopic study. Journal of Applied Physiology, 76, 65-71.
5. Kuebler, W.M., Kuhnle, G.E., Groh, J., and Goetz, A.E. (1997) Contribution of selectins to leucocyte sequestration in pulmonary microvessels by intravital microscopy in rabbits. The Journal of Physiology, 501, 375-86.
6. Hudlicka, O., Brown, M.D., May, S. et al. (2006) Changes in capillary shear stress in skeletal muscles exposed to long-term activity: role of nitric oxide. Microcirculation, 13, 249-59.
7. Bergel, D.H., Caro, C.G., and Seed, W.A. (1967) Asymmetrical transmission of pressure waves in the pulmonary vascular system of the dog. The Journal of Physiology, 188, 41P-42P.
8. Presson, R.G. Jr., Baumgartner, W.A. Jr., Peterson, A.J. et al. (2002) Pulmonary capillaries are recruited during pulsatile flow. Journal of Applied Physiology, 92, 1183-90.
9. Wagner, W.W. Jr., Todoran, T.M., Tanabe, N. et al. (1999) Pulmonary capillary perfusion: intra-alveolar fractal patterns and interalveolar independence. Journal of Applied Physiology, 86, 825-31.
10. Baumgartner, W.A. Jr., Peterson, A.J., Presson, R.G. Jr. et al. (2004) Blood flow switching among pulmonary capillaries is decreased during high hematocrit. Journal of Applied Physiology, 97, 522-26.
11. Yu, Q., Zhou, J., and Fung, Y.C. (1993) Neutral axis location in bending and Young's modulus of different layers of arterial wall. American Journal of Physiology: Heart and Circulatory Physiology, 265, H52-60.
12. 2+ oscillations in lung capillaries. American Journal of Physiology: Lung Cellular and Molecular Physiology, 282, L917-23.
13. Sadurski, R., Tsukada, H., Ying, X. et al. (1994) Diameters of juxtacapillary venules determined by oil-drop method in rat lung. Journal of Applied Physiology, 77, 718-25.
14. Hillier, S.C., Godbey, P.S., Hanger, C.C. et al. (1993) Direct measurement of pulmonary microvascular distensibility. Journal of Applied Physiology, 75, 2106-11.
15. Spohr, F., Cornelissen, A.J., Busch, C. et al. (2005) Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice. American Journal of Physiology: Heart and Circulatory Physiology, 289, H823-31.
16. al-Tinawi, A., Madden, J.A., Dawson, C.A. et al. (1991) Distensibility of small arteries of the dog lung. Journal of Applied Physiology, 71, 1714-22.
17. Molthen, R.C., Karau, K.L., and Dawson, C.A. (2004) Quantitative models of the rat pulmonary arterial tree morphometry applied to hypoxia-induced arterial remodeling. Journal of Applied Physiology, 97, 2372-84.
18. al-Tinawi, A., Clough, A.V., Harder, D.R. et al. (1992) Distensibility of small veins of the dog lung. Journal of Applied Physiology, 73, 2158-65.
19. Eiken, O. and Kolegard, R. (2004) Comparison of vascular distensibility in the upper and lower extremity. Acta Physiologica Scandinavica, 181, 281-87.
20. Kassab, G.S., Le, K.N., and Fung, Y.C. (1999) A hemodynamic analysis of coronary capillary blood flow based on anatomic and distensibility data. American Journal of Physiology: Heart and Circulatory Physiology, 277, H2158-66.
21. Kindig, C.A. and Poole, D.C. (1999) Effects of skeletal muscle sarcomere length on in vivo capillary distensibility. Microvascular Research, 57, 144-52.
22. Howell, J.B., Permutt, S., Proctor, D.F., and Riley, R.L. (1961) Effect of inflation of the lung on different parts of pulmonary vascular bed. Journal of Applied Physiology, 16, 71-76.
23. Marini, J.J. (2004) Microvasculature in ventilator-induced lung injury: target or cause? Minerva Anestesiologica, 70, 167-73.
24. Lai-Fook, S.J. (1982) Perivascular interstitial fluid pressure measured by micropipettes in isolated dog lung. Journal of Applied Physiology, 52, 9-15.
25. Albert, R.K., Lamm, W.J., Rickaby, D.A. et al. (1993) Lung inflation distends small arteries (<1mm) in excised dog lungs. Journal of Applied Physiology, 75, 2595-601.
26. Wanner, A., Zarzecki, S., and Sackner, M.A. (1975) Effects of lung inflation on pulmonary arterial blood volume in intact dogs. Journal of Applied Physiology, 38, 675-80.
27. Macklin, C.C. (1946) Evidence of increase in the capacity of the pulmonary arteries and veins of dogs, cats and rabbits, during inflation of the freshly excised lung. Revue Canadienne de Biolo-gie, 5, 199-232.
28. Sun, R.Y., Nieman, G.F., Hakim, T.S., and Chang, H.K. (1987) Effects of lung volume and alveolar surface tension on pulmonary vascular resistance. Journal of Applied Physiology, 62, 1622-26.
29. Kuebler, W.M. (2005) Inflammatory pathways and microvascular responses in the lung. Pharmacological Reports, 57 (Suppl), 196-205.
30. Ali, M.H. and Schumacker, P.T. (2002) Endothelial responses to mechanical stress: where is the mechanosensor? Critical Care Medicine, 30, S198-S206.
31. Helmke, B.P. and Davies, P.F. (2002) The cy-toskeleton under external fluid mechanical forces: hemodynamic forces acting on the endothelium. Annals of Biomedical Engineering, 30, 284-96.
32. Ingber, D.E. (1997) Tensegrity: the architectural basis of cellular mechanotransduction. Annual Review of Physiology, 59, 575-99.
33. Wang, N., Butler, J.P., and Ingber, D.E. (1993) Mechanotransduction across the cell surface and through the cytoskeleton. Science, 260, 1124-27.
34. Janmey, P.A., Euteneuer, U., Traub, P., and Schliwa, M. (1991) Viscoelastic properties of vimentin compared with other filamentous biopolymer networks. The Journal of Cell Biology, 113, 155-60.
35. Davies, P.F. and Tripathi, S.C. (1993) Mechanical stress mechanisms and the cell. An endothelial paradigm. Circulation Research, 72, 239-45.
36. Chen, K.D., Li, Y.S., Kim, M. et al. (1999) Mechanotransduction in response to shear stress. Roles of receptor tyrosine kinases, integrins, and Shc. The Journal of Biological Chemistry, 274, 18393-400.
37. Takahashi, M., Ishida, T., Traub, O. et al. (1997) Mechanotransduction in endothelial cells: temporal signaling events in response to shear stress. Journal of Vascular Research, 34, 212-19.
38. Sastry, S.K. and Burridge, K. (2000) Focal adhesions: a nexus for intracellular signaling and cy-toskeletal dynamics. Experimental Cell Research, 261, 25-36.
39. Ko, K.S., Arora, P.D., and McCulloch, C.A. (2001) Cadherins mediate intercellular mechanical signaling in fibroblasts by activation of stretch-sensitive calcium-permeable channels. The Journal of Biological Chemistry, 276, 35967-77.
40. Shasby, D.M. (2007) Cell-cell adhesion in lung endothelium. American Journal of Physiology: Lung Cellular and Molecular Physiology, 292, L593-607.
41. Kawamura, S., Miyamoto, S., and Brown, J.H. (2003) Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. The Journal of Biological Chemistry, 278, 31111-17.
42. van Deurs, B., Roepstorff, K., Hommelgaard, A.M., and Sandvig, K. (2003) Caveolae: anchored, multifunctional platforms in the lipid ocean. Trends in Cell Biology, 13, 92-100.
43. Pries, A.R. and Kuebler, W.M. (2006) Normal endothelium, in Handbook ofExperimental Pharmacology: The Vascular Endothelium, (eds S. Mon-cada and A. Higgs), Springer, Berlin, pp. 1-40.
44. Weinbaum, S., Zhang, X., Han, Y. et al. (2003) Mechanotransduction and flow across the endothelial glycocalyx. Proceedings of the National Academy of Sciences of the United States of America, 100, 7988-95.
45. Olesen, S.P., Clapham, D.E., and Davies, P.F. (1988) Haemodynamic shear stress activates a K+ current in vascular endothelial cells. Nature, 331, 168-70.
46. 86Rb+ efflux from calf pulmonary artery endothelial cells. Annals of Biomedical Engineering, 21, 1-7.
47. Hutcheson, I.R. and Griffith, T.M. (1994) Heterogeneous populations of K+ channels mediate EDRF release to flow but not agonists in rabbit aorta. American Journal ofPhysiology: Heart and Circulatory Physiology, 266, H590-96.
48. Schwarz, G., Callewaert, G., Droogmans, G., and Nilius, B. (1992) Shear stress-induced calcium transients in endothelial cells from human umbilical cord veins. The Journal of Physiology, 458, 527-38.
49. Schwarz, G., Droogmans, G., and Nilius, B. (1992) Shear stress induced membrane currents and calcium transients in human vascular endothelial cells. Pflugers Archiv, 421, 394-96.
50. Lansman, J.B., Hallam, T.J., and Rink, T.J. (1987) Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers? Nature, 325, 811-13.
51. 2+-permeable cation channel in intact vascular endothelium of hypertensive rats. Proceedings of the National Academy of Sciences of the United States of America, 93, 11253-58.
52. Hoyer, J., Kohler, R., and Distler, A. (1997) Mechanosensitive cation channels in aortic endothelium of normotensive and hypertensive rats. Hypertension, 30, 112-19.
53. Kohler, R., Schonfelder, G., Hopp, H. et al. (1998) Stretch-activated cation channel in human umbilical vein endothelium in normal pregnancy and in preeclampsia. Journal of Hypertension, 16, 1149-56.
54. 2+ mobilization to mechanical stretch in endothelial cells. American Journal of Physiology: Cell Physiology, 264, C1037-44.
55. Naruse, K., Yamada, T., and Sokabe, M. (1998) Involvement of SA channels in orienting response of cultured endothelial cells to cyclic stretch. American Journal of Physiology: Heart and Circulatory Physiology, 274, H1532-38.
56. Yang, X.C. and Sachs, F. (1989) Block of stretch-activated ion channels in Xenopus oocytes by gadolinium and calcium ions. Science, 243, 1068-71.
57. O'Neil, R.G. and Heller, S. (2005) The mechanosensitive nature of TRPV channels. Pflugers Archiv, 451, 193-203.
58. Hoenderop, J.G., Nilius, B., and Bindels, R.J. (2005) Calcium absorption across epithelia. Physiological Reviews, 85, 373-422.
59. Alvarez, D.F., King, J.A., Weber, D. et al. (2006) Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. Circulation Research, 99, 988-95.
60. 2+ entry in human pulmonary artery endothelial cells. American Journal ofPhysiology: Lung Cellular and Molecular Physiology, 285, L1233-45.
61. Liedtke, W. and Kim, C. (2005) Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon Cellular and Molecular Life Sciences, 62, 2985-3001.
62. Hartmannsgruber, V., Heyken, W.T., Kacik, M. et al. (2007) Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS One, 2, e827.
63. Kohler, R., Heyken, W.T., Heinau, P. et al. (2006) Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation. Arteriosclerosis, Thrombosis, and Vascular Biology, 26, 1495-502.
64. Jian, M.Y., King, J.A., Al-Mehdi, A.B. et al. (2008) High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. American Journal of Respiratory Cell and Molecular Biology, 38, 386-92.
65. Yin, J., Hoffmann, J., Kaestle, S.M. et al. (2008) Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. Circulation Research, 102, 966-74.
66. Muraki, K., Iwata, Y., Katanosaka, Y. et al. (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circulation Research, 93, 829-38.
67. Birder, L.A., Nakamura, Y., Kiss, S. et al. (2002) Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nature Neuroscience, 5, 856-60.
68. Gevaert, T., Vandepitte, J., Hutchings, G. et al. (2007) TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist. Neurourology and Urodynamics, 26, 440-50.
69. Nauli, S.M., Alenghat, F.J., Luo, Y. et al. (2003) Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nature Genetics, 33, 129-37.
70. Yoder, B.K., Hou, X., and Guay-Woodford, L.M. (2002) The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. Journal of the American Society of Nephrology, 13, 2508-16.
71. Praetorius, H.A. and Spring, K.R. (2001) Bending the MDCK cell primary cilium increases intracellular calcium. The Journal of Membrane Biology, 184, 71-79.
72. Yao, X. and Garland, C.J. (2005) Recent developments in vascular endothelial cell transient receptor potential channels. Circulation Research, 97, 853-63.
73. Corey, D.P., Garcia-Anoveros, J., Holt, J.R. et al. (2004) TRPA1 is a candidate for the mechanosen-sitive transduction channel of vertebrate hair cells. Nature, 432, 723-30.
74. Sidi, S., Friedrich, R.W., and Nicolson, T. (2003) NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science, 301, 96-99.
75. Inoue, R., Jensen, L.J., Shi, J. et al. (2006) Transient receptor potential channels in cardiovascular function and disease. Circulation Research, 99, 119-31.
76. Tseng, H., Peterson, T.E., and Berk, B.C. (1995) Fluid shear stress stimulates mitogen-activated protein kinase in endothelial cells. Circulation Research, 77, 869-78.
77. Jin, Z.G., Wong, C., Wu, J., and Berk, B.C. (2005) Flow shear stress stimulates Gab1 tyrosine phosphorylation to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells. The Journal of Biological Chemistry, 280, 12305-9.
78. Tai, L.K., Okuda, M., Abe, J. et al. (2002) Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 1790-96.
79. Park, H., Go, Y.M., Darji, R. et al. (2000) Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase. American Journal of Physiology: Heart and Circulatory Physiology, 278, H1285-93.
80. 2+-dependent signal transduction. Traffic, 4, 717-23.
81. Murata, T., Lin, M.I., Stan, R.V. et al. (2007) Ge netic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. The Journal of Biological Chemistry, 282, 16631-43.
82. 2+ signaling and hyperpolarization in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 27, 2612-18.
83. 2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells. Molecular Pharmacology, 70, 1174-83.
84. Conrad, P.A., Smart, E.J., Ying, Y.S. et al. (1995) Caveolin cycles between plasma membrane caveolae and the Golgi complex by microtubule-dependent and microtubule-independent steps. The Journal of Cell Biology, 131, 1421-33.
85. Sun, R.J., Muller, S., Zhuang, F.Y. et al. (2003) Caveolin-1 redistribution in human endothelial cells induced by laminar flow and cytokine. Biorheology, 40, 31-39.
86. Rizzo, V., Morton, C., DePaola, N. et al. (2003) Recruitment of endothelial caveolae into mechan-otransduction pathways by flow conditioning in vitro. American Journal of Physiology: Heart and Circulatory Physiology, 285, H1720-29.
87. Boyd, N.L., Park, H., Yi, H. et al. (2003) Chronic shear induces caveolae formation and alters ERK and Akt responses in endothelial cells. American Journal of Physiology: Heart and Circulatory Physiology, 285, H1113-22.
88. Albertini, H.F. (1748) Animadversiones super quibusdam difficilis respirationis vitiis a laesa cordis et praecordiorum structura pendentibus. De Bononiensi Scientiarum et Artium Instituto Atque Academia Comentarii, 1, 382-404.
89. Jarcho, S. (1972) The Animadversiones of Ippolito Francesco Albertini (1748) on cardiac and precordial diseases which cause dyspnea. Proceedings of the American Philosophical Society, 116, 163-81.
90. Starling, E.H. (1896) On the absorption of fluids from the connective tissue spaces. The Journal of Physiology, 19, 312-26.
91. Gaar, K.A. Jr., Taylor, A.E., Owens, L.J., and Guyton, A.C. (1967) Effect of capillary pressure and plasma protein on development of pulmonary edema. American Journal of Physiology, 213, 79-82.
92. Bachofen, H., Schurch, S., Michel, R.P., and Weibel, E.R. (1993) Experimental hydrostatic pulmonary edema in rabbit lungs: morphology. The American Review of Respiratory Disease, 147, 989-96.
93. Bachofen, H., Schurch, S., and Weibel, E.R. (1993) Experimental hydrostatic pulmonary edema in rabbit lungs. Barrier lesions. The American Review of Respiratory Disease, 147, 997-1004.
94. Tsukimoto, K., Yoshimura, N., Ichioka, M. et al. (1994) Protein, cell, and LTB4 concentrations of lung edema fluid produced by high capillary pressures in rabbit. Journal ofApplied Physiology, 76, 321-27.
95. West, J.B., Tsukimoto, K., Mathieu-Costello, O., and Prediletto, R. (1991) Stress failure in pulmonary capillaries. Journal of Applied Physiology, 70, 1731-42.
96. Namba, Y., Kurdak, S.S., Fu, Z. et al. (1995) Effect of reducing alveolar surface tension on stress failure in pulmonary capillaries. Journal of Applied Physiology, 79, 2114-21.
97. Elliott, A.R., Fu, Z., Tsukimoto, K. et al. (1992) Short-term reversibility of ultrastructural changes in pulmonary capillaries caused by stress failure. Journal of Applied Physiology, 73, 1150-58.
98. Nicolaysen, G., Waaler, B.A., and Aarseth, P. (1979) On the existence of stretchable pores in the exchange vessels of the isolated rabbit lung preparation. Lymphology, 12, 201-7.
99. Rippe, B., Townsley, M., Thigpen, J. et al. (1984) Effects of vascular pressure on the pulmonary microvasculature in isolated dog lungs. Journal of Applied Physiology, 57, 233-39.
100. Nakos, G., Pneumatikos, J., Tsangaris, I. et al. (1997) Proteins and phospholipids in BAL from patients with hydrostatic pulmonary edema. American Journal of Respiratory and Critical Care Medicine, 155, 945-51.
101. West, J.B. (2000) Invited review: pulmonary capillary stress failure. Journal of Applied Physiology, 89, 2483-89.
102. Givertz, M.M., Slawsky, M.T., Moraes, D.L. et al. (2001) Noninvasive determination of pulmonary artery wedge pressure in patients with chronic heart failure. The American Journal of Cardiology, 87, 1213-15.
103. Maggiorini, M., Melot, C., Pierre, S. et al. (2001) High-altitude pulmonary edema is initially caused by an increase in capillary pressure. Circulation, 103, 2078-83.
104. Sarnoff, S.J., Berglund, E., and Sarnoff, L.C. (1953) Neurohemodynamics of pulmonary edema. III. Estimated changes in pulmonary blood volume accompanying systemic vasoconstriction and vasodilation. Journal of Applied Physiology, 5, 367-74.
105. West, J.B. (1998) Left ventricular filling pressures during exercise: a cardiological blind spot? Chest, 113, 1695-97.
106. Hopkins, S.R., Schoene, R.B., Henderson, W.R. et al. (1997) Intense exercise impairs the integrity of the pulmonary blood-gas barrier in elite athletes. American Journal of Respiratory and Critical Care Medicine, 155, 1090-94.
107. Wagner, P.D., Gale, G.E., Moon, R.E. et al. (1986) Pulmonary gas exchange in humans exercising at sea level and simulated altitude. Journal of Applied Physiology, 61, 260-70.
108. Hiraga, A., Hobo, S., Birks, E.K. et al. (1999) Changes in left ventricular dynamics during graded exercise. Equine Veterinary Journal: Supplement, 30, 122-25.
109. West, J.B., Mathieu-Costello, O., Jones, J.H. et al. (1993) Stress failure of pulmonary capillaries in racehorses with exercise-induced pulmonary hemorrhage. Journal of Applied Physiology, 75, 1097-109.
110. Birks, E.K., Mathieu-Costello, O., Fu, Z. et al. (1997) Very high pressures are required to cause stress failure of pulmonary capillaries in thoroughbred racehorses. Journal of Applied Physiology, 82, 1584-92.
111. Fu, Z., Heldt, G.P., and West, J.B. (2003) Increased fragility of pulmonary capillaries in newborn rabbit. American Journal ofPhysiology: Lung Cellular and Molecular Physiology, 284, L703-9.
112. Bhattacharya, J., Nakahara, K., and Staub, N.C. (1980) Effect of edema on pulmonary blood flow in the isolated perfused dog lung lobe. Journal of Applied Physiology, 48, 444-49.
113. Parker, J.C. and Ivey, C.L. (1997) Isoproterenol attenuates high vascular pressure-induced permeability increases in isolated rat lungs. Journal of Applied Physiology, 83, 1962-67.
114. Kuebler, W.M., Parthasarathi, K., Lindert, J., and Bhattacharya, J. (2007) Real-time lung microscopy. Journal of Applied Physiology, 102, 1255-64.
115. Watanabe, H., Vriens, J., Prenen, J. et al. (2003) Anandamide and arachidonic acid use epoxye-icosatrienoic acids to activate TRPV4 channels. Nature, 424, 434-38.
116. D'Hoedt, D., Owsianik, G., Prenen, J. et al. (2008) Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. The Journal of Biological Chemistry, 10, 6272-80.
117. Kuebler, W.M., Ying, X., Singh, B. et al. (1999) Pressure is proinflammatory in lung venular capillaries. The Journal of Clinical Investigation, 104, 495-502.
118. Betz, W.J. and Bewick, G.S. (1992) Optical analysis of synaptic vesicle recycling at the frog neuromuscular junction. Science, 255, 200-3.
119. McEver, R.P., Beckstead, J.H., Moore, K.L. et al. (1989) GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies. The Journal of Clinical Investigation, 84, 92-99.
120. Wagner, D.D., Olmsted, J.B., and Marder, V.J. (1982) Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. The Journal of Cell Biology, 95, 355-60.
121. Wolff, B., Burns, A.R., Middleton, J., and Rot, A. (1998) Endothelial cell "memory" of inflammatory stimulation: human venular endothelial cells store interleukin 8 in Weibel-Palade bodies. The Journal ofExperimental Medicine, 188, 1757-62.
122. Kuebler, W.M. (2006) Selectins revisited: the emerging role of platelets in inflammatory lung disease. The Journal of Clinical Investigation, 116, 3106-8.
123. Ichimura, H., Parthasarathi, K., Issekutz, A.C., and Bhattacharya, J. (2005) Pressure-induced leukocyte margination in lung postcapillary venules. American Journal of Physiology: Lung Cellular and Molecular Physiology, 289, L407-12.
124. De Pasquale, C.G., Arnolda, L.F., Doyle, I.R. et al. (2003) Prolonged alveolocapillary barrier damage after acute cardiogenic pulmonary edema. Critical Care Medicine, 31, 1060-67.
125. Fleming, I. and Busse, R. (2003) Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 284, R1-12.
126. Kaestle, S.M., Reich, C.A., Yin, N. et al. (2007) Nitric oxide-dependent inhibition of alveolar fluid clearance in hydrostatic lung edema. American Journal of Physiology: Lung Cellular and Molecular Physiology, 293, L859-69.
127. Kuebler, W.M., Uhlig, U., Goldmann, T. et al. (2003) Stretch activates nitric oxide production in pulmonary vascular endothelial cells in situ. American Journal of Respiratory and Critical Care Medicine, 168, 1391-98.
128. Tabuchi, A., Mertens, M., Kuppe, H. et al. (2008) Intravital microscopy of the murine pulmonary microcirculation. Journal of Applied Physiology, 104, 338-46.
129. Song, W. and Matalon, S. (2007) Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates. American Journal ofPhys-iology: Lung Cellular and Molecular Physiology, 293, L855-58.
130. Kaestle, S.M., Kuppe, H., and Kuebler, W.M. (2004) Compartmentalisation of the inflammatory response, in Anaesthesia, Pain, Intensive Care and Emergency Medicine, (ed. A. Gullo), Springer, Milan, pp. 639-54.
131. Wang, P.M., Fujita, E., and Bhattacharya, J. (2002) Vascular regulation of type II cell exocytosis. American Journal of Physiology: Lung Cellular and Molecular Physiology, 282, L912-16.
132. Ghio, S., Gavazzi, A., Campana, C. et al. (2001) Independent and additive prognostic value of right ventricular systolic function and pulmonary artery pressure in patients with chronic heart failure. Journal of the American College of Cardiology, 37, 183-88.
133. Huang, W., Kingsbury, M.P., Turner, M.A. et al. (2001) Capillary filtration is reduced in lungs adapted to chronic heart failure: morphological and haemodynamic correlates. Cardiovascular Research, 49, 207-17.
134. Kingsbury, M.P., Huang, W., Donnelly, J.L. et al. (2003) Structural remodelling of lungs in chronic heart failure. Basic Research in Cardiology, 98, 295-303.
135. Hentschel, T., Yin, N., Riad, A. et al. (2007) Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology, 106, 124-31.
136. Moraes, D.L., Colucci, W.S., and Givertz, M.M. (2000) Secondary pulmonary hypertension in chronic heart failure: the role of the endothelium in pathophysiology and management. Circulation, 102, 1718-23.
137. Ontkean, M., Gay, R., and Greenberg, B. (1991) Diminished endothelium-derived relaxing factor activity in an experimental model of chronic heart failure. Circulation Research, 69, 1088-96.
138. Kuebler, W.M., Kerem, A., Kaestle, S. et al. (2004) Mechanism of pulmonary endothelial dysfunction in congestive heart failure. The FASEB Journal, 18, A714.
139. Dyess, D.L., Hunter, J.L., Lakey, J.R. et al. (2000) Attenuation of histamine-induced endothelial permeability responses after pacing-induced heart failure: role for endogenous catecholamines. Microcirculation, 7, 307-15.
140. 2+ signaling. American Journal of Physiology: Heart and Circulatory Physiology, 275, H844-51.
141. Roy, B.J., Pitts, V.H., and Townsley, M.I. (1996) Pulmonary vascular response to angiotensin II in canine pacing-induced heart failure. American Journal of Physiology: Heart and Circulatory Physiology, 271, H222-27.
142. Townsley, M.I., Fu, Z., Mathieu-Costello, O., and West, J.B. (1995) Pulmonary microvascular permeability. Responses to high vascular pressure after induction of pacing-induced heart failure in dogs. Circulation Research, 77, 317-25.
143. Alvarez, D.F., King, J.A., and Townsley, M.I. (2005) Resistance to store depletion-induced endothelial injury in rat lung after chronic heart failure. American Journal of Respiratory and Critical Care Medicine, 172, 1153-60.
144. Davies, S.W., Wilkinson, P., Keegan, J. et al. (1991) Pulmonary microvascular permeability in patients with severe mitral stenosis. British Heart Journal, 65, 89-93.
145. Davies, S.W., Bailey, J., Keegan, J. et al. (1992) Reduced pulmonary microvascular permeability in severe chronic left heart failure. American Heart Journal, 124, 137-42.
146. Barakat, A. and Lieu, D. (2003) Differential responsiveness of vascular endothelial cells to different types of fluid mechanical shear stress. Cell Biochemistry and Biophysics, 38, 323-43.
147. Brooks, A.R., Lelkes, P.I., and Rubanyi, G.M. (2004) Gene expression profiling of vascular endothelial cells exposed to fluid mechanical forces: relevance for focal susceptibility to atherosclerosis. Endothelium, 11, 45-57.
148. Zakrzewicz, A., Secomb, T.W., and Pries, A.R. (2002) Angioadaptation: keeping the vascular system in shape. News in Physiological Sciences, 17, 197-201.
149. Birukov, K.G., Birukova, A.A., Dudek, S.M. et al. (2002) Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cells. American Journal of Respiratory Cell and Molecular Biology, 26, 453-64.
150. Al-Mehdi, A.B., Zhao, G., Dodia, C. et al. (1998) Endothelial NADPH oxidase as the source of oxidants in lungs exposed to ischemia or high K+. Circulation Research, 83, 730-37.
151. Al-Mehdi, A.B., Shuman, H., and Fisher, A.B. (1997) Intracellular generation of reactive oxygen species during nonhypoxic lung ischemia. American Journal of Physiology: Lung Cellular and Molecular Physiology, 272, L294-300.
152. Tozawa, K., Al-Mehdi, A.B., Muzykantov, V., and Fisher, A.B. (1999) In situ imaging of intracellular calcium with ischemia in lung subpleural microvascular endothelial cells. Antioxidants and Redox Signaling, 1, 145-54.
153. Wei, Z., Costa, K., Al-Mehdi, A.B. et al. (1999) Simulated ischemia in flow-adapted endothelial cells leads to generation of reactive oxygen species and cell signaling. Circulation Research, 85, 682-89.
154. Wei, Z., Al-Mehdi, A.B., and Fisher, A.B. (2001) Signaling pathway for nitric oxide generation with simulated ischemia in flow-adapted endothelial cells. American Journal ofPhysiology: Heart and Circulatory Physiology, 281, H2226-32.
155. 2+-and phosphatidylinosi-tol 3-kinase-dependent nitric oxide generation in lung endothelial cells in situ with ischemia. The Journal of Biological Chemistry, 275, 39807-10.
156. Sniderman, A., Burdon, T., Homan, J., and Salerno, T.A. (1984) Pulmonary blood flow. A potential factor in the pathogenesis of pulmonary edema. The Journal of Thoracic and Cardiovascular Surgery, 87, 130-35.
157. Ehrhart, I.C., McCloud, L.L., Orfanos, S.E. et al. (1994) Effect of high blood flow on pulmonary vascular permeability to protein. Journal of Applied Physiology, 76, 2342-47.
158. Tancredi, R.G. and Yipintsoi, T. (1980) Interrelationships of flow, intravascular pressure, and tissue perfusion in the measurement of capillary permeability to sodium in isolated dog lung lobes. Circulation Research, 46, 669-80.
159. Verghese, G.M., Ware, L.B., Matthay, B.A., and Matthay, M.A. (1999) Alveolar epithelial fluid transport and the resolution of clinically severe hydrostatic pulmonary edema. Journal of Applied Physiology, 87, 1301-12.
160. Kramer, K., Kirkman, P., Kitzman, D., and Little, W.C. (2000) Flash pulmonary edema: association with hypertension and reoccurrence despite coronary revascularization. American Heart Journal, 140, 451-55.
161. Light, R.W. and George, R.B. (1983) Serial pulmonary function in patients with acute heart failure. Archives of Internal Medicine, 143, 429-33.
162. Kubo, K., Hanaoka, M., Yamaguchi, S. et al. (1996) Cytokines in bronchoalveolar lavage fluid in patients with high altitude pulmonary oedema at moderate altitude in Japan. Thorax, 51, 739-42.
163. Schoene, R.B., Swenson, E.R., Pizzo, C.J. et al. (1988) The lung at high altitude: bronchoalveo-lar lavage in acute mountain sickness and pulmonary edema. Journal ofApplied Physiology 64, 2605-13.
164. Hultgren, H.N., Lopez, C.E., Lundberg, E., and Miller, H. (1964) Physiologic studies of pulmonary edema at high altitude. Circulation, 29, 393-408.
165. Hultgren, H.N., Grover, R.F., and Hartley, L.H. (1971) Abnormal circulatory responses to high altitude in subjects with a previous history of high-altitude pulmonary edema. Circulation, 44, 759-70.
166. Charu, R., Stobdan, T., Ram, R.B. et al. (2006) Susceptibility to high altitude pulmonary oedema: role of ACE and ET-1 polymorphisms. Thorax, 61, 1011-12.
167. Droma, Y., Hanaoka, M., Ota, M. et al. (2002) Positive association of the endothelial nitric oxide synthase gene polymorphisms with high-altitude pulmonary edema. Circulation, 106, 826-30.
168. West, J.B., Colice, G.L., Lee, Y.J. et al. (1995) Pathogenesis of high-altitude pulmonary oedema: direct evidence of stress failure of pulmonary capillaries. The European Respiratory Journal, 8, 523-29.
169. Gao, Y. and Raj, J.U. (2005) Role of veins in regulation of pulmonary circulation. American Journal ofPhysiology: Lung Cellular and Molecular Physiology, 288, L213-26.
170. Hillier, S.C., Graham, J.A., Hanger, C.C. et al. (1997) Hypoxic vasoconstriction in pulmonary arterioles and venules. Journal of Applied Physiology, 82, 1084-90.
171. Horsfield, K. (1978) Morphometry of the small pulmonary arteries in man. Circulation Research, 42, 593-97.
172. Bhattacharya, S., Glucksberg, M.R., and Bhat-tacharya, J. (1989) Measurement of lung microvas-cular pressure in the intact anesthetized rabbit by the micropuncture technique. Circulation Research, 64, 167-72.
173. Goetz, A.E., Kuebler, W.M., and Peter, K. (1996) High-altitude pulmonary edema. The New England Journal of Medicine, 335, 206-7.
174. Hultgren, H.N. and Hegnauer, A.H. (eds) (1969) High altitude pulmonary edema, in Biomedicine Problems of High Terrestrial Altitude, (ed. A.H. Hegnauer), Springer, New York, pp. 131-41.
175. Hlastala, M.P., Lamm, W.J., Karp, A. et al. (2004) Spatial distribution of hypoxic pulmonary vasoconstriction in the supine pig. Journal of Applied Physiology, 96, 1589-99.
176. Lamm, W.J., Starr, I.R., Neradilek, B. et al. (2004) Hypoxic pulmonary vasoconstriction is heterogeneously distributed in the prone dog. Respiratory Physiology and Neurobiology, 144, 281-94.
177. Hopkins, S.R., Garg, J., Bolar, D.S. et al. (2005) Pulmonary blood flow heterogeneity during hypoxia and high-altitude pulmonary edema. American Journal of Respiratory and Critical Care Medicine, 171, 83-87.
178. Bartsch, P., Mairbaurl, H., Maggiorini, M., and Swenson, E.R. (2005) Physiological aspects of high-altitude pulmonary edema. Journal of Applied Physiology, 98, 1101-10.
179. Maggiorini, M. (2006) High altitude-induced pulmonary oedema. Cardiovascular Research, 72, 41-50.
180. Younes, M., Bshouty, Z., and Ali, J. (1987) Longitudinal distribution of pulmonary vascular resistance with very high pulmonary blood flow. Journal of Applied Physiology, 62, 344-58.
181. c i{ogonek} in lung and skeletal muscle. Journal of Applied Physiology, 61, 127-32.
182. Nelin, L.D., Roerig, D.L., Rickaby, D.A. et al. (1992) Influence of flow on pulmonary vascular surface area inferred from blue dextran efflux data. Journal of Applied Physiology, 72, 874-80.
183. Maron, M.B. (1985) A canine model of neurogenic pulmonary edema. Journal of Applied Physiology, 59, 1019-25.
184. Wray, N.P. and Nicotra, M.B. (1978) Pathogenesis of neurogenic pulmonary edema. The American Review of Respiratory Disease, 118, 783-86.
185. Baumann, A., Audibert, G., McDonnell, J., and Mertes, P.M. (2007) Neurogenic pulmonary edema. Acta Anaesthesiologica Scandinavica, 51, 447-55.
186. Kowalski, M.L., Didier, A., and Kaliner, M.A. (1989) Neurogenic inflammation in the airways. I. Neurogenic stimulation induces plasma protein extravasation into the rat airway lumen. The American Review of Respiratory Disease, 140, 101-9.
187. Minnear, F.L., Kite, C., Hill, L.A., and van der Zee, H. (1987) Endothelial injury and pulmonary congestion characterize neurogenic pulmonary edema in rabbits. Journal of Applied Physiology, 63, 335-41.
188. Fein, A., Grossman, R.F., Jones, J.G. et al. (1979) The value of edema fluid protein measurement in patients with pulmonary edema. American Journal of Medicine, 67, 32-8.
189. Sprung, C.L., Rackow, E.C., Fein, I.A. et al. (1981) The spectrum of pulmonary edema: differentiation of cardiogenic, intermediate, and noncar-diogenic forms of pulmonary edema. The American Review ofRespiratory Disease, 124, 718-22.
190. Hirabayashi, A., Nishiwaki, K., Shimada, Y., and Ishikawa, N. (1996) Role of neuropeptide Y and its receptor subtypes in neurogenic pulmonary edema. European Journal of Pharmacology, 296, 297-305.
191. Novitzky, D., Wicomb, W.N., Rose, A.G. et al. (1987) Pathophysiology of pulmonary edema following experimental brain death in the chacma baboon. The Annals of Thoracic Surgery, 43, 288-94.
192. Carlson, R.W., Schaeffer, R.C. Jr., Michaels, S.G., and Weil, M.H. (1979) Pulmonary edema following intracranial hemorrhage. Chest, 75, 731-34.
193. Smith, W.S. and Matthay, M.A. (1997) Evidence for a hydrostatic mechanism in human neurogenic pulmonary edema. Chest, 111, 1326-33.
194. Dreyfuss, D. and Saumon, G. (1998) Ventilator-induced lung injury: lessons from experimental studies. American Journal of Respiratory and Critical Care Medicine, 157, 294-323.
195. Uhlig, S. and Uhlig, U. (2004) Pharmacological interventions in ventilator-induced lung injury. Trends in Pharmacological Sciences, 25, 592-600.
196. Parker, J.C., Ivey, C.L., and Tucker, J.A. (1998) Gadolinium prevents high airway pressure-induced permeability increases in isolated rat lungs. Journal of Applied Physiology, 84, 1113-18.
197. Parker, J.C. and Yoshikawa, S. (2002) Vascular segmental permeabilities at high peak inflation pressure in isolated rat lungs. American Journal of Physiology: Lung Cellular and Molecular Physiology, 283, L1203-9.
198. Hamanaka, K., Jian, M.Y., Weber, D.S. et al. (2007) TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. American Journal of Physiology: Lung Cellular and Molecular Physiology, 293, L923-32.
199. Frank, J.A., Pittet, J.F., Lee, H. et al. (2003) High tidal volume ventilation induces NOS2 and impairs cAMP-dependent air space fluid clearance. American Journal of Physiology: Lung Cellular and Molecular Physiology, 284, L791-98.
200. Bhattacharya, S., Sen, N., Yiming, M.T. et al. (2003) High tidal volume ventilation induces proinflammatory signaling in rat lung endothelium. American Journal of Respiratory Cell and Molecular Biology, 28, 218-24.
201. Yiming, M.T., Parthasarathi, K., Issekutz, A.C., and Bhattacharya, S. (2005) Sequence of endothelial signaling during lung expansion. American Journal of Respiratory Cell and Molecular Biology, 33, 549-54.