Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure

Anesthesiology

Volumn 106, Issue 1, 2007, Pages 124-131

  Hentschel, Thomas ^a   Yin, Ning ^c   Riad, Alexander ^d   Habbazettl, Helmut ^a,b   Weimann, Jörg ^b   Koster, Andreas ^a   Tschope, Carsten ^d   Kuppe, Hermann ^a   Kuebler, Wolfgang M ^b,c  

^a DEUTSCHES HERZZENTRUM BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c Institute of Physiological Chemistry   (Germany)

^d Department of Cardiology and Pneumatology ^*

Author keywords

[No Author keywords available]

Indexed keywords

COROTROP; MILRINONE; PHOSPHODIESTERASE III INHIBITOR; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY ARTERY; HEMODYNAMICS; INHALATION ANESTHESIA; LUNG ARTERY PRESSURE; LUNG BLOOD VESSEL; LUNG EDEMA; LUNG FLUID; MALE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RAT; REPEATED DRUG DOSE; VASCULAR RESISTANCE; VASODILATATION; WATER CONTENT;

ADMINISTRATION, INHALATION; ANIMALS; CYCLIC AMP; CYCLIC GMP; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROCARDIOGRAPHY; HEART FAILURE, CONGESTIVE; HYPERTENSION, PULMONARY; MALE; MILRINONE; PHOSPHODIESTERASE INHIBITORS; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33845926227     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/00000542-200701000-00021     Document Type: Article

References (34)

1. Cody RJ, Haas GJ, Binkley PF, Capers Q, Kelley R: Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation 1992; 85:504-9
2. Christman BW, McPherson CD, Newman JH, King GA, Bernard GR, Groves BM, Loyd JE: An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 1992; 327:70-5
3. Moraes DL, Colucci WS, Givertz MM: Secondary pulmonary hypertension in chronic heart failure: The role of the endothelium in pathophysiology and management. Circulation 2000; 102:1718-23
4. Delgado JF, Conde E, Sanchez V, Lopez-Rios F, Gomez-Sanchez MA, Escribano P, Sotelo T, Gomez de la Camara A, Cortina J, de la Calzada CS: Pulmonary vascular remodelling in pulmonary hypertension due to chronic heart failure. Eur Heart J 2005; 7:1011-6
5. Abramson SV, Burke JF, Kelly JJ, Kitchen JG III, Dougherty MJ, Yih DF, McGeehin FC III, Shuck JW, Phiambolis TP: Pulmonary hypertension predicts mortality and morbidity in patients with dilated cardiomyopathy. Ann Intern Med 1992; 116:888-95
6. Polak JF, Holman BL, Wynne J, Colucci WS: Right ventricular ejection fraction: An indicator of increased mortality in patients with congestive heart failure associated with coronary artery disease. J Am Coll Cardiol 1983; 2:217-24
7. Di Salvo TG, Mathier M, Semigran MJ, Dec GW: Preserved right ventricular ejection fraction predicts exercise capacity and survival in advanced heart failure. J Am Coll Cardiol 1995; 25:1143-53
8. Packer M, Carver JR, Rodeheffer RJ, Ivanhoe RJ, DiBianco R, Zeldis SM, Hendrix GH, Bommer WJ, Elkayam U, Kukin ML, Mallis GI, Sollano JA, Shannon J, Tandon PK, DeMets DL: Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med 1991; 325:1468-75
9. Califf RM, Adams KF, McKenna WJ, Gheorghiade M, Uretsky BF, McNulty SE, Darius H, Schulman K, Zannad F, Handberg-Thurmond E, Harrell FE Jr, Wheeler W, Soler-Soler J, Swedberg K. A randomized controlled trial of epoprostenol therapy for severe congestive heart failure: The Flolan International Randomized Survival Trial (FIRST). Am Heart J 1997; 134:44-54
10. Haraldsson A, Niels Kieler-Jensen, Ricksten S: The additive pulmonary vasodilatory effects of inhaled prostacyclin and inhaled milrinone in postcardiac surgical patients with pulmonary hypertension. Anesth Analg 2001; 93:1439-45
11. Olschewski H, Olschewski A, Rose F, Schermuly R, Schütte H, Weissmann N, Seeger W, Grimminger F: Physiologic basis for the treatment of pulmonary hypertension. J Lab Clin Med 2001; 138:287-97
12. Natori S, Hasebe N, Jin YT, Matsusaka T, Ido A, Matsuhashi H, Ihara T, Kikuchi K: Inhaled nitric oxide modifies left ventricular diastolic stress in the presence of vasoactive agents in heart failure. Am J Respir Crit Care Med 2003; 167:895-901
13. Institute of Laboratory Animal Resources, Commission on Life Sciences: Guide for the Care and Use of Laboratory Animals, 7th edition. Washington, DC, National Academy Press, 1996
14. Backs J, Haunstetter A, Gerber SH, Metz J, Borst MM, Strasser R, Kübler W, Haass M: The neuronal norepinephrine transporter in experimental heart failure: Evidence for a posttranscriptional downregulation. J Mol Cell Cardiol 2001; 33:461-72
15. Habazettl H, Lindert J, Baeter S, Neumann K, Kuppe H, Kuebler WM, Pries AR, Koster A: Effects of unfractionated heparin, low molecular weight heparin and r-hirudin on leukocyte adhesion in ischemia/reperfusion. Blood Coagul Fibrinolysis 2004; 15:375-81
16. Lahana A, Costantopoulos S, Nakos G: The local component of the acute cardiovascular response to simulated apneas in brain-dead humans. Chest 2005; 128:634-9
17. Brueckl C, Kaestle S, Kerem A, Habazettl H, Krombach F, Kuppe H, Kuebler WM: Hyperoxia-induced reactive oxygen species formation in pulmonary capillary endothelial cells in situ. Am J Respir Cell Mol Biol 2005; 34:453-63
18. Walther T, Steendijk P, Westermann D, Hohmann C, Schulze K, Heringer-Walther S, Schultheiss HP, Tschope C: Angiotensin deficiency in mice leads to dilated cardiomyopathy. Eur J Pharmacol 2004; 493:161-5
19. Peterson BT, Brooks JA, Zack AG: Use of microwave oven for determination of postmortem water volume of lung. J Appl Physiol 1982; 52:1661-3
20. Tanaka H, Tajimi K, Kobayashi K: Milrinone improves arterial oxygenation in dogs with acute lung injury induced by oleic acid. J Cardiovasc Pharmacol 1999; 34:806-10
21. Kuebler WM, Uhlig U, Goldmann T, Schael G, Kerem A, Exner K, Martin C, Vollmer E, Uhlig S: Stretch activates nitric oxide production in pulmonary vascular endothelial cells in situ. Am J Respir Crit Care Med 2003; 168:1391-8
22. He GW, Yang CQ: Inhibition of vasoconstriction by phosphodiesterase III inhibitor milrinone in human conduit arteries used as coronary bypass grafts. J Cardiovasc Pharmacol 1996; 28:208-14
23. Jaski BE, Fifer MA, Wright RF, Braunwald E, Colucci WS: Positive inotropic and vasodilator actions of milrinone in patients with severe congestive heart failure: Dose-response relationships and comparison to nitroprusside. J Clin Invest 1985; 75:643-9
24. Levy JH, Bailey JM, Deeb GM: Intravenous milrinone in cardiac surgery. Ann Thorac Surg 2002; 73:325-30
25. Tanigawa T, Yano M, Kohno M, Yamamoto T, Hisaoka T, Ono K, Ueyama T, Kobayashi S, Hisamatsu Y, Ohkusa T, Matsuzaki M: Mechanism of preserved lusitropy by cAMP-dependent drugs in heart failure. Am J Physiol Heart Circ Physiol 2000; 278:H313-20
26. Packer M, Lee WH, Medina N, Yushak M, Bernstein JL, Kessler PD: Prognostic importance of the immediate hemodynamic response to nifedipine in patients with severe left ventricular dysfunction. J Am Coll Cardiol 1987; 10:1303-11
27. Van Veldhuisn DJ, Poole-Wilson PA: The underreporting of results and possible mechanisms of "negative" drug trials in patients with chronic heart failure. Int J Cardiol 2001; 80:19-27
28. Langer F, Wendler O, Wilhelm W, Tscholl D, Schafers HJ: Treatment of a case of acute right heart failure by inhalation of iloprost, a long-acting prostacyclin analogue. Eur J Anaesthesiol 2001; 18:770-3
29. Sablotzki A, Starzmann W, Scheubel R, Grond S, Czeslick EG: Selective pulmonary vasodilation with inhaled aerosolized milrinone in heart transplant candidates. Can J Anaesth 2005; 52:1076-82
30. Schamarin PI: About the Kitajew reflex: Mechanism of mitral valve vitium compensation. Terapiszeskij Archiv 1952; 24:79-85
31. Moore TM, Chetham PM, Kelly JJ, Stevens T: Signal transduction and regulation of lung endothelial permeability: Interaction between calcium and cAMP. Am J Physiol 1998; 275:L574-82
32. Tarpey SB, Sawmiller DR, Kelly C, Thompson WJ, Townsley MI: Phosphodiesterase 3 activity is reduced in dog lung following pacing-induced heart failure. Am J Physiol Lung Cell Mol Physiol 2003; 284:L766-73
33. Bocchi EA, Bacal F, Auler JO, Carmone MJ, Bellotti G, Pileggi F: Inhaled nitric oxide leading to pulmonary edema in stable severe heart failure. Am J Cardiol 1994; 74:70-2
34. Loh E, Stamler JS, Hare JM, Loscalzo J, Colucci WS: Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation 1994; 90:2780-5