Intravital microscopy of the murine pulmonary microcirculation

Journal of Applied Physiology

Volumn 104, Issue 2, 2008, Pages 338-346

  Tabuchi, Arata ^a   Mertens, Michael ^a   Kuppe, Hermann ^b   Pries, Axel R ^a   Kuebler, Wolfgang M ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b DEUTSCHES HERZZENTRUM BERLIN   (Germany)

Author keywords

Hypoxic pulmonary vasoconstriction; Thromboxane analog U 46619

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CYANOACRYLATE DERIVATIVE; FLUORESCEIN ISOTHIOCYANATE DEXTRAN; POLYVINYLIDENE FLUORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN TENSION; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; GOLD STANDARD; HYPOXIC LUNG VASOCONSTRICTION; INTRAVITAL MICROSCOPY; LUNG ALVEOLUS; LUNG BLOOD VESSEL; LUNG CAPILLARY; LUNG CIRCULATION; MALE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; MICROSCOPY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; VENULE;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; ANOXIA; ARTERIOLES; BLOOD PRESSURE; CAPILLARIES; DEXTRANS; EXHALATION; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; LUNG; MALE; MICE; MICE, INBRED BALB C; MICROSCOPY, VIDEO; MODELS, ANIMAL; PULMONARY CIRCULATION; TIME FACTORS; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VENULES;

EID: 38949096417     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00348.2007     Document Type: Article

References (44)

1. Corno AF, Boone Y, Mallabiabarrena I, Augstburger M, Tozzi P, Ferrari E, von Segesser LK. Myocardial and pulmonary effects of aqueous oxygen with acute hypoxia. Ann Thorac Surg 78: 956-960, 2004.
2. Davies P, Burke G, Reid L. The structure of the wall of the rat intraacinar pulmonary artery: an electron microscopic study of microdissected preparations. Microvasc Res 32: 50-63, 1986.
3. Dawson CA. Role of pulmonary vasomotion in physiology of the lung. Physiol Rev 64: 544-616, 1984.
4. Enhorning G, van SS, Lundgren C, Vargas I. Whole-body plethysmography, does it measure tidal volume of small animals? Can J Physiol Pharmacol 76: 945-951, 1998.
5. Erhardt W, Hebestedt A, Aschenbrenner G, Pichotka B, Blumel G. A comparative study with various anesthetics in mice (pentobarbitone, ketamine-xylazine, carfentanyl-etomidate). Res Exp Med (Berl) 184: 159-169, 1984.
6. Gao Y, Raj JU. Role of veins in regulation of pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 288: L213-L226, 2005.
7. Groh J, Kuhnle GE, Ney L, Sckell A, Goetz AE. Effects of isoflurane on regional pulmonary blood flow during one-lung ventilation. Br J Anaesth 74: 209-216, 1995.
8. Hakim TS. Is flow in subpleural region typical of the rest of the lung? A study using laser-Doppler flowmetry. J Appl Physiol 72: 1860-1867, 1992.
9. Hentschel T, Yin N, Riad A, Habbazettl H, Weimann J, Koster A, Tschope C, Kuppe H, Kuebler WM. Inhalation of the phosphodiesterase-3 inhibitor milrinone attenuates pulmonary hypertension in a rat model of congestive heart failure. Anesthesiology 106: 124-131, 2007.
10. Hillier SC, Godbey PS, Hanger CC, Graham JA, Presson RG Jr, Okada O, Linehan JH, Dawson CA, Wagner WW Jr. Direct measurement of pulmonary microvascular distensibility. J Appl Physiol 75: 2106-2111, 1993.
11. Hillier SC, Graham JA, Hanger CC, Godbey PS, Glenny RW, Wagner WW Jr. Hypoxic vasoconstriction in pulmonary arterioles and venules. J Appl Physiol 82: 1084-1090, 1997.
12. Hislop A, Reid L. Normal structure and dimensions of the pulmonary arteries in the rat. J Anat 125: 71-83, 1978.
13. Hunter CJ, Dejam A, Blood AB, Shields H, Kim-Shapiro DB, Machado RF, Tarekegn S, Mulla N, Hopper AO, Schechter AN, Power GG, Gladwin MT. Inhaled nebulized nitrite is a hypoxia-sensitive NO-dependent selective pulmonary vasodilator. Nat Med 10: 1122-1127, 2004.
14. Kataoka H, Kim SW, Plesnila N. Leukocyte-endothelium interactions during permanent focal cerebral ischemia in mice. J Cereb Blood Flow Metab 24: 668-676, 2004.
15. Kay JM. Comparative morphologic features of the pulmonary vasculature in mammals. Am Rev Respir Dis 128: S53-S57, 1983.
16. Khandoga A, Kessler JS, Meissner H, Hanschen M, Corada M, Motoike T, Enders G, Dejana E, Krombach F. Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration. Blood 106: 725-733, 2005.
17. Kramer K, Voss HP, Grimbergen JA, Mills PA, Huetteman D, Zwiers L, Brockway B. Telemetric monitoring of blood pressure in freely moving mice: a preliminary study. Lab Anim 34: 272-280, 2000.
18. Kuebler WM, Parthasarathi K, Lindert J, Bhattacharya J. Real-time lung microscopy. J Appl Physiol 102: 1255-1264, 2007.
19. Kuhnle GEH, Leipfinger FH, Goetz AE. Measurement of microhemodynamics in the ventilated rabbit lung by intravital fluorescence microscopy. J Appl Physiol 74: 1462-1471, 1993.
20. Lindert J, Perlman CE, Parthasarathi K, Bhattacharya J. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy. Am J Respir Cell Mol Biol 36: 688-696, 2007.
21. McCormack DG, Mehta S, Tyml K, Scott JA, Potter R, Rohan M. Pulmonary microvascular changes during sepsis: evaluation using intravital videomicroscopy. Microvasc Res 60: 131-140, 2000.
22. Mempel TR, Moser C, Hutter J, Kuebler WM, Krombach F. Visualization of leukocyte transendothelial and interstitial migration using reflected light oblique transillumination in intravital video microscopy. J Vasc Res 40: 435-441, 2003.
23. Michel RP. Arteries and veins of the normal dog lung: qualitative and quantitative structural differences. Am J Anat 164: 227-241, 1982.
24. Molthen RC, Karau KL, Dawson CA. Quantitative models of the rat pulmonary arterial tree morphometry applied to hypoxia-induced arterial remodeling. J Appl Physiol 97: 2372-2384, 2004.
25. Moudgil R, Michelakis ED, Archer SL. Hypoxic pulmonary vasoconstriction. J Appl Physiol 98: 390-403, 2005.
26. Nagasaka Y, Bhattacharya J, Nanjo S, Gropper MA, Staub NC. Micropuncture measurement of lung microvascular profile during hypoxia in rats. Circ Res 54: 90-95, 1984.
27. Ogasawara H, Koizumi T, Yamamoto H, Kubo K. Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep. J Cardiovasc Pharmacol 42: 521-526, 2003.
28. Paddenberg R, Konig P, Faulhammer P, Goldenberg A, Pfeil U, Kummer W. Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices. Respir Res 7: 93, 2006.
29. Presson RG Jr, Fisher A, Glenny RW, Lamm WJE. Pulmonary microvascular reserve in the intact rat (Abstract). Proc Am Thorac Soc 3: A682, 2006.
30. Pries AR. A versatile video image analysis system for microcirculatory research. Int J Microcirc Clin Exp 7: 327-345, 1988.
31. Razavi HM, Wang LF, Weicker S, Rohan M, Law C, McCormack DG, Mehta S. Pulmonary neutrophil infiltration in murine sepsis: role of inducible nitric oxide synthase. Am J Respir Crit Care Med 170: 227-233, 2004.
32. Schraufnagel DE, Mehta D, Harshbarger R, Treviranus K, Wang NS. Capillary remodeling in bleomycin-induced pulmonary fibrosis. Am J Pathol 125: 97-106, 1986.
33. Schwarte LA, Zuurbier CJ, Ince C. Mechanical ventilation of mice. Basic Res Cardiol 95: 510-520, 2000.
34. Sckell A, Kuebler WM, Kiefmann R, Borges J, Goetz AE. Effects of insufflated nitric oxide on pulmonary microcirculation during alveolar hypoxia (Abstract). Int J Microcirc Clin Exp 16, Suppl 1: 260, 1996.
35. Short AC, Montoya ML, Gebb SA, Presson RG Jr, Wagner WW Jr, Capen RL. Pulmonary capillary diameters and recruitment characteristics in subpleural and interior networks. J Appl Physiol 80: 1568-1573, 1996.
36. Spohr F, Cornelissen AJ, Busch C, Gebhard MM, Motsch J, Martin EO, Weimann J. Role of endogenous nitric oxide in endotoxin-induced alteration of hypoxic pulmonary vasoconstriction in mice. Am J Physiol Heart Circ Physiol 289: H823-H831, 2005.
37. Wagner WW Jr. Pulmonary microcirculatory observations in vivo under physiological conditions. J Appl Physiol 26: 375-377, 1969.
38. Walker DC, Behzad AR, Chu F. Neutrophil migration through preexisting holes in the basal laminae of alveolar capillaries and epithelium during streptococcal pneumonia. Microvasc Res 50: 397-416, 1995.
39. Waypa GB, Schumacker PT. Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing. J Appl Physiol 98: 404-414, 2005.
40. Weissmann N, Dietrich A, Fuchs B, Kalwa H, Ay M, Dumitrascu R, Olschewski A, Storch U, Mederos y Schnitzler M, Ghofrani HA, Schermuly RT, Pinkenburg O, Seeger W, Grimminger F, Gudermann T. Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange. Proc Natl Acad Sci USA 103: 19093-19098, 2006.
41. Weissmann N, Zeller S, Schafer RU, Turowski C, Ay M, Quanz K, Ghofrani HA, Schermuly RT, Fink L, Seeger W, Grimminger F. Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction. Am J Respir Cell Mol Biol 34: 505-513, 2006.
42. Yamaguchi K, Suzuki K, Naoki K, Nishio K, Sato N, Takeshita K, Kudo H, Aoki T, Suzuki Y, Miyata A, Tsumura H. Response of intra-acinar pulmonary microvessels to hypoxia, hypercapnic acidosis, and isocapnic acidosis. Circ Res 82: 722-728, 1998.
43. 2+ waves in lung capillary endothelium. Circ Res 79: 898-908, 1996.
44. Zuurbier CJ, Emons VM, Ince C. Hemodynamics of anesthetized ventilated mouse models: aspects of anesthetics, fluid support, and strain. Am J Physiol Heart Circ Physiol 282: H2099-H2105, 2002.