Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy

Journal of Biological Chemistry

Volumn 285, Issue 22, 2010, Pages 16864-16873

  Gupta, Vibhor ^a   Kalaiarasan, Ponnusamy ^a   Faheem, Mohammad ^a   Singh, Nishant ^a   Iqbal, Mohammad Askandar ^a   Bamezai, Rameshwar N K ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOM SYNDROME; CELLULAR BEHAVIORS; CELLULAR GROWTH; CELLULAR MILIEUS; CO-EXPRESSION; DOMINANT NEGATIVE; HETERO-OLIGOMERIZATION; IN-SILICO; IN-VITRO; MAMMALIAN CELLS; MULTIFUNCTIONAL PROTEIN; OLIGOMERIC STATE; PYRUVATE KINASE; THERAPEUTIC INTERVENTION; TUMOR PROGRESSIONS; WILD TYPES;

ESCHERICHIA COLI; MAMMALS; MONOMERS; TUMORS;

OLIGOMERIZATION;

ARGININE; HISTIDINE; LYSINE; PHOSPHOTRANSFERASE; PYRUVATE KINASE M2; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BACTERIAL GROWTH; BINDING AFFINITY; CELL GROWTH; COMPUTER MODEL; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; ESCHERICHIA COLI; GENE MUTATION; HETEROZYGOSITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR INTERACTION; MUTANT; NONHUMAN; OLIGOMERIZATION; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH; WILD TYPE;

ANIMALS; CELL PROLIFERATION; DISEASE PROGRESSION; ESCHERICHIA COLI; FLOW CYTOMETRY; GENES, DOMINANT; GLUTATHIONE TRANSFERASE; HELA CELLS; HUMANS; ISOENZYMES; KINETICS; MUTATION; POLYPLOIDY; PYRUVATE KINASE; TWO-HYBRID SYSTEM TECHNIQUES;

ESCHERICHIA COLI; MAMMALIA;

EID: 77952776777     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.065029     Document Type: Article

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