Modulation of M2-type pyruvate kinase activity by the cytoplasmic PML tumor suppressor protein

Genes to Cells

Volumn 13, Issue 3, 2008, Pages 245-254

  Shimada, Nobukazu ^a   Shinagawa, Toshie ^a   Ishii, Shunsuke ^a  

^a RIKEN TSUKUBA INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LACTIC ACID; PHOSPHOENOLPYRUVATE; PROMYELOCYTIC LEUKEMIA PROTEIN; PYRUVATE KINASE; PYRUVATE KINASE M2; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER INHIBITION; CONTROLLED STUDY; ENERGY YIELD; ENZYME ACTIVITY; GENE OVEREXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

ANIMALS; CELL LINE, TUMOR; CYTOPLASM; ENERGY METABOLISM; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; MICE; MICE, SCID; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR PROTEINS; PYRUVATE KINASE; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 39749116297     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2008.01165.x     Document Type: Article

References (53)

1. Bergmeyer, H.U. (ed.) (1985) Methods of Enzymatic Analysis, 3rd edn, Vol. 7. Weinheim: Verlag-Chemie.
2. Bernardi, R., Guernah, I., Jin, D., Grisendi, S., Alimonti, A., Teruya-Feldstein, J., Cordon-Cardo, C., Simon, M.C., Rafii, S. & Pandolfi, P.P. (2006) PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR. Nature 442, 779-785.
3. Bischof, O., Kirsh, O., Pearson, M., Itahana, K., Pelicci, P.G. & Dejean, A. (2002) Deconstructing PML-induced premature senescence. EMBO J. 21, 3358-3369.
4. Boros, L.G., Puigjaner, J., Cascante, M., Lee, W.-N., Brandes, J.L., Bassilian, S., Yusuf, F.I., William, R.D., Muscarella, P., Melvin, W.S. & Schirmer. W.J. (1997) Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res. 57, 4242-4248.
5. Boros, L.G., Torday, J.S., Lim, S., Bassilian, S., Cascante, M. & Lee, W.-N.P. (2000) Transforming growth factor β2 promotes glucose carbon incorporation into nucleic acid ribose through the nonoxidative pentose cycle in lung epithelial carcinoma cells. Cancer Res. 60, 1183-1185.
6. Cascante, M., Centelles, J.J., Veech, R.L., Lee, W.-N.P. & Boros, L.G. (2000) Role of thiamin (vitamin B-1) and transketolase in tumor cell proliferation. Nutr. Cancer 36, 150-154.
7. Chen, C., Pore, N., Behrooz, A., Ismail-Beigi, F. & Maity, A. (2001) Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia. J. Biol. Chem. 276, 9519-9525.
8. Dabrowska, A., Pietkiewicz, J., Dabrowska, K., Czapinska, E. & Danielewicz, R. (1998) Interaction of M1 and M2 isozymes pyruvate kinase from human tissues with phospholipids. Biochim. Biophys. Acta 1383, 123-129.
9. de The, H., Lavau, C., Marchio, A., Chomienne, C., Degos, L. & Dejean, A. (1991) The PML-RARa fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell 66, 675-684.
10. Duprez, E., Saurin, A.J., Desterro, J.M., Lallemand-Breitenbach, V., Howe, K., Boddy, M.N., Solomon, E., de The, H., Hay, R.T. & Freemont, P.S. (1999) SUMO-1 modification of the acute promyelocytic leukaemia protein PML: Implications for nuclear localisation. J. Cell Sci. 112, 381-393.
11. Dyck, J.A., Maul, G.G., Miller, W.H. Jr, Chen, J.D., Kakizuka, A. & Evans, R.M. (1994) A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell 76, 333-343.
12. Eigenbrodt, E., Reinacher, M., Scheefers-Borchel, U., Scheefers, H. & Friis, R. (1992) Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit. Rev. Oncol. 3, 91-115.
13. Ferbeyre, G., de Stanchina, E., Querido, E., Baptiste, N., Prives, C. & Lowe, S.W. (2000) PML is induced by oncogenic ras and promotes premature senescence. Genes Dev. 14, 2015-2027.
14. Garcia-Gonzalo, F.R., Cruz, C., Munoz, P., Mazurek, S., Eigenbrodt, E., Ventura, F., Bartrons, R. & Rosa, J.L. (2003) Interaction between HERC1 and M2-type pyruvate kinase. FEBS Lett. 539, 78-84.
15. García-Mata, R., Bebök, Z., Sorscher, E.J. & Sztul, E.S. (1999) Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera. J. Cell Biol. 146, 1239-1254.
16. Gatenby, R.A. & Gillies, R.J. (2004) Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4, 891-899.
17. Glossmann, H., Presek, P. & Eigenbrodt, E. (1981) Association of the src-gene product of Rous sarcoma virus with a pyruvate-kinase inactivation factor. Mol. Cell. Endocrinol. 23, 49-63.
18. Hatzivassiliou, G., Zhao, F., Bauer, D.E., Andreadis, C., Shaw, A.N., Dhanak, D., Hingorani, S.R., Tuveson, D.A. & Thompson, C.B. (2005) ATP citrate lyase inhibition can suppress tumor cell growth. Cancer Cell 8, 311-321.
19. Henderson, B.R. & Eleftheriou, A. (2000) A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals. Exp. Cell Res. 256, 213-224.
20. Ibsen, K. & Trippet, P. (1974) Effects of amino acids on the kinetic properties of three noninterconvertible rat pyruvate kinases. Arch. Biochem. Biophys. 163, 70-580.
21. Jensen, K., Shiels, C. & Freemont, P.S. (2001) PML protein isoforms and the RBCC/TRIM motif. Oncogene 20, 7223-7233.
22. Jiang, B.H., Agani, F., Passaniti, A. & Semenza, G.L. (1997). V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression. Cancer Res. 57, 5328-5335.
23. Kakizuka, A., Miller, W.H. Jr, Umesono, K., Warrell, R.P. Jr, Frankel, S.R., Murty, V.V., Dmitrovsky, E. & Evans, R.M. (1991) Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR a with a novel putative transcription factor, PML. Cell 66, 663-674.
24. Karpanen, T., Egeblad, M., Karkkainen, M.J., Kubo, H., Yla-Herttuala, S., Jaattela, M. & Alitalo, K. (2001) Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. Cancer Res. 61, 1786-1790.
25. Kentsis, A., Dwyer, E.C., Perez, J.M., Sharma, M., Chen, A., Pan, Z.Q. & Borden, K.L. (2001) The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. J. Mol. Biol. 312, 609-623.
26. Khan, M.M., Nomura, T., Kim, H., Kaul, S.C., Wadhwa, R., Shinagawa, T., Ichikawa-Iwata, E., Zhong, S., Pandolfi, P.P. & Ishii, S. (2001a) Role of PML and PML-RARa in Mad-mediated transcriptional repression. Mol. Cell 7, 1233-1243.
27. Khan, M.M., Nomura, T., Kim, H., Kaul, S.C., Wadhwa, R., Zhong, S., Pandolfi, P.P. & Ishii, S. (2001b) PML-RARa alleviates the transcriptinal repression mediated by tumor suppressor Rb. J. Biol. Chem. 276, 43491-43494.
28. Kim, C.Y., Tsai, M.H., Osmanian, C., Graeber, T.G., Lee, J.E., Giffard, R.G., DiPaolo, J.A., Peehl, D.M. & Giaccia, A.J. (1997) Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res. 57, 4200-4204.
29. Kim, J.W. & Dang, C.V. (2006) Cancer's molecular sweet tooth and the Warburg effect. Cancer Res. 66, 8927-8930.
30. Kim, J.W., Zeller, K.I., Wang, Y., Jegga, A.G., Aronow, B.J., O'Donnell. K.A. & Dang, C.V. (2004) Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays. Mol. Cell. Biol. 24, 5923-5936.
31. Lin, H.K., Bergmann, S. & Pandolfi, P.P. (2004) Cytoplasmic PML function in TGF-β signalling. Nature 431, 205-211.
32. Mazurek, S., Zwerschke, W., Jansen-Dürr, P. & Eigenbrodt, E. (2001) Effects of the human papilloma virus HPV-16 E7 oncoprotein on glycolysis and glutaminolysis: Role of pyruvate kinase type M2 and the glycolytic-enzyme complex. Biochem. J. 356, 247-256.
33. Mu, Z.M., Chin, K.V., Liu, J.H., Lozano, G. & Chang, K.S. (1994) PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol. Cell. Biol. 14, 6858-6867.
34. Nakatani, Y. & Ogryzko, V. (2003) Immunoaffinity purification of mammalian protein complexes. Methods Enzymol. 370, 430-444.
35. Nomura, T., Khan, M.M., Kaul, S.C., Dong, H.D., Wadhwa, R., Colmanares, C., Kohno, I. & Ishii, S. (1999) Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes Dev. 13, 412-423.
36. Nowak, T. & Suelter, C. (1981) Pyruvate kinase: Activation by and catalytic role of the monovalent and divalent cations. Mol. Cell. Biochem. 35, 65-75.
37. Pearson, M., Carbone, R., Sebastiani, C., Cioce, M., Fagioli, M., Saito, S., Higashimoto, Y., Appella, E., Minucci, S., Pandolfi, P.P. & Pelicci, P.G. (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406, 207-210.
38. Plas, D.R., Talapatra, S., Edinger, A.L., Rathmell, J.C. & Thompson, C.B. (2001) Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem. 276, 12041-12048.
39. Quignon, F., De Bels, F., Koken, M., Feunteun, J., Ameisen, J.C. & de The, H. (1998) PML induces a novel caspase-independent death process. Nat. Genet. 20, 259-265.
40. + exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes. FASEB J. 14, 2185-2197.
41. Semenza, G.L., Jiang, B.H., Leung, S.W., Passantino, R., Concordet, J.P., Maire, P. & Giallongo, A. (1996). Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 271, 32529-32537.
42. Semenza, G.L., Roth, P.H., Fang, H.M. & Wang, G.L. (1994). Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 23757-23763.
43. Shaw, R.J. (2006) Glucose metabolism and cancer. Curr. Opin. Cell Biol. 18, 598-608.
44. Steták, A., Veress, R., Ovadi, J., Csermely, P., Keri, G. & Ullrich, A. (2007) Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Res. 67, 1602-1608.
45. Takenaka, M., Yamada, K., Lu, T., Kang, R., Tanaka, T. & Noguchi, T. (1996) Alternative splicing of the pyruvate kinase M gene in a minigene system. Eur. J. Biochem. 235, 366-371.
46. Tanaka, T., Harano, Y., Sue, F. & Morimura, H. (1967) Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues. J. Biochem. (Tokyo) 62, 71-91.
47. Turelli, P., Doucas, V., Craig, E., Mangeat, B., Klages, N., Evans, R., Kalpana, G. & Trono, D. (2001) Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: Interference with early steps of viral replication. Mol. Cell 7, 1245-1254.
48. Wang, Z.G., Delva, L., Gaboli, M., Rivi, R., Giorgio, M., Cordon-Cardo, C., Grosveld, F. & Pandolfi, P.P. (1998a) Role of PML in cell growth and the retinoic acid pathway. Science 279, 1547-1551.
49. Wang, Z.G., Ruggero, D., Ronchetti, S., Zhong, S., Gaboli, M., Rivi, R. & Pandolfi, P.P. (1998b) PML is essential for multiple apoptotic pathways. Nat. Genet. 20, 266-272.
50. Weis, K., Rambaud, S., Lavau, C., Jansen, J., Carvalho, T., Carmo-Fonseca, M., Lamond, A. & Dejean, A. (1994) Retinoic acid regulates aberrant nuclear localization of PML-RARa in acute promyelocytic leukemia cells. Cell 76, 345-356.
51. Xu, Z.X., Zou, W.X., Lin, P. & Chang, K.S. (2005) A role for PML3 in centrosome duplication and genome stability. Mol. Cell 17, 721-732.
52. Zhong, S., Delva, L., Rachez, C., Cenciarelli, C., Gandini, D., Zhang, H., Kalantry, S., Freedman, L.P. & Pandolfi, P.P. (1999) A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARa and T18 oncoproteins. Nat. Genet. 23, 287-295.
53. Zwerschke, W., Mazurek, S., Massimi, P., Banks, L., Eigenbrodt, E. & Jansen-Dürr, P. (1999) Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein. Proc. Natl. Acad. Sci. USA 96, 1291-1296.