Transfection of BLM into cultured Bloom syndrome cells reduces the sister-chromatid exchange rate toward normal

American Journal of Human Genetics

Volumn 65, Issue 5, 1999, Pages 1368-1374

  Ellis, Nathan A ^a   Proytcheva, Maria ^c   Sanz, Maureen M ^b   Ye, Tian Zhang ^a   German, James ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR PROTEIN;

ARTICLE; BLOOM SYNDROME; CONTROLLED STUDY; FIBROBLAST CULTURE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SISTER CHROMATID EXCHANGE;

HUMAN HERPESVIRUS 4;

EID: 0345680627     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302616     Document Type: Article

References (11)

1. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds) (1999) Current protocols in molecular biology. John Wiley & Sons, New York
2. Ellis NA, Groden J, Ye T-Z, Straughen J, Lennon DJ, Ciocci S, Proytcheva M, et al (1995) The Bloom's syndrome gene product is homologous to RecQ helicases. Cell 83:655-666
3. German J (1993) Bloom syndrome: a mendelian prototype of somatic mutational disease. Medicine (Baltimore) 72:393-406
4. German J, Ellis NA. Bloom syndrome. In: Scriver CR, Beaudet AL, Sly WS, Valle D, Vogelstein B, Childs B (eds). Metabolic and molecular bases of inherited disease, 8th ed. McGraw-Hill (in press)
5. German J, Proytcheva M, Ye T-Z, Sanz M, Neff N, Ellis NA (1996) Correction of the high-SCE phenotype in Bloom's syndrome (BS) cells by transfection of the wild-type gene. Am J Hum Genet Suppl 59:A2
6. German J, Schonberg S, Louie E, Chaganti RS (1977) Bloom's syndrome. IV. Sister-chromatid exchanges in lymphocytes. Am J Hum Genet 29:248-255
7. Giesler T, Baker K, Zhang B, McDaniel LD, Schultz RA (1997) Correction of the Bloom syndrome cellular phenotypes. Somat Cell Mol Genet 23:303-312
8. Harlow E, Lane D (1988) Cell staining. In: Antibodies: a laboratory manual. Cold Spring Harbor, NY, pp 363-419
9. McDaniel LD, Schultz RA (1992) Elevated sister chromatid exchange phenotype of Bloom syndrome cells is complemented by human chromosome 15. Proc Natl Acad Sci USA 89:7968-7972
10. Neff NF, Ellis NA, Ye T-Z, Noonan J, Huang K, Sanz M, Proytcheva M (1999) The DNA helicase activity of BLM is necessary for the correction of the genomic instability of Bloom syndrome cells. Mol Biol Cell 10:665-676
11. Strathdee CA, Gavish H, Shannon WR, Buchwald M (1992) Cloning of cDNAs for Fanconi's anaemia by functional complementation. Nature 356:763-767