Differential behavior of missense mutations in the intersubunit contact domain of the human pyruvate kinase M2 isozyme

Journal of Biological Chemistry

Volumn 284, Issue 18, 2009, Pages 11971-11981

  Akhtar, Kamal ^a   Gupta, Vibhor ^a   Koul, Anita ^a   Alam, Neelima ^a   Bhat, Rajiv ^a   Bamezai, Rameshwar N K ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC INHIBITOR; ALLOSTERIC PROTEINS; AMINO ACID RESIDUES; BLOOM SYNDROME; COOPERATIVE BINDING; FRUCTOSE 1 ,6-BISPHOSPHATE; IN-CELL; LONG-RANGE COMMUNICATIONS; MULTIMERIC; MUTANT PROTEINS; PH OPTIMA; PH VALUE; PHOSPHOENOLPYRUVATE; PYRUVATE; PYRUVATE KINASE; STRUCTURAL ALTERATIONS; THERMAL STABILITY; WILD-TYPE PROTEINS;

AMINES; AMINO ACIDS; BIOCHEMISTRY; BLOOMS (METAL); ORGANIC ACIDS; PROTEINS;

PH EFFECTS;

AMINO ACID; FRUCTOSE 1,6 BISPHOSPHATE; ISOENZYME; MUTANT PROTEIN; PHOSPHOENOLPYRUVATE; PROTEIN SUBUNIT; PYRUVATE KINASE; PYRUVATE KINASE M2; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BLOOM SYNDROME; CANCER SUSCEPTIBILITY; CONTROLLED STUDY; ENZYME BINDING; ENZYME DEFECT; ENZYME MECHANISM; ENZYME REGULATION; ENZYME STABILITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; MISSENSE MUTATION; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN STRUCTURE; THERMOSTABILITY; TUMOR GROWTH; TUMOR PROMOTION; WILD TYPE; AMINO ACID SUBSTITUTION; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; NEOPLASM; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; BLOOM SYNDROME; ENZYME STABILITY; HUMANS; HYDROGEN-ION CONCENTRATION; MUTATION, MISSENSE; NEOPLASMS; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PYRUVATE KINASE;

EID: 66449097196     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M808761200     Document Type: Article

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