Cyclosporine, FK-506, rapamycin, and other immunomodulators

Rheumatic Disease Clinics of North America

Volumn 22, Issue 1, 1996, Pages 133-154

  Yocum, D E ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; DIETHYLDITHIOCARBAMIC ACID; GOLD; IMMUNOMODULATING AGENT; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS; TILOMISOLE;

AUTOIMMUNITY; BEHCET DISEASE; DERMATOMYOSITIS; DRUG EFFICACY; DRUG THERAPY; ETIOLOGY; HUMAN; IMMUNOMODULATION; NEPHROTIC SYNDROME; NEPHROTOXICITY; POLYMYOSITIS; PRIORITY JOURNAL; PSORIASIS; PSORIATIC ARTHRITIS; REVIEW; RHEUMATOID ARTHRITIS; SCLERODERMA; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE;

EID: 0029983604     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-857X(05)70266-0     Document Type: Article

References (161)

1. A.G. Alexander N.C. Barnes A.B. Kay Trial of cyclosporine in corticosteroid-dependent chronic severe asthma Lancet 339 1992 324 328
2. B. Amor D. Herson A. Cherot Follow-up study of patients with rheumatoid arthritis over a period of more than 10 years (1966–1978): Analysis of disease progression and treatment in 100 cases Ann Intern Med 132 1981 168 173
3. B. Amor M. Dougados Cyclosporin in rheumatoid arthritis: Open trials with different dosages. Schindler R. Cyclosporin in Autoimmune Diseases 1985 Springer Berlin 283 287
4. S.M. Andrew B.D. Edwards J. O'Driscoll Relapse markers in psoriatic epidermis after systemic cyclosporin therapy [abstract] Br J Derm 125 1991 488
5. C. Arita T. Hotokebuchi H. Miyahara Inhibition by FK-506 of established lesions of collagen-induced arthritis in rats Clin Exp Immunol 82 1990 456 461
6. H. Barthelemy A. Frappaz F. Cambazard Treatment of nine cases of pemphigus vulgaris with cyclosporine J Am Acad Dermatol 18 1988 1262 1266
7. D. BenEzra E. Cohen T. Chajek Evaluation of conventional therapy versus cyclosporine A in Behçet's syndrome Transplant Proc 20 suppl 4 1988 136 143
8. W. Bensen P. Tugwell R. Roberts Combination therapy of cyclosporin with methotrexate and gold in rheumatoid arthritis (2 pilot studies) [abstract] Arthritis Rheum 37 1994 S335
9. B.E. Bierer P.S. Mattila R.F. Standaert Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK-506 or rapamycin Proc Natl Acad Sci USA 87 1990 9231 9235
10. A.I. Binder E.M. Graham M.D. Sanders Cyclosporin A in the treatment of severe Behçet's uveitis Br J Rheumatol 26 1987 285 291
11. J.A. Biro A.M. Segal A.H. MacKenzie The combination of methotrexate and azathioprine for resistant rheumatoid arthritis [abstract] Arthritis Rheum 30 1987 S18
12. J.C.C. Borleffs Cyclosporine as monotherapy for polymyositis Transplant Proc 20 suppl 4 1988 333 334
13. J.C.C. Borleffs J.C. Van der Zwan Cyclosporin in Wegener's granulomatosis with renal failure: Correspondence Ann Rheum Dis 49 1990 568
14. J.F. Bourke J. Berth-Jones R.A.C. Graham-Brown Sweet's syndrome responding to cyclosporin Br J Dermatol 127 1992 36 38
15. M.T. Bousema B. Tank F. Heule Placebo-controlled study of psoriasis patients treated topically with a 10% cyclosporine gel [abstract] J Am Acad Dermatol 22 1990 126 127
16. C.A. Bowles Long-term treatment of rheumatoid arthritis with cyclosporin (CsA) [abstract] Arthritis Rheum 32 1989 S61
17. E. Brahn D.J. Peacock M.L. Banquerigo Suppression of collagen-induced arthritis by combination cyclosporin A and methotrexate therapy Arthritis Rheum 34 1991 1282 1288
18. W. Braun J. Kallen V. Mikol Three-dimensional structure and actions of immunosuppressants and their immunophilins FASEB J 9 1995 63 72
19. J. Brynskov L. Freund S.N. Rasmussen A placebo-controlled, double-blind, randomized trial of cyclosporine therapy in active chronic Crohn's disease N Engl J Med 321 1989 845 850
20. M.K. Burns C.N. Ellis D. Eisen Intralesional cyclosporine for psoriasis: Relationship of dose, tissue levels, and efficacy Arch Dermatol 128 1992 786 790
21. Canadian-European Randomized Control Trial Group Cyclosporin-induced remission of IDDM after early intervention: Association of 1 year of cyclosporin treatment with enhanced insulin secretion Diabetes 37 1998 1574 1582
22. M. Casato L. Bonomo D. Caccavo Clinical effects of cyclosporin in dermatomyositis Clin Exp Dermatol 15 1990 121 123
23. V. Churg L. Florentin G. Renoux Effects of imuthiol administration to normal and immunodeficient mice on IL-1 and IL-2 production and immune responses regulated by these medications Int J Immunopharmacol 2 1986 163 169
24. P.J. Clements P.A. Lachenbrack M. Sterz Cyclosporine in systemic sclerosis: Results of a forty-eight-week open safety study in ten patients Arthritis Rheum 36 1993 75 83
25. K.D. Cooper J.J. Voorhees G.J. Fisher Effects of cyclosporine on immunologic mechanisms in psoriasis J Am Acad Dermatol 23 1990 1318 1328
26. K.D. Cooper O. Baadsgaard C.N. Ellis Mechanisms of cyclosporine A inhibition of antigen-presenting activity in uninvolved and lesional psoriatic epidermis J Invest Dermatol 94 1990 649 656
27. C.F. Corke V. Gul E.C. Huskisson Imuthiol (sodium diethyldithiocarbamate) and rheumatoid arthritis International Journal of Immunotherapy 2 1986 163 169
28. O. Correia J. Polonia J.P. Nunes Severe acute form of adult dermatomyositis treated with cyclosporine Int J Dermatol 31 1992 517 519
29. M. Csuka G.F. Carreara D.J. McCarty Treatment of intractable rheumatoid arthritis with combined cyclophosphamide, azathioprine, and hydroxychloroquine: A followup study JAMA 255 1986 2315 2319
30. R.K. Curley C.A. Holden Steroid-resistant bullous pemphigoid treated with cyclosporin A Clin Exp Dermatol 16 1991 68 69
31. Y. de Prost C. Bodemer D. Teillac Double-blind randomized placebo-controlled trial of local cyclosporine in atopic dermatitis: Correspondence Arch Dermatol 125 1989 570
32. M. Diaz-Llopis M. Cervera J.L. Menezo Cyclosporin-A treatment of Behçet's disease. A long-term study Curr Eye Res 9 suppl 1990 17 23
33. M. Dougados B. Amor Cyclosporin A in rheumatoid arthritis: Preliminary clinical results of an open trial Arthritis Rheum 30 1987 83 87
34. M. Dougados H. Awada B. Amor Cyclosporin in rheumatoid arthritis: A double-blind, placebo-controlled study in 52 patients Ann Rheum Dis 47 1988 127 133
35. M. Dougados L. Duchesne H. Awada Assessment of efficacy and acceptability of low-dose cyclosporin in patients with rheumatoid arthritis Ann Rheum Dis 48 1989 550 556
36. F.J. Dumont M.R. Melino M.J. Staruch The immunosuppressive macrolides FK-506 and rapamycin act as reciprocal antagonists in murine T cells J Immunol 144 1990 1418 1424
37. A. Edefonti L. Ghoi G. Rizzoni Cyclosporine (CsA) vs cyclophosphamide (Cyc) for children with frequently relapsing/steroid-dependent nephrotic syndrome (FR/SDNS): Long-term study [abstract FC-III.2] Pediatr Nephrol 6 1992 C97
38. G. Elgart P. Stover K. Larson Treatment of pyoderma gangrenosum with cyclosporin: Results in seven patients J Am Acad Dermatol 24 1991 83 86
39. J. Elidan H. Levi E. Cohen Effect of cyclosporine A on the hearing loss in Behçet's disease Ann Otol Rhinol Laryngol 100 1991 464 468
40. C.N. Ellis M.S. Fradin J.M. Messana Cyclosporin for plaque-type psoriasis: Results of a multidose, double-blind trial N Engl J Med 324 1991 277 284
41. C.N. Ellis D.C. Gorsulowsky T.A. Hamilton Cyclosporine improves psoriasis in a double-blind study JAMA 256 1986 3110 3116
42. E.M. Euqui S.J. Almquist C.D. Muller Lymphocyte-selective cytostatic and immunosuppressive effects of mycophenolic acid in vitro: Role of deoxy guanosine nucleotide depletion Scand J Immunol 33 1991 1616 1673
43. G. Feutren S. Querin L.H. Noel Effects of cyclosporine in severe systemic lupus erythematosus J Pediatr 111 1987 1063 1068
44. A.F. Finzi Cyclosporin in psoriasis: The Italian experience. Bonomo L. Cyclosporin in autoimmune diseases 1990 Pensiero Scientifico Editore Rome 27 39
45. Förre ϕ, Norwegian Arthritis Disease Study Group: Cyclosporine as a disease modifier in rheumatoid arthritis [abstract 197]. Second Congress on Immunointervention in Autoimmune Diseases, Paris, 1991
46. Φ. Förre F. Bjerkhoel C.F. Salvesen An open, controlled, randomized comparison of cyclosporine and azathioprine in the treatment of rheumatoid arthritis: A preliminary report Arthritis Rheum 30 1987 88 92
47. M.S. Fradin C.N. Ellis M.T. Goldfart Oral cyclosporine for severe chronic idiopathic urticaria and angioedema J Am Acad Dermatol 25 1991 1065 1067
48. K. Friedrich H. Henning Cyclosporin A bei aktiver chronischer Hepatitis. Ergebnisse einer Pilotstudie bei 20 Patienten Zeitschrift fur Gastroenterologie 26 1988 265 270
49. F.R. Gale L.M. Atkins A.B. Smith Comparative effects of parenteral and oral administration of selective dithiocarbamates on body burdens and organ distribution of cadmium in mice Res Commun Chem Pathol Pharmacol 53 1987 129 132
50. A. Gilhar G. Winterstein D.T. Golan Topical cyclosporine in psoriasis J Am Acad Dermatol 18 1988 378 379
51. S.C. Gilman R.P. Carlson A.J. Lewis Immunomodulatory activity of WY-18,251 (3-(p-chlorophenol)thiazole[3,2-a]benzimidazole-2-acetic) Journal of Immunopharmacology 7 1985 479 488
52. S.C. Gilman R.P. Carlson J.F. Daniels Immunological abnormalities in rats with adjuvant-induced arthritis: II. Effect of antiarthritic therapy on immune function in relation to disease involvement Int J Immunopharmacol 9 1987 9 16
53. H. Gisslinger O.C. Burghuber G. Stacher Efficacy of cyclosporin A in systemic sclerosis Clin Exp Rheumatol 9 1991 383 390
54. R. Goldblum M.M.C. Rees E. Eaqui Immunologic changes in patients with rheumatoid arthritis treated for one year with a new DMARD, mycophenolate mofetil Arthritis Rheum 34 suppl 1991 5157
55. A.B. Gottlieb R.M. Grossman L. Khandke Studies of the effect of cyclosporine in psoriasis in vivo: Combined effects on activated T lymphocytes and epidermal regenerative maturation J Invest Dermatol 98 1992 302 309
56. A. Granelli-Piperno In situ hybridization for interleukin 2 and interleukin 2 receptor mRNA in T cells activated in the presence or absence of cyclosporin A J Exp Med 168 1988 1649 1658
57. C.E.M. Griffiths A.V. Powles J. McFadden Long-term cyclosporin for psoriasis Br J Dermatol 120 1989 253 260
58. C.E.M. Griffiths A.V. Powles B.S. Baker Combination of cyclosporine A and topical corticosteroid in the treatment of psoriasis Transplant Proc 3 suppl 4 1988 50 52
59. H.C. Gunn Successful treatment of autoimmunity in (N2B × N2W) F, mice with cyclosporin and (Nva2)-cyclosporin: I. Reduction of autoantibodies Clin Exp Immunol 64 1986 225 233
60. A.K. Gupta C.N. Ellis B.J. Nickoloff Oral cyclosporine in the treatment of inflammatory and non-inflammatory dermatoses Arch Dermatol 126 1990 339 350
61. C. Haagsma P. Van Riel D.J. deRooij Combination therapy in RA: Sulphasalazine and methotrexate [abstract] Arthritis Rheum 36 1993 S53
62. B. Haraoui R.L. Wilder D.G. Malone Immune function in severe, active rheumatoid arthritis: A relationship between peripheral blood mononuclear cell proliferation to soluble antigens and mononuclear cell subset profiles J Immunol 133 1984 697 701
63. N. Harley B. Ihle Wegener's granulomatosis use of cyclosporin A: A case report Aust N Z J Med 20 1990 71 73
64. B. Hermann W. Meuller Die therapie der chronischen polyarthritis mit Cyclosporin A, einens neuen immun-suppressivum Akt Rheumatol 4 1979 173 186
65. K.C. Herold D.W. Lancki R.L. Moldwin Immunosuppressive effects of cyclosporin A on cloned T cells J Immunol 136 1986 1315 1321
66. E. Higgins C. Munro J. Marks Relapse rates in moderately severe chronic psoriasis treated with cyclosporin A Br J Deramtol 121 1989 71 74
67. V.C. Ho C.E.M. Griffiths C.N. Ellis Intralesional cyclosporine in the treatment of psoriasis J Am Acad Dermatol 22 1990 94 100
68. D.A. Isenberg M.L. Snaith W.J.W. Morrow Cyclosporin A for the treatment of systemic lupus erythematosus Int J Immunopharmacol 3 1981 163 165
69. B.D. Kahan S. Gibbons N. Tejpal Synergistic interactions of cyclosporine and rapamycin to inhibit immune performances of normal human peripheral blood lymphocytes in vitro Transplant 51 1991 232 239
70. L. Kappos U. Patzold D. Dommasch Cyclosporine versus azathioprine in the long-term treatment of multiple sclerosis: Results of the German multicenter study Ann Neurol 23 1988 56 63
71. J.E. Kay L. Kromwel S.E.A. Doe Inhibition of T and B lymphocyte proliferation by rapamycin Immunology 72 1991 544 549
72. M.J. Korstanje W.J.B.M. Van de Staak Combination-therapy cyclosporin-A-etretinate for psoriasis Clin Exp Dermatol 15 1990 172 173
73. M. Krönke W.J. Leonard J.M. Depper Cyclosporin A inhibits T cell growth factor gene expression at the level of mRNA transcription Proc Natl Acad Sci USA 81 1984 5214 5218
74. M. Kurosaka M. Ziff Immunoelectron microscopic study of distribution of T cell subsets and HLA-DR expressing cells in rheumatoid synovium Arthritis Rheum 26 1983 S53
75. R.B.M. Landewé H.S. GoeiThe A.W.A.M. Van Rijthoven A randomized, double-blind, 24-week controlled study of low-dose cyclosporine versus chloroquine for early rheumatoid arthritis Arthritis Rheum 37 1994 637 643
76. R.B.M. Landewé H.S. GoeiThe A.W.A.M. Van Rijthoven Cyclosporine in early rheumatoid arthritis: Delayed onset of optimal efficacy Cyclosporine in Rheumatoid Arthritis 1994 71 88
77. R.B.M. Landewé A.M.M. Miltenburg F.C. Breedveld Cyclosporine and chloroquine synergistically inhibit the interferon gamma production by CD4-positive and CD8-positive synovial T cell clones derived from a patient with rheumatoid arthritis Cyclosporine in Rheumatoid Arthritis 1994 111 123
78. R.B.M. Landewé A.M.M. Miltenburg M.J.A. Verdonk Cyclosporine and chloroquine synergistically inhibit T cell proliferation by interference with IL-2 production and IL-2 responsiveness Cyclosporine in Rheumatoid Arthritis 1994 125 146
79. S. Lichtiger D.H. Present Cyclosporin A in the treatment of severe ulcerative colitis [abstract] Gastroenterology 102 1992 A653
80. C.S. Lin R.C. Boltz J.J. Siekierka FK-506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes Cell Immunol 133 1991 269 284
81. T. Lingenfelser H. Duerk A. Stevens Generalized myositis in Behçet's disease: Treatment with cyclosporine Ann Intern Med 116 1992 651 653
82. A.J. Lobo L.D. Juby J. Rothwell Long-term treatment of Crohn's disease with cyclosporine: The effect of a very low dose on maintenance of remission J Clin Gastroenterol 13 1991 42 45
83. M. Lombard B. Portmann J. Neuberger Cyclosporin A treatment in primary biliary cirrhosis: Results of a long-term placebo controlled trial Gastroenterology 104 1993 519 526
84. C.J. Lueck P. Trend M. Swash Cyclosporin in the management of polymyositis and dermatomyositis J Neurol Neurosurg Psychiatry 54 1991 1007 1008
85. R. Madhok H.I. Torley H.A. Capell A study of the long-term efficacy and toxicity of cyclosporine A in rheumatoid arthritis J Rheumatol 18 1991 1485 1489
86. G. Mahrle H.-J. Schulze L. Farber Cyclosporin A vs etretinate in the treatment of psoriasis: Preliminary results. Wolff K. Cyclosporin and the Skin 1992 Alden Press Oxford 27 28
87. D.G. Malone S.M. Wahl M. Tsokos Immune function in severe, active rheumatoid arthritis: A relationship between peripheral blood mononuclear cell proliferation to soluble antigens and synovial tissue immunohistologic characteristics J Clin Invest 74 1984 1173 1185
88. R.R. Martel J. Klicius S. Galet Inhibition of the immune response by rapamycin, a new antifungal antibiotic Can J Physiol Pharmacol 55 1977 48 51
89. K. Masuda A. Urayama A. Nakajima Cyclosporin A treatment of Behçet's disease: A multi-centre double-masked trial. Barnes Lehner Recent Advances in Behçet's Disease. Royal Society of Medicine Services International Congress and Symposium Series No. 103 1986 Published by Royal Society of Medicine Services Limited
90. K. Masuda A. Urayama M. Kogure Double-masked trial of cyclosporin versus colchicine and long-term open therapy study of cyclosporin in Behçet's disease Lancet 1 1989 1093 1096
91. W.L. Matis C.N. Ellis C.E.M. Griffiths Treatment of pyoderma gangrenosum with cyclosporine Arch Dermatol 128 1992 1060 1064
92. D.R. Mehregan W.P. Su Cyclosporine treatment for dermatomyositis/polmyositis Cutis 51 1993 59 61
93. T. Melvin W. Bennett Management of nephrotic syndrome in childhood Drugs 42 1991 30 51
94. W. Meuller B. Hermann Cyclosporin A for psoriasis N Engl J Med 301 1979 555
95. P.A. Miescher Treatment of systemic lupus erythematosus Springer Semin Immunopathol 9 1986 271 282
96. P.A. Miescher H. Favre M.J. Mihatsch The place of cyclosporine A in the treatment of connective tissue diseases Transplant Proc suppl 4 1988 224 237
97. H. Miyahara T. Hotokebachi C. Arita Comparative studies of the effects of FK 506 and cyclosporin A on passively transferred collagen-induced arthritis in rats Clin Immunol Immunopathol 60 1991 278 288
98. U. Mrowietz The enigma of cyclosporin A treatment for psoriasis: Systemic efficacy versus topical non-responsiveness Acta Derm Venereol (Stockh) 72 1992 321 326
99. A.U. Muftuoglu H. Pazarli S. Yurdakul Short term cyclosporin A treatment of Behçet's disease Br J Ophthalmol 71 1987 387 390
100. Multiple Sclerosis Study Group Efficacy and toxicity of cyclosporine in chronic progressive multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial Ann Neurol 27 1990 591 605
101. P. Niaudet French Society of Pediatric Nephrology Comparison of cyclosporin and chlorambucil in the treatment of steroid-dependent idiopathic nephrotic syndrome: A multicentre randomized controlled trial Pediatr Nephrol 6 1992 1 3
102. J. O'Dell C. Haire N. Erikson Triple DMARD therapy for rheumatoid arthritis: Efficacy [abstract] Arthritis Rheum 37 1994 S295
103. ϕystein Förre and the Norwegian Arthritis Study Group Radiologic evidence of disease modification in rheumatoid arthritis patients treated with cyclosporine: Results of a 48-week multicenter study comparing low-dose cyclosporine with placebo Arthritis Rheum 37 1994 1506 1512
104. Ozyazgan Y, Yurdakul S, Yazici H, et al: Low dose cyclosporin A versus pulsed cyclophosphamide in Behçet's syndrome: A single masked trial book of abstracts Behçet's disease. Fifth International Conference, Rochester, Minnesota, 1989
105. A.G. Palestine H.A. Austin J.E. Balow Renal histopathologic alterations in patients treated with cyclosporine for uveitis N Engl J Med 314 1986 1293 1298
106. G. Palimeris G. Theodossiades B. Constantinidou The macula in the Adamantiades-Behçet's disease J Fr Ophthalmol 12 1989 887 890
107. G.S. Panayi The immunopathogenesis of rheumatoid arthritis Br J Rheumatol 32 suppl 1 1993 4 14
108. G.S. Panayi P. Tugwell An international consensus report: The use of cyclosporin A in rheumatoid arthritis Br J Rheumatol 32 suppl 1 1993 1 3
109. M. Paroli A. Franco I. Santilio Cyclosporin A in the treatment of autoimmune chronic active hepatitis occurring with or without circulating antibodies against hepatitis C virus International Journal of Immunotherapy 8 1992 135 140
110. J.P. Perchellet N.L. Abney R.M. Thomas Inhibition of multistage tumor promotion in mouse skin by diethyldithiocarbamate Cancer Res 47 1987 6302 6309
111. A.M. Peters J.Z. Heckmatt N. Hasson Renal haemodynamics of cyclosporin A nephrotoxicity in children with juvenile dermatomyositis Clin Sci (Colch) 81 1991 153 159
112. P. Petzelbauer H. Honigsmann K. Langer Cyclosporin A in combination with photochemotherapy (PUVA) in the treatment of psoriasis Br J Dermatol 123 1990 641 647
113. P. Petzelbauer G. Stingl K. Wolff Cyclosporin A suppresses ICAM-1 expression by papillary endothelium in healing psoriatic plaques J Invest Dermatol 96 1991 362 369
114. K.P. Platz H.W. Sollinger D.A. Hulleh Rs-61443: A new, potent immunosuppressive agent Transplantation 51 1991 27 31
115. C.S. Prickett C.D. Johnston The in vivo production of carbon disulfide from tetraethylthiuramdisulfide (Antabuse) Biochem Biophys Acta 12 1977 542 546
116. D.J. Rawlings L. Richardson I.S. Szer Cyclosporine is safe and effective in refractory JRA and JMDS: Results of an open clinical trial[abstract C130] Arthritis Rheum 35 suppl 9 1992 S188
117. G. Renoux M. Renoux The effects of sodium diethyldithiocarbamate, azathioprine, cyclophosphamide or hydrocortisone acetate administered alone or in association for four weeks on the immune responses of Balb/c mice Clin Immunol Immunopathol 2 1980 49
118. G. Renoux M. Renoux Thymus-like activities of sulfur derivatives on T cell differentiation J Exp Med 145 1977 466 471
119. G. Renoux J.L. Touraine M. Renoux Induction of human null cells into T lymphocytes by the serum of mice treated with sodium diethyldithiocarbamate J Immunopharmacol 2 1980 49
120. G. Renoux M. Renoux K. Biziere Involvement of brain neocortex and liver in the regulation of T cells: The mode of action of sodium diethyldithiocarbamate (imuthiol) Immunopharmacology 7 1984 89 100
121. C.M. Rogers T.J. Rogers S.C. Gilman Effects of WY-188251 (3-(p-chlorophenyl) thiazole [3,2-a]benzimidazole-2-acetic acid), levamisole and indomethacin in the generation of murine T suppressor cell in vitro J Immunopharmacol 7 1985 479 488
122. W.J. Sandborn R.H. Wiesner W.J. Tremaine Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin Gut 34 1993 242 246
123. B.C.G. Schalke L. Kappos E. Rohrbach Immunosuppressive treatment of myasthenia gravis: Results of a double-blind trial-cyclosporin A (CsA) versus azathioprine (AZA) Jikeikai Medical Journal 37 suppl 1990 165 169
124. Schattenkirchner M, Kruger K: Cyclosporine vs azathioprine in the treatment of rheumatoid arthritis: A controlled double blind study [abstract 198]. 2nd Congress on Immunointervention in Autoimmune Diseases, Paris, 1991
125. M.H. Schiff R. Goldmlum M.M.C. Rees New DMARD, mycophenolate mofetil, effectively treats refractory rheumatoid arthritis patients for one year Arthritis Rheum 34 suppl 1991 S89
126. R. Segal E. Mozes M. Yaron The effects of methotrexate on the production and activity of interleukin-1 Arthritis Rheum 32 1989 370 377
127. Seterah M, Yocum DE, Parsons J: Inhibition of streptococcal cell wall-induced arthritis by rapamycin (personal communication).
128. K.E. Sherman P.C. Pinto Cyclosporin treatment of type 1 autoimmune chronic active hepatitis [abstract 597] Hepatology 16 1992 194A
129. T. Shiohara K. Imanishi Y. Sagawa Differential effects of cyclosporine and etretinate on serum cytokine levels in patients with psoriasis J Am Acad Dermatol 27 1992 568 574
130. N.H. Sigal F.J. Dumont Cyclosporin A, FK-506, and rapamycin: Pharmacologic probes of lymphocyte signal transduction Ann Rev Immunol 10 1992 519 560
131. J.S. Skyler A. Rabinovitch Miami Cyclosporine Diabetes Study Group Cyclosporine in recent onset type 1 diabetes mellitus: Effects on islet β cell function J Diabetes Complications 6 1992 77 88
132. C. Soria F. Allegue M. Martin Treatment of pyoderma gangrenosum with cyclosporin A Clin Exp Dermatol 16 1991 392 394
133. T.E. Starzl J. Fung M. Jordan Kidney transplantation under FK 506 JAMA 264 1990 63 67
134. C.M. Stein T. Pincus R.H. Brooks Combination therapy with cyclosporine and methotrexate: Results of a 24 week extension study subsequent to a 24 week doubleblind study [abstract] Arthritis Rheum 37 1994 S5252
135. A. Szczeklik E. Nizankowska R. Dworski Cyclosporin for steroid-dependent asthma Allergy 46 1991 312 315
136. E.H. Taylor E.M. Walker M. Bartelt In vitro antimicrobial activity of diethyldithiocarbamate and dimethyldithiocarbamate against methicillin-resistant staphylococcus Ann Clin Lab Sci 17 1987 171 177
137. M.J.A.M. Tegelberg-Stassen A.M. Lammers W.A. van Volten Responsiveness of moderate psoriatic skin lesions to 1, 2, or 3 mg/kg/day cyclosporin A: A multicenter study Eur J Dermatol 2 1992 147 150
138. A. Tejani K. Butt H. Trachtman Cyclosporin-induced remission of relapsing nephrotic syndrome in children Kidney Int 33 1988 729 734
139. A. Tejani M. Suthanthiran A. Pomrantz A randomized controlled trial of low-dose prednisone and cyclosporin versus high-dose prednisone in nephrotic syndrome of children Nephron 59 1991 96 99
140. Ter Borg EJ, Tegzess AM, Kallenberg CGM: Unexpected severe reversible cyclosporine A induced nephrotoxicity in a patient with systemic lupus erythematosus and tubulointerstitial renal disease. Clin Nephrol 29:93–95
141. P. Timonen D. Friend K. Abeywickrama Efficacy of low-dose cyclosporine A in psoriasis: Results of dose-finding studies Br J Dermatol 122 suppl 36 1990 33 39
142. R.S.A. Tindall J.A. Rollins J.T. Phillips Preliminary results of a double-blind, randomized, placebo-controlled trial of cyclosporine in myasthenia gravis N Engl J Med 316 1987 719 724
143. M.J. Tocci D.A. Matkovich K.A. Collier The immunosuppressant FK-506 selectively inhibits expression of early T cell activation genes J Immunol 143 1989 718 726
144. M. Tokuda N. Karata A. Mizoguchi Effect of low-dose cyclosporin A on systemic lupus erythematosus disease activity Arthritis Rheum 37 1994 551 558
145. P. Tugwell C. Bombardier M. Gent Low dose cyclosporin in rheumatoid arthritis: A pilot study J Rheumatol 14 1987 1108 1114
146. P.C. Tugwell M. Bombardier M. Gent Low dose cyclosporin versus placebo in patients with rheumatoid arthritis Lancet 335 1990 1051 1055
147. P. Tugwell T. Pincus D. Yocum A multi-centre, double-blind, randomized trial of low-dose cyclosporin and placebo therapy in combination with methotrexate in patients with severe rheumatoid arthritis [abstract] Arthritis Rheum 37 1994 S361
148. T.H. van Joost J.D. Bos F. Huele Low-dose cyclosporin A in severe psoriasis. A double-blind study Br J Dermatol 118 1988 183 190
149. A.W.A.M. Van Rijthoven B.A.C. Dijkmans H.S. Goei The Cyclosporin treatment for rheumatoid arthritis: A placebo controlled, double blind, multicentre study Ann Rheum Dis 45 1986 726 731
150. A.W.A.M. Van Rijthoven B.A.C. Dijkmans H.S. Goei The Comparison of cyclosporine and D-penicillamine for rheumatoid arthritis: A randomized, double blind muticenter study J Rheumatol 18 1991 815 820
151. B. Von Graffenried D. Friend N. Shand Cyclosporin A (Sandimmun) in autoimmune disorders. Schindler R. Cyclosporin in Autoimmune Diseases 1985 Springer Berlin 59 73
152. C.-F. Wahlgren A. Scheynius Hagermark Antipruritic effect of oral cyclosporin A in atopic dermatitis Acta Derm Venereol (Stockh) 70 1990 323 329
153. E.M. Walker D.J. Cannon M.E. Reiffsteck Effects of diethyldithiocarbamate and structural analogues in mice with systemic candida infections Res Commun Chem Pathol Pharmacol 56 1987 253 263
154. M.E. Weinblatt J.S. Coblyn P.A. Fraser Cyclosporin A treatment of refractory rheumatoid arthritis Arthritis Rheum 30 1987 11 17
155. L.S. Wicker R.C. Boltz V. Matt Suppression of B-cell activation by cyclosporine A, FK506 and rapamycin Eur J Immunol 20 1990 2277 2283
156. R.H. Wiesner J. Ludwig K.D. Lindor A controlled trial of cyclosporine in the treatment of primary biliary cirrhosis N Engl J Med 322 1990 1419 1424
157. R.F. Willkens M.B. Urowits D.M. Stablei Comparison of azathioprine, methotrexate, and the combination of both in the treatment of rheumatoid arthritis: A controlled clinical trial Arthritis Rheum 35 1992 849 856
158. B. Wörle R. Hein T. Krieg Cyclosporin in localized and systemic scleroderma: A clinical study Dermatologica 181 1990 215 220
159. H. Yazici C.G. Barnes Practical treatment recommendations for pharmacotherapy of Behçet's syndrome Practical Therapeutics 1 1991 796 804
160. D.E. Yocum J.H. Klippel R.L. Wilder Cyclosporin A in severe, treatment-refractory rheumatoid arthritis: A randomized study Ann Intern Med 109 1988 863 869
161. H. Zachariae L. Halkier-Srensen L. Heickendorff Cyclosporin A treatment of systemic sclerosis Br J Dermatol 122 1990 677 681