RasGRP1 is essential for Ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes

Journal of Biological Chemistry

Volumn 285, Issue 21, 2010, Pages 15724-15730

  Sharma, Amrish ^a   Luke, Courtney T ^a   Dower, Nancy A ^b   Stone, James C ^b   Lorenzo, Patricia S ^a  

^a UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIACYLGLYCEROL; DOWNSTREAM TARGET; EPIDERMAL CELLS; ERK ACTIVATION; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HAIRPIN RNA; HIGH AFFINITY; ISOFORMS; JNK ACTIVATION; KERATINOCYTES; KNOCK OUTS; MOUSE KERATINOCYTES; MOUSE MODELS; PHORBOL ESTERS; SKIN CARCINOGENESIS; SKIN TUMOR; TETRADECANOYLPHORBOL 13 ACETATES; WILD TYPES;

ESTERS; GLYCEROL; PATHOLOGY; PHOSPHORYLATION; RNA; TUMORS;

ACTIVATION ANALYSIS;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; RAS GUANYL NUCLEOTIDE RELEASING PROTEIN; RAS PROTEIN; SHORT HAIRPIN RNA; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; GENE SILENCING; KERATINOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SKIN CARCINOGENESIS;

ANIMALS; CARCINOGENS; CELL LINE; ENZYME ACTIVATION; EPIDERMIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE SILENCING; GUANINE NUCLEOTIDE EXCHANGE FACTORS; KERATINOCYTES; MAP KINASE KINASE 4; MICE; MICE, KNOCKOUT; PROTO-ONCOGENE PROTEINS P21(RAS); TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 77952411677     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.100016     Document Type: Article

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