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Volumn 17, Issue 5, 2003, Pages 629-637

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

Author keywords

Apoptosis; Cancer; JNK; MAP kinase; Ras; Tumor suppressor

Indexed keywords

STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

EID: 0037337694     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1062903     Document Type: Article
Times cited : (129)

References (49)
  • 1
    • 0034682264 scopus 로고    scopus 로고
    • Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation
    • Behrens, A., Jochum, W., Sibilia, M., and Wagner, E.F. 2000. Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. Oncogene 19: 2657-2663.
    • (2000) Oncogene , vol.19 , pp. 2657-2663
    • Behrens, A.1    Jochum, W.2    Sibilia, M.3    Wagner, E.F.4
  • 3
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos, J.L. 1989. Ras oncogenes in human cancer: A review. Cancer Res. 49: 4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 4
    • 0032980723 scopus 로고    scopus 로고
    • The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
    • Bost, F., McKay, R., Bost, M., Potapova, O., Dean, N.M., and Mercola, D. 1999. The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol. Cell. Biol. 19: 1938-1949.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1938-1949
    • Bost, F.1    McKay, R.2    Bost, M.3    Potapova, O.4    Dean, N.M.5    Mercola, D.6
  • 6
    • 0342463159 scopus 로고
    • Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges
    • Danos, O. and Mulligan, R.C. 1988. Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges. Proc. Natl. Acad. Sci. 85: 6460-6464.
    • (1988) Proc. Natl. Acad. Sci. , vol.85 , pp. 6460-6464
    • Danos, O.1    Mulligan, R.C.2
  • 7
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta, S.R., Brunet, A., and Greenberg, M.E. 1999. Cellular survival: A play in three Akts. Genes & Dev. 13: 2905-2927.
    • (1999) Genes & Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 8
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the INK group of MAP kinases
    • Davis, R.J. 2000. Signal transduction by the INK group of MAP kinases. Cell 103: 239-252.
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 10
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle, and apoptosis in cancer
    • Evan, G.I. and Vousden, K.H. 2001. Proliferation, cell cycle, and apoptosis in cancer. Nature 411: 342-348.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 11
    • 0032499687 scopus 로고    scopus 로고
    • SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
    • Ganiatsas, S., Kwee, L., Fujiwara, Y., Perkins, A., Ikeda, T., Labow, M.A., and Zon, L.I. 1998. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc. Natl. Acad. Sci. 95:6881-6886.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 6881-6886
    • Ganiatsas, S.1    Kwee, L.2    Fujiwara, Y.3    Perkins, A.4    Ikeda, T.5    Labow, M.A.6    Zon, L.I.7
  • 12
    • 0026648674 scopus 로고
    • Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
    • Gavrieli, Y., Sherman, Y., and Ben-Sasson, S.A. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119: 493-501.
    • (1992) J. Cell Biol. , vol.119 , pp. 493-501
    • Gavrieli, Y.1    Sherman, Y.2    Ben-Sasson, S.A.3
  • 13
    • 0019903249 scopus 로고
    • Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication
    • Gratzner, H.G. 1982. Monoclonal antibody to 5-bromo- and 5-iododeoxyuridine: A new reagent for detection of DNA replication. Science 218: 474-475.
    • (1982) Science , vol.218 , pp. 474-475
    • Gratzner, H.G.1
  • 14
    • 0033179760 scopus 로고    scopus 로고
    • BCL-2 family members and the mitochondria in apoptosis
    • Gross, A., McDonnell, J.M., and Korsmeyer, S.J. 1999. BCL-2 family members and the mitochondria in apoptosis. Genes & Dev. 13: 1899-1911.
    • (1999) Genes & Dev. , vol.13 , pp. 1899-1911
    • Gross, A.1    McDonnell, J.M.2    Korsmeyer, S.J.3
  • 16
    • 0036730122 scopus 로고    scopus 로고
    • Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts
    • Hess, P., Pihan, G., Sawyers, C.L., Flavell, R.A., and Davis, R.J. 2002. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nat. Genet. 32: 201-205.
    • (2002) Nat. Genet. , vol.32 , pp. 201-205
    • Hess, P.1    Pihan, G.2    Sawyers, C.L.3    Flavell, R.A.4    Davis, R.J.5
  • 17
    • 0029998491 scopus 로고    scopus 로고
    • Cellular transformation and malignancy induced by ras require c-jun
    • Johnson, R., Spiegelman, B., Hanahan, D., and Wisdom, R. 1996. Cellular transformation and malignancy induced by ras require c-jun. Mol. Cell. Biol. 16: 4504-4511.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4504-4511
    • Johnson, R.1    Spiegelman, B.2    Hanahan, D.3    Wisdom, R.4
  • 18
    • 0032803236 scopus 로고    scopus 로고
    • Suppression of Ras-induced apoptosis by the Rac GTPase
    • Joneson, T. and Bar-Sagi, D. 1999. Suppression of Ras-induced apoptosis by the Rac GTPase. Mol. Cell. Biol. 19: 5892-5901.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5892-5901
    • Joneson, T.1    Bar-Sagi, D.2
  • 19
    • 0035300477 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers
    • Kim, H.L., Griend, D.J., Yang, X., Benson, D.A., Dubauskas, Z., Yoshida, B.A., Chekmareva, M.A., Ichikawa, Y., Sokoloff, M.H., Zhan, P., et al. 2001. Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. Cancer Res. 61: 2833-2837.
    • (2001) Cancer Res. , vol.61 , pp. 2833-2837
    • Kim, H.L.1    Griend, D.J.2    Yang, X.3    Benson, D.A.4    Dubauskas, Z.5    Yoshida, B.A.6    Chekmareva, M.A.7    Ichikawa, Y.8    Sokoloff, M.H.9    Zhan, P.10
  • 20
    • 0033118607 scopus 로고    scopus 로고
    • The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    • Kuan, C.Y., Yang, D.D., Samanta Roy, D.R., Davis, R.J., Rakic, P., and Flavell, R.A. 1999. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22: 667-676.
    • (1999) Neuron , vol.22 , pp. 667-676
    • Kuan, C.Y.1    Yang, D.D.2    Samanta Roy, D.R.3    Davis, R.J.4    Rakic, P.5    Flavell, R.A.6
  • 22
    • 0034912744 scopus 로고    scopus 로고
    • PTEN and myotubularin: Novel phosphoinositide phosphatases
    • Maehama, T., Taylor, G.S., and Dixon, J.E. 2001. PTEN and myotubularin: Novel phosphoinositide phosphatases. Annu. Rev. Biochem. 70: 247-279.
    • (2001) Annu. Rev. Biochem. , vol.70 , pp. 247-279
    • Maehama, T.1    Taylor, G.S.2    Dixon, J.E.3
  • 23
    • 0025352187 scopus 로고
    • Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
    • Morgenstern, J.P. and Land, H. 1990. Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res. 18: 3587-3596.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 3587-3596
    • Morgenstern, J.P.1    Land, H.2
  • 24
    • 0035265686 scopus 로고    scopus 로고
    • PUMA, a novel proapoptotic gene, is induced by p53
    • Nakano, K. and Vousden, K.H. 2001. PUMA, a novel proapoptotic gene, is induced by p53. Mol. Cell 7: 683-694.
    • (2001) Mol. Cell , vol.7 , pp. 683-694
    • Nakano, K.1    Vousden, K.H.2
  • 26
    • 0027236954 scopus 로고
    • Production of high-titer helper-free retroviruses by transient transfection
    • Pear, W.S., Nolan, G.P., Scott, M.L., and Baltimore, D. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. 90: 8392-8396.
    • (1993) Proc. Natl. Acad. Sci. , vol.90 , pp. 8392-8396
    • Pear, W.S.1    Nolan, G.P.2    Scott, M.L.3    Baltimore, D.4
  • 27
    • 0030920914 scopus 로고    scopus 로고
    • The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin
    • Potapova, O., Haghighi, A., Bost, F., Liu, C., Birrer, M.J., Gjerset, R., and Mercola, D. 1997. The Jun kinase/stress-activated protein kinase pathway functions to regulate DNA repair and inhibition of the pathway sensitizes tumor cells to cisplatin. J. Biol. Chem. 272: 14041-14044.
    • (1997) J. Biol. Chem. , vol.272 , pp. 14041-14044
    • Potapova, O.1    Haghighi, A.2    Bost, F.3    Liu, C.4    Birrer, M.J.5    Gjerset, R.6    Mercola, D.7
  • 29
    • 0028935270 scopus 로고
    • Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine
    • Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J., and Davis, R.J. 1995. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270: 7420-7426.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7420-7426
    • Raingeaud, J.1    Gupta, S.2    Rogers, J.S.3    Dickens, M.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 30
    • 0032724021 scopus 로고    scopus 로고
    • Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
    • Sabapathy, K., Jochum, W., Hochedlinger, K., Chang, L., Karin, M., and Wagner, E.F. 1999. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech. Dev. 89:115-124.
    • (1999) Mech. Dev. , vol.89 , pp. 115-124
    • Sabapathy, K.1    Jochum, W.2    Hochedlinger, K.3    Chang, L.4    Karin, M.5    Wagner, E.F.6
  • 31
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: Mitotic clock or culture shock?
    • Sherr, C.J. and DePinho, R.A. 2000. Cellular senescence: Mitotic clock or culture shock? Cell 102: 407-410.
    • (2000) Cell , vol.102 , pp. 407-410
    • Sherr, C.J.1    DePinho, R.A.2
  • 34
    • 0032100617 scopus 로고    scopus 로고
    • Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
    • Su, G.H., Hilgers, W., Shekher, M.C., Tang, DJ., Yeo, C.J., Hruban, R.H., and Kern, S.E. 1998. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res. 58: 2339-2342.
    • (1998) Cancer Res. , vol.58 , pp. 2339-2342
    • Su, G.H.1    Hilgers, W.2    Shekher, M.C.3    Tang, D.J.4    Yeo, C.J.5    Hruban, R.H.6    Kern, S.E.7
  • 38
    • 0034992168 scopus 로고    scopus 로고
    • MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
    • Tournier, C., Dong, C., Turner, T.K., Jones, S.N., Flavell, R.A., and Davis, R.J. 2001. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes & Dev. 15: 1419-1426.
    • (2001) Genes & Dev. , vol.15 , pp. 1419-1426
    • Tournier, C.1    Dong, C.2    Turner, T.K.3    Jones, S.N.4    Flavell, R.A.5    Davis, R.J.6
  • 40
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein, B., Lane, D., and Levine, A.J. 2000. Surfing the p53 network. Nature 408: 307-310.
    • (2000) Nature , vol.408 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 41
    • 0033872092 scopus 로고    scopus 로고
    • Human gastric cancer kinase profile and prognostic significance of MKK4 kinase
    • Wu, C.W., Li, A.F., Chi, C.W., Huang, C.L., Shen, K.H., Liu, W.Y., and Lin, W. 2000. Human gastric cancer kinase profile and prognostic significance of MKK4 kinase. Am. J. Pathol. 156: 2007-2015.
    • (2000) Am. J. Pathol. , vol.156 , pp. 2007-2015
    • Wu, C.W.1    Li, A.F.2    Chi, C.W.3    Huang, C.L.4    Shen, K.H.5    Liu, W.Y.6    Lin, W.7
  • 43
    • 0030908341 scopus 로고    scopus 로고
    • Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity
    • Yang, D., Tournier, C., Wysk, M., Lu, H.T., Xu, J., Davis, R.J., and Flavell, R.A. 1997a. Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc. Natl. Acad. Sci. 94: 3004-3009.
    • (1997) Proc. Natl. Acad. Sci. , vol.94 , pp. 3004-3009
    • Yang, D.1    Tournier, C.2    Wysk, M.3    Lu, H.T.4    Xu, J.5    Davis, R.J.6    Flavell, R.A.7
  • 45
    • 0033229853 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17
    • Yoshida, B.A., Dubauskas, Z., Chekmareva, M.A., Christiano, T.R., Stadler, W.M., and Rinker-Schaeffer, C.W. 1999. Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. Cancer Res. 59: 5483-5487.
    • (1999) Cancer Res. , vol.59 , pp. 5483-5487
    • Yoshida, B.A.1    Dubauskas, Z.2    Chekmareva, M.A.3    Christiano, T.R.4    Stadler, W.M.5    Rinker-Schaeffer, C.W.6
  • 46
    • 0034744305 scopus 로고    scopus 로고
    • The c-Jun NH2-terminal kinase3 (JNK3) gene: Genomic structure, chromosomal assignment, and loss of expression in brain tumors
    • Yoshida, S., Fukino, K., Harada, H., Nagai, H., Imoto, I., Inazawa, J., Takahashi, H., Teramoto, A., and Emi, M. 2001. The c-Jun NH2-terminal kinase3 (JNK3) gene: Genomic structure, chromosomal assignment, and loss of expression in brain tumors. J. Hum. Genet. 46: 182-187.
    • (2001) J. Hum. Genet. , vol.46 , pp. 182-187
    • Yoshida, S.1    Fukino, K.2    Harada, H.3    Nagai, H.4    Imoto, I.5    Inazawa, J.6    Takahashi, H.7    Teramoto, A.8    Emi, M.9
  • 47
    • 0035265823 scopus 로고    scopus 로고
    • PUMA induces the rapid apoptosis of colorectal cancer cells
    • Yu, J., Zhang, L., Hwang, P.M., Kinzler, K.W., and Vogelstein, B. 2001. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol. Cell 7: 673-682.
    • (2001) Mol. Cell , vol.7 , pp. 673-682
    • Yu, J.1    Zhang, L.2    Hwang, P.M.3    Kinzler, K.W.4    Vogelstein, B.5
  • 48
  • 49
    • 0035876483 scopus 로고    scopus 로고
    • BH3-only proteins that bind prosurvival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
    • Zong, W.X., Lindsten, T., Ross, A.J., MacGregor, G.R., and Thompson, C.B. 2001. BH3-only proteins that bind prosurvival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes & Dev. 15: 1481-1486.
    • (2001) Genes & Dev. , vol.15 , pp. 1481-1486
    • Zong, W.X.1    Lindsten, T.2    Ross, A.J.3    MacGregor, G.R.4    Thompson, C.B.5


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