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Volumn 6, Issue 23, 2007, Pages 2928-2931

Ras/Erk MAPK signaling in epidermal homeostasis and neoplasia

Author keywords

Epidermis; Erk; MAP kinase; Proliferation; Ras

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; RAS PROTEIN;

EID: 37549065911     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.6.23.4998     Document Type: Review
Times cited : (119)

References (54)
  • 1
    • 0036245242 scopus 로고    scopus 로고
    • Getting under the skin of epidermal morphogenesis
    • Fuchs E, Raghavan S. Getting under the skin of epidermal morphogenesis. Nat Rev Genet 2002; 3:199-209.
    • (2002) Nat Rev Genet , vol.3 , pp. 199-209
    • Fuchs, E.1    Raghavan, S.2
  • 2
    • 0033594491 scopus 로고    scopus 로고
    • p63 is a p53 homologue required for limb and epidermal morphogenesis
    • Mills AA, Zheng B, Wang XJ, Vogel H, Roop DR, Bradley A. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature 1999; 398:708-13.
    • (1999) Nature , vol.398 , pp. 708-713
    • Mills, A.A.1    Zheng, B.2    Wang, X.J.3    Vogel, H.4    Roop, D.R.5    Bradley, A.6
  • 4
    • 34247511981 scopus 로고    scopus 로고
    • p63 is essential for the proliferative potential of stem cells in stratified epithelia
    • Senoo M, Pinto F, Crum CP, McKeon F. p63 is essential for the proliferative potential of stem cells in stratified epithelia. Cell 2007; 129:523-36.
    • (2007) Cell , vol.129 , pp. 523-536
    • Senoo, M.1    Pinto, F.2    Crum, C.P.3    McKeon, F.4
  • 6
    • 33751230475 scopus 로고    scopus 로고
    • p63 regulates proliferation and differentiation of developmentally mature keratinocytes
    • Truong AB, Kretz M, Ridky TW, Kimmel R, Khavari PA. p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Genes Dev 2006; 20:3185-97.
    • (2006) Genes Dev , vol.20 , pp. 3185-3197
    • Truong, A.B.1    Kretz, M.2    Ridky, T.W.3    Kimmel, R.4    Khavari, P.A.5
  • 9
    • 0035091032 scopus 로고    scopus 로고
    • RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations
    • Li M, Chiba H, Warot X, Messaddeq N, Gerard C, Chambon P, Metzger D. RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. Development 2001; 128:675-88.
    • (2001) Development , vol.128 , pp. 675-688
    • Li, M.1    Chiba, H.2    Warot, X.3    Messaddeq, N.4    Gerard, C.5    Chambon, P.6    Metzger, D.7
  • 10
    • 33751078603 scopus 로고    scopus 로고
    • Canonical notch signaling functions as a commitment switch in the epidermal lineage
    • Blanpain C, Lowry WE, Pasolli HA, Fuchs E. Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev 2006; 20:3022-35.
    • (2006) Genes Dev , vol.20 , pp. 3022-3035
    • Blanpain, C.1    Lowry, W.E.2    Pasolli, H.A.3    Fuchs, E.4
  • 12
    • 7744240345 scopus 로고    scopus 로고
    • Gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis
    • Pan Y, Lin MH, Tian X, Cheng HT, Gridley T, Shen J, Kopan R. Gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell 2004; 7:731-43.
    • (2004) Dev Cell , vol.7 , pp. 731-743
    • Pan, Y.1    Lin, M.H.2    Tian, X.3    Cheng, H.T.4    Gridley, T.5    Shen, J.6    Kopan, R.7
  • 13
    • 0034192461 scopus 로고    scopus 로고
    • Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters
    • Lowell S, Jones P, Le Roux I, Dunne J, Watt FM. Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol 2000; 10:491-500.
    • (2000) Curr Biol , vol.10 , pp. 491-500
    • Lowell, S.1    Jones, P.2    Le Roux, I.3    Dunne, J.4    Watt, F.M.5
  • 14
    • 0036024023 scopus 로고    scopus 로고
    • Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
    • Nickoloff BJ, Qin JZ, Chaturvedi V, Denning MF, Bonish B, Miele L. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ 2002; 9:842-55.
    • (2002) Cell Death Differ , vol.9 , pp. 842-855
    • Nickoloff, B.J.1    Qin, J.Z.2    Chaturvedi, V.3    Denning, M.F.4    Bonish, B.5    Miele, L.6
  • 15
    • 0029045856 scopus 로고
    • Strain-dependent epithelial defects in mice lacking the EGF receptor
    • Sibilia M, Wagner EF. Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 1995; 269:234-8.
    • (1995) Science , vol.269 , pp. 234-238
    • Sibilia, M.1    Wagner, E.F.2
  • 17
    • 0034604845 scopus 로고    scopus 로고
    • Conditional ablation of beta1 integrin in skin: Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination
    • Raghavan S, Bauer C, Mundschau G, Li Q, Fuchs E. Conditional ablation of beta1 integrin in skin: Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination. J Cell Biol 2000; 150:1149-60.
    • (2000) J Cell Biol , vol.150 , pp. 1149-1160
    • Raghavan, S.1    Bauer, C.2    Mundschau, G.3    Li, Q.4    Fuchs, E.5
  • 18
    • 0029666420 scopus 로고    scopus 로고
    • Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
    • Dowling J, Yu QC, Fuchs E. Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol 1996; 134:559-72.
    • (1996) J Cell Biol , vol.134 , pp. 559-572
    • Dowling, J.1    Yu, Q.C.2    Fuchs, E.3
  • 19
    • 0032528060 scopus 로고    scopus 로고
    • Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain
    • Murgia C, Blaikie P, Kim N, Dans M, Petrie HT, Giancotti FG. Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. Embo J 1998; 17:3940-51.
    • (1998) Embo J , vol.17 , pp. 3940-3951
    • Murgia, C.1    Blaikie, P.2    Kim, N.3    Dans, M.4    Petrie, H.T.5    Giancotti, F.G.6
  • 20
    • 33845393660 scopus 로고    scopus 로고
    • FGFR3 mutations in benign skin tumors
    • Hafner C, Vogt T, Hartmann A. FGFR3 mutations in benign skin tumors. Cell Cycle 2006; 5:2723-8.
    • (2006) Cell Cycle , vol.5 , pp. 2723-2728
    • Hafner, C.1    Vogt, T.2    Hartmann, A.3
  • 21
    • 0035936807 scopus 로고    scopus 로고
    • Hyperproliferation and defects in epitheial polarity upon conditional ablation of alpha-catenin in skin
    • Vasioukhin V, Bauer C, Degenstein L, Wise B, Fuchs E. Hyperproliferation and defects in epitheial polarity upon conditional ablation of alpha-catenin in skin. Cell 2001; 104:605-17.
    • (2001) Cell , vol.104 , pp. 605-617
    • Vasioukhin, V.1    Bauer, C.2    Degenstein, L.3    Wise, B.4    Fuchs, E.5
  • 22
    • 0035967241 scopus 로고    scopus 로고
    • Cutaneous squamous-cell carcinoma
    • Alam M, Ratner D. Cutaneous squamous-cell carcinoma. N Engl J Med 2001; 344:975-83.
    • (2001) N Engl J Med , vol.344 , pp. 975-983
    • Alam, M.1    Ratner, D.2
  • 25
    • 33846207546 scopus 로고    scopus 로고
    • Deregulated Ras signaling in developmental disorders: New tricks for an old dog
    • Schubbert S, Bollag G, Shannon K. Deregulated Ras signaling in developmental disorders: New tricks for an old dog. Curr Opin Genet Dev 2007; 17:15-22.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 15-22
    • Schubbert, S.1    Bollag, G.2    Shannon, K.3
  • 28
    • 25444526166 scopus 로고    scopus 로고
    • Crosstalk between Pten and Ras signaling pathways in tumor development
    • To MD, Perez-Losada J, Mao JH, Balmain A. Crosstalk between Pten and Ras signaling pathways in tumor development. Cell Cycle 2005; 4:1185-8.
    • (2005) Cell Cycle , vol.4 , pp. 1185-1188
    • To, M.D.1    Perez-Losada, J.2    Mao, J.H.3    Balmain, A.4
  • 29
    • 4544286927 scopus 로고    scopus 로고
    • Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte
    • Woodworth CD, Michael E, Smith L, Vijayachandra K, Glick A, Hennings H, Yuspa SH. Strain-dependent differences in malignant conversion of mouse skin tumors is an inherent property of the epidermal keratinocyte. Carcinogenesis 2004; 25:1771-8.
    • (2004) Carcinogenesis , vol.25 , pp. 1771-1778
    • Woodworth, C.D.1    Michael, E.2    Smith, L.3    Vijayachandra, K.4    Glick, A.5    Hennings, H.6    Yuspa, S.H.7
  • 30
    • 33745745892 scopus 로고    scopus 로고
    • Spatio-temporal segregation of Ras signals: One ship, three anchors, many harbors
    • Rocks O, Peyker A, Bastiaens PI. Spatio-temporal segregation of Ras signals: One ship, three anchors, many harbors. Curr Opin Cell Biol 2006; 18:351-7.
    • (2006) Curr Opin Cell Biol , vol.18 , pp. 351-357
    • Rocks, O.1    Peyker, A.2    Bastiaens, P.I.3
  • 31
    • 22744445886 scopus 로고    scopus 로고
    • Signaling interplay in Ras superfamily function
    • Mitin N, Rossman KL, Der CJ. Signaling interplay in Ras superfamily function. Curr Biol 2005; 15:R563-74.
    • (2005) Curr Biol , vol.15
    • Mitin, N.1    Rossman, K.L.2    Der, C.J.3
  • 34
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature 2001; 410:37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 36
    • 0035942177 scopus 로고    scopus 로고
    • Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation
    • Lin AW, Lowe SW. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc Natl Acad Sci USA 2001; 98:5025-30.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5025-5030
    • Lin, A.W.1    Lowe, S.W.2
  • 37
    • 0034745388 scopus 로고    scopus 로고
    • p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes
    • Roper E, Weinberg W, Watt FM, Land H. p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes. EMBO Rep 2001; 2:145-50.
    • (2001) EMBO Rep , vol.2 , pp. 145-150
    • Roper, E.1    Weinberg, W.2    Watt, F.M.3    Land, H.4
  • 39
    • 0033535838 scopus 로고    scopus 로고
    • Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro
    • Zhu AJ, Haase I, Watt FM. Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. Proc Natl Acad Sci USA 1999; 96:6728-33.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6728-6733
    • Zhu, A.J.1    Haase, I.2    Watt, F.M.3
  • 40
    • 0028609621 scopus 로고
    • Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha
    • Dlugosz AA, Cheng C, Williams EK, Dharia AG, Denning MF, Yuspa SH. Alterations in murine keratinocyte differentiation induced by activated rasHa genes are mediated by protein kinase C-alpha. Cancer Res 1994; 54:6413-20.
    • (1994) Cancer Res , vol.54 , pp. 6413-6420
    • Dlugosz, A.A.1    Cheng, C.2    Williams, E.K.3    Dharia, A.G.4    Denning, M.F.5    Yuspa, S.H.6
  • 41
    • 0032559976 scopus 로고    scopus 로고
    • The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted
    • Brown K, Strathdee D, Bryson S, Lambie W, Balmain A. The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted. Curr Biol 1998; 8:516-24.
    • (1998) Curr Biol , vol.8 , pp. 516-524
    • Brown, K.1    Strathdee, D.2    Bryson, S.3    Lambie, W.4    Balmain, A.5
  • 42
    • 85047698904 scopus 로고    scopus 로고
    • Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation
    • Dajee M, Tarutani M, Deng H, Cai T, Khavari PA. Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation. Oncogene 2002; 21:1527-38.
    • (2002) Oncogene , vol.21 , pp. 1527-1538
    • Dajee, M.1    Tarutani, M.2    Deng, H.3    Cai, T.4    Khavari, P.A.5
  • 45
    • 0025041030 scopus 로고
    • Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter
    • Bailleul B, Surani MA, White S, Barton SC, Brown K, Blessing M, Jorcano J, Balmain A. Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell 1990; 62:697-708.
    • (1990) Cell , vol.62 , pp. 697-708
    • Bailleul, B.1    Surani, M.A.2    White, S.3    Barton, S.C.4    Brown, K.5    Blessing, M.6    Jorcano, J.7    Balmain, A.8
  • 46
    • 0037439686 scopus 로고    scopus 로고
    • Inducible activation of ras and raf in adult epidermis
    • Tarutani M, Cai T, Dajee M, Khavari PA. Inducible activation of ras and raf in adult epidermis. Cancer Res 2003; 63:319-23.
    • (2003) Cancer Res , vol.63 , pp. 319-323
    • Tarutani, M.1    Cai, T.2    Dajee, M.3    Khavari, P.A.4
  • 47
    • 4344620189 scopus 로고    scopus 로고
    • Mek1 alters epidermal growth and differentiation
    • Scholl FA, Dumesic PA, Khavari PA. Mek1 alters epidermal growth and differentiation. Cancer Res 2004; 64:6035-40.
    • (2004) Cancer Res , vol.64 , pp. 6035-6040
    • Scholl, F.A.1    Dumesic, P.A.2    Khavari, P.A.3
  • 50
    • 33645285881 scopus 로고    scopus 로고
    • Is the loss of pRb essential for the mouse skin carcinogenesis?
    • Ruiz S, Santos M, Paramio JM. Is the loss of pRb essential for the mouse skin carcinogenesis? Cell Cycle 2006; 5:625-9.
    • (2006) Cell Cycle , vol.5 , pp. 625-629
    • Ruiz, S.1    Santos, M.2    Paramio, J.M.3
  • 52
    • 34248582787 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia
    • Zhang JY, Adams AE, Ridky TW, Tao S, Khavari PA. Tumor necrosis factor receptor 1/c-Jun-NH2-kinase signaling promotes human neoplasia. Cancer Res 2007; 67:3827-34.
    • (2007) Cancer Res , vol.67 , pp. 3827-3834
    • Zhang, J.Y.1    Adams, A.E.2    Ridky, T.W.3    Tao, S.4    Khavari, P.A.5
  • 54
    • 33645280333 scopus 로고    scopus 로고
    • Elimination of keratinocytes stagnant in s-phase through epidermal turnover instead of in situ apoptosis
    • de Gruijl FR, Mullenders LH, Stout GJ. Elimination of keratinocytes stagnant in s-phase through epidermal turnover instead of in situ apoptosis. Cell Cycle 2006; 5:565-6.
    • (2006) Cell Cycle , vol.5 , pp. 565-566
    • de Gruijl, F.R.1    Mullenders, L.H.2    Stout, G.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.