-
1
-
-
41349099104
-
Cancer statistics, 2008
-
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin 2008; 58: 71-96.
-
(2008)
CA Cancer J Clin
, vol.58
, pp. 71-96
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Hao, Y.4
Xu, J.5
Murray, T.6
-
2
-
-
0030997924
-
Identification of genes with specific expression in pancreatic cancer by cDNA representational difference analysis
-
Gress TM, Wallrapp C, Frohme M, Müller-Pillasch F, Lacher U, Friess H, et al. Identification of genes with specific expression in pancreatic cancer by cDNA representational difference analysis. Genes Chromosomes Cancer 1997; 19: 97-103.
-
(1997)
Genes Chromosomes Cancer
, vol.19
, pp. 97-103
-
-
Gress, T.M.1
Wallrapp, C.2
Frohme, M.3
Müller-Pillasch, F.4
Lacher, U.5
Friess, H.6
-
3
-
-
17844408229
-
Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression
-
Hustinx SR, Cao D, Maitra A, Sato N, Martin ST, Sudhir D, et al. Differentially expressed genes in pancreatic ductal adenocarcinomas identified through serial analysis of gene expression. Cancer Biol Ther 2004; 3: 1254-1261.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 1254-1261
-
-
Hustinx, S.R.1
Cao, D.2
Maitra, A.3
Sato, N.4
Martin, S.T.5
Sudhir, D.6
-
4
-
-
9144241047
-
Highly expressed genes in pancreatic ductal adenocarcinomas: A comprehensive characterization and comparison of the transcription profiles obtained from three major technologies
-
Iacobuzio-Donahue CA, Ashfaq R, Maitra A, Adsay NV, Shen-Ong GL, Berg K, et al. Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologies. Cancer Res 2003; 63: 8614-8622.
-
(2003)
Cancer Res
, vol.63
, pp. 8614-8622
-
-
Iacobuzio-Donahue, C.A.1
Ashfaq, R.2
Maitra, A.3
Adsay, N.V.4
Shen-Ong, G.L.5
Berg, K.6
-
5
-
-
0037379406
-
Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays
-
Iacobuzio-Donahue CA, Maitra A, Olsen M, Lowe AW, van Heek NT, Rosty C, et al. Exploration of global gene expression patterns in pancreatic adenocarcinoma using cDNA microarrays. Am J Pathol 2003; 162: 1151-1162.
-
(2003)
Am J Pathol
, vol.162
, pp. 1151-1162
-
-
Iacobuzio-Donahue, C.A.1
Maitra, A.2
Olsen, M.3
Lowe, A.W.4
van Heek, N.T.5
Rosty, C.6
-
6
-
-
0036107889
-
Discovery of novel tumor markers of pancreatic cancer using global gene expression technology
-
Iacobuzio-Donahue CA, Maitra A, Shen Ong GL, van Heek T, Ashfaq R, Meyer R, et al. Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Pathol 2002; 160: 1239-1249.
-
(2002)
Am J Pathol
, vol.160
, pp. 1239-1249
-
-
Iacobuzio-Donahue, C.A.1
Maitra, A.2
Shen Ong, G.L.3
van Heek, T.4
Ashfaq, R.5
Meyer, R.6
-
7
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321: 1801-1806.
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
-
8
-
-
0027232296
-
Detection of RAS gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma
-
Tada, M, Omata M, Kawai S, Saisho H, Ohto M, Saiki RK, et al. Detection of RAS gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res 1993; 53: 2472-2474.
-
(1993)
Cancer Res
, vol.53
, pp. 2472-2474
-
-
Tada, M.1
Omata, M.2
Kawai, S.3
Saisho, H.4
Ohto, M.5
Saiki, R.K.6
-
9
-
-
0141425732
-
BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: Potential therapeutic targets
-
Calhoun ES, Jones JB, Ashfaq R, Adsay V, Baker SJ, Valentine V, et al. BRAF and FBXW7 (CDC4, FBW7, AGO, SEL10) mutations in distinct subsets of pancreatic cancer: potential therapeutic targets. Am J Pathol 2003; 163: 1255-1260.
-
(2003)
Am J Pathol
, vol.163
, pp. 1255-1260
-
-
Calhoun, E.S.1
Jones, J.B.2
Ashfaq, R.3
Adsay, V.4
Baker, S.J.5
Valentine, V.6
-
10
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
11
-
-
0041846652
-
Ral-GTPases: Approaching their 15 minutes of fame
-
Feig LA. Ral-GTPases: approaching their 15 minutes of fame. Trends Cell Biol 2003; 13: 419-425.
-
(2003)
Trends Cell Biol
, vol.13
, pp. 419-425
-
-
Feig, L.A.1
-
12
-
-
45849097153
-
Pilot study of mutant RAS peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers
-
Toubaji A, Achtar M, Provenzano M, Herrin VE, Behrens R, Hamilton M, et al. Pilot study of mutant RAS peptide-based vaccine as an adjuvant treatment in pancreatic and colorectal cancers. Cancer Immunol Immunother 2008; 57: 1413-1420.
-
(2008)
Cancer Immunol Immunother
, vol.57
, pp. 1413-1420
-
-
Toubaji, A.1
Achtar, M.2
Provenzano, M.3
Herrin, V.E.4
Behrens, R.5
Hamilton, M.6
-
13
-
-
34249885111
-
K-RAS oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment
-
Rejiba S, Wack S, Aprahamian M, Hajri A. K-RAS oncogene silencing strategy reduces tumor growth and enhances gemcitabine chemotherapy efficacy for pancreatic cancer treatment. Cancer Sci 2007; 98: 1128-1136.
-
(2007)
Cancer Sci
, vol.98
, pp. 1128-1136
-
-
Rejiba, S.1
Wack, S.2
Aprahamian, M.3
Hajri, A.4
-
14
-
-
34147160767
-
Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer
-
Jimeno A, Rubio-Viqueira B, Amador ML, Grunwald V, Maitra A, Iacobuzio-Donahue C, et al. Dual mitogen-activated protein kinase and epidermal growth factor receptor inhibition in biliary and pancreatic cancer. Mol Cancer Ther 2007; 6: 1079-1088.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1079-1088
-
-
Jimeno, A.1
Rubio-Viqueira, B.2
Amador, M.L.3
Grunwald, V.4
Maitra, A.5
Iacobuzio-Donahue, C.6
-
15
-
-
42749091401
-
MeK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth
-
Takayama Y, Kokuryo T, Yokoyama Y, Nagino M, Nimura Y, Senga T, et al. MeK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth. Cancer Lett 2008; 264: 241-249.
-
(2008)
Cancer Lett
, vol.264
, pp. 241-249
-
-
Takayama, Y.1
Kokuryo, T.2
Yokoyama, Y.3
Nagino, M.4
Nimura, Y.5
Senga, T.6
-
16
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW, McMahon AP. Hedgehog signaling in animal development: paradigms and principles. Genes Dev 2001; 15: 3059-3087.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
17
-
-
33645075720
-
Hedgehog signaling in pancreas development and disease
-
Lau J, Kawahira H, Hebrok M. Hedgehog signaling in pancreas development and disease. Cell Mol Life Sci 2006; 63: 642-652
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 642-652
-
-
Lau, J.1
Kawahira, H.2
Hebrok, M.3
-
18
-
-
33751209187
-
Hedgehog/RAS interactions regulate early stages of pancreatic cancer
-
Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M. Hedgehog/RAS interactions regulate early stages of pancreatic cancer. Genes Dev 2006; 20: 3161-3173.
-
(2006)
Genes Dev
, vol.20
, pp. 3161-3173
-
-
Pasca di Magliano, M.1
Sekine, S.2
Ermilov, A.3
Ferris, J.4
Dlugosz, A.A.5
Hebrok, M.6
-
19
-
-
34247646461
-
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis
-
Mongeau ME, Klimstra DS, Morris JP, Morris JP, Lee YC, Kawaguchi Y, et al. Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A 2007; 104: 5103-5108.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 5103-5108
-
-
Mongeau, M.E.1
Klimstra, D.S.2
Morris, J.P.3
Morris, J.P.4
Lee, Y.C.5
Kawaguchi, Y.6
-
20
-
-
33947254016
-
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
-
Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007; 67: 2187-2196.
-
(2007)
Cancer Res
, vol.67
, pp. 2187-2196
-
-
Feldmann, G.1
Dhara, S.2
Fendrich, V.3
Bedja, D.4
Beaty, R.5
Mullendore, M.6
-
21
-
-
34347253037
-
Oncogenic K-RAS activates hedgehog signaling pathway in pancreatic cancer cells
-
Ji Z, Mei FC, Xie J, Cheng X. Oncogenic K-RAS activates hedgehog signaling pathway in pancreatic cancer cells. J Biol Chem 2007; 282: 14048-14055.
-
(2007)
J Biol Chem
, vol.282
, pp. 14048-14055
-
-
Ji, Z.1
Mei, F.C.2
Xie, J.3
Cheng, X.4
-
22
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
Thayer SP, di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, et al. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature 2003; 425: 851-856.
-
(2003)
Nature
, vol.425
, pp. 851-856
-
-
Thayer, S.P.1
di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
-
23
-
-
0242268525
-
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
-
Berman DM, Karhadkar SS, Maitra A, Montes De Oca R, Gerstenblith MR, Briggs K, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003; 425: 846-851.
-
(2003)
Nature
, vol.425
, pp. 846-851
-
-
Berman, D.M.1
Karhadkar, S.S.2
Maitra, A.3
Montes De Oca, R.4
Gerstenblith, M.R.5
Briggs, K.6
-
24
-
-
68149124175
-
Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer
-
Xu FG, Ma QY, Wang Z. Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer. Cancer Lett 2009; 283: 119-124.
-
(2009)
Cancer Lett
, vol.283
, pp. 119-124
-
-
Xu, F.G.1
Ma, Q.Y.2
Wang, Z.3
-
25
-
-
33748469128
-
Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells
-
Shafaee Z, Schmidt H, Du W, Posner M. Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells. Cancer Chemother Pharmacol 2006; 58: 765-770.
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 765-770
-
-
Shafaee, Z.1
Schmidt, H.2
Du, W.3
Posner, M.4
-
26
-
-
33947254016
-
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
-
Feldmann G, Dhara S, Fendrich V, Bedja D, Beaty R, Mullendore M, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007; 67: 2187-2196.
-
(2007)
Cancer Res
, vol.67
, pp. 2187-2196
-
-
Feldmann, G.1
Dhara, S.2
Fendrich, V.3
Bedja, D.4
Beaty, R.5
Mullendore, M.6
-
27
-
-
34547597687
-
Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of eGFr inhibitor in pancreatic cancer cells
-
Hu WG, Liu T, Xiong JX. Blockade of sonic hedgehog signal pathway enhances antiproliferative effect of eGFr inhibitor in pancreatic cancer cells. Acta Pharmacol Sin 2007; 28: 1224-1230.
-
(2007)
Acta Pharmacol Sin
, vol.28
, pp. 1224-1230
-
-
Hu, W.G.1
Liu, T.2
Xiong, J.X.3
-
28
-
-
69249156565
-
Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer
-
Mueller MT, Hermann PC, Witthauer J, Rubio-Viqueira B, Leicht SF, Huber S, et al. Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer. Gastroenterology 2009; 137: 1102-1113.
-
(2009)
Gastroenterology
, vol.137
, pp. 1102-1113
-
-
Mueller, M.T.1
Hermann, P.C.2
Witthauer, J.3
Rubio-Viqueira, B.4
Leicht, S.F.5
Huber, S.6
-
29
-
-
0033623872
-
Disruption of TGFbeta signaling pathways in human pancreatic cancer cells
-
Simeone DM, Pham T, Logsdon CD. Disruption of TGFbeta signaling pathways in human pancreatic cancer cells. Ann Surg 2000; 232: 73-80.
-
(2000)
Ann Surg
, vol.232
, pp. 73-80
-
-
Simeone, D.M.1
Pham, T.2
Logsdon, C.D.3
-
30
-
-
0034003075
-
TIEG proteins join the SMADs as TGF-beta-regulated transcription factors that control pancreatic cell growth
-
Cook T, Urrutia R. TIEG proteins join the SMADs as TGF-beta-regulated transcription factors that control pancreatic cell growth. Am J Physiol Gastrointest Liver Physiol 2000; 278: G513-G521.
-
(2000)
Am J Physiol Gastrointest Liver Physiol
, vol.278
-
-
Cook, T.1
Urrutia, R.2
-
32
-
-
0032404111
-
Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas
-
Goggins M, Shekher M, Turnacioglu K, Yeo CJ, Hruban RH, Kern SE. Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas. Cancer Res 1998; 58: 5329-5332.
-
(1998)
Cancer Res
, vol.58
, pp. 5329-5332
-
-
Goggins, M.1
Shekher, M.2
Turnacioglu, K.3
Yeo, C.J.4
Hruban, R.H.5
Kern, S.E.6
-
33
-
-
24344483878
-
SMAD4 dependency defines two classes of transforming growth factor? (TGF-?) target genes and distinguishes TGF-?-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses
-
Levy L, Hill CS. SMAD4 dependency defines two classes of transforming growth factor? (TGF-?) target genes and distinguishes TGF-?-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol 2005; 25: 8108-8125.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 8108-8125
-
-
Levy, L.1
Hill, C.S.2
-
34
-
-
42249099019
-
LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
-
Melisi D, Ishiyama S, Sclabas GM, Fleming JB, Xia Q, Tortora G, et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Ther 2008; 7: 829-840.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 829-840
-
-
Melisi, D.1
Ishiyama, S.2
Sclabas, G.M.3
Fleming, J.B.4
Xia, Q.5
Tortora, G.6
-
35
-
-
37549048912
-
Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment
-
Medicherla S, Li L, Ma JY, Kapoun AM, Gaspar NJ, Liu YW, et al. Antitumor activity of TGF-beta inhibitor is dependent on the microenvironment. Anticancer Res 2007; 27: 4149-4157.
-
(2007)
Anticancer Res
, vol.27
, pp. 4149-4157
-
-
Medicherla, S.1
Li, L.2
Ma, J.Y.3
Kapoun, A.M.4
Gaspar, N.J.5
Liu, Y.W.6
-
36
-
-
37549027274
-
Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: A randomised, multicentre, phase II trial
-
Cascinu S, Berardi R, Labianca R, Siena S, Falcone A, Aitini E, et al. Cetuximab plus gemcitabine and cisplatin compared with gemcitabine and cisplatin alone in patients with advanced pancreatic cancer: a randomised, multicentre, phase II trial. Lancet Oncol 2008; 9: 39-44.
-
(2008)
Lancet Oncol
, vol.9
, pp. 39-44
-
-
Cascinu, S.1
Berardi, R.2
Labianca, R.3
Siena, S.4
Falcone, A.5
Aitini, E.6
-
37
-
-
33646425568
-
Aberrant wnt/beta-catenin signaling in pancreatic adenocarcinoma
-
Zeng G, Germinaro M, Micsenyi A, Monga NK, Bell A, Sood A, et al. Aberrant wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia 2006; 8: 279-289.
-
(2006)
Neoplasia
, vol.8
, pp. 279-289
-
-
Zeng, G.1
Germinaro, M.2
Micsenyi, A.3
Monga, N.K.4
Bell, A.5
Sood, A.6
-
38
-
-
42649138943
-
Common activation of canonical wnt signaling in pancreatic adenocarcinoma
-
Pasca di Magliano M, Biankin AV, Heiser PW, Cano DA, Gutierrez PJ, Deramaudt T, et al. Common activation of canonical wnt signaling in pancreatic adenocarcinoma. PLoS ONE 2007; 2: e1155.
-
(2007)
PLoS ONE
, vol.2
-
-
Pasca di Magliano, M.1
Biankin, A.V.2
Heiser, P.W.3
Cano, D.A.4
Gutierrez, P.J.5
Deramaudt, T.6
-
39
-
-
55349119506
-
Extracellular sulfatases, elements of the wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
-
Nawroth R, van Zante A, Cervantes S, McManus M, Hebrok M, Rosen SD. Extracellular sulfatases, elements of the wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS ONE 2007; 2: e392.
-
(2007)
PLoS ONE
, vol.2
-
-
Nawroth, R.1
van Zante, A.2
Cervantes, S.3
McManus, M.4
Hebrok, M.5
Rosen, S.D.6
-
40
-
-
47249108568
-
Functional blockade of SMAD4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells
-
Romero D, Iglesias M, Vary CP, Quintanilla M. Functional blockade of SMAD4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells. Carcinogenesis 2008; 29: 1070-1076.
-
(2008)
Carcinogenesis
, vol.29
, pp. 1070-1076
-
-
Romero, D.1
Iglesias, M.2
Vary, C.P.3
Quintanilla, M.4
-
41
-
-
33645473185
-
Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
-
Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006; 5: 483-493.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 483-493
-
-
Wang, Z.1
Zhang, Y.2
Li, Y.3
Banerjee, S.4
Liao, J.5
Sarkar, F.H.6
-
42
-
-
33646877856
-
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
-
Wang Z, Zhang Y, Banerjee S, Li Y, Sarkar FH. Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells. Cancer 2006; 106: 2503-2513.
-
(2006)
Cancer
, vol.106
, pp. 2503-2513
-
-
Wang, Z.1
Zhang, Y.2
Banerjee, S.3
Li, Y.4
Sarkar, F.H.5
-
43
-
-
67650919061
-
The role of Notch3 signaling pathway in pancreatic cancer
-
Dang T, Vo K, Washington K, Berlin J. The role of Notch3 signaling pathway in pancreatic cancer. J Clin Oncol 2007; 25: 21049.
-
(1049)
J Clin Oncol
, vol.25
, Issue.2
, pp. 2007
-
-
Dang, T.1
Vo, K.2
Washington, K.3
Berlin, J.4
-
44
-
-
38149142478
-
Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlateswith the expression of sTAT3 and phosphorylated Akt
-
Doucas H, Mann CD, Sutton CD, Garcea G, Neal CP, Berry DP, et al. Expression of nuclear Notch3 in pancreatic adenocarcinomas is associated with adverse clinical features, and correlateswith the expression of sTAT3 and phosphorylated Akt. J Surg Oncol 2008; 97: 63-68.
-
(2008)
J Surg Oncol
, vol.97
, pp. 63-68
-
-
Doucas, H.1
Mann, C.D.2
Sutton, C.D.3
Garcea, G.4
Neal, C.P.5
Berry, D.P.6
-
46
-
-
33645473185
-
Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
-
Wang Z, Zhang Y, Li Y, Banerjee S, Liao J, Sarkar FH. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther 2006; 5: 483-493.
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 483-493
-
-
Wang, Z.1
Zhang, Y.2
Li, Y.3
Banerjee, S.4
Liao, J.5
Sarkar, F.H.6
-
47
-
-
10744223624
-
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis
-
Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, et al. Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003; 3: 565-576.
-
(2003)
Cancer Cell
, vol.3
, pp. 565-576
-
-
Miyamoto, Y.1
Maitra, A.2
Ghosh, B.3
Zechner, U.4
Argani, P.5
Iacobuzio-Donahue, C.A.6
-
48
-
-
34547830182
-
Molecular pathogenesis of pancreatic cancer: Advances and challenges
-
Welsch T, Kleeff J, Friess H. Molecular pathogenesis of pancreatic cancer: advances and challenges. Curr Mol Med 2007; 7: 504-521.
-
(2007)
Curr Mol Med
, vol.7
, pp. 504-521
-
-
Welsch, T.1
Kleeff, J.2
Friess, H.3
-
49
-
-
30044445726
-
Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma
-
Magistrelli P, Coppola R, Tonini G, Vincenzi B, Santini D, Borzomati D, et al. Apoptotic index or a combination of Bax/Bcl-2 expression correlate with survival after resection of pancreatic adenocarcinoma. J Cell Biochem 2006; 97: 98-108.
-
(2006)
J Cell Biochem
, vol.97
, pp. 98-108
-
-
Magistrelli, P.1
Coppola, R.2
Tonini, G.3
Vincenzi, B.4
Santini, D.5
Borzomati, D.6
-
50
-
-
51149102850
-
Aberrant expression of Wnt antagonist SFRP1 in pancreatic cancer
-
Bu XM, Zhao CH, Dai XW. Aberrant expression of Wnt antagonist SFRP1 in pancreatic cancer. Chin Med J 2008; 121: 952-955.
-
(2008)
Chin Med J
, vol.121
, pp. 952-955
-
-
Bu, X.M.1
Zhao, C.H.2
Dai, X.W.3
-
51
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-1321.
-
(1998)
Science
, vol.282
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
-
52
-
-
0030702123
-
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
-
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-241.
-
(1997)
Cell
, vol.91
, pp. 231-241
-
-
Datta, S.R.1
Dudek, H.2
Tao, X.3
Masters, S.4
Fu, H.5
Gotoh, Y.6
-
53
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nuñez G. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 1997; 278: 687-689.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nuñez, G.5
-
54
-
-
0034658320
-
Protein kinase B regulates T lymphocyte survival,nuclear factor kappaB activation, and Bcl-X(L) levels in vivo
-
Jones RG, Parsons M, Bonnard M, Chan VS, Yeh WC, Woodgett JR, et al. Protein kinase B regulates T lymphocyte survival,nuclear factor kappaB activation, and Bcl-X(L) levels in vivo. J Exp Med 2000; 191: 1721-1734.
-
(2000)
J Exp Med
, vol.191
, pp. 1721-1734
-
-
Jones, R.G.1
Parsons, M.2
Bonnard, M.3
Chan, V.S.4
Yeh, W.C.5
Woodgett, J.R.6
-
55
-
-
0348049845
-
Incidence, mechanism and prognostic value of activated AKT in pancreas cancer
-
Schlieman MG, Fahy BN, Ramsamooj R, Beckett L, Bold RJ. Incidence, mechanism and prognostic value of activated AKT in pancreas cancer. Br J Cancer 2003; 89: 2110-2115.
-
(2003)
Br J Cancer
, vol.89
, pp. 2110-2115
-
-
Schlieman, M.G.1
Fahy, B.N.2
Ramsamooj, R.3
Beckett, L.4
Bold, R.J.5
-
58
-
-
34547770901
-
Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer
-
Esposito I, Kleeff J, Abiatari I, Shi X, Giese N, Bergmann F, et al. Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer. J Clin Pathol 2007; 60: 885-895.
-
(2007)
J Clin Pathol
, vol.60
, pp. 885-895
-
-
Esposito, I.1
Kleeff, J.2
Abiatari, I.3
Shi, X.4
Giese, N.5
Bergmann, F.6
-
59
-
-
34548662911
-
Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells
-
Mori T, Doi R, Kida A, Nagai K, Kami K, Ito D, et al. Effect of the XIAP inhibitor Embelin on TRAIL-induced apoptosis of pancreatic cancer cells. J Surg Res 2007; 142: 281-286.
-
(2007)
J Surg Res
, vol.142
, pp. 281-286
-
-
Mori, T.1
Doi, R.2
Kida, A.3
Nagai, K.4
Kami, K.5
Ito, D.6
-
60
-
-
35549007260
-
Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAP inhibition
-
Giagkousiklidis S, Vellanki SH, Debatin KM, Fulda S. Sensitization of pancreatic carcinoma cells for gamma-irradiation-induced apoptosis by XIAP inhibition. Oncogene 2007; 26: 7006-7016.
-
(2007)
Oncogene
, vol.26
, pp. 7006-7016
-
-
Giagkousiklidis, S.1
Vellanki, S.H.2
Debatin, K.M.3
Fulda, S.4
-
61
-
-
9644253003
-
The Pi 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-?B and c-Myc in pancreatic cancer cells
-
Asano T, Yao Y, Zhu J, Li D, Abbruzzese JL, Reddy SA. The Pi 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-?B and c-Myc in pancreatic cancer cells. Oncogene 2004; 23: 8571-8580.
-
(2004)
Oncogene
, vol.23
, pp. 8571-8580
-
-
Asano, T.1
Yao, Y.2
Zhu, J.3
Li, D.4
Abbruzzese, J.L.5
Reddy, S.A.6
-
62
-
-
0034088188
-
Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins
-
Abe N, Watanabe T, Masaki T, Mori T, Sugiyama M, Uchimura H, et al. Pancreatic duct cell carcinomas express high levels of high mobility group I(Y) proteins. Cancer Res 2000; 60: 3117-3122.
-
(2000)
Cancer Res
, vol.60
, pp. 3117-3122
-
-
Abe, N.1
Watanabe, T.2
Masaki, T.3
Mori, T.4
Sugiyama, M.5
Uchimura, H.6
-
63
-
-
40949087142
-
HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma
-
Liau SS, Whang E. HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma. Clin Cancer Res 2008; 14: 1470-1477.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1470-1477
-
-
Liau, S.S.1
Whang, E.2
-
64
-
-
33750986493
-
Lentivirus-mediated rNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma
-
Liau SS, Ashley SW, Whang EE. Lentivirus-mediated rNA interference of HMGA1 promotes chemosensitivity to gemcitabine in pancreatic adenocarcinoma. J Gastrointest Surg 2006; 10: 1254-1262.
-
(2006)
J Gastrointest Surg
, vol.10
, pp. 1254-1262
-
-
Liau, S.S.1
Ashley, S.W.2
Whang, E.E.3
-
65
-
-
4444232826
-
Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models
-
Trapasso F, Sarti M, Cesari R, Yendamuri S, Dumon KR, Aqeilan RI, et al. Therapy of human pancreatic carcinoma based on suppression of HMGA1 protein synthesis in preclinical models. Cancer Gene Ther 2004; 11: 633-641.
-
(2004)
Cancer Gene Ther
, vol.11
, pp. 633-641
-
-
Trapasso, F.1
Sarti, M.2
Cesari, R.3
Yendamuri, S.4
Dumon, K.R.5
Aqeilan, R.I.6
-
66
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, et al. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 1994; 8: 27-32.
-
(1994)
Nat Genet
, vol.8
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
da Costa, L.T.3
Redston, M.S.4
Schutte, M.5
Seymour, A.B.6
-
67
-
-
0029612231
-
A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites
-
Sellers WR, Rodgers JW, Kaelin WG Jr. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc Natl Acad Sci U S A 1995; 92: 11544-11548.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 11544-11548
-
-
Sellers, W.R.1
Rodgers, J.W.2
Kaelin Jr., W.G.3
-
68
-
-
36248962105
-
The genomic landscapes of human breast and colorectal cancers
-
Wood LD, Parsons DW, Jones S, Lin J, Sjöblom T, Leary RJ, et al. The genomic landscapes of human breast and colorectal cancers. Science 2007; 318: 1108-1113.
-
(2007)
Science
, vol.318
, pp. 1108-1113
-
-
Wood, L.D.1
Parsons, D.W.2
Jones, S.3
Lin, J.4
Sjöblom, T.5
Leary, R.J.6
-
69
-
-
34548388340
-
A multidimensional analysis of genes mutated in breast and colorectal cancers
-
Lin J, Gan CM, Zhang X, Jones S, Sjöblom T, Wood LD, et al. A multidimensional analysis of genes mutated in breast and colorectal cancers. Genome Res 2007; 17: 1304-1318.
-
(2007)
Genome Res
, vol.17
, pp. 1304-1318
-
-
Lin, J.1
Gan, C.M.2
Zhang, X.3
Jones, S.4
Sjöblom, T.5
Wood, L.D.6
-
70
-
-
57049128193
-
Design and analysis issues in genome-wide somatic mutation studies of cancer
-
Parmigiani G, Boca S, Lin J, Kinzler KW, Velculescu V, Vogelstein B. Design and analysis issues in genome-wide somatic mutation studies of cancer. Genomics 2009; 93: 17-21.
-
(2009)
Genomics
, vol.93
, pp. 17-21
-
-
Parmigiani, G.1
Boca, S.2
Lin, J.3
Kinzler, K.W.4
Velculescu, V.5
Vogelstein, B.6
|