The role of Smad signaling in vascular and hematopoietic development revealed by studies using genetic mouse models

Science China Life Sciences

Volumn 53, Issue 4, 2010, Pages 485-489

  Lan, Yu ^a   Yang, Xiao ^a  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

Author keywords

Angiogenesis; Bone morphogenetic protein (BMP); Development; Hematopoiesis; Knock out; Smad; Transforming growth factor (TGF )

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; PROTEIN SERINE THREONINE KINASE; SMAD PROTEIN; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANGIOGENESIS; ANIMAL; ANIMAL MODEL; CELL DIFFERENTIATION; COMPARATIVE STUDY; DRUG EFFECT; GENETICS; HEMATOPOIESIS; MESODERM; METABOLISM; MOUSE; MOUSE MUTANT; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; BONE MORPHOGENETIC PROTEIN 4; CELL DIFFERENTIATION; HEMATOPOIESIS; MESODERM; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, ANIMAL; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA;

EID: 77952309691     PISSN: 16747305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11427-010-0087-3     Document Type: Review

References (45)

1. Ten Dijke P, Hill C S. New insights into TGF-beta-Smad signalling. Trends Biochem Sci, 2004, 29: 265-273.
2. Derynck R, Zhang Y E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature, 2003, 425: 577-584.
3. Bobik A. Transforming growth factor-betas and vascular disorders. Arterioscler Thromb Vasc Biol, 2006, 26: 1712-1720.
4. Kim S J, Letterio J. Transforming growth factor-beta signaling in normal and malignant hematopoiesis. Leukemia, 2003, 17: 1731-1737.
5. Goumans M J, Valdimarsdottir G, Itoh S, et al. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. Embo J, 2002, 21: 1743-1753.
6. Lebrin F, Deckers M, Bertolino P, et al. TGF-beta receptor function in the endothelium. Cardiovasc Res, 2005, 65: 599-608.
7. Armulik A, Abramsson A, Betsholtz C. Endothelial/pericyte interactions. Circ Res, 2005, 97: 512-523.
8. Larsson J, Goumans M J, Sjostrand L J, et al. Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. Embo J, 2001, 20: 1663-1673.
9. Oh S P, Seki T, Goss K A, et al. Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis. Proc Natl Acad Sci USA, 2000, 97: 2626-2631.
10. Yang X, Castilla L H, Xu X, et al. Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development, 1999, 126: 1571-1580.
11. Li D Y, Sorensen L K, Brooke B S, et al. Defective angiogenesis in mice lacking endoglin. Science, 1999, 284: 1534-1537.
12. Oshima M, Oshima H, Taketo M M. TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol, 1996, 179: 297-302.
13. Dickson M C, Martin J S, Cousins F M, et al. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development, 1995, 121: 1845-1854.
14. Wu X, Ma J, Han J D, et al. Distinct regulation of gene expression in human endothelial cells by TGF-beta and its receptors. Microvasc Res, 2006, 71: 12-19.
15. Ota T, Fujii M, Sugizaki T, et al. Targets of transcriptional regulation by two distinct type I receptors for transforming growth factor-beta in human umbilical vein endothelial cells. J Cell Physiol, 2002, 193: 299-318.
16. Ishimura A, Ng J K, Taira M, et al. Man1, an inner nuclear membrane protein, regulates vascular remodeling by modulating transforming growth factor beta signaling. Development, 2006, 133: 3919-3928.
17. Yang X, Li C, Xu X, et al. The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice. Proc Natl Acad Sci USA, 1998, 95: 3667-3672.
18. Mishina Y, Suzuki A, Ueno N, et al. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis. Genes Dev, 1995, 9: 3027-3037.
19. Lan Y, Liu B, Yao H, et al. Essential role of endothelial Smad4 in vascular remodeling and integrity. Mol Cell Biol, 2007, 27: 7683-7692.
20. Park C, Lavine K, Mishina Y, et al. Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation. Development, 2006, 133: 3473-3484.
21. Umans L, Cox L, Tjwa M, et al. Inactivation of Smad5 in endothelial cells and smooth muscle cells demonstrates that Smad5 is required for cardiac homeostasis. Am J Pathol, 2007, 170: 1460-1472.
22. Arnold S J, Maretto S, Islam A, et al. Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol, 2006, 296: 104-118.
23. Bosman E A, Lawson K A, Debruyn J, et al. Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels. Development, 2006, 133: 3399-3409.
24. Carvalho R L, Jonker L, Goumans M J, et al. Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia. Development, 2004, 131: 6237-6247.
25. Park S O, Lee Y J, Seki T, et al. ALK5- and TGFBR2-independent role of ALK1 in the pathogenesis of hereditary hemorrhagic telangiectasia type 2. Blood, 2008, 111: 633-642.
26. Song L, Fassler R, Mishina Y, et al. Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts. Dev Biol, 2007, 301: 276-286.
27. Meng F, Shi L, Cheng X, et al. Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice. Matrix Biol, 2007, 26: 54-57.
28. Godin I, Cumano A. The hare and the tortoise: an embryonic haematopoietic race. Nat Rev Immunol, 2002, 2: 593-604.
29. Yokomizo T, Takahashi S, Mochizuki N, et al. Characterization of GATA-1(+) hemangioblastic cells in the mouse embryo. Embo J, 2007, 26: 184-196.
30. Huber T L, Kouskoff V, Fehling H J, et al. Haemangioblast commitment is initiated in the primitive streak of the mouse embryo. Nature, 2004, 432: 625-630.
31. Kennedy M, Firpo M, Choi K, et al. A common precursor for primitive erythropoiesis and definitive haematopoiesis. Nature, 1997, 386: 488-493.
32. Sugiyama D, Tsuji K. Definitive hematopoiesis from endothelial cells in the mouse embryo; a simple guide. Trends Cardiovasc Med, 2006, 16: 45-49.
33. Liu B, Sun Y, Jiang F, et al. Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis. Blood, 2003, 101: 124-133.
34. Larsson J, Karlsson S. The role of Smad signaling in hematopoiesis. Oncogene, 2005, 24: 5676-5692.
35. Blank U, Karlsson G, Karlsson S. Signaling pathways governing stem-cell fate. Blood, 2008, 111: 492-503.
36. Larsson J, Blank U, Helgadottir H, et al. TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro. Blood, 2003, 102: 3129-3135.
37. Singbrant S, Moody J L, Blank U, et al. Smad5 is dispensable for adult murine hematopoiesis. Blood, 2006, 108: 3707-3712.
38. Blank U, Karlsson G, Moody J L, et al. Smad7 promotes self-renewal of hematopoietic stem cells. Blood, 2006, 108: 4246-4254.
39. Karlsson G, Blank U, Moody J L, et al. Smad4 is critical for self-renewal of hematopoietic stem cells. J Exp Med, 2007, 204: 467-474.
40. Soderberg S S, Karlsson G, Karlsson S. Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling. Ann N Y Acad Sci, 2009, 1176: 55-69.
41. He W, Dorn D C, Erdjument-Bromage H, et al. Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. Cell, 2006, 125: 929-941.
42. Zovein A C, Hofmann J J, Lynch M, et al. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell, 2008, 3: 625-636.
43. Eilken H M, Nishikawa S, Schroeder T. Continuous single-cell imaging of blood generation from haemogenic endothelium. Nature, 2009, 457: 896-900.
44. Lancrin C, Sroczynska P, Stephenson C, et al. The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature, 2009, 457: 892-895.
45. Chen M J, Yokomizo T, Zeigler B M, et al. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature, 2009, 457: 887-891.