메뉴 건너뛰기




Volumn 8, Issue , 2010, Pages

The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; ACTIVATING TRANSCRIPTION FACTOR 4; AMIFOSTINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LENTIVIRUS VECTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN ELF 2ALPHA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 2; ANGIOGENESIS MODULATOR; SCAVENGER; VEGFA PROTEIN, HUMAN;

EID: 77952283596     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/1741-7015-8-19     Document Type: Article
Times cited : (18)

References (57)
  • 1
    • 0001429612 scopus 로고    scopus 로고
    • News and products notes
    • News and products notes. Formulary 1996, 31:152.
    • (1996) Formulary , vol.31 , pp. 152
  • 2
    • 0028127149 scopus 로고
    • Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse
    • Shaw LM, Bonner HS, Brown DQ. Metabolic pathways of WR-2721 (ethyol, amifostine) in the BALB/c mouse. Drug Metab Dispos 1994, 22:895-902.
    • (1994) Drug Metab Dispos , vol.22 , pp. 895-902
    • Shaw, L.M.1    Bonner, H.S.2    Brown, D.Q.3
  • 3
    • 0021914053 scopus 로고
    • Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721
    • 10.1080/09553008514550041, 2982751
    • Calabro-Jones PM, Fahey RC, Smoluk GD, Ward JF. Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721. Int J Radiat Biol Relat Stud Phys Chem Med 1985, 47:23-27. 10.1080/09553008514550041, 2982751.
    • (1985) Int J Radiat Biol Relat Stud Phys Chem Med , vol.47 , pp. 23-27
    • Calabro-Jones, P.M.1    Fahey, R.C.2    Smoluk, G.D.3    Ward, J.F.4
  • 4
    • 0036245127 scopus 로고    scopus 로고
    • Amifostine in clinical oncology: current use and future applications
    • 10.1097/00001813-200203000-00001, 11984063
    • Koukourakis MI. Amifostine in clinical oncology: current use and future applications. Anticancer Drugs 2002, 13:181-209. 10.1097/00001813-200203000-00001, 11984063.
    • (2002) Anticancer Drugs , vol.13 , pp. 181-209
    • Koukourakis, M.I.1
  • 5
    • 0023793476 scopus 로고
    • Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection
    • Smoluk GD, Fahey RC, Calabro-Jones PM, Aguilera JA, Ward JF. Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection. Cancer Res 1988, 48:3641-3647.
    • (1988) Cancer Res , vol.48 , pp. 3641-3647
    • Smoluk, G.D.1    Fahey, R.C.2    Calabro-Jones, P.M.3    Aguilera, J.A.4    Ward, J.F.5
  • 6
    • 1642558247 scopus 로고    scopus 로고
    • Amifostine: is there evidence of tumor protection?
    • 10.1053/j.seminoncol.2003.11.014, 14727237
    • Koukourakis MI. Amifostine: is there evidence of tumor protection?. Semin Oncol 2003, 30:18-30. 10.1053/j.seminoncol.2003.11.014, 14727237.
    • (2003) Semin Oncol , vol.30 , pp. 18-30
    • Koukourakis, M.I.1
  • 7
    • 0033762373 scopus 로고    scopus 로고
    • Amifostine: a tonic or toxin to myeloid progenitors
    • 10.1016/S0145-2126(00)00081-3, 11077114
    • List AF, Gerner EW. Amifostine: a tonic or toxin to myeloid progenitors. Leuk Res 2000, 24:1009-1011. 10.1016/S0145-2126(00)00081-3, 11077114.
    • (2000) Leuk Res , vol.24 , pp. 1009-1011
    • List, A.F.1    Gerner, E.W.2
  • 8
    • 0018839016 scopus 로고
    • Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid
    • Yuhas JM. Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid. Cancer Res 1980, 40:1519-1524.
    • (1980) Cancer Res , vol.40 , pp. 1519-1524
    • Yuhas, J.M.1
  • 9
    • 0037430041 scopus 로고    scopus 로고
    • P53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection
    • 10.1038/sj.bjc.6600779, 2376343, 12618886
    • Lee EJ, Gerhold M, Palmer MW, Christen RD. p53 protein regulates the effects of amifostine on apoptosis, cell cycle progression, and cytoprotection. Br J Cancer 2003, 88:754-759. 10.1038/sj.bjc.6600779, 2376343, 12618886.
    • (2003) Br J Cancer , vol.88 , pp. 754-759
    • Lee, E.J.1    Gerhold, M.2    Palmer, M.W.3    Christen, R.D.4
  • 10
    • 0034708220 scopus 로고    scopus 로고
    • The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway
    • 10.1038/sj.onc.1203413, 10713709
    • North S, El-Ghissassi F, Pluquet O, Verhaegh G, Hainaut P. The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway. Oncogene 2000, 19:1206-1214. 10.1038/sj.onc.1203413, 10713709.
    • (2000) Oncogene , vol.19 , pp. 1206-1214
    • North, S.1    El-Ghissassi, F.2    Pluquet, O.3    Verhaegh, G.4    Hainaut, P.5
  • 11
    • 0012549224 scopus 로고    scopus 로고
    • The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase
    • 10.1074/jbc.M207396200, 12531896
    • Pluquet O, North S, Bhoumik A, Dimas K, Ronai Z, Hainaut P. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem 2003, 278:11879-11887. 10.1074/jbc.M207396200, 12531896.
    • (2003) J Biol Chem , vol.278 , pp. 11879-11887
    • Pluquet, O.1    North, S.2    Bhoumik, A.3    Dimas, K.4    Ronai, Z.5    Hainaut, P.6
  • 12
    • 0037378392 scopus 로고    scopus 로고
    • Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity
    • 10.1016/S0006-2952(02)01655-6, 12663048
    • Pluquet O, North S, Richard MJ, Hainaut P. Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity. Biochem Pharmacol 2003, 65:1129-1137. 10.1016/S0006-2952(02)01655-6, 12663048.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1129-1137
    • Pluquet, O.1    North, S.2    Richard, M.J.3    Hainaut, P.4
  • 14
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • 10.1038/nrc1187, 13130303
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003, 3:721-732. 10.1038/nrc1187, 13130303.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 15
    • 0031039243 scopus 로고    scopus 로고
    • The biology of vascular endothelial growth factor
    • 10.1210/er.18.1.4, 9034784
    • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997, 18:4-25. 10.1210/er.18.1.4, 9034784.
    • (1997) Endocr Rev , vol.18 , pp. 4-25
    • Ferrara, N.1    Davis-Smyth, T.2
  • 16
    • 33947370773 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) signaling in tumor progression
    • 10.1016/j.critrevonc.2007.01.006, 17324579
    • Roskoski R. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit Rev Oncol Hematol 2007, 62:179-213. 10.1016/j.critrevonc.2007.01.006, 17324579.
    • (2007) Crit Rev Oncol Hematol , vol.62 , pp. 179-213
    • Roskoski, R.1
  • 17
    • 33646107369 scopus 로고    scopus 로고
    • VEGF receptor signalling - in control of vascular function
    • 10.1038/nrm1911, 16633338
    • Olsson AK, Dimberg A, Kreuger J, Claesson-Welsh L. VEGF receptor signalling - in control of vascular function. Nat Rev Mol Cell Biol 2006, 7:359-371. 10.1038/nrm1911, 16633338.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 359-371
    • Olsson, A.K.1    Dimberg, A.2    Kreuger, J.3    Claesson-Welsh, L.4
  • 19
    • 0033562569 scopus 로고    scopus 로고
    • Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    • 10.1006/dbio.1999.9253, 10328919
    • Kotch LE, Iyer NV, Laughner E, Semenza GL. Defective vascularization of HIF-1alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 1999, 209:254-267. 10.1006/dbio.1999.9253, 10328919.
    • (1999) Dev Biol , vol.209 , pp. 254-267
    • Kotch, L.E.1    Iyer, N.V.2    Laughner, E.3    Semenza, G.L.4
  • 20
    • 15444362131 scopus 로고    scopus 로고
    • Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma
    • 10.1074/jbc.M412994200, 15640157
    • Yun H, Lee M, Kim SS, Ha J. Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. J Biol Chem 2005, 280:9963-9972. 10.1074/jbc.M412994200, 15640157.
    • (2005) J Biol Chem , vol.280 , pp. 9963-9972
    • Yun, H.1    Lee, M.2    Kim, S.S.3    Ha, J.4
  • 21
    • 34547114745 scopus 로고    scopus 로고
    • IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo
    • 10.1158/0008-5472.CAN-06-3235, 17638880
    • Drogat B, Auguste P, Nguyen DT, Bouchecareilh M, Pineau R, Nalbantoglu J, Kaufman RJ, Chevet E, Bikfalvi A, Moenner M. IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. Cancer Res 2007, 67:6700-6707. 10.1158/0008-5472.CAN-06-3235, 17638880.
    • (2007) Cancer Res , vol.67 , pp. 6700-6707
    • Drogat, B.1    Auguste, P.2    Nguyen, D.T.3    Bouchecareilh, M.4    Pineau, R.5    Nalbantoglu, J.6    Kaufman, R.J.7    Chevet, E.8    Bikfalvi, A.9    Moenner, M.10
  • 22
    • 34347389910 scopus 로고    scopus 로고
    • Acute L-glutamine deprivation compromises VEGF-a upregulation in A549/8 human carcinoma cells
    • 10.1002/jcp.21044, 17348020
    • Drogat B, Bouchecareilh M, North S, Petibois C, Deleris G, Chevet E, Bikfalvi A, Moenner M. Acute L-glutamine deprivation compromises VEGF-a upregulation in A549/8 human carcinoma cells. J Cell Physiol 2007, 212:463-472. 10.1002/jcp.21044, 17348020.
    • (2007) J Cell Physiol , vol.212 , pp. 463-472
    • Drogat, B.1    Bouchecareilh, M.2    North, S.3    Petibois, C.4    Deleris, G.5    Chevet, E.6    Bikfalvi, A.7    Moenner, M.8
  • 23
    • 34247137486 scopus 로고    scopus 로고
    • Activation of the unfolded protein response and alternative splicing of ATF6alpha in HLA-B27 positive lymphocytes
    • 10.1016/j.febslet.2007.03.069, 17442311
    • Lemin AJ, Saleki K, van Lith M, Benham AM. Activation of the unfolded protein response and alternative splicing of ATF6alpha in HLA-B27 positive lymphocytes. FEBS Lett 2007, 581:1819-1824. 10.1016/j.febslet.2007.03.069, 17442311.
    • (2007) FEBS Lett , vol.581 , pp. 1819-1824
    • Lemin, A.J.1    Saleki, K.2    van Lith, M.3    Benham, A.M.4
  • 24
    • 2442572249 scopus 로고    scopus 로고
    • Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4
    • 10.1074/jbc.M312948200, 14747470
    • Roybal CN, Yang S, Sun CW, Hurtado D, Vander Jagt DL, Townes TM, Abcouwer SF. Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem 2004, 279:14844-14852. 10.1074/jbc.M312948200, 14747470.
    • (2004) J Biol Chem , vol.279 , pp. 14844-14852
    • Roybal, C.N.1    Yang, S.2    Sun, C.W.3    Hurtado, D.4    Vander Jagt, D.L.5    Townes, T.M.6    Abcouwer, S.F.7
  • 25
    • 0035929641 scopus 로고    scopus 로고
    • Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response
    • 10.1074/jbc.M100747200, 11447214
    • Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S. Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem 2001, 276:35867-35874. 10.1074/jbc.M100747200, 11447214.
    • (2001) J Biol Chem , vol.276 , pp. 35867-35874
    • Zhang, C.1    Cai, Y.2    Adachi, M.T.3    Oshiro, S.4    Aso, T.5    Kaufman, R.J.6    Kitajima, S.7
  • 26
    • 0036479214 scopus 로고    scopus 로고
    • Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR
    • 10.1074/jbc.M107711200, 11719508
    • Colavitti R, Pani G, Bedogni B, Anzevino R, Borrello S, Waltenberger J, Galeotti T. Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. J Biol Chem 2002, 277:3101-3108. 10.1074/jbc.M107711200, 11719508.
    • (2002) J Biol Chem , vol.277 , pp. 3101-3108
    • Colavitti, R.1    Pani, G.2    Bedogni, B.3    Anzevino, R.4    Borrello, S.5    Waltenberger, J.6    Galeotti, T.7
  • 27
    • 36849080211 scopus 로고    scopus 로고
    • NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways
    • 10.1074/jbc.M702175200, 17908694
    • Abid MR, Spokes KC, Shih SC, Aird WC. NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways. J Biol Chem 2007, 282:35373-35385. 10.1074/jbc.M702175200, 17908694.
    • (2007) J Biol Chem , vol.282 , pp. 35373-35385
    • Abid, M.R.1    Spokes, K.C.2    Shih, S.C.3    Aird, W.C.4
  • 28
    • 0028963971 scopus 로고
    • Cells transfected with the basic fibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the brain
    • 10.1097/00006123-199504000-00020, 7596510
    • Gately S, Tsanaclis AM, Takano S, Klagsbrun M, Brem S. Cells transfected with the basic fibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the brain. Neurosurgery 1995, 36:780-788. 10.1097/00006123-199504000-00020, 7596510.
    • (1995) Neurosurgery , vol.36 , pp. 780-788
    • Gately, S.1    Tsanaclis, A.M.2    Takano, S.3    Klagsbrun, M.4    Brem, S.5
  • 30
    • 0033605663 scopus 로고    scopus 로고
    • Angiostatin formation involves disulfide bond reduction and proteolysis in kringle 5 of plasmin
    • 10.1074/jbc.274.13.8910, 10085135
    • Stathakis P, Lay AJ, Fitzgerald M, Schlieker C, Matthias LJ, Hogg PJ. Angiostatin formation involves disulfide bond reduction and proteolysis in kringle 5 of plasmin. J Biol Chem 1999, 274:8910-8916. 10.1074/jbc.274.13.8910, 10085135.
    • (1999) J Biol Chem , vol.274 , pp. 8910-8916
    • Stathakis, P.1    Lay, A.J.2    Fitzgerald, M.3    Schlieker, C.4    Matthias, L.J.5    Hogg, P.J.6
  • 31
    • 36348938884 scopus 로고    scopus 로고
    • Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor
    • 10.1158/0008-5472.CAN-07-0783, 18006827
    • Xia C, Meng Q, Liu LZ, Rojanasakul Y, Wang XR, Jiang BH. Reactive oxygen species regulate angiogenesis and tumor growth through vascular endothelial growth factor. Cancer Res 2007, 67:10823-10830. 10.1158/0008-5472.CAN-07-0783, 18006827.
    • (2007) Cancer Res , vol.67 , pp. 10823-10830
    • Xia, C.1    Meng, Q.2    Liu, L.Z.3    Rojanasakul, Y.4    Wang, X.R.5    Jiang, B.H.6
  • 33
    • 0032778496 scopus 로고    scopus 로고
    • Microvessel density and endothelial cell proliferation after amifostine (Ethyol) administration in vivo
    • Plasswilm L, Hanjalic A, Hoeper J, Cordes N, Tannapfel A. Microvessel density and endothelial cell proliferation after amifostine (Ethyol) administration in vivo. Anticancer Res 1999, 19:4241-4245.
    • (1999) Anticancer Res , vol.19 , pp. 4241-4245
    • Plasswilm, L.1    Hanjalic, A.2    Hoeper, J.3    Cordes, N.4    Tannapfel, A.5
  • 34
    • 0142180042 scopus 로고    scopus 로고
    • Amifostine has antiangiogenic properties in vitro by changing the redox status of human endothelial cells
    • 10.1080/10715760310001612559, 14703731
    • Giannopoulou E, Papadimitriou E. Amifostine has antiangiogenic properties in vitro by changing the redox status of human endothelial cells. Free Radic Res 2003, 37:1191-1199. 10.1080/10715760310001612559, 14703731.
    • (2003) Free Radic Res , vol.37 , pp. 1191-1199
    • Giannopoulou, E.1    Papadimitriou, E.2
  • 36
    • 0036987577 scopus 로고    scopus 로고
    • Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice
    • 10.1053/sonc.2002.37357, 12577239
    • Grdina DJ, Kataoka Y, Murley JS, Swedberg K, Lee JY, Hunter N, Weichselbaum RR, Milas L. Antimetastatic effectiveness of amifostine therapy following surgical removal of Sa-NH tumors in mice. Semin Oncol 2002, 29:22-28. 10.1053/sonc.2002.37357, 12577239.
    • (2002) Semin Oncol , vol.29 , pp. 22-28
    • Grdina, D.J.1    Kataoka, Y.2    Murley, J.S.3    Swedberg, K.4    Lee, J.Y.5    Hunter, N.6    Weichselbaum, R.R.7    Milas, L.8
  • 37
    • 33847109008 scopus 로고    scopus 로고
    • Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells
    • 10.1124/mol.106.027698, 17167033
    • Namba T, Hoshino T, Tanaka K, Tsutsumi S, Ishihara T, Mima S, Suzuki K, Ogawa S, Mizushima T. Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells. Mol Pharmacol 2007, 71:860-870. 10.1124/mol.106.027698, 17167033.
    • (2007) Mol Pharmacol , vol.71 , pp. 860-870
    • Namba, T.1    Hoshino, T.2    Tanaka, K.3    Tsutsumi, S.4    Ishihara, T.5    Mima, S.6    Suzuki, K.7    Ogawa, S.8    Mizushima, T.9
  • 38
    • 0029129978 scopus 로고
    • Degradation of 2-(3-aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of Chinese hamster ovary cells
    • 10.1016/0006-2952(95)00164-U, 7646554
    • Meier T, Issels RD. Degradation of 2-(3-aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of Chinese hamster ovary cells. Biochem Pharmacol 1995, 50:489-496. 10.1016/0006-2952(95)00164-U, 7646554.
    • (1995) Biochem Pharmacol , vol.50 , pp. 489-496
    • Meier, T.1    Issels, R.D.2
  • 40
    • 18144388714 scopus 로고    scopus 로고
    • Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR
    • 10.1016/j.febslet.2005.03.077, 15862298
    • Averous J, Maurin AC, Bruhat A, Jousse C, Arliguie C, Fafournoux P. Induction of IGFBP-1 expression by amino acid deprivation of HepG2 human hepatoma cells involves both a transcriptional activation and an mRNA stabilization due to its 3'UTR. FEBS Lett 2005, 579:2609-2614. 10.1016/j.febslet.2005.03.077, 15862298.
    • (2005) FEBS Lett , vol.579 , pp. 2609-2614
    • Averous, J.1    Maurin, A.C.2    Bruhat, A.3    Jousse, C.4    Arliguie, C.5    Fafournoux, P.6
  • 41
    • 0024077722 scopus 로고
    • Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis
    • 10.1083/jcb.107.3.1199, 2115297, 3417781
    • Sato Y, Rifkin DB. Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis. J Cell Biol 1988, 107:1199-1205. 10.1083/jcb.107.3.1199, 2115297, 3417781.
    • (1988) J Cell Biol , vol.107 , pp. 1199-1205
    • Sato, Y.1    Rifkin, D.B.2
  • 42
    • 9244228026 scopus 로고    scopus 로고
    • Tissue levels of WR-1065, the active metabolite of amifostine (Ethyol), are equivalent following intravenous or subcutaneous administration in cynomolgus monkeys
    • 10.1159/000081316, 15557777
    • Bachy CM, Fazenbaker CA, Kifle G, McCarthy MP, Cassatt DR. Tissue levels of WR-1065, the active metabolite of amifostine (Ethyol), are equivalent following intravenous or subcutaneous administration in cynomolgus monkeys. Oncology 2004, 67:187-193. 10.1159/000081316, 15557777.
    • (2004) Oncology , vol.67 , pp. 187-193
    • Bachy, C.M.1    Fazenbaker, C.A.2    Kifle, G.3    McCarthy, M.P.4    Cassatt, D.R.5
  • 44
    • 0142059951 scopus 로고    scopus 로고
    • XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
    • 10.1128/MCB.23.21.7448-7459.2003, 207643, 14559994
    • Lee AH, Iwakoshi NN, Glimcher LH. XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 2003, 23:7448-7459. 10.1128/MCB.23.21.7448-7459.2003, 207643, 14559994.
    • (2003) Mol Cell Biol , vol.23 , pp. 7448-7459
    • Lee, A.H.1    Iwakoshi, N.N.2    Glimcher, L.H.3
  • 45
    • 0035966269 scopus 로고    scopus 로고
    • XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
    • 10.1016/S0092-8674(01)00611-0, 11779464
    • Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K. XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 2001, 107:881-891. 10.1016/S0092-8674(01)00611-0, 11779464.
    • (2001) Cell , vol.107 , pp. 881-891
    • Yoshida, H.1    Matsui, T.2    Yamamoto, A.3    Okada, T.4    Mori, K.5
  • 47
    • 0035947778 scopus 로고    scopus 로고
    • Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    • 10.1083/jcb.153.5.1011, 2174339, 11381086
    • Novoa I, Zeng H, Harding HP, Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol 2001, 153:1011-1022. 10.1083/jcb.153.5.1011, 2174339, 11381086.
    • (2001) J Cell Biol , vol.153 , pp. 1011-1022
    • Novoa, I.1    Zeng, H.2    Harding, H.P.3    Ron, D.4
  • 48
    • 0034714265 scopus 로고    scopus 로고
    • Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability
    • 10.1074/jbc.M002104200, 10849421
    • Pages G, Berra E, Milanini J, Levy AP, Pouyssegur J. Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability. J Biol Chem 2000, 275:26484-26491. 10.1074/jbc.M002104200, 10849421.
    • (2000) J Biol Chem , vol.275 , pp. 26484-26491
    • Pages, G.1    Berra, E.2    Milanini, J.3    Levy, A.P.4    Pouyssegur, J.5
  • 49
    • 34547673869 scopus 로고    scopus 로고
    • Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells
    • Yoshino Y, Aoyagi M, Tamaki M, Duan L, Morimoto T, Ohno K. Activation of p38 MAPK and/or JNK contributes to increased levels of VEGF secretion in human malignant glioma cells. Int J Oncol 2006, 29:981-987.
    • (2006) Int J Oncol , vol.29 , pp. 981-987
    • Yoshino, Y.1    Aoyagi, M.2    Tamaki, M.3    Duan, L.4    Morimoto, T.5    Ohno, K.6
  • 50
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • 10.1126/science.287.5453.664, 10650002
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000, 287:664-666. 10.1126/science.287.5453.664, 10650002.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 52
    • 0036191959 scopus 로고    scopus 로고
    • Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1
    • 10.1002/mc.10038, 11870884
    • North S, Pluquet O, Maurici D, El-Ghissassi F, Hainaut P. Restoration of wild-type conformation and activity of a temperature-sensitive mutant of p53 (p53(V272M)) by the cytoprotective aminothiol WR1065 in the esophageal cancer cell line TE-1. Mol Carcinog 2002, 33:181-188. 10.1002/mc.10038, 11870884.
    • (2002) Mol Carcinog , vol.33 , pp. 181-188
    • North, S.1    Pluquet, O.2    Maurici, D.3    El-Ghissassi, F.4    Hainaut, P.5
  • 53
    • 0035874637 scopus 로고    scopus 로고
    • Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells
    • 10.1016/S0891-5849(01)00554-8, 11390188
    • Murley JS, Kataoka Y, Hallahan DE, Roberts JC, Grdina DJ. Activation of NFkappaB and MnSOD gene expression by free radical scavengers in human microvascular endothelial cells. Free Radic Biol Med 2001, 30:1426-1439. 10.1016/S0891-5849(01)00554-8, 11390188.
    • (2001) Free Radic Biol Med , vol.30 , pp. 1426-1439
    • Murley, J.S.1    Kataoka, Y.2    Hallahan, D.E.3    Roberts, J.C.4    Grdina, D.J.5
  • 54
    • 0028606469 scopus 로고
    • Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations
    • Potgens AJ, Lubsen NH, van Altena MC, Vermeulen R, Bakker A, Schoenmakers JG, Ruiter DJ, de Waal RM. Covalent dimerization of vascular permeability factor/vascular endothelial growth factor is essential for its biological activity. Evidence from Cys to Ser mutations. J Biol Chem 1994, 269:32879-32885.
    • (1994) J Biol Chem , vol.269 , pp. 32879-32885
    • Potgens, A.J.1    Lubsen, N.H.2    van Altena, M.C.3    Vermeulen, R.4    Bakker, A.5    Schoenmakers, J.G.6    Ruiter, D.J.7    de Waal, R.M.8
  • 55
    • 34247102347 scopus 로고    scopus 로고
    • VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing
    • 10.1016/j.yexcr.2007.02.020, 17382929
    • Santos SC, Miguel C, Domingues I, Calado A, Zhu Z, Wu Y, Dias S. VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing. Exp Cell Res 2007, 313:1561-1574. 10.1016/j.yexcr.2007.02.020, 17382929.
    • (2007) Exp Cell Res , vol.313 , pp. 1561-1574
    • Santos, S.C.1    Miguel, C.2    Domingues, I.3    Calado, A.4    Zhu, Z.5    Wu, Y.6    Dias, S.7
  • 56
    • 61849162824 scopus 로고    scopus 로고
    • P38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047
    • 10.1016/j.canlet.2008.11.034, 19138820
    • Adachi S, Natsume H, Yamauchi J, Matsushima-Nishiwaki R, Joe AK, Moriwaki H, Kozawa O. p38 MAP kinase controls EGF receptor downregulation via phosphorylation at Ser1046/1047. Cancer Lett 2009, 277:108-113. 10.1016/j.canlet.2008.11.034, 19138820.
    • (2009) Cancer Lett , vol.277 , pp. 108-113
    • Adachi, S.1    Natsume, H.2    Yamauchi, J.3    Matsushima-Nishiwaki, R.4    Joe, A.K.5    Moriwaki, H.6    Kozawa, O.7
  • 57
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • 10.1126/science.1104819, 15637262
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307:58-62. 10.1126/science.1104819, 15637262.
    • (2005) Science , vol.307 , pp. 58-62
    • Jain, R.K.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.