Amifostine: A tonic or toxin to myeloid progenitors

Leukemia Research

Volumn 24, Issue 12, 2000, Pages 1009-1011

  List, Alan F ^a   Gerner, Eugene W ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; AMIFOSTINE; BIS[2 (3 AMINOPROPYLAMINO)ETHYL] DISULFIDE; POLYAMINE; TRANSCRIPTION FACTOR GATA 1;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER INHIBITION; CELL DEATH; DRUG TRANSFORMATION; HUMAN; LEUKEMIA; MYELODYSPLASTIC SYNDROME; NOTE; OXIDATIVE STRESS; POLYAMINE METABOLISM; PRIORITY JOURNAL;

AMIFOSTINE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL SURVIVAL; HUMANS; LEUKEMIA, MYELOID; MERCAPTOETHYLAMINES; MYELOID PROGENITOR CELLS; RADIATION-PROTECTIVE AGENTS;

EID: 0033762373     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0145-2126(00)00081-3     Document Type: Note

References (37)

1. Amifostine stimulates the formation of multipotent and erythroid hematopoietic progenitors
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3. Human pharmacokinetics of WR-2721
4. Uptake of WR-2721 derivatives by cells in culture: Identification of the transported form of the drug
5. Differential protection against cytotoxic chemotherapeutic effects on bone marrow CFUs by Wr-2721
6. Protection and potentiation of nitrogen mustard cytotoxicity by WR-2721
7. Amifostine (WR-2721) shortens the engraftment period of 4-hydroperoxycyclophosphamide-purged bone marrow in breast cancer patients receiving high-dose chemotherapy with autologous bone marrow support
8. Amifostine protects primitive hematopoietic progenitors against chemotherapy cytotoxicity
9. Use of amifostine in hematologic malignancies in hematologic malignancies, myelodysplastic syndromes and acute leukemia
10. Hematopoietic stimulation by amifostine and sodium phenylbutyrate: What is the potential in MDS?
11. Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278
12. Competition for polyamine uptake into rat lung slices by WR-2721 and analogues
13. Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens
14. p44/42 mitogen-activated protein kinase is involved in the expression of ornithine decarboxylase in leukemia L1210 cells
15. Binding of radioprotective thiols and disulfides in Chinese hamster V79 cell nuclei
16. Degradation of 2-(3-aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence of glutathione status of Chinese hamster ovary cells
17. ABC-me: A novel mitochondrial transporter induced by GATA-1 during erythroid differentiation
18. The cytoprotective aminothiol WR1065 activates p21 waf-1 and down regulates cell cycle progression through a p53-dependent pathway
19. Inhibition of topoisomerase II alpha activity in CHO K1 cells by 2-[(aminopropyl)amino]ethanethiol (WR-1065)
20. The effect of chemical radiation protectors on cell cycle progression after gamma or neutron irradiation
21. Chemical protection and cell-cycle effects on radiation-induced mutagenesis
22. Differential reconstitution of mitochondrial respiratory chain activity and plasma redox state by cysteine and ornithine in a model of cancer cachexia
23. Structural specificity of polyamines and polyamine analogues in the protection of DNA from strand breaks induced by reactive oxygen species
24. The natural polyamine spermine functions directly as a free radical scavenger
25. The antizyme-dependent polyamine transporter mediates radioprotection by the amifostine derivative WR-1065
26. Autoregulatory frameshifting in decoding mammalian ornithine decarboxylase antizyme
27. Destabilization of ornithine decarboxylase by transfected antizyme gene expression in hepatoma tissue culture cells
28. Amifostine inhibits hematopoietic progenitor cell apoptosis by activating NF-κB/Rel transcription factors
29. Amifostine stimulates formation of multipotent progenitors and generates macroscopic colonies in normal and myelodysplastic bone marrow
30. Amifostine suppresses apoptosis in myelodysplastic CD34+ cells and promotes progenitor growth via polyamine-like effects
31. Amifostine cytotoxicity and induction of apoptosis in a human myelodysplastic cell line
32. Amifostine improves the antileukemic therapeutic index of mafosfamide: Implications for bone marrow purging
33. Protection and potentiation of nitrogen mustard cytotoxicity by WR-2721
34. The effects of amifostine on the clonogenic proliferation in vitro of myelodysplastic and acute and chronic myelogenous leukemia cells
35. Phase II study of amifostine in patients with myelodysplastic syndrome (MDS)
36. Effective treatment of poor prognosis AML
37. High CR rate and normal organ cytoprotection using dose escalation of idarubicin with amifostine in high risk patients with AML