Inhibition of spontaneous metastases formation by amifostine

International Journal of Cancer

Volumn 97, Issue 2, 2002, Pages 135-141

  Grdina, David J ^a   Kataoka, Yasushi ^a   Murley, Jeffrey S ^a   Hunter, Nancy ^b   Weichselbaum, Ralph R ^a   Milas, Luka ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Amifostine; Angiostatin; Matrix metalloproteinases; Spontaneous metastases prevention; Thiols

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; AMIFOSTINE; ANGIOSTATIN; GELATIN; GELATINASE A; GELATINASE B; MATRIGEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CANCER GROWTH; CANCER SIZE; CELL INVASION; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DOSE TIME EFFECT RELATION; DRUG EFFECT; DRUG EFFICACY; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; GROWTH INHIBITION; LUNG METASTASIS; MALE; METASTASIS INHIBITION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SARCOMA; WESTERN BLOTTING; ZYMOGRAPHY;

AMIFOSTINE; ANGIOSTATINS; ANIMALS; BLOTTING, WESTERN; CELL DIVISION; DOSE-RESPONSE RELATIONSHIP, DRUG; LUNG NEOPLASMS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MERCAPTOETHYLAMINES; MICE; MICE, INBRED C3H; MUSCLE NEOPLASMS; NEOPLASM INVASIVENESS; PEPTIDE FRAGMENTS; PLASMINOGEN; RADIATION-PROTECTIVE AGENTS; SARCOMA, EXPERIMENTAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0037050003     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1592     Document Type: Article

References (36)

1. News and product notes
2. The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine
3. Tumor rejection in experimental animals treated with radioprotective thiols
4. Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats
5. Inhibition of invasion, gelatinase activity, tumor take and metastases of malignant cells by N-acetylcysteine
6. Angiogenesis and tumor metastasis
7. Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin
8. Angiogenesis in cancer, vascular, rheumatoid and other disease
9. Angiostatin formation involves disulfide bond reduction and proteolysis in kringle 5 of plasmin
10. The mechanism of cancer-mediated conversion of plasminogen to angiogenesis inhibitor angiostatin
11. Matrix metalloproteinases and metastasis
12. Zinc ejection as a new rationale for the use of cystamine and related disulfide-containing antiviral agents in the treatment of AIDS
13. Metastatic properties of murine sarcomas and carcinomas. I. Positive correlation with lung colonization and lack of correlation with s.c. tumor take
14. Effect of the radiosensitizer misonidazole and the radioprotector diethyldithiocarbamate on spontaneous metastasis formation of murine tumors
15. Lack of correlation between mitotic arrest or apoptosis and antitumor effect of docetaxel
16. Effect of tumor size on S-2-(3-aminopropylamino)-ethylphosphorothioic acid and misonidazole alteration of tumor response to cyclophosphamide
17. Chemopreventive doses of amifostine confer no cytoprotection to tumor nodules growing in the lungs of mice treated with cyclophosphamide
18. Angiostatin induces mitotic death of proliferating endothelial cells
19. Effect of tumor type, size, and end point on tumor protection by WR-2721
20. The radioprotector WR-2721 reduces neutron-induced mutations at the hypoxanthine-guanine phosphoribosy transferase locus in mouse splenocytes when administered prior to or following irradiation
21. Amifostine: A review of its pharmacodynamic and pharmacokinetic properties, and the therapeutic potential as a radioprotector and cytotoxic chemoprotector
22. Metabolic pathways of WR-2721 (Ethyol, amifostine) in the BALB/c mouse
23. Inhibition of gelatinase A (MMP-2) by batimastat and captopril reduces tumor growth and lung metastases in mice bearing Lewis lung carcinoma
24. Influence of misonidazole, SR-2508, RSU- 1069, and WR-2721 on spontaneous metastases in C57BL mice
25. Homeostatic control of angiogenesis: A newly identified function of the liver?
26. N-acetylcysteine inhibits endothelial cell invasion and angiogenesis
27. Generation of angiostatin by reduction and proteolysis of plasmin
28. Wound fluid from venous leg ulcers degrades plasminogen and reduces plasmin generation by keratinocytes
29. Diurnal variations in angiostatin in human tear fluid: A possible role in prevention of corneal neovascularization
30. Matrix metalloproteinases and their inhibitors in tumor growth and invasion
31. Use of tetracycline as an inhibitor of matrix metalloproteinase activity secreted by human bone-metastasizing cancer cells
32. Design and synthesis of thiol containing inhibitors of matrix metalloproteinases
33. Can N-acetyl-L-cysteine affect zinc metabolism when used as a paracetamol antidote?
34. Discovery of a novel series of selective MMP inhibitors: Identification of the γ-sulfonethiols
35. Protection from cellular oxidative injury and calcium intrusion by n-(2-mercaptoethyl)-1,3-propanediamine, WR1065
36. Interference of WR-2721 with magnesium metabolism: Mechanism of action