Amplification of the cyclin-dependent kinase 4 (CDK4) gene is associated with high cdk4 protein levels in glioblastoma multiforme

Acta Neuropathologica

Volumn 92, Issue 1, 1996, Pages 70-74

  Rollbrocker, Britta ^a   Waha, Andreas ^a   Louis, David N ^b   Wiestler, Otmar D ^a   Von Deimling, Andreas ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Brain tumors; CDK4; Gene amplification; LOH12q; Protein level

Indexed keywords

CYCLIN DEPENDENT KINASE; POLYCLONAL ANTIBODY;

ARTICLE; CHROMOSOME 12; CHROMOSOME 12Q; CHROMOSOME LOSS; GENE AMPLIFICATION; GLIOBLASTOMA; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

BRAIN NEOPLASMS; CYCLIN-DEPENDENT KINASES; GENE AMPLIFICATION; GLIOBLASTOMA; HUMANS; POLYMERASE CHAIN REACTION;

EID: 0029897610     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050491     Document Type: Article

References (24)

1. Bender B, Wiestler OD, Deimling A von (1994) A device for processing large acrylamide gels. Biotechniques 16: 204-206
2. Deimling A von, Louis DN, Ammon K von, Petersen I, Hoell T, Chung RY, Martuza R, Schoenfeld D, Yasargil MG, Wiestier OD, Seizinger BR (1992) Association of epidermal growth factor receptor gene amplification with loss of chromosome 10 in human glioblastoma multiforme. J Neurosurg 77: 295-301
3. Deimling A von, Bender B, Louis DN, Wiestler OD (1993) A rapid and non-radioactive PCR-based assay for the detection of allelic loss in human gliomas. Neuropathol Appl Neurobiol 19: 524-529
4. He J, Allen JR, Collins VP, Allalunis-Turner MJ, Godbout R, Day RS III, James CD (1994) CDK4 amplification is an alternative mechanism to p16 homozygous deletion in glioma cell lines. Cancer Res 54: 5804-5807
5. He J, Olson JJ, James CD (1995) Lack of p16INK4 or retinoblastoma protein (pRb), or amplification-associated over-expression of cdk4 is observed in distinct subsets of malignant glial tumors and cell lines. Cancer Res 55: 4833-4836
6. Hunter T, Pines J (1994) Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 79: 573-582
7. Jiang W, Kahn SM, Tomita N, Zhang Y-J, Lu S-H, Weinstein IB (1992) Amplification and expression of the human cyclin D gene in esophageal cancer. Cancer Res 52: 2980-2983
8. Khatib ZA, Matsushime H, Valentine M, Shapiro DN, Sherr CJ, Look AT (1993) Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas. Cancer Res 53: 5535-5541
9. Kleihues P, Burger PC, Scheithauer BW (1993) Histological typing of tumours of the central nervous system, 2nd edn. Springer, Berlin Heidelberg New York
10. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685
11. Libermann TA, Nusbaum HR, Razon N, Kris R, Lax I, Soreq H, Whittle N, Waterfield MD, Ullrich A, Schlessinger J (1984) Amplification, enhanced expression and possible rearrangement of EGF receptor in primary human brain tumors of glial origin. Nature 313: 144-147
12. Louis DN, Deimling A von, Seizinger BR (1992) A (CA)n dinucleotide repeat assay for evaluating loss of allelic heterozygosity in small and archival human brain tumor specimens. Am J Pathol 141: 777-782
13. Morgan DO (1995) Principles of CDK regulation. Nature 374: 131-134
14. Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B (1992) Amplification of a gene encoding a p53 associated protein in human sarcomas. Nature 358: 80-83
15. Raffel C, Ueki K, Harsh GR, Louis DN (1995) The multiple tumor suppressor 1/cyclin-dependent kinase inhibitor 2 gene in human central nervous system primitive neuroectodermal tumor. Neurosurgery 36: 971-975
16. Reifenberger G, Reifenberger J, Ichimura K, Meltzer PS, Collins VP (1994) Amplification of multiple genes from chromosomal region 12q13-q14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS and MDM2. Cancer Res 54: 4299-4303
17. Reifenberger G, Reifenberger J, Ichimura K, Collins VP (1995) Amplification at 12q13-14 in human malignant gliomas is frequently accompanied by loss of heterozygosity at loci proximal and distal to the amplification site. Cancer Res 55: 731-734
18. Sambrook J, Fritsch EF, Maniatis T (eds) (1989) Molecular cloning, 2nd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
19. Schmidt EE, Ichimura K, Reifenberger G, Collins VP (1995) CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas. Cancer Res 54: 6321-6324
20. Sherr CJ (1993) Mammalian G1 cyclins. Cell 73: 1059-1065
21. Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235: 177-182
22. Ueki K, Ono Y, Henson JW, Deimling A von, Louis DN (1996) CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res (in press)
23. Waha A, Rollbrocker B, Wiestler OD, Deimling A von (1996) A polymerase chain reaction-based assay for the rapid detection of gene amplification in human tumors. Diagn Mol Pathol (in press)
24. Walker D, Duan W, Popovic EA, Kaye AH, Tomlinson FH, Lavin M (1995) Homozygous deletions of multiple tumor suppressor gene 1 in the progression of human astrocytomas. Cancer Res 55: 20-23