Decreased cyclin dependent kinase in brain of patients with Down syndrome

Neuroscience Letters

Volumn 216, Issue 1, 1996, Pages 68-70

  Bernert, Guenther ^a   Nemethova, Maria ^a   Herrera Marschitz, Mario ^b   Cairns, Nigel ^c   Lubec, Gert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b KAROLINSKA INSTITUTE   (Sweden)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Alzheimer disease; Choline acetyltransferase; Cyclin dependent kinase; Down syndrome; Mitosis; Phosphokinase A; Phosphokinase C; Proliferation

Indexed keywords

CHOLINE ACETYLTRANSFERASE; CYCLIN DEPENDENT KINASE; PROTEIN KINASE C;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN SYNDROME; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRONTAL LOBE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL;

EID: 0030595298     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12988-8     Document Type: Article

References (20)

1. [1] Baumann, K., Mandelkow, E.M., Biernat, J., Piwnica-Worms, H. and Mandelkow, E., Abnormal Alzheimer like phosphorylation of tau protein by cyclin dependent kinases CDK2 and CDK5, FEBS Lett., 336 (1993) 417-424.
2. [2] Chauhan, A., Chauhan, V.P., Brockerhoff, H. and Wisniewski, H.M., Action of amyloid beta protein on protein kinase C activity, Life Sci., 49 (1991) 1555-1562.
3. [3] Doree, M. and Galas, S., The cyclin dependent protein kinases and the control of cell division, FASEB J., 8 (1994) 1114-1121.
4. +/CDC28 protein kinase, is stimulated during adenovirus induced proliferation of primary baby rat kidney cells, Oncogene, 6 (1988) 553-557.
5. [5] Dutta, A. and Stillman, B., Cdc2 family kinases phosphorylate a human cell DNA replication factor RPA and activate DNA replication, EMBOJ., 11 (1993) 2189-2199.
6. [6] Elson, A., Weiss, Y. and Groner, Y., Protein kinase C (PKC) level is increased in PC12 cells overexpressing transfected liver type phosphofructokinase. Biol. Cell, 81 (1994) 23-29.
7. [7] Florez, J.C., Nelson, R.B. and Routtenberg, A., Contrasting patterns of protein phosphorylation in human normal and Alzheimer brain, Exp. Neurol., 112 (1991) 264-272.
8. [8] Labbe, J.C., Lee, M.G., Nurse, P., Picard, A. and Doree, M., Activation at M phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2, Nature, 335 (1988) 251-254.
9. [9] Lucas, J.J., Terada, N., Szepesi, A. and Gelfand, E.W., Regulation of synthesis of p34(cdc2)and its homologues and their relationship to p110(Rb) phosphorylation during cell cycle progression of normal human T cells, J. Immunol., 148 (1992) 1804-1811.
10. [10] Mattson, M.P., Evidence for the involvement of protein kinase C in neurodegenerative changes in cultured human cortical neurons, Exp. Neurol., 112 (1991) 95-103.
11. [11] McGowan, C.H., Russell, P. and Reed, S.I., Periodic biosynthesis of the human M-phase promoting factor catalytic subunit p34 during the cell cycle, Mol. Cell Biol., 10 (1990) 3847-3851.
12. [12] Mirra, S.S., Heyman, A., McKeel, D., Sumi, S.M. and Crain, B.J., The consortium to establish a registry for Alzheimer's disease (CERAD) II standardization of the neuropathological assessment of Alzheimer's disease, Neurology, 41 (1991) 479-486.
13. [13] Riabowol, K., Draetta, G., Brizuela, L., Vandre, D. and Beach, D., The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells, Cell, 57 (1989) 393-401.
14. [14] Sheu, F.S., Azmitia, E.C., Marshak, D.R., Parker, P.J. and Routtenberg, A., Glial derived S100b protein selectively inhibits recombinant beta protein kinase C(PKC) phosphorylation of neuron specific protein F1/GAP43, Brain Res. Mol. Brain Res., 21 (1994) 62-66.
15. [15] Shi, L., Nishioka, W.K., Thing, J., Bradbury, M., Lichtfield, D.W. and Greenberg, A.H., Premature p34cdc2 activation required for apoptosis, Science, 263 (1994) 1143-1145.
16. [16] Shiekhattar, R., Mermelstein, F., Fisher, R.P., Drapkin, R., Dynlacht, B., Wessling, H.C., Morgan, D.O. and Reinberg, D., CDK activating kinase complex is a component of human transcription factor TFIIH, Nature, 374 (1995) 283-287.
17. [17] Sterner, B., Mandelkow, E.M., Biernat, J., Gustke, N., Meyer, H.E., Schmidt, B., Mieskes, G., Soling, H.D., Drechsel, D. and Kirschner, M.W., Phosphorylation of microtubule associated protein tau: identification of the site for Ca2(+) calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles, EMBO J., 9 (1990) 3539-3544.
18. [18] Tanaka, C., Taniyama, K. and Kusunoki, M., A phorbol ester and A23187 act synergistically to release acetylcholine from guinea pig ileum. FEBS Lett., 175 (1984) 165-169.
19. [19] Tierney, M.C., Fisher, R.H., Lewis, A.J., Zorzitto, M.L., Snow, W.G., Reid, D.W. and Nieuwstraten, P., The NINCDA-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer's disease, Neurology, 38 (1988) 359-364.
20. [20] Tsai, L.H., Takahashi, T., Caviness, V.S. and Harlow, E., Activity and expression pattern of cyclin-dependent protein kinase 5 in the embryonic mouse nervous system, Development, 119 (1993) 1029-1040.