A 4-hydroxypyrrolidine-catalyzed mannich reaction of aldehydes: Control of anti-selectivity by hydrogen bonding assisted by bronsted acids

Chemistry - A European Journal

Volumn 16, Issue 18, 2010, Pages 5333-5342

  Gómez Bengoa, Enrique ^a   Maestro, Miguel ^b   Mielgo, Antonia ^a   Otazo, Itziar ^a   Palomo, Claudio ^a   Velilla, Irene ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

Author keywords

Asymmetric catalysis; Br nsted acids; Enamine activation; Hydrogen bonds; Mannich reaction

Indexed keywords

AMINO ALCOHOLS; ANTI-SELECTIVITY; ASYMMETRIC CATALYSIS; BRONSTED ACIDS; CATALYST DESIGNS; CATALYTIC SYSTEM; DEPROTECTION; ENAMINE ACTIVATION; ENAMINES; GOOD YIELD; HYDROGEN BONDINGS; HYDROXY GROUPS; MANNICH REACTIONS; PYRROLIDINES;

ALCOHOLS; ALDEHYDES; AMINO ACIDS; CATALYSIS; CHEMICAL ELEMENTS; COMPLEXATION; HYDROGEN; NITROGEN COMPOUNDS; ORGANIC ACIDS;

HYDROGEN BONDS;

4 HYDROXYPYRROLIDINE; 4-HYDROXYPYRROLIDINE; ACID; ALDEHYDE; AMINO ACID; AMINOALCOHOL; IMINE; N SULFONYLIMINE; N-SULFONYLIMINE; PYRROLIDINE DERIVATIVE; SULFONE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; HYDROGEN BOND; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION;

ACIDS; ALDEHYDES; AMINO ACIDS; AMINO ALCOHOLS; CATALYSIS; HYDROGEN BONDING; IMINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PYRROLIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 77951952526     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200903537     Document Type: Article

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