Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: Importance of the 3-acid group on pyrrolidine for stereocontrol

Journal of the American Chemical Society

Volumn 130, Issue 3, 2008, Pages 875-886

  Zhang, Haile ^a   Mitsumori, Susumu ^a   Utsumi, Naoto ^a   Imai, Masanori ^a   Garcia Delgado, Noemi ^a   Mifsud, Maria ^a   Albertshofer, Klaus ^a   Cheong, Paul Ha Yeon ^b   Houk, K N ^b   Tanaka, Fujie ^a   Barbas III, Carlos F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDES; CATALYSIS; ENANTIOSELECTIVITY; KETONES; REACTION KINETICS; STEREOCHEMISTRY;

PYRROLIDINE DERIVATIVES; STEREOCONTROL;

CARBOXYLIC ACIDS;

3 PYRROLIDINECARBOXYLIC ACID; 5 METHYL 3 PYRROLIDINECARBOXYLIC ACID; ALDEHYDE; CARBON; CARBONYL DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; ESTER; IMINE; KETONE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; CHIRALITY; DIASTEREOISOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MANNICH REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 38349089956     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja074907+     Document Type: Article

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