메뉴 건너뛰기




Volumn 69, Issue 5, 2010, Pages 455-472

Mechanisms of axonal spheroid formation in central nervous system wallerian degeneration

Author keywords

Axon; Axonal degeneration; Axonal transport; Neuroaxonal dystrophy; Neurodegeneration; Neuroprotection

Indexed keywords

BRAIN PROTEIN; CALCIUM; UNCLASSIFIED DRUG; WALLERIAN DEGENERATION SLOW GENE;

EID: 77951880455     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181da84db     Document Type: Article
Times cited : (89)

References (100)
  • 1
    • 0001754953 scopus 로고
    • Experiments on the section of glossopharyngeal and hypoglossal nerves of the frog and observations of the alternatives produced thereby in the structure of their primitive fibres
    • Waller A. Experiments on the section of glossopharyngeal and hypoglossal nerves of the frog and observations of the alternatives produced thereby in the structure of their primitive fibres. Philos Trans R Soc Lond B Biol Sci 1850;140:423-429
    • (1850) Philos Trans R Soc Lond B Biol Sci , vol.140 , pp. 423-429
    • Waller, A.1
  • 2
    • 0037012844 scopus 로고    scopus 로고
    • Axonal self-destruction and neuro-degeneration
    • Raff MC, Whitmore AV, Finn JT. Axonal self-destruction and neuro-degeneration. Science 2002;296:868-871
    • (2002) Science , vol.296 , pp. 868-871
    • Raff, M.C.1    Whitmore, A.V.2    Finn, J.T.3
  • 3
    • 34748819496 scopus 로고    scopus 로고
    • Mechanisms of axon degeneration: From development to disease
    • Saxena S, Caroni P. Mechanisms of axon degeneration: From development to disease. Prog Neurobiol 2007;83:174-191
    • (2007) Prog Neurobiol , vol.83 , pp. 174-191
    • Saxena, S.1    Caroni, P.2
  • 4
    • 27644591304 scopus 로고    scopus 로고
    • Axon degeneration mechanisms: Commonality amid diversity
    • Coleman M. Axon degeneration mechanisms: Commonality amid diversity. Nat Rev Neurosci 2005;6:889-898
    • (2005) Nat Rev Neurosci , vol.6 , pp. 889-898
    • Coleman, M.1
  • 5
    • 63649153518 scopus 로고    scopus 로고
    • A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration
    • Miller BR, Press C, Daniels RW, et al. A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nat Neurosci 2009;12:387-389
    • (2009) Nat Neurosci , vol.12 , pp. 387-389
    • Miller, B.R.1    Press, C.2    Daniels, R.W.3
  • 6
    • 0036774951 scopus 로고    scopus 로고
    • Axon pathology in neurological disease: A neglected therapeutic target
    • Coleman MP, Perry VH. Axon pathology in neurological disease: A neglected therapeutic target. Trends Neurosci 2002;25:532-537
    • (2002) Trends Neurosci , vol.25 , pp. 532-537
    • Coleman, M.P.1    Perry, V.H.2
  • 7
    • 34547652325 scopus 로고    scopus 로고
    • Why is Wallerian degeneration in the CNS so slow?
    • Vargas ME, Barres BA. Why is Wallerian degeneration in the CNS so slow? Annu Rev Neurosci 2007;30:153-179
    • (2007) Annu Rev Neurosci , vol.30 , pp. 153-179
    • Vargas, M.E.1    Barres, B.A.2
  • 8
    • 0028586052 scopus 로고
    • Quantification of the mononuclear phagocyte response to Wallerian degeneration of the optic nerve
    • Lawson LJ, Frost L, Risbridger J, et al. Quantification of the mononuclear phagocyte response to Wallerian degeneration of the optic nerve. J Neurocytol 1994;23:729-744
    • (1994) J Neurocytol , vol.23 , pp. 729-744
    • Lawson, L.J.1    Frost, L.2    Risbridger, J.3
  • 9
    • 24344506747 scopus 로고    scopus 로고
    • The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves
    • Beirowski B, Adalbert R, Wagner D, et al. The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves. BMC Neurosci 2005;6:6
    • (2005) BMC Neurosci , vol.6 , pp. 6
    • Beirowski, B.1    Adalbert, R.2    Wagner, D.3
  • 10
    • 1242328756 scopus 로고    scopus 로고
    • Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice
    • Beirowski B, Berek L, Adalbert R, et al. Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice. J Neurosci Methods 2004;134:23-35
    • (2004) J Neurosci Methods , vol.134 , pp. 23-35
    • Beirowski, B.1    Berek, L.2    Adalbert, R.3
  • 12
    • 0028102801 scopus 로고
    • The proximo-distal spread of axonal degeneration in the dorsal columns of the rat
    • George R, Griffin JW. The proximo-distal spread of axonal degeneration in the dorsal columns of the rat. J Neurocytol 1994;23:657-667
    • (1994) J Neurocytol , vol.23 , pp. 657-667
    • George, R.1    Griffin, J.W.2
  • 13
    • 20044385920 scopus 로고    scopus 로고
    • Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease
    • Stokin GB, Lillo C, Falzone TL, et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 2005; 307:1282-1288
    • (2005) Science , vol.307 , pp. 1282-1288
    • Stokin, G.B.1    Lillo, C.2    Falzone, T.L.3
  • 14
    • 60149092294 scopus 로고    scopus 로고
    • Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies
    • Adalbert R, Nogradi A, Babetto E, et al. Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies. Brain 2008;132:402-416
    • (2008) Brain , vol.132 , pp. 402-416
    • Adalbert, R.1    Nogradi, A.2    Babetto, E.3
  • 15
    • 2342493785 scopus 로고    scopus 로고
    • Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C
    • Ohara S, Ukita Y, Ninomiya H, et al. Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C. Exp Neurol 2004;187:289-298
    • (2004) Exp Neurol , vol.187 , pp. 289-298
    • Ohara, S.1    Ukita, Y.2    Ninomiya, H.3
  • 16
    • 0031804903 scopus 로고    scopus 로고
    • Pathological study of mice with total deficiency of sphingolipid activator proteins (SAP knockout mice)
    • Oya Y, Nakayasu H, Fujita N, et al. Pathological study of mice with total deficiency of sphingolipid activator proteins (SAP knockout mice). Acta Neuropathol 1998;96:29-40
    • (1998) Acta Neuropathol , vol.96 , pp. 29-40
    • Oya, Y.1    Nakayasu, H.2    Fujita, N.3
  • 17
    • 20444372657 scopus 로고    scopus 로고
    • Neuroprotective strategies in MS: Lessons from C57BL/Wld(S) mice
    • Coleman MP, Adalbert R, Beirowski B. Neuroprotective strategies in MS: Lessons from C57BL/Wld(S) mice. J Neurol Sci 2005;233: 133-138
    • (2005) J Neurol Sci , vol.233 , pp. 133-138
    • Coleman, M.P.1    Adalbert, R.2    Beirowski, B.3
  • 18
    • 15444363122 scopus 로고    scopus 로고
    • Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport
    • Takeuchi H, Mizuno T, Zhang G, et al. Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport. J Biol Chem 2005;280:10444-10454
    • (2005) J Biol Chem , vol.280 , pp. 10444-10454
    • Takeuchi, H.1    Mizuno, T.2    Zhang, G.3
  • 19
    • 35448938087 scopus 로고    scopus 로고
    • Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration
    • Komatsu M, Wang QJ, Holstein GR, et al. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci USA 2007; 104:14489-14494
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14489-14494
    • Komatsu, M.1    Wang, Q.J.2    Holstein, G.R.3
  • 20
    • 0030752893 scopus 로고    scopus 로고
    • A mechanistic analysis of nondisruptive axonal injury: A review
    • Maxwell WL, Povlishock JT, Graham DL. A mechanistic analysis of nondisruptive axonal injury: A review. J Neurotrauma 1997;14:419-440
    • (1997) J Neurotrauma , vol.14 , pp. 419-440
    • Maxwell, W.L.1    Povlishock, J.T.2    Graham, D.L.3
  • 21
    • 5044225054 scopus 로고    scopus 로고
    • Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury
    • Stone JR, Okonkwo DO, Dialo AO, et al. Impaired axonal transport and altered axolemmal permeability occur in distinct populations of damaged axons following traumatic brain injury. Exp Neurol 2004;190: 59-69
    • (2004) Exp Neurol , vol.190 , pp. 59-69
    • Stone, J.R.1    Okonkwo, D.O.2    Dialo, A.O.3
  • 22
    • 0029896102 scopus 로고    scopus 로고
    • Characterization of a distinct set of intra-axonal ultrastructural changes associated with traumatically induced alteration in axolemmal permeability
    • Pettus EH, Povlishock JT. Characterization of a distinct set of intra-axonal ultrastructural changes associated with traumatically induced alteration in axolemmal permeability. Brain Res 1996;722: 1-11
    • (1996) Brain Res , vol.722 , pp. 1-11
    • Pettus, E.H.1    Povlishock, J.T.2
  • 23
    • 0037370914 scopus 로고    scopus 로고
    • Axonal damage: A key predictor of outcome in human CNS diseases
    • Medana IM, Esiri MM. Axonal damage: A key predictor of outcome in human CNS diseases. Brain 2003;126:515-530
    • (2003) Brain , vol.126 , pp. 515-530
    • Medana, I.M.1    Esiri, M.M.2
  • 24
    • 0034987047 scopus 로고    scopus 로고
    • Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis
    • Kornek B, Storch MK, Bauer J et al. Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis. Brain 2001;124:1114-1124
    • (2001) Brain , vol.124 , pp. 1114-1124
    • Kornek, B.1    Storch, M.K.2
  • 25
    • 0033366384 scopus 로고    scopus 로고
    • Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
    • Williamson TL, Cleveland DW. Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat Neurosci 1999;2:50-56
    • (1999) Nat Neurosci , vol.2 , pp. 50-56
    • Williamson, T.L.1    Cleveland, D.W.2
  • 26
    • 1342310772 scopus 로고    scopus 로고
    • Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport
    • Ferreirinha F, Quattrini A, Pirozzi M, et al. Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport. J Clin Invest 2004;113:231-242
    • (2004) J Clin Invest , vol.113 , pp. 231-242
    • Ferreirinha, F.1    Quattrini, A.2    Pirozzi, M.3
  • 27
    • 33748154216 scopus 로고    scopus 로고
    • Induction of autophagy in axonal dystrophy and degeneration
    • Wang QJ, Ding Y, Kohtz S, et al. Induction of autophagy in axonal dystrophy and degeneration. J Neurosci 2006;26:8057-8068
    • (2006) J Neurosci , vol.26 , pp. 8057-8068
    • Wang, Q.J.1    Ding, Y.2    Kohtz, S.3
  • 28
    • 35848944122 scopus 로고    scopus 로고
    • Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death
    • Nishiyama J, Miura E, Mizushima N, et al. Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death. Autophagy 2007;3:591-596
    • (2007) Autophagy , vol.3 , pp. 591-596
    • Nishiyama, J.1    Miura, E.2    Mizushima, N.3
  • 29
    • 0032544036 scopus 로고    scopus 로고
    • An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse
    • Coleman MP, Conforti L, Buckmaster EA, et al. An 85-kb tandem triplication in the slow Wallerian degeneration (Wlds) mouse. Proc Natl Acad Sci USA 1998;95:9985-9990
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9985-9990
    • Coleman, M.P.1    Conforti, L.2    Buckmaster, E.A.3
  • 30
    • 0035195636 scopus 로고    scopus 로고
    • Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene
    • Mack TG, Reiner M, Beirowski B, et al. Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene. Nat Neurosci 2001;4:1199-1206
    • (2001) Nat Neurosci , vol.4 , pp. 1199-1206
    • MacK, T.G.1    Reiner, M.2    Beirowski, B.3
  • 31
    • 0024373441 scopus 로고
    • Absence of Wallerian degeneration does not hinder regeneration in peripheral Nerve
    • Lunn ER, Perry VH, Brown MC, et al. Absence of Wallerian degeneration does not hinder regeneration in peripheral Nerve. Eur J Neurosci 1989;1:27-33
    • (1989) Eur J Neurosci , vol.1 , pp. 27-33
    • Lunn, E.R.1    Perry, V.H.2    Brown, M.C.3
  • 32
    • 51649087203 scopus 로고    scopus 로고
    • The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model
    • Beirowski B, Babetto E, Coleman MP, et al. The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model. Eur J Neurosci 2008;28:1166-1179
    • (2008) Eur J Neurosci , vol.28 , pp. 1166-1179
    • Beirowski, B.1    Babetto, E.2    Coleman, M.P.3
  • 33
    • 0025974211 scopus 로고
    • Very slow retrograde and Wallerian degeneration in the CNS of C57BL/Ola mice
    • Perry VH, Brown MC, Lunn ER. Very slow retrograde and Wallerian degeneration in the CNS of C57BL/Ola mice. Eur J Neurosci 1991;3: 102-105
    • (1991) Eur J Neurosci , vol.3 , pp. 102-105
    • Perry, V.H.1    Brown, M.C.2    Lunn, E.R.3
  • 34
    • 0344950387 scopus 로고    scopus 로고
    • Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease
    • Ferri A, Sanes JR, Coleman MP, et al. Inhibiting axon degeneration and synapse loss attenuates apoptosis and disease progression in a mouse model of motoneuron disease. Curr Biol 2003;13:669-673
    • (2003) Curr Biol , vol.13 , pp. 669-673
    • Ferri, A.1    Sanes, J.R.2    Coleman, M.P.3
  • 35
    • 38049075806 scopus 로고    scopus 로고
    • Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma
    • Howell GR, Libby RT, Jakobs TC, et al. Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma. J Cell Biol 2007;179:1523-1537
    • (2007) J Cell Biol , vol.179 , pp. 1523-1537
    • Howell, G.R.1    Libby, R.T.2    Jakobs, T.C.3
  • 36
    • 1542380508 scopus 로고    scopus 로고
    • Wld(s)-mediated protection of dopaminergic fibers in an animal model of Parkinson disease
    • Sajadi A, Schneider BL, Aebischer P. Wld(s)-mediated protection of dopaminergic fibers in an animal model of Parkinson disease. Curr Biol 2004;14:326-330
    • (2004) Curr Biol , vol.14 , pp. 326-330
    • Sajadi, A.1    Schneider, B.L.2    Aebischer, P.3
  • 37
    • 13544273848 scopus 로고    scopus 로고
    • The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice
    • Mi W, Beirowski B, Gillingwater TH, et al. The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice. Brain 2005;128:405-416
    • (2005) Brain , vol.128 , pp. 405-416
    • Mi, W.1    Beirowski, B.2    Gillingwater, T.H.3
  • 38
    • 58849126602 scopus 로고    scopus 로고
    • Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo
    • Beirowski B, Babetto E, Gilley J, et al. Non-nuclear Wld(S) determines its neuroprotective efficacy for axons and synapses in vivo. J Neurosci 2009;29:653-668
    • (2009) J Neurosci , vol.29 , pp. 653-668
    • Beirowski, B.1    Babetto, E.2    Gilley, J.3
  • 39
    • 66249146403 scopus 로고    scopus 로고
    • Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo
    • Sasaki Y, Vohra BP, Baloh RH, et al. Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo. J Neurosci 2009;29:6526-6534
    • (2009) J Neurosci , vol.29 , pp. 6526-6534
    • Sasaki, Y.1    Vohra, B.P.2    Baloh, R.H.3
  • 40
    • 66049102890 scopus 로고    scopus 로고
    • Nicotinamide mononucleotide adenylyl-transferase expression in mitochondrial matrix delays Wallerian degeneration
    • Yahata N, Yuasa S, Araki T. Nicotinamide mononucleotide adenylyl-transferase expression in mitochondrial matrix delays Wallerian degeneration. J Neurosci 2009;29:6276-6284
    • (2009) J Neurosci , vol.29 , pp. 6276-6284
    • Yahata, N.1    Yuasa, S.2    Araki, T.3
  • 41
    • 0033634813 scopus 로고    scopus 로고
    • Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    • Feng G, Mellor RH, Bernstein M, et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 2000;28:41-51
    • (2000) Neuron , vol.28 , pp. 41-51
    • Feng, G.1    Mellor, R.H.2    Bernstein, M.3
  • 42
    • 0026658151 scopus 로고
    • The effectiveness of the gene which slows the rate of Wallerian degeneration in C57BL/Ola mice declines with age
    • Perry VH, Brown MC, Tsao JW. The effectiveness of the gene which slows the rate of Wallerian degeneration in C57BL/Ola mice declines with age. Eur J Neurosci 1992;4:1000-1002
    • (1992) Eur J Neurosci , vol.4 , pp. 1000-1002
    • Perry, V.H.1    Brown, M.C.2    Tsao, J.W.3
  • 43
  • 44
    • 0035690458 scopus 로고    scopus 로고
    • Intra-axonal neurofilament compaction does not evoke local axonal swelling in all traumatically injured axons
    • Stone JR, Singleton RH, Povlishock JT. Intra-axonal neurofilament compaction does not evoke local axonal swelling in all traumatically injured axons. Exp Neurol 2001;172:320-331
    • (2001) Exp Neurol , vol.172 , pp. 320-331
    • Stone, J.R.1    Singleton, R.H.2    Povlishock, J.T.3
  • 45
    • 0023715247 scopus 로고
    • The effect of traumatic brain injury on the visual system: A morphologic characterization of reactive axonal change
    • Cheng CL, Povlishock JT. The effect of traumatic brain injury on the visual system: A morphologic characterization of reactive axonal change. J Neurotrauma 1988;5:47-60
    • (1988) J Neurotrauma , vol.5 , pp. 47-60
    • Cheng, C.L.1    Povlishock, J.T.2
  • 46
    • 3142674927 scopus 로고    scopus 로고
    • Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia
    • Edgar JM, McLaughlin M, Yool D, et al. Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia. J Cell Biol 2004;166:121-131
    • (2004) J Cell Biol , vol.166 , pp. 121-131
    • Edgar, J.M.1    McLaughlin, M.2    Yool, D.3
  • 47
    • 0032486428 scopus 로고    scopus 로고
    • Axonal swellings and degeneration in mice lacking the major proteolipid of myelin
    • Griffiths I, Klugmann M, Anderson T, et al. Axonal swellings and degeneration in mice lacking the major proteolipid of myelin. Science 1998;280:1610-1613
    • (1998) Science , vol.280 , pp. 1610-1613
    • Griffiths, I.1    Klugmann, M.2    Anderson, T.3
  • 48
    • 0034060114 scopus 로고    scopus 로고
    • Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma
    • Pease ME, McKinnon SJ, Quigley HA, et al. Obstructed axonal transport of BDNF and its receptor TrkB in experimental glaucoma. Invest Ophthalmol Vis Sci 2000;41:764-774
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 764-774
    • Pease, M.E.1    McKinnon, S.J.2    Quigley, H.A.3
  • 49
    • 18844436224 scopus 로고    scopus 로고
    • In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    • Kerschensteiner M, Schwab ME, Lichtman JW, et al. In vivo imaging of axonal degeneration and regeneration in the injured spinal cord. Nat Med 2005;11:572-577
    • (2005) Nat Med , vol.11 , pp. 572-577
    • Kerschensteiner, M.1    Schwab, M.E.2    Lichtman, J.W.3
  • 50
    • 0024810802 scopus 로고
    • Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons
    • Mukoyama M, Yamazaki K, Kikuchi T, et al. Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons. Acta Neuropathol 1989; 79:294-299
    • (1989) Acta Neuropathol , vol.79 , pp. 294-299
    • Mukoyama, M.1    Yamazaki, K.2    Kikuchi, T.3
  • 51
    • 0342803685 scopus 로고    scopus 로고
    • Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
    • Probst A, Gotz J, Wiederhold KH, et al. Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathol 2000;99:469-481
    • (2000) Acta Neuropathol , vol.99 , pp. 469-481
    • Probst, A.1    Gotz, J.2    Wiederhold, K.H.3
  • 52
    • 38949173916 scopus 로고    scopus 로고
    • Abnormal cellular translocation of alpha-internexin in spinal motor neurons of Dystonia musculorum mice
    • Tseng KW, Chau YP, Yang MF, et al. Abnormal cellular translocation of alpha-internexin in spinal motor neurons of Dystonia musculorum mice. J Comp Neurol 2008;507:1053-1064
    • (2008) J Comp Neurol , vol.507 , pp. 1053-1064
    • Tseng, K.W.1    Chau, Y.P.2    Yang, M.F.3
  • 53
    • 0025313039 scopus 로고
    • Axonal swellings in the corticospinal tracts in amyotrophic lateral sclerosis
    • Okamoto K, Hirai S, Shoji M, et al. Axonal swellings in the corticospinal tracts in amyotrophic lateral sclerosis. Acta Neuropathol 1990;80:222-226
    • (1990) Acta Neuropathol , vol.80 , pp. 222-226
    • Okamoto, K.1    Hirai, S.2    Shoji, M.3
  • 54
    • 33747881231 scopus 로고    scopus 로고
    • Autophagy in neurodegenerative disease: Friend, foe or turncoat?
    • Nixon RA. Autophagy in neurodegenerative disease: Friend, foe or turncoat? Trends Neurosci 2006;29:528-535
    • (2006) Trends Neurosci , vol.29 , pp. 528-535
    • Nixon, R.A.1
  • 55
    • 26444515364 scopus 로고    scopus 로고
    • Autophagy and its possible roles in nervous system diseases, damage and repair
    • Rubinsztein DC, DiFiglia M, Heintz N, et al. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 2005;1:11-22
    • (2005) Autophagy , vol.1 , pp. 11-22
    • Rubinsztein, D.C.1    Difiglia, M.2    Heintz, N.3
  • 56
  • 57
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B, Matyszak MK, Esiri MM, et al. Axonal damage in acute multiple sclerosis lesions. Brain 1997;120:393-399
    • (1997) Brain , vol.120 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3
  • 59
    • 0034698233 scopus 로고    scopus 로고
    • Antibodies to the C-terminus of the beta-amyloid precursor protein (APP): A site specific marker for the detection of traumatic axonal injury
    • Stone JR, Singleton RH, Povlishock JT. Antibodies to the C-terminus of the beta-amyloid precursor protein (APP): A site specific marker for the detection of traumatic axonal injury. Brain Res 2000;871:288-302
    • (2000) Brain Res , vol.871 , pp. 288-302
    • Stone, J.R.1    Singleton, R.H.2    Povlishock, J.T.3
  • 60
    • 34548553576 scopus 로고    scopus 로고
    • Age-dependent axonal degeneration in an Alzheimer mouse model
    • Wirths O, Weis J, Kayed R, et al. Age-dependent axonal degeneration in an Alzheimer mouse model. Neurobiol Aging 2007;28:1689-1699
    • (2007) Neurobiol Aging , vol.28 , pp. 1689-1699
    • Wirths, O.1    Weis, J.2    Kayed, R.3
  • 61
    • 33646817416 scopus 로고    scopus 로고
    • Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice
    • Irvine KA, Blakemore WF. Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice. J Neuroimmunol 2006;175:69-76
    • (2006) J Neuroimmunol , vol.175 , pp. 69-76
    • Irvine, K.A.1    Blakemore, W.F.2
  • 62
    • 0035865002 scopus 로고    scopus 로고
    • Demyelination and axonal damage in a non-human primate model of multiple sclerosis
    • Mancardi G, Hart B, Roccatagliata L, et al. Demyelination and axonal damage in a non-human primate model of multiple sclerosis. J Neurol Sci 2001;184:41-49
    • (2001) J Neurol Sci , vol.184 , pp. 41-49
    • Mancardi, G.1    Hart, B.2    Roccatagliata, L.3
  • 63
    • 0037215483 scopus 로고    scopus 로고
    • Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice
    • Saatman KE, Abai B, Grosvenor A, et al. Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice. J Cereb Blood Flow Metab 2003;23:34-42
    • (2003) J Cereb Blood Flow Metab , vol.23 , pp. 34-42
    • Saatman, K.E.1    Abai, B.2    Grosvenor, A.3
  • 64
    • 38049056160 scopus 로고    scopus 로고
    • Neuronal autophagy: Going the distance to the axon
    • Yue Z, Wang QJ, Komatsu M. Neuronal autophagy: Going the distance to the axon. Autophagy 2008;4:94-96
    • (2008) Autophagy , vol.4 , pp. 94-96
    • Yue, Z.1    Wang, Q.J.2    Komatsu, M.3
  • 65
    • 20444386558 scopus 로고    scopus 로고
    • General mechanisms of axonal damage and its prevention
    • Stys PK. General mechanisms of axonal damage and its prevention. J Neurol Sci 2005;233:3-13
    • (2005) J Neurol Sci , vol.233 , pp. 3-13
    • Stys, P.K.1
  • 66
    • 34247148652 scopus 로고    scopus 로고
    • White matter axon vulnerability to AMPA/kainate receptorYmediated ischemic injury is developmentally regulated
    • McCarran WJ, Goldberg MP. White matter axon vulnerability to AMPA/kainate receptorYmediated ischemic injury is developmentally regulated. J Neurosci 2007;27:4220-4229
    • (2007) J Neurosci , vol.27 , pp. 4220-4229
    • McCarran, W.J.1    Goldberg, M.P.2
  • 67
    • 33751180140 scopus 로고    scopus 로고
    • Axonal conduction and injury in multiple sclerosis: The role of sodium channels
    • Waxman SG. Axonal conduction and injury in multiple sclerosis: The role of sodium channels. Nat Rev Neurosci 2006;7:932-941
    • (2006) Nat Rev Neurosci , vol.7 , pp. 932-941
    • Waxman, S.G.1
  • 68
    • 0037350196 scopus 로고    scopus 로고
    • Preinjury administration of the calpain inhibitor MDL-28170 attenuates traumatically induced axonal injury
    • Buki A, Farkas O, Doczi T, et al. Preinjury administration of the calpain inhibitor MDL-28170 attenuates traumatically induced axonal injury. J Neurotrauma 2003;20:261-268
    • (2003) J Neurotrauma , vol.20 , pp. 261-268
    • Buki, A.1    Farkas, O.2    Doczi, T.3
  • 70
    • 0030944883 scopus 로고    scopus 로고
    • Mechanism of calcium entry during axon injury and degeneration
    • LoPachin RM, Lehning EJ. Mechanism of calcium entry during axon injury and degeneration. Toxicol Appl Pharmacol 1997;143:233-244
    • (1997) Toxicol Appl Pharmacol , vol.143 , pp. 233-244
    • Lopachin, R.M.1    Lehning, E.J.2
  • 71
    • 0034735726 scopus 로고    scopus 로고
    • Calcium imaging in live rat optic nerve myelinated axons in vitro using confocal laser microscopy
    • Ren Y, Ridsdale A, Coderre E, et al. Calcium imaging in live rat optic nerve myelinated axons in vitro using confocal laser microscopy. J Neurosci Methods 2000;102:165-176
    • (2000) J Neurosci Methods , vol.102 , pp. 165-176
    • Ren, Y.1    Ridsdale, A.2    Coderre, E.3
  • 72
    • 0022474674 scopus 로고
    • Multiple calcium-activated neutral proteinases (CANP) in mouse retinal ganglion cell neurons: Specificities for endogenous neuronal substrates and comparison to purified brain CANP
    • Nixon RA, Quackenbush R, Vitto A. Multiple calcium-activated neutral proteinases (CANP) in mouse retinal ganglion cell neurons: Specificities for endogenous neuronal substrates and comparison to purified brain CANP. J Neurosci 1986;6:1252-1263
    • (1986) J Neurosci , vol.6 , pp. 1252-1263
    • Nixon, R.A.1    Quackenbush, R.2    Vitto, A.3
  • 73
    • 0017753869 scopus 로고
    • Structural alterations of peripheral nerve induced by the calcium ionophore A23187
    • Schlaepfer WW. Structural alterations of peripheral nerve induced by the calcium ionophore A23187. Brain Res 1977;136:1-9
    • (1977) Brain Res , vol.136 , pp. 1-9
    • Schlaepfer, W.W.1
  • 74
    • 0042848910 scopus 로고    scopus 로고
    • Involvement of the ubiquitin-proteasome system in the early stages of Wallerian degeneration
    • Zhai Q, Wang J, Kim A, et al. Involvement of the ubiquitin-proteasome system in the early stages of Wallerian degeneration. Neuron 2003;39: 217-225
    • (2003) Neuron , vol.39 , pp. 217-225
    • Zhai, Q.1    Wang, J.2    Kim, A.3
  • 75
    • 2442662940 scopus 로고    scopus 로고
    • Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors
    • Iwata A, Stys PK, Wolf JA, et al. Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors. J Neurosci 2004;24:4605-4613
    • (2004) J Neurosci , vol.24 , pp. 4605-4613
    • Iwata, A.1    Stys, P.K.2    Wolf, J.A.3
  • 76
    • 0035869473 scopus 로고    scopus 로고
    • Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels
    • Wolf JA, Stys PK, Lusardi T, et al. Traumatic axonal injury induces calcium influx modulated by tetrodotoxin-sensitive sodium channels. J Neurosci 2001;21:1923-1930
    • (2001) J Neurosci , vol.21 , pp. 1923-1930
    • Wolf, J.A.1    Stys, P.K.2    Lusardi, T.3
  • 77
    • 36148960499 scopus 로고    scopus 로고
    • Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons
    • Yang Y, Fukui K, Koike T, et al. Induction of autophagy in neurite degeneration of mouse superior cervical ganglion neurons. Eur J Neurosci 2007;26:2979-2988
    • (2007) Eur J Neurosci , vol.26 , pp. 2979-2988
    • Yang, Y.1    Fukui, K.2    Koike, T.3
  • 78
    • 0024310469 scopus 로고
    • Wallerian degeneration in the peripheral nervous system: Participation of both Schwann cells and macrophages in myelin degradation
    • Stoll G, Griffin JW, Li CY, et al. Wallerian degeneration in the peripheral nervous system: Participation of both Schwann cells and macrophages in myelin degradation. J Neurocytol 1989;18:671-683
    • (1989) J Neurocytol , vol.18 , pp. 671-683
    • Stoll, G.1    Griffin, J.W.2    Li, C.Y.3
  • 79
    • 42049123010 scopus 로고    scopus 로고
    • Soluble complement receptor 1 protects the peripheral nerve from early axon loss after injury
    • Ramaglia V, Wolterman R, de Kok M, et al. Soluble complement receptor 1 protects the peripheral nerve from early axon loss after injury. Am J Pathol 2008;172:1043-1052
    • (2008) Am J Pathol , vol.172 , pp. 1043-1052
    • Ramaglia, V.1    Wolterman, R.2    De Kok, M.3
  • 80
    • 0037614919 scopus 로고    scopus 로고
    • Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin v positive staining and loss of mitochondrial membrane potential
    • Sievers C, Platt N, Perry VH, et al. Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential. Neurosci Res 2003;46:161-169
    • (2003) Neurosci Res , vol.46 , pp. 161-169
    • Sievers, C.1    Platt, N.2    Perry, V.H.3
  • 82
    • 43249098296 scopus 로고    scopus 로고
    • Axon-glial signaling and the glial support of axon function
    • Nave KA, Trapp BD. Axon-glial signaling and the glial support of axon function. Annu Rev Neurosci 2008;31:535-561
    • (2008) Annu Rev Neurosci , vol.31 , pp. 535-561
    • Nave, K.A.1    Trapp, B.D.2
  • 83
    • 33646759268 scopus 로고    scopus 로고
    • Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons
    • Pilling AD, Horiuchi D, Lively CM, et al. Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol Biol Cell 2006;17:2057-2068
    • (2006) Mol Biol Cell , vol.17 , pp. 2057-2068
    • Pilling, A.D.1    Horiuchi, D.2    Lively, C.M.3
  • 84
    • 0028793887 scopus 로고
    • Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels
    • George EB, Glass JD, Griffin JW. Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels. J Neurosci 1995;15:6445-6452
    • (1995) J Neurosci , vol.15 , pp. 6445-6452
    • George, E.B.1    Glass, J.D.2    Griffin, J.W.3
  • 85
    • 0037090434 scopus 로고    scopus 로고
    • Very early activation of m-calpain in peripheral nerve during Wallerian degeneration
    • Glass JD, Culver DG, Levey AI, et al. Very early activation of m-calpain in peripheral nerve during Wallerian degeneration. J Neurol Sci 2002;196:9-20
    • (2002) J Neurol Sci , vol.196 , pp. 9-20
    • Glass, J.D.1    Culver, D.G.2    Levey, A.I.3
  • 87
    • 0025925116 scopus 로고
    • 2+ influx during anoxia in mammalian central nervous system white matter
    • 2+ influx during anoxia in mammalian central nervous system white matter. Ann Neurol 1991;30:375-380
    • (1991) Ann Neurol , vol.30 , pp. 375-380
    • Stys, P.K.1    Waxman, S.G.2    Ransom, B.R.3
  • 88
    • 0344688458 scopus 로고    scopus 로고
    • Local blockade of sodium channels by te-trodotoxin ameliorates tissue loss and long-term functional deficits resulting from experimental spinal cord injury
    • Teng YD, Wrathall JR. Local blockade of sodium channels by te-trodotoxin ameliorates tissue loss and long-term functional deficits resulting from experimental spinal cord injury. J Neurosci 1997;17:4359-4366
    • (1997) J Neurosci , vol.17 , pp. 4359-4366
    • Teng, Y.D.1    Wrathall, J.R.2
  • 89
    • 3242806710 scopus 로고    scopus 로고
    • Calpain inhibitor 2 prevents axonal degeneration of opossum optic nerve fibers
    • Araujo Couto L, Sampaio Narciso M, Hokoc JN, et al. Calpain inhibitor 2 prevents axonal degeneration of opossum optic nerve fibers. J Neurosci Res 2004;77:410-419
    • (2004) J Neurosci Res , vol.77 , pp. 410-419
    • Araujo Couto, L.1    Sampaio Narciso, M.2    Hokoc, J.N.3
  • 90
    • 0027300771 scopus 로고
    • Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium
    • Waxman SG, Black JA, Ransom BR, et al. Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium. Brain Res 1993;614:137-145
    • (1993) Brain Res , vol.614 , pp. 137-145
    • Waxman, S.G.1    Black, J.A.2    Ransom, B.R.3
  • 91
    • 0028353605 scopus 로고
    • Loss of the compound action potential: An electrophysiological, biochemical and morphological study of early events in axonal degeneration in the C57BL/Ola mouse
    • Tsao JW, Brown MC, Carden MJ, et al. Loss of the compound action potential: An electrophysiological, biochemical and morphological study of early events in axonal degeneration in the C57BL/Ola mouse. Eur J Neurosci 1994;6:516-524
    • (1994) Eur J Neurosci , vol.6 , pp. 516-524
    • Tsao, J.W.1    Brown, M.C.2    Carden, M.J.3
  • 92
    • 0036183729 scopus 로고    scopus 로고
    • Abnormal ubiquitination of axons in normally myelinated white matter in multiple sclerosis brain
    • Giordana MT, Richiardi P, Trevisan E, et al. Abnormal ubiquitination of axons in normally myelinated white matter in multiple sclerosis brain. Neuropathol Appl Neurobiol 2002;28:35-41
    • (2002) Neuropathol Appl Neurobiol , vol.28 , pp. 35-41
    • Giordana, M.T.1    Richiardi, P.2    Trevisan, E.3
  • 93
    • 0033048202 scopus 로고    scopus 로고
    • Neuroaxonal pathology in Creutzfeldt-Jakob disease
    • Liberski PP, Budka H. Neuroaxonal pathology in Creutzfeldt-Jakob disease. Acta Neuropathol 1999;97:329-334
    • (1999) Acta Neuropathol , vol.97 , pp. 329-334
    • Liberski, P.P.1    Budka, H.2
  • 94
    • 0032941952 scopus 로고    scopus 로고
    • Immunoreactivity of beta-amyloid precursor protein in amyotrophic lateral sclerosis
    • Sasaki S, Iwata M. Immunoreactivity of beta-amyloid precursor protein in amyotrophic lateral sclerosis. Acta Neuropathol 1999;97:463-468
    • (1999) Acta Neuropathol , vol.97 , pp. 463-468
    • Sasaki, S.1    Iwata, M.2
  • 95
    • 49049119042 scopus 로고    scopus 로고
    • Autosomal dominant sensory ataxia: A neuroaxonal dystrophy
    • Moeller JJ, Macaulay RJ, Valdmanis PN, et al. Autosomal dominant sensory ataxia: A neuroaxonal dystrophy. Acta Neuropathol 2008;116: 331-336
    • (2008) Acta Neuropathol , vol.116 , pp. 331-336
    • Moeller, J.J.1    MacAulay, R.J.2    Valdmanis, P.N.3
  • 96
    • 0033053635 scopus 로고    scopus 로고
    • Drug development for stroke: Importance of protecting cerebral white matter
    • Dewar D, Yam P, McCulloch J. Drug development for stroke: Importance of protecting cerebral white matter. Eur J Pharmacol 1999;375:41-50
    • (1999) Eur J Pharmacol , vol.375 , pp. 41-50
    • Dewar, D.1    Yam, P.2    McCulloch, J.3
  • 97
    • 43449094629 scopus 로고    scopus 로고
    • Mild traumatic brain injury to the infant mouse causes robust white matter axonal degeneration which precedes apoptotic death of cortical and thalamic neurons
    • Dikranian K, Cohen R, Mac Donald C, et al. Mild traumatic brain injury to the infant mouse causes robust white matter axonal degeneration which precedes apoptotic death of cortical and thalamic neurons. Exp Neurol 2008;211:551-560
    • (2008) Exp Neurol , vol.211 , pp. 551-560
    • Dikranian, K.1    Cohen, R.2    Mac Donald, C.3
  • 98
    • 0034842960 scopus 로고    scopus 로고
    • Transection of major histocompatibility complex class IYinduced neurites by cytotoxic T lymphocytes
    • Medana I, Martinic MA, Wekerle H, et al. Transection of major histocompatibility complex class IYinduced neurites by cytotoxic T lymphocytes. Am J Pathol 2001;159:809-815
    • (2001) Am J Pathol , vol.159 , pp. 809-815
    • Medana, I.1    Martinic, M.A.2    Wekerle, H.3
  • 99
    • 33645764470 scopus 로고    scopus 로고
    • Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease
    • Wirths O, Weis J, Szczygielski J, et al. Axonopathy in an APP/PS1 transgenic mouse model of Alzheimer's disease. Acta Neuropathol 2006;111:312-319
    • (2006) Acta Neuropathol , vol.111 , pp. 312-319
    • Wirths, O.1    Weis, J.2    Szczygielski, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.