Axonal degeneration in paraplegin-deficient mice is associated with abnormal mitochondria and impairment of axonal transport

Journal of Clinical Investigation

Volumn 113, Issue 2, 2004, Pages 231-242

  Ferreirinha, Fatima ^a,b   Quattrini, Angelo ^c   Pirozzi, Marinella ^a   Valsecchi, Valentina ^a   Dina, Giorgia ^c   Broccoli, Vania ^a,e   Auricchio, Alberto ^a   Piemonte, Fiorella ^d   Tozzi, Giulia ^d   Gaeta, Laura ^d   Casari, Giorgio ^e   Ballabio, Andrea ^a,f   Rugarli, Elena I ^a  

^a TELETHON INSTITUTE OF GENETICS AND MEDICINE TIGEM   (Italy)

^b UNIVERSITY OF PORTO   (Portugal)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^d BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^e SAN RAFFAELE HOSPITAL   (Italy)

^f UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

NERVE PROTEIN; PARAPLEGIN; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; COMPLEMENTARY DNA; METALLOPROTEINASE; SPG7 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENE; GENE MUTATION; HEREDITARY MOTOR SENSORY NEUROPATHY; MOTOR DYSFUNCTION; MOUSE; NERVE CELL NECROSIS; NERVE FIBER DEGENERATION; NERVE FIBER TRANSPORT; NEUROFILAMENT; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL TRACT; RETROGRADE NERVE FIBER TRANSPORT; SPG7 GENE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CHEMISTRY; ELECTRON TRANSPORT; FEMALE; GENETIC RECOMBINATION; GENETICS; GENOTYPE; METABOLISM; MITOCHONDRION; MUSCLE; MUTATION; NERVE FIBER; PATHOLOGY; PHENOTYPE; SOUTHERN BLOTTING; SPINAL CORD; TIME; TRANSPORT AT THE CELLULAR LEVEL; ULTRASTRUCTURE; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; ANIMALS; AXONS; BIOLOGICAL TRANSPORT; BLOTTING, SOUTHERN; BLOTTING, WESTERN; DNA, COMPLEMENTARY; ELECTRON TRANSPORT; FEMALE; GENOTYPE; METALLOENDOPEPTIDASES; MICE; MICE, INBRED C57BL; MITOCHONDRIA; MODELS, GENETIC; MUSCLES; MUTATION; NEURODEGENERATIVE DISEASES; PHENOTYPE; RECOMBINATION, GENETIC; SPASTIC PARAPLEGIA, HEREDITARY; SPINAL CORD; TIME FACTORS;

EID: 1342310772     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200420138     Document Type: Article

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