Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitis

Brain

Volumn 124, Issue 6, 2001, Pages 1114-1124

  Kornek, Barbara ^a   Storch, Maria K ^a,d   Bauer, Jan ^a   Djamshidian, Atbin ^b   Weissert, Robert ^e   Wallstroem, Erik ^e   Stefferl, Andreas ^a,f   Zimprich, Fritz ^b   Olsson, Tomas ^e   Linington, Christopher ^f   Schmidbauer, Manfred ^c   Lassmann, Hans ^a,g  

^a Brain Research Institute   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

^c GENERAL HOSPITAL LINZ   (Austria)

^d UNIVERSITY OF GRAZ   (Austria)

^e KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^f MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^g MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Axon degeneration; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Voltage gated calcium channels

Indexed keywords

AMYLOID PRECURSOR PROTEIN; CALCIUM; CALCIUM CHANNEL; CALCIUM CHANNEL N TYPE; NEUTRAL PROTEINASE; PROTEIN SUBUNIT;

ADULT; ALLERGIC ENCEPHALOMYELITIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MULTIPLE SCLEROSIS; NERVE FIBER DEGENERATION; NERVE FIBER MEMBRANE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL;

EID: 0034987047     PISSN: 00068950     EISSN: None     Source Type: Journal    
DOI: 10.1093/brain/124.6.1114     Document Type: Article

References (60)

1. Mechanisms of secondary injury to spinal cord axons in vitro: Role of Na+, Na+-K+-ATPase, the Na+-H+-exchanger, and the Na+-Ca2+ exchanger
2. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice. Models for multiple sclerosis with primary oligodendrogliopathy
3. The cells of the nervous system: An overview of their structure and function
4. Calpain activity in spinal cord injury
5. Increased calpain content and progressive degradation of neurofilament protein in spinal cord injury
6. Inflammatory CNS demyelination: Histopathologic correlation with in vivo quantitative proton MR spectroscopy
7. Acute axonal injury in multiple sclerosis: Correlation with demyelination and inflammation
8. Distribution of sodium channels in chronically demyelinated spinal cord axons: Immuno-ultrastructural localization and electrophysiological observations
9. In situ hybridization with digoxigenin-labeled probes. Sensitive and reliable detection method applied to myelinating rat brain
10. Monocyte/macrophage differentiation in early multiple sclerosis lesions
11. Inflammatory central nervous system demyelination: Correlation of magnetic resonance imaging findings with lesion pathology
12. The role of calpain-mediated spectrin proteolysis in traumatically induced axonal injury
13. Histologie de la sclérose en plaques
14. Symposium: Immunopathogenesis of demyelinating diseases
15. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss
16. Distribution of α1A, α1B, and α1E voltage-dependent calcium channel sububnits in the human hippocampus and parahippocampal gyrus
17. Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study
18. Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis
19. Axonal damage in acute multiple sclerosis lesions
20. Voltage-gated calcium channels in CNS white matter: Role in anoxic injury
21. Capsular infarcts: The underlying vascular lesions
22. Spinal cord axonal loss in multiple sclerosis: A post-mortem study
23. Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury
24. Axotomy-induced axonal degeneration is mediated by calcium influx through ion-specific channels
25. Mechanisms of calpain proteolysis following traumatic brain injury. Implications for pathology and therapy: A review and update
26. Axonal pathology in multiple sclerosis: A historical note
27. Multiple sclerosis and chronic autoimmune encephalomyelitis: A comparative quantitative study of axonal injury in active, inactive and remyelinated lesions
28. Neuropathology in multiple sclerosis. New concepts
29. The pathology of multiple slerosis
30. Axonal injury or loss in the internal capsule and motor impairment in multiple sclerosis
31. Spinal cord atrophy and disability in multiple sclerosis: A new reproducible and sensitive MRI method with potential to monitor disease progression
32. Axonal changes in chronic demyelinated cervical spinal cord plaques
33. Defining the clinical course of multiple sclerosis: Results of an international survey
34. Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis
35. White matter lucencies on computed tomography, subacute arteriosclerotic encephalopathy (Binswanger's disease), and blood pressure
36. Oligodendrocyte and axon pathology in clinically silent multiple sclerosis lesions
37. Sensorimotor stroke due to thalamocapsular ischemia
38. Increase of sodium channels in demyelinated lesions of multiple sclerosis
39. Traumatically induced axonal damage: Evidence for enduring changes in axolemmal permeability with associated cytoskeletal change
40. Axonal dystrophy as a consequence of long-term demyelination
41. The pathophysiology of anoxic injury in central nervous system white matter
42. Relating axonal injury to functional recovery in MS
43. Mechanisms underlying the neuronal response to ischemic injury. Calcium-activated proteolysis of neurofilaments
44. Early detection of axonal injury after human head trauma using immunocytochemistry for β-amyloid precursor protein
45. Autoimmunity to myelin oligodendrocyte glycoprotein in rats mimics the spectrum of multiple sclerosis pathology
46. Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons
47. Na+-Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matter
48. Ionic mechanisms of anoxic injury in mammalian CNS white matter: Role of Na+ channels and Na+-Ca2+ exchanger
49. Axonal transection in the lesions of multiple sclerosis
50. Accumulation of hypointense lesions ('black holes') on T1 spin-echo MRI correlates with disease progression in multiple sclerosis
51. Histopathologic correlate of hypointense lesions on T1-weighted spin-echo MRI in multiple sclerosis
52. The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis
53. Subunit interaction sites in voltage-dependent Ca2+ channels: Role in channel function
54. Molecular dissection of the myelinated axon
55. Protection of the axonal cytoskeleton in anoxic optic nerve by decreased extracellular calcium
56. The natural history of multiple sclerosis: A geographically based study. I. Clinical course and disability
57. Biochemical properties and subcellular distribution of an N-type calcium channel α1 subunit
58. Localization of Ca2+ channel subtypes on rat spinal motor neurons, interneurons, and nerve terminals
59. Upregulation of L-type Ca2+ channels in reactive astrocytes after brain injury, hypomyelination, and ischemia