Hitting the hot spots of cell signaling cascades

Science

Volumn 312, Issue 5772, 2006, Pages 377-378

  Tesmer, John Joseph Grubb ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DRUG THERAPY; GENES; PROTEINS;

CELL SIGNALING; PROTEIN INTERACTIONS; SIGNALING PROTEINS;

BIOMEDICAL ENGINEERING;

CELL SURFACE RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE 2; GUANINE NUCLEOTIDE BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN GAMMA SUBUNIT; PEPTIDE; PEPTIDE LIBRARY;

INHIBITOR; MOLECULAR ANALYSIS; PROTEIN;

ALLOSTERISM; BINDING AFFINITY; CRYSTALLOGRAPHY; DRUG DESIGN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER PROGRAM; COMPUTER SIMULATION; DRUG SCREENING; METABOLISM; METHODOLOGY; NOTE; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC SITE; ANIMALS; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEIN BETA SUBUNITS; GTP-BINDING PROTEIN GAMMA SUBUNITS; MODELS, MOLECULAR; PEPTIDE LIBRARY; PEPTIDES; PROTEIN BINDING; SIGNAL TRANSDUCTION; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646001407     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1126903     Document Type: Review

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