Vascularization of cutaneous melanoma involves vessel co-option and has clinical significance

Journal of Pathology

Volumn 197, Issue 3, 2002, Pages 355-362

  Dme, Balzs ^a   Paku, Sndor ^a   Somlai, Beta ^a   Tmr, Jzsef ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

Author keywords

Intratumoral vessels; Melanoma; Prognosis; Vessel incorporation

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GROWTH; CANCER PATIENT; CANCER SURVIVAL; CAPILLARY DENSITY; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; METASTASIS; MICROVASCULATURE; MORPHOMETRICS; MOUSE; NONHUMAN; PERICYTE; PRIORITY JOURNAL; PROGNOSIS; SURVIVAL RATE; THREE DIMENSIONAL IMAGING; TUMOR VASCULARIZATION; ULTRASTRUCTURE; VASODILATATION;

ANALYSIS OF VARIANCE; ANIMALS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICROCIRCULATION; MICROSCOPY, ELECTRON; PERICYTES; SKIN NEOPLASMS; SURVIVAL ANALYSIS;

EID: 0036067866     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1124     Document Type: Article

References (31)

1. Intratumour microvessel density as a prognostic factor in cancer
2. The vascularity of primary cutaneous melanoma
3. Vascular architecture of melanocytic skin tumours: A quantitative immunohistochemical study using automated image analysis
4. Neovascularization in human cutaneous melanoma: A quantitative morphological and Doppler ultrasound study
5. The prognostic significance of tumour vascularity in intermediate-thickness (0.76-4.0 mm thick) skin melanoma: A quantitative histologic study
6. Extent of vascularization as a prognostic indicator in thin (<0.76 mm) malignant melanomas
7. Angiogenesis is prognostically important in vertical growth phase melanomas
8. Tumour vascularity is not a prognostic factor for malignant melanoma of the skin
9. The vascularity of cutaneous melanoma: A quantitative histological study of lesions 0.85-1.25 mm in thickness
10. Immunohistochemical assessment of tumour vascularity in recurrent Clark II melanomas using antibody to type IV collagen
11. Angiogenesis and vascular growth factor receptor expression in malignant melanoma
12. Vascular density and survival in cutaneous melanoma
13. Prognostic value of tumour vascularity in primary melanoma
14. Quantification of angiogenesis in solid human tumours: An international consensus on the methodology and criteria of evaluation
15. First steps of tumour-related angiogenesis
16. Current concepts of tumour-induced angiogenesis
17. Non-small-cell lung carcinoma tumour growth without morphological evidence of neo-angiogenesis
18. Vessel cooption, regression, and growth in tumours mediated by angiopoietins and VEGF
19. Tumours acquire their vasculature by vessel incorporation, not vessel ingrowth
20. Selective ablation of immature blood vessels in established human tumours follows vascular endothelial growth factor withdrawal
21. Tumours: Wounds that do not heal. Similarities between tumour stroma generation and wound healing
22. Heterogeneity of angiogenesis and blood vessel maturation in human tumours: Implications for antiangiogenic tumour therapies
23. Vascular volume in B16 allografts and human melanoma xenografts estimated by means of Hoechst 33342
24. Microscopic studies of the early growth of a transplantable melanoma of the mouse, using the transparent-chamber technique
25. Morphological aspects of angiogenesis in experimental liver metastases
26. Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor
27. Cytokinetics of tumour and endothelial cells and vascularization of lung metastases in C3H/He mice
28. Endothelial-cell proliferation in experimental tumours
29. Local imbalance of proangiogenic and antiangiogenic factors: A potential mechanism of focal necrosis and dormancy in tumours
30. Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: Role of extracellular matrix
31. Vascular invasion in malignant melanomas: An independent prognostic variable?