메뉴 건너뛰기




Volumn 184, Issue 7, 2010, Pages 3866-3877

Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer- binding protein α

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; INTERLEUKIN 12; INTERLEUKIN 23; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SERINE; THREONINE; TRIPTOLIDE; DITERPENE; EPITOPE; EPOXIDE; IMMUNOSUPPRESSIVE AGENT; P40, IODINATED C TERMINAL PEPTIDE, HUMAN; P40, IODINATED C-TERMINAL PEPTIDE, HUMAN; PEPTIDE FRAGMENT; PHENANTHRENE DERIVATIVE;

EID: 77951644674     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0903417     Document Type: Article
Times cited : (43)

References (74)
  • 1
    • 0015494046 scopus 로고
    • Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii
    • Kupchan, S. M., W. A. Court, R. G. Dailey, Jr., C. J. Gilmore, and R. F. Bryan. 1972. Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii. J. Am. Chem. Soc. 94: 7194-7195.
    • (1972) J. Am. Chem. Soc. , vol.94 , pp. 7194-7195
    • Kupchan, S.M.1    Court, W.A.2    Dailey Jr., R.G.3    Gilmore, C.J.4    Bryan, R.F.5
  • 2
    • 0024390013 scopus 로고
    • A prospective, controlled, double-blind, cross-over study of tripterygium wilfodii hook F in treatment of rheumatoid arthritis
    • Tao, X. L., Y. Sun, Y. Dong, Y. L. Xiao, D. W. Hu, Y. P. Shi, Q. L. Zhu, H. Dai, and N. Z. Zhang. 1989. A prospective, controlled, double-blind, cross-over study of tripterygium wilfodii hook F in treatment of rheumatoid arthritis. Chin. Med. J. (Engl.) 102: 327-332.
    • (1989) Chin. Med. J. (Engl.) , vol.102 , pp. 327-332
    • Tao, X.L.1    Sun, Y.2    Dong, Y.3    Xiao, Y.L.4    Hu, D.W.5    Shi, Y.P.6    Zhu, Q.L.7    Dai, H.8    Zhang, N.Z.9
  • 3
    • 0020775518 scopus 로고
    • Clinical observations on Tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus
    • Qin, W. Z., G. D. Zhu, S. M. Yang, K. Y. Han, and J. Wang. 1983. Clinical observations on Tripterygium wilfordii in treatment of 26 cases of discoid lupus erythematosus. J. Tradit. Chin. Med. 3: 131-132.
    • (1983) J. Tradit. Chin. Med. , vol.3 , pp. 131-132
    • Qin, W.Z.1    Zhu, G.D.2    Yang, S.M.3    Han, K.Y.4    Wang, J.5
  • 4
    • 0028358443 scopus 로고
    • Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome
    • Jiang, X. 1994. Clinical observations on the use of the Chinese herb Tripterygium wilfordii Hook for the treatment of nephrotic syndrome. Pediatr. Nephrol. 8: 343-344.
    • (1994) Pediatr. Nephrol. , vol.8 , pp. 343-344
    • Jiang, X.1
  • 5
    • 0021932640 scopus 로고
    • Tripterygium in dermatologic therapy
    • Xu, W. Y., J. R. Zheng, and X. Y. Lu. 1985. Tripterygium in dermatologic therapy. Int. J. Dermatol. 24: 152-157.
    • (1985) Int. J. Dermatol. , vol.24 , pp. 152-157
    • Xu, W.Y.1    Zheng, J.R.2    Lu, X.Y.3
  • 6
    • 51749101292 scopus 로고    scopus 로고
    • Mycophenolate mofetil and triptolide alleviating airway inflammation in asthmatic model mice partly by inhibiting bone marrow eosinophilopoiesis
    • Mao, H., X. R. Chen, Q. Yi, S. Y. Li, Z. L. Wang, and F. Y. Li. 2008. Mycophenolate mofetil and triptolide alleviating airway inflammation in asthmatic model mice partly by inhibiting bone marrow eosinophilopoiesis. Int. Immunopharmacol. 8: 1039-1048.
    • (2008) Int. Immunopharmacol. , vol.8 , pp. 1039-1048
    • Mao, H.1    Chen, X.R.2    Yi, Q.3    Li, S.Y.4    Wang, Z.L.5    Li, F.Y.6
  • 7
    • 57549093077 scopus 로고    scopus 로고
    • Prolongation of rat intestinal allograft survival by administration of triptolide-modified donor bone marrow-derived dendritic cells
    • Chen, T., H. Xu, H. Q. Wang, Y. Zhao, C. F. Zhu, Y. H. Zhang, M. J. Ji, Y. B. Hua, and W. X. Wu. 2008. Prolongation of rat intestinal allograft survival by administration of triptolide-modified donor bone marrow-derived dendritic cells. Transplant. Proc. 40: 3711-3713.
    • (2008) Transplant. Proc. , vol.40 , pp. 3711-3713
    • Chen, T.1    Xu, H.2    Wang, H.Q.3    Zhao, Y.4    Zhu, C.F.5    Zhang, Y.H.6    Ji, M.J.7    Hua, Y.B.8    Wu, W.X.9
  • 8
    • 41749112206 scopus 로고    scopus 로고
    • Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation
    • Liu, Y., Y. Chen, F. Q. Liu, J. R. Lamb, and P. K. Tam. 2008. Combined treatment with triptolide and rapamycin prolongs graft survival in a mouse model of cardiac transplantation. Transpl. Int. 21: 483-494.
    • (2008) Transpl. Int. , vol.21 , pp. 483-494
    • Liu, Y.1    Chen, Y.2    Liu, F.Q.3    Lamb, J.R.4    Tam, P.K.5
  • 9
    • 0033532177 scopus 로고    scopus 로고
    • Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation
    • Qiu, D., G. Zhao, Y. Aoki, L. Shi, A. Uyei, S. Nazarian, J. C. Ng, and P. N. Kao. 1999. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J. Biol. Chem. 274: 13443-13450.
    • (1999) J. Biol. Chem. , vol.274 , pp. 13443-13450
    • Qiu, D.1    Zhao, G.2    Aoki, Y.3    Shi, L.4    Uyei, A.5    Nazarian, S.6    Ng, J.C.7    Kao, P.N.8
  • 10
    • 33646258473 scopus 로고    scopus 로고
    • Cytokine and anti-cytokine therapies for psoriasis and atopic dermatitis
    • Numerof, R. P., and K. Asadullah. 2006. Cytokine and anti-cytokine therapies for psoriasis and atopic dermatitis. BioDrugs 20: 93-103.
    • (2006) BioDrugs , vol.20 , pp. 93-103
    • Numerof, R.P.1    Asadullah, K.2
  • 11
    • 0042662901 scopus 로고    scopus 로고
    • Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medical herb Tripterygium wilfordii Hook F
    • Qiu, D, and P. N. Kao. 2003. Immunosuppressive and anti-inflammatory mechanisms of triptolide, the principal active diterpenoid from the Chinese medical herb Tripterygium wilfordii Hook F. Drugs R D. 4: 1-18.
    • (2003) Drugs R D , vol.4 , pp. 1-18
    • Qiu, D.1    Kao, P.N.2
  • 12
    • 2942618624 scopus 로고    scopus 로고
    • Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation
    • Liu, Q., T. Chen, H. Chen, M. Zhang, N. Li, Z. Lu, P. Ma, and X. Cao. 2004. Triptolide (PG-490) induces apoptosis of dendritic cells through sequential p38 MAP kinase phosphorylation and caspase 3 activation. Biochem. Biophys. Res. Commun. 319: 980-986.
    • (2004) Biochem. Biophys. Res. Commun. , vol.319 , pp. 980-986
    • Liu, Q.1    Chen, T.2    Chen, H.3    Zhang, M.4    Li, N.5    Lu, Z.6    Ma, P.7    Cao, X.8
  • 13
    • 33646349442 scopus 로고    scopus 로고
    • Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226
    • Liu, H. K., S. Perrier, C. Lipina, D. Finlay, H. McLauchlan, C. J. Hastie, H. S. Hundal, and C. Sutherland. 2006. Functional characterisation of the regulation of CAAT enhancer binding protein alpha by GSK-3 phosphorylation of Threonines 222/226. BMC Mol. Biol. 7: 14.
    • (2006) BMC Mol. Biol. , vol.7 , pp. 14
    • Liu, H.K.1    Perrier, S.2    Lipina, C.3    Finlay, D.4    McLauchlan, H.5    Hastie, C.J.6    Hundal, H.S.7    Sutherland, C.8
  • 14
    • 20444460254 scopus 로고    scopus 로고
    • Triptolide affects the differentiation, maturation and function of human dendritic cells
    • Zhu, K. J., Q. Y. Shen, H. Cheng, X. H. Mao, L. M. Lao, and G. L. Hao. 2005. Triptolide affects the differentiation, maturation and function of human dendritic cells. Int. Immunopharmacol. 5: 1415-1426.
    • (2005) Int. Immunopharmacol. , vol.5 , pp. 1415-1426
    • Zhu, K.J.1    Shen, Q.Y.2    Cheng, H.3    Mao, X.H.4    Lao, L.M.5    Hao, G.L.6
  • 15
    • 0028970060 scopus 로고
    • Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
    • Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13: 251-276.
    • (1995) Annu. Rev. Immunol. , vol.13 , pp. 251-276
    • Trinchieri, G.1
  • 16
    • 0031803057 scopus 로고    scopus 로고
    • Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis
    • Tarrant, T. K., P. B. Silver, C. C. Chan, B. Wiggert, and R. R. Caspi. 1998. Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. J. Immunol. 161: 122-127. (Pubitemid 28285514)
    • (1998) Journal of Immunology , vol.161 , Issue.1 , pp. 122-127
    • Tarrant, T.K.1    Silver, P.B.2    Chan, C.-C.3    Wiggert, B.4    Caspi, R.R.5
  • 19
    • 27144467100 scopus 로고    scopus 로고
    • Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking
    • DOI 10.1182/blood-2005-03-0854
    • Chen, X., T. Murakami, J. J. Oppenheim, and O. M. Howard. 2005. Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking. Blood 106: 2409-2416. (Pubitemid 41510814)
    • (2005) Blood , vol.106 , Issue.7 , pp. 2409-2416
    • Chen, X.1    Murakami, T.2    Oppenheim, J.J.3    Howard, O.M.Z.4
  • 20
    • 13444305372 scopus 로고    scopus 로고
    • Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells
    • Liu, J., Q. L. Wu, Y. H. Feng, Y. F. Wang, X. Y. Li, and J. P. Zuo. 2005. Triptolide suppresses CD80 and CD86 expressions and IL-12 production in THP-1 cells. Acta Pharmacol. Sin. 26: 223-227.
    • (2005) Acta Pharmacol. Sin. , vol.26 , pp. 223-227
    • Liu, J.1    Wu, Q.L.2    Feng, Y.H.3    Wang, Y.F.4    Li, X.Y.5    Zuo, J.P.6
  • 23
    • 0037111372 scopus 로고    scopus 로고
    • Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma
    • Cao, S., J. Liu, M. Chesi, P. L. Bergsagel, I. C. Ho, R. P. Donnelly, and X. Ma. 2002. Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. J. Immunol. 169: 5715-5725.
    • (2002) J. Immunol. , vol.169 , pp. 5715-5725
    • Cao, S.1    Liu, J.2    Chesi, M.3    Bergsagel, P.L.4    Ho, I.C.5    Donnelly, R.P.6    Ma, X.7
  • 24
    • 37049031230 scopus 로고    scopus 로고
    • Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1
    • Chung, E. Y., J. Liu, Y. Homma, Y. Zhang, A. Brendolan, M. Saggese, J. Han, R. Silverstein, L. Selleri, and X. Ma. 2007. Interleukin-10 expression in macrophages during phagocytosis of apoptotic cells is mediated by homeodomain proteins Pbx1 and Prep-1. Immunity 27: 952-964.
    • (2007) Immunity , vol.27 , pp. 952-964
    • Chung, E.Y.1    Liu, J.2    Homma, Y.3    Zhang, Y.4    Brendolan, A.5    Saggese, M.6    Han, J.7    Silverstein, R.8    Selleri, L.9    Ma, X.10
  • 25
    • 0030872393 scopus 로고    scopus 로고
    • Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: Evidence of functional synergy between C/EBP and Rel proteins
    • Plevy, S. E., J. H. Gemberling, S.Hsu, A. J. Dorner, and S. T. Smale. 1997.Multiple control elements mediate activation of the murine and human interleukin 12 p40 promoters: evidence of functional synergy between C/EBP and Rel proteins. Mol. Cell. Biol. 17: 4572-4588.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 4572-4588
    • Plevy, S.E.1    Gemberling, J.H.2    Hsu, S.3    Dorner, A.J.4    Smale, S.T.5
  • 26
    • 0036683653 scopus 로고    scopus 로고
    • CCAAT/enhancer-binding proteins: Structure, function and regulation
    • DOI 10.1042/BJ20020508
    • Ramji, D. P., and P. Foka. 2002. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J. 365: 561-575. (Pubitemid 34864439)
    • (2002) Biochemical Journal , vol.365 , Issue.3 , pp. 561-575
    • Ramji, D.P.1    Foka, P.2
  • 27
    • 0033802516 scopus 로고    scopus 로고
    • Differential regulation of macrophage CCAAT-enhancer binding protein isoforms by lipopolysaccharide and cytokines
    • Tengku-Muhammad, T. S., T. R. Hughes, H. Ranki, A. Cryer, and D. P. Ramji. 2000. Differential regulation of macrophage CCAAT-enhancer binding protein isoforms by lipopolysaccharide and cytokines. Cytokine 12: 1430-1436.
    • (2000) Cytokine , vol.12 , pp. 1430-1436
    • Tengku-Muhammad, T.S.1    Hughes, T.R.2    Ranki, H.3    Cryer, A.4    Ramji, D.P.5
  • 28
    • 0032491401 scopus 로고    scopus 로고
    • The role of C/EBP isoforms in the control of inflammatory and native immunity functions
    • Poli, V. 1998. The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J. Biol. Chem. 273: 29279-29282.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29279-29282
    • Poli, V.1
  • 29
    • 0027217386 scopus 로고
    • The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms
    • Ramji, D. P., A. Vitelli, F. Tronche, R. Cortese, and G. Ciliberto. 1993. The two C/EBP isoforms, IL-6DBP/NF-IL6 and C/EBP delta/NF-IL6 beta, are induced by IL-6 to promote acute phase gene transcription via different mechanisms. Nucleic Acids Res. 21: 289-294.
    • (1993) Nucleic Acids Res. , vol.21 , pp. 289-294
    • Ramji, D.P.1    Vitelli, A.2    Tronche, F.3    Cortese, R.4    Ciliberto, G.5
  • 30
    • 0025936177 scopus 로고
    • A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
    • Descombes, P., and U. Schibler. 1991. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67: 569-579. (Pubitemid 121001471)
    • (1991) Cell , vol.67 , Issue.3 , pp. 569-579
    • Descombes, P.1    Schibler, U.2
  • 32
    • 0027276292 scopus 로고
    • High level activity of the mouse CCAAT/enhancer binding protein (C/EBPα) gene promoter involves autoregulation and several ubiquitous transcription factors
    • Legraverend, C., P. Antonson, P. Flodby, and K. G. Xanthopoulos. 1993. High level activity of the mouse CCAAT/enhancer binding protein (C/EBP alpha) gene promoter involves autoregulation and several ubiquitous transcription factors. Nucleic Acids Res. 21: 1735-1742. (Pubitemid 23178886)
    • (1993) Nucleic Acids Research , vol.21 , Issue.8 , pp. 1735-1742
    • Legraverend, C.1    Antonson, P.2    Flodby, P.3    Xanthopoulos, K.G.4
  • 33
    • 0026029709 scopus 로고
    • CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes
    • Christy, R. J., K. H. Kaestner, D. E. Geiman, and M. D. Lane. 1991. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc. Natl. Acad. Sci. USA 88: 2593-2597.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2593-2597
    • Christy, R.J.1    Kaestner, K.H.2    Geiman, D.E.3    Lane, M.D.4
  • 34
    • 49649120008 scopus 로고    scopus 로고
    • Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes
    • Cha, H. C., N. R. Oak, S. Kang, T. A. Tran, S. Kobayashi, S. H. Chiang, D. G. Tenen, and O. A. MacDougald. 2008. Phosphorylation of CCAAT/enhancer- binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes. J. Biol. Chem. 283: 18002-18011.
    • (2008) J. Biol. Chem. , vol.283 , pp. 18002-18011
    • Cha, H.C.1    Oak, N.R.2    Kang, S.3    Tran, T.A.4    Kobayashi, S.5    Chiang, S.H.6    Tenen, D.G.7    MacDougald, O.A.8
  • 35
    • 34047263219 scopus 로고    scopus 로고
    • Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade
    • Datta, J., S. Majumder, H. Kutay, T. Motiwala, W. Frankel, R. Costa, H. C. Cha, O. A. MacDougald, S. T. Jacob, and K. Ghoshal. 2007. Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivation of CCAAT/enhancer binding protein alpha by phosphatidylinositol 3-kinase signaling cascade. Cancer Res. 67: 2736-2746.
    • (2007) Cancer Res. , vol.67 , pp. 2736-2746
    • Datta, J.1    Majumder, S.2    Kutay, H.3    Motiwala, T.4    Frankel, W.5    Costa, R.6    Cha, H.C.7    MacDougald, O.A.8    Jacob, S.T.9    Ghoshal, K.10
  • 36
    • 0033499747 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3 is an insulin-regulated C/EBPalpha kinase
    • Ross, S. E., R. L. Erickson, N. Hemati, and O. A. MacDougald. 1999. Glycogen synthase kinase 3 is an insulin-regulated C/EBPalpha kinase. Mol. Cell. Biol. 19: 8433-8441.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 8433-8441
    • Ross, S.E.1    Erickson, R.L.2    Hemati, N.3    MacDougald, O.A.4
  • 37
    • 33847197478 scopus 로고    scopus 로고
    • Distinct C/EBPα motifs regulate lipogenic and gluconeogenic gene expression in vivo
    • DOI 10.1038/sj.emboj.7601563, PII 7601563
    • Pedersen, T. A., O. Bereshchenko, S. Garcia-Silva, O. Ermakova, E. Kurz, S. Mandrup, B. T. Porse, and C. Nerlov. 2007. Distinct C/EBPalpha motifs regulate lipogenic and gluconeogenic gene expression in vivo. EMBO J. 26: 1081-1093. (Pubitemid 46303586)
    • (2007) EMBO Journal , vol.26 , Issue.4 , pp. 1081-1093
    • Pedersen, T.A.1    Bereshchenko, O.2    Garcia-Silva, S.3    Ermakova, O.4    Kurz, E.5    Mandrup, S.6    Porse, B.T.7    Nerlov, C.8
  • 40
    • 0029776032 scopus 로고    scopus 로고
    • A molecular mechanism for the effect of lithium on development
    • Klein, P. S., and D. A. Melton. 1996. A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. USA 93: 8455-8459.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 8455-8459
    • Klein, P.S.1    Melton, D.A.2
  • 41
    • 34248595035 scopus 로고    scopus 로고
    • Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases
    • DOI 10.1038/sj.onc.1210412, PII 1210412
    • Owens, D. M., and S. M. Keyse. 2007. Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases. Oncogene 26: 3203-3213. (Pubitemid 46763015)
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3203-3213
    • Owens, D.M.1    Keyse, S.M.2
  • 43
    • 0036884621 scopus 로고    scopus 로고
    • Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages
    • Chen, P., J. Li, J. Barnes, G. C. Kokkonen, J. C. Lee, and Y. Liu. 2002. Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. J. Immunol. 169: 6408-6416. (Pubitemid 36903490)
    • (2002) Journal of Immunology , vol.169 , Issue.11 , pp. 6408-6416
    • Chen, P.1    Li, J.2    Barnes, J.3    Kokkonen, G.C.4    Lee, J.C.5    Liu, Y.6
  • 44
    • 0032904432 scopus 로고    scopus 로고
    • PTEN: A tumour suppressor that functions as a phospholipid phosphatase
    • DOI 10.1016/S0962-8924(99)01519-6, PII S0962892499015196
    • Maehama, T., and J. E. Dixon. 1999. PTEN: a tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 9: 125-128. (Pubitemid 29161437)
    • (1999) Trends in Cell Biology , vol.9 , Issue.4 , pp. 125-128
    • Maehama, T.1    Dixon, J.E.2
  • 48
    • 0032032204 scopus 로고    scopus 로고
    • Redundancy of C/EBP alpha, -beta, and -delta in supporting the lipopolysaccharide-induced transcription of IL-6 and monocyte chemoattractant protein-1
    • Hu, H. M., M. Baer, S. C. Williams, P. F. Johnson, and R. C. Schwartz. 1998. Redundancy of C/EBP alpha, -beta, and -delta in supporting the lipopolysaccharide-induced transcription of IL-6 and monocyte chemoattractant protein-1. J. Immunol. 160: 2334-2342.
    • (1998) J. Immunol. , vol.160 , pp. 2334-2342
    • Hu, H.M.1    Baer, M.2    Williams, S.C.3    Johnson, P.F.4    Schwartz, R.C.5
  • 49
    • 0026580335 scopus 로고
    • A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6
    • Kinoshita, S., S. Akira, and T. Kishimoto. 1992. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc. Natl. Acad. Sci. USA 89: 1473-1476.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 1473-1476
    • Kinoshita, S.1    Akira, S.2    Kishimoto, T.3
  • 50
    • 0033988811 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines induce the transcription factors C/EBPbeta and C/EBPdelta in astrocytes
    • Cardinaux, J. R., I. Allaman, and P. J. Magistretti. 2000. Pro-inflammatory cytokines induce the transcription factors C/EBPbeta and C/EBPdelta in astrocytes. Glia 29: 91-97.
    • (2000) Glia , vol.29 , pp. 91-97
    • Cardinaux, J.R.1    Allaman, I.2    Magistretti, P.J.3
  • 53
    • 0032582677 scopus 로고    scopus 로고
    • Biological role of the CCAAT/enhancer-binding protein family of transcription factors
    • Lekstrom-Himes, J., and K. G. Xanthopoulos. 1998. Biological role of the CCAAT/enhancer-binding protein family of transcription factors. J. Biol. Chem. 273: 28545-28548.
    • (1998) J. Biol. Chem. , vol.273 , pp. 28545-28548
    • Lekstrom-Himes, J.1    Xanthopoulos, K.G.2
  • 54
    • 0028824952 scopus 로고
    • Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen
    • Hendricks-Taylor, L. R., and G. J. Darlington. 1995. Inhibition of cell proliferation by C/EBP alpha occurs in many cell types, does not require the presence of p53 or Rb, and is not affected by large T-antigen. Nucleic Acids Res. 23: 4726-4733.
    • (1995) Nucleic Acids Res. , vol.23 , pp. 4726-4733
    • Hendricks-Taylor, L.R.1    Darlington, G.J.2
  • 55
    • 0031029557 scopus 로고    scopus 로고
    • Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice
    • Zhang, D. E., P. Zhang, N. D. Wang, C. J. Hetherington, G. J. Darlington, and D. G. Tenen. 1997. Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice. Proc. Natl. Acad. Sci. USA 94: 569-574.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 569-574
    • Zhang, D.E.1    Zhang, P.2    Wang, N.D.3    Hetherington, C.J.4    Darlington, G.J.5    Tenen, D.G.6
  • 57
    • 0034096201 scopus 로고    scopus 로고
    • Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
    • Keyse, S. M. 2000. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr. Opin. Cell Biol. 12: 186-192.
    • (2000) Curr. Opin. Cell Biol. , vol.12 , pp. 186-192
    • Keyse, S.M.1
  • 58
    • 0030794511 scopus 로고    scopus 로고
    • Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells
    • Franklin, C. C., and A. S. Kraft. 1997. Conditional expression of the mitogen-activated protein kinase (MAPK) phosphatase MKP-1 preferentially inhibits p38 MAPK and stress-activated protein kinase in U937 cells. J. Biol. Chem. 272: 16917-16923.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16917-16923
    • Franklin, C.C.1    Kraft, A.S.2
  • 59
    • 33646470960 scopus 로고    scopus 로고
    • -/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis
    • -/- mice exhibit Th1 cell polarization and increased susceptibility to experimental autoimmune encephalomyelitis. J. Immunol. 176: 5788-5796.
    • (2006) J. Immunol. , vol.176 , pp. 5788-5796
    • Agrawal, A.1    Dillon, S.2    Denning, T.L.3    Pulendran, B.4
  • 60
    • 0033118982 scopus 로고    scopus 로고
    • Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice
    • Lu, H. T., D. D. Yang, M. Wysk, E. Gatti, I. Mellman, R. J. Davis, and R. A. Flavell. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18: 1845-1857.
    • (1999) EMBO J. , vol.18 , pp. 1845-1857
    • Lu, H.T.1    Yang, D.D.2    Wysk, M.3    Gatti, E.4    Mellman, I.5    Davis, R.J.6    Flavell, R.A.7
  • 61
    • 15044363028 scopus 로고    scopus 로고
    • Recent advances in the protein kinase B signaling pathway
    • Woodgett, J. R. 2005. Recent advances in the protein kinase B signaling pathway. Curr. Opin. Cell Biol. 17: 150-157.
    • (2005) Curr. Opin. Cell Biol. , vol.17 , pp. 150-157
    • Woodgett, J.R.1
  • 62
    • 34548649547 scopus 로고    scopus 로고
    • Role of phosphoinositide 3-kinase in innate immunity
    • Hazeki, K., K. Nigorikawa, and O. Hazeki. 2007. Role of phosphoinositide 3-kinase in innate immunity. Biol. Pharm. Bull. 30: 1617-1623.
    • (2007) Biol. Pharm. Bull. , vol.30 , pp. 1617-1623
    • Hazeki, K.1    Nigorikawa, K.2    Hazeki, O.3
  • 63
    • 1342292522 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: Diverse roles in immune cell activation
    • Deane, J. A., and D. A. Fruman. 2004. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Annu. Rev. Immunol. 22: 563-598.
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 563-598
    • Deane, J.A.1    Fruman, D.A.2
  • 65
    • 23944486750 scopus 로고    scopus 로고
    • Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
    • Martin, M., K. Rehani, R. S. Jope, and S. M. Michalek. 2005. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat. Immunol. 6: 777-784.
    • (2005) Nat. Immunol. , vol.6 , pp. 777-784
    • Martin, M.1    Rehani, K.2    Jope, R.S.3    Michalek, S.M.4
  • 66
    • 20444400257 scopus 로고    scopus 로고
    • Redox redux: Revisiting PTPs and the control of cell signaling
    • Tonks, N. K. 2005. Redox redux: revisiting PTPs and the control of cell signaling. Cell 121: 667-670.
    • (2005) Cell , vol.121 , pp. 667-670
    • Tonks, N.K.1
  • 67
    • 1542406446 scopus 로고    scopus 로고
    • NOX enzymes and the biology of reactive oxygen
    • Lambeth, J. D. 2004. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 4: 181-189.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 181-189
    • Lambeth, J.D.1
  • 68
    • 0034803321 scopus 로고    scopus 로고
    • Atrial natriuretic peptide attenuates ANG II-induced hypertrophy of renal tubular cells
    • Hannken, T., R. Schroeder, R. A. Stahl, and G. Wolf. 2001. Atrial natriuretic peptide attenuates ANG II-induced hypertrophy of renal tubular cells. Am. J. Physiol. Renal Physiol. 281: F81-F90.
    • (2001) Am. J. Physiol. Renal Physiol. , vol.281
    • Hannken, T.1    Schroeder, R.2    Stahl, R.A.3    Wolf, G.4
  • 69
    • 0035891671 scopus 로고    scopus 로고
    • Development of high-density DNA microarray membrane for profiling smoke- and hydrogen peroxide-induced genes in a human bronchial epithelial cell line
    • Yoneda, K., K. Peck, M. M. Chang, K. Chmiel, Y. P. Sher, J. Chen, P. C. Yang, Y. Chen, and R. Wu. 2001. Development of high-density DNA microarray membrane for profiling smoke- and hydrogen peroxide-induced genes in a human bronchial epithelial cell line. Am. J. Respir. Crit. Care Med. 164: S85-S89.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.164
    • Yoneda, K.1    Peck, K.2    Chang, M.M.3    Chmiel, K.4    Sher, Y.P.5    Chen, J.6    Yang, P.C.7    Chen, Y.8    Wu, R.9
  • 70
    • 11844272574 scopus 로고    scopus 로고
    • Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation
    • Fürst, R., C. Brueckl, W. M. Kuebler, S. Zahler, F. Krötz, A. Görlach, A. M. Vollmar, and A. K. Kiemer. 2005. Atrial natriuretic peptide induces mitogen-activated protein kinase phosphatase-1 in human endothelial cells via Rac1 and NAD(P)H oxidase/Nox2-activation. Circ. Res. 96: 43-53.
    • (2005) Circ. Res. , vol.96 , pp. 43-53
    • Fürst, R.1    Brueckl, C.2    Kuebler, W.M.3    Zahler, S.4    Krötz, F.5    Görlach, A.6    Vollmar, A.M.7    Kiemer, A.K.8
  • 71
    • 33646192953 scopus 로고    scopus 로고
    • Human alveolarmacrophages are deficient in PTEN. The role of endogenous oxidants
    • Flaherty, D. M., M. M. Monick, and S. L. Hinde. 2006. Human alveolarmacrophages are deficient in PTEN. The role of endogenous oxidants. J. Biol. Chem. 281: 5058-5064.
    • (2006) J. Biol. Chem. , vol.281 , pp. 5058-5064
    • Flaherty, D.M.1    Monick, M.M.2    Hinde, S.L.3
  • 73
    • 0016255753 scopus 로고
    • Selective alkylation: A biomimetic reaction of the antileukemic triptolides?
    • Kupchan, S. M., and R. M. Schubert. 1974. Selective alkylation: a biomimetic reaction of the antileukemic triptolides? Science 185: 791-793.
    • (1974) Science , vol.185 , pp. 791-793
    • Kupchan, S.M.1    Schubert, R.M.2
  • 74
    • 48449107159 scopus 로고    scopus 로고
    • Thiol chemistry and specificity in redox signaling
    • Winterbourn, C. C., and M. B. Hampton. 2008. Thiol chemistry and specificity in redox signaling. Free Radic. Biol. Med. 45: 549-561.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 549-561
    • Winterbourn, C.C.1    Hampton, M.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.