Prolongation of Rat Intestinal Allograft Survival by Administration of Triptolide-Modified Donor Bone Marrow-Derived Dendritic Cells

Transplantation Proceedings

Volumn 40, Issue 10, 2008, Pages 3711-3713

  Chen, T ^a   Xu, H ^a   Wang, H Q ^a   Zhao, Y ^a   Zhu, C F ^a   Zhang, Y H ^a   Ji, M J ^a   Hua, Y B ^a   Wu, W X ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TRIPTOLIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; GRAFT RECIPIENT; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; INTESTINE GRAFT; INTESTINE TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SURVIVAL TIME; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD80; BONE MARROW CELLS; DENDRITIC CELLS; DITERPENES; EPOXY COMPOUNDS; GRAFT SURVIVAL; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOSUPPRESSIVE AGENTS; INTESTINE, SMALL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE TEST, MIXED; MALE; PHENANTHRENES; RATS; RATS, INBRED WF; RATS, SPRAGUE-DAWLEY; T-LYMPHOCYTES; TRANSPLANTATION, HOMOLOGOUS;

EID: 57549093077     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2008.06.056     Document Type: Article

References (13)

1. Xu H., Chen T., Wang H.Q., et al. Combination treatment with donor interleukin-12p35 silenced dendritic cells and cyclosporine induces long-term survival of intestinal allografts in rats. Transplant Proc 39 (2007) 286
2. Morelli A.E., and Thomson A.W. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev Immunol 7 (2007) 610
3. Schlichting C.L., Schareck W.D., Kofler S., et al. Involvement of dendritic cells in allograft rejection: new implications of dendritic cell-endothelial cell interactions. Mini Rev Med Chem 7 (2007) 423
4. Crews G.M., Erickson L., Pan F., et al. Down-regulation of TGF-beta and VCAM-1 is associated with successful treatment of chronic rejection in rats. Transplant Proc 37 (2005) 1926
5. Li R., Takazawa K., Suzuki H., et al. Synergistic effect of triptolide and tacrolimus on rat cardiac allotransplantation. Jpn Heart J 45 (2004) 657
6. Beriou G., Peche H., Guillonneau C., et al. Donor-specific allograft tolerance by administration of recipient-derived immature dendritic cells and suboptimal immunosuppression. Transplantation 79 (2005) 969
7. Monchik G.J., and Russell P.S. Transplantation of small bowel in the rat: technical and immunological considerations. Surgery 70 (1971) 693
8. Starzl T.E., Murase N., Abu-Elmagd K., et al. Tolerogenic immunosuppression for organ transplantation. Lancet 361 (2003) 1502
9. Wang J., Xu R., Jin R., et al. Immunosuppressive activity of the Chinese medicinal plant Tripterygium wilfordii. I. Prolongation of rat cardiac and renal allograft survival by the PG27 extract and immunosuppressive synergy in combination therapy with cyclosporine. Transplantation 70 (2000) 447
10. Chen B.J., Chen Y., Cui X., et al. Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. Transplantation 73 (2002) 115
11. Qiu D., Zhao G., Aoki Y., et al. Immunosuppressant PG490 (triptolide) inhibits T-cell interleukin-2 expression at the level of purine-box/nuclear factor of activated T-cells and NF-kappaB transcriptional activation. J Biol Chem 274 (1999) 13443
12. Chan M.A., Kohlmeier J.E., Branden M., et al. Triptolide is more effective in preventing T cell proliferation and interferon-gamma production than is FK506. Phytother Res 13 (1999) 464
13. Liu Q., Chen T., Chen G., et al. Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-kappaB pathways. Mol Immunol 44 (2007) 2686