Effects of Nifurtimox and benznidazole upon glutathione and trypanothione content in epimastigote, trypomastigote and amastigote forms of Trypanosoma cruzi

Molecular and Biochemical Parasitology

Volumn 86, Issue 1, 1997, Pages 101-106

  Maya, Juan Diego ^a   Repetto, Yolanda ^a   Agosín, Moisés ^a   Ojeda, José Manuel ^a   Tellez, Rowena ^b   Gaule, Carlos ^c   Morello, Antonio ^a,b  

^a UNIVERSIDAD CES   (Colombia)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

amastigotes; benznidazole; epimastigotes; glutathione; nifurtimox; Trypanosoma cruzi; trypanothione; trypomastigote s

Indexed keywords

BENZNIDAZOLE; GLUTATHIONE; NIFURTIMOX; TRYPANOTHIONE;

AMASTIGOTE; ANIMAL EXPERIMENT; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG EFFECT; EPIMASTIGOTE; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE;

ANIMALS; GLUTATHIONE; NIFURTIMOX; NITROIMIDAZOLES; SPERMIDINE; SULFHYDRYL COMPOUNDS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

ANIMALIA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0030911717     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(96)02837-X     Document Type: Article

References (38)

1. Moncayo, A. (1993) Chagas disease, in Tropical disease research: progress 1991-92, pp. 67-76, WHO, Geneve.
2. Castro, J.A. and Diaz de Toranzo, E.G. (1988) Toxic effects of nifurtimox and benznidazole, two drugs used against Trypanosomiasis (Chagas' disease). Biomed. Env. Sci. 1, 19-33.
3. Gorla, N.B., Ledesma, O.S., Barbieri, G.P. and Larripa, I.B. (1989) Thirteen fold increase of chromosomal aberrations non-randomly distributed in chagasic children treated with nifurtimox. Mutation Res. 224(2), 263-267.
4. Docampo, R. and Stoppani, A.O.M. (1979) Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. Arch. Biochem. Biophys. 191, 317-321.
5. Docampo, R. and Moreno, S.N.J. (1984) Free radical metabolites in the mode of action of chemoterapeutic agents and phagocytic cells on Trypanosoma cruzi. Rev. Infect. Dis. 6, 223-238.
6. Docampo, R. and Moreno, S.N.J. (1986) Free radical metabolism of antiparasitic agents. Fed. Proc. 45, 2471-2476.
7. Masana, M., Toranzo, E.G.D. and Castro, J.A. (1984) Reductive metabolism and activation of benznidazole. Biochem. Pharmac. 33, 1041-45
8. Aguilar, E.G., Koldobsky, C., Toranzo, E.G.D. and Castro, J.A. (1987) Species and sex differences in the liver microsomal nitroreductive biotransformation of nifurtimox and benznidazole. Arch. Int. Pharmacodyn. Ther. 287, 181-187.
9. Masana, M., Toranzo, E.G.D. and Castro, J.A. (1984) Reductive metabolism and activation of benznidazole. Biochem. Pharmacol. 33, 1041-1045.
10. Filardi, L.S. and Brener, Z. (1987) Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease. Trans. R. Soc. Trop. Med. Hyg. 81, 755-759.
11. Moncada, C., Repetto, Y., Aldunate, J., Letelier, M.E. and Morello, A. (1989) Role of glutathione in the susceptibility of Trypanosoma cruzi to drugs. Comp. Biochem. Physiol. 94c, 87-91.
12. Morello, A. (1988) The biochemistry of the mode of action of drugs and detoxication mechanism in Trypanosoma cruzi. Comp. Biochem. Physiol. 90c: 1-12.
13. Aldunate, J. and Morello, A. (1993) Free radicals in the mode of action of antiparasitic drugs. In: Free radicals in tropical diseases (Aruoma, O.I., ed.) pp. 137-165, Harwood Academic Publishers, Switzerland.
14. Fairlamb, A.H. and Cerami, A. (1985) Identification of a novel, thiol-containing cofactor essential for glutathione reductase enzyme activity in trypanosomatids. Mol. Biochem. Parasitol. 14, 187-198.
15. Fairlamb, A.H. and Henderson, G.B. (1987) Metabolism of trypanothione and glutathionyl-spermidine in trypanosomatids. In: Host-parasite cellular and molecular interactions in protozoal infections (Chang, K.P. and Snary, D., eds.) pp. 29-44. Springer-Verlag, Berlin.
16. Fairlamb, A.H. and Cerami, A. (1992) Metabolism and functions of trypanothione in the kinetoplastida. Annu. Rev. Microbiol. 46, 695-729.
17. Fairlamb, A.H., Henderson, G.B., Bacchi, C.J. and Cerami, A. (1987) In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei. Mol. Biochem. Parasitol. 24, 185-191.
18. Henderson, G.B., Ulrich, P., Fairlamb, A.H., Rosenberg, I., Pereira, M., Sela, M. and Cerami, A. (1988) 'Subversive' sustrates for the enzyme trypanothione disulfide reductase: Alternative approachs to chemotherapy of Chagas disease. Proc. Natl. Acad. Sci. USA 85, 5374-5378.
19. Repetto, Y., Opazo, F., Maya, J.D., Agosin, M. and Morello, A. Glutathione and trypanothione in several strains of Trypanosoma cruzi. Effect of drugs. Comp. Biochem. Physiol. 115B(2), 281-285.
20. Diamond L.S. (1968) Improved method for the non-axemic cultivation of Entamoeba histolytica Schaudin (1903) and E. histolytica-like amoebae with trypanosomatids. J. Parasitol. 54, 715-719.
21. Contreras V.T., Salles J.M., Thomas N., Morel C.M. and Goldenberg S. (1985). In vitro differentiation of Trypanosoma cruzi under chemically defined conditions. Mol. Biochem. Parasitol. 16: 315-327.
22. Goldenberg, S., Contreras, V.T., Salles, J.M., Bonaldo, M.C., Franco, M.P.A.L., Lafaille, J.J., González-Perdomo, M., Linss, J. and Morel, C.M. (1987) In vitro differentiating systems for the study of differential gene expression during Trypanosoma cruzi development. In: Molecular Strategies of Parasitic Invasion, UCLA Symp. Molec. Cell Biology. New Series, Vol. 42. (N. Agabian, Goodman and Nogueira, eds.) pp. 203-212. Alan R. Liss, New York.
23. Villalta, F. and Kierszenbaum, F. (1982) Growth of isolated amastigotes of Trypanosoma cruzi in cell-free medium. J. Protozool. 29(4), 570-576.
24. Aldunate, J., Vásquez, X., Muñoz, L., Lipchenka, I. y Repetto, Y. (1988) Efecto de la glucosa y del oxigeno en cultivos de epimastigotos de Trypanosoma cruzi. Parasitologia al Dia 12(2), 52-56.
25. Goldenberg, S., Contreras, V.T., Salles, J.M., Franco, M.P.A.L., Bonaldo, M.C., Valle, D., Goncalves, A.M. and Morel, C.M. (1984) Perspectives of vaccina against Chagas' Disease through biotechnology. Gene expression in Trypanosoma cruzi trypomastigotes and free-cell translation of mRNAs coding for relevant surface antigens. In: Approaches to Vaccine Development (Ada, G.L., Torrigiana, G., eds.) pp. 442-459. UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases, Geneva.
26. Muñoz, S., Lorca, M., Muñoz, P. y Solari, A. (1994) Poblaciones de Trypanosoma cruzi altamente homogéneas en una region de baja endemia chagásica: relevancia en la patogenia de la Enfermedad de Chagas en Chile. Rev. Med. Chile. 122, 1231-1238.
27. Tsuhako, M.H., Alves, M.J.M., Colli, W., Filardi, L., Brener, Z. and Augusto, O. (1991) Comparative studies of nifurtimox uptake and metabolism by drug-resistant and susceptible strains of Trypanosoma cruzi. Comp. Biochem. Physiol. 99c(3), 317-321.
28. Dubin, M., Moreno, S.N., Martino, E., Docampo, R. and Stoppani, A.O.M. (1983) Increased biliary secretion and loss of hepatic glutathione in rat liver after Nifurtimox treatment. Biochem. Pharmacol. 32, 483-487.
29. Docampo, R., Dubin, M., Martino, E., Moreno, S.N. and Stoppani, A.O.M. (1983) Influencia del Nifurtimox sobre el contenido en glutatión del hígado y de la bilis en la rata. Medicina (Buenos Aires) 43, 33-40.
30. Cunningham, M.L., Zvelebil, M.J.J.M. and Fairlamb, A.H. (1994) Mechanism of inhibition of trypanothione reductase and glutathione reductase by trivalent organic arsenicals. J. Biochem. 221: 285-295.
31. Fairlamb, A.H., Henderson, G.B. and Cerami, A. (1989) Trypanothione is the primary target for arsenical drugs against African trypanosomas. Proc. Natl. Acad. Sci. USA 86, 2607-2611.
32. Moreno, S.N.J., Carnieri, E.G.S. and Docampo, R. (1994) Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet. Mol. Biochem. Parasitol. 67, 313-320.
33. Lowry O.H., Rosebrough N.J., Farr A.L. and Randall J.R. (1951) Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265-275.
34. Dey, S., Ouellette, M., Lightbody, J., Papadopoulou, B. and Rosen, B.P. (1996) An ATP-dependent As (III)-glutathione transport system in membrane vesicles of Leishmania tarentolar. Proc. Natl. Acad. Sci. USA 93, 2192-2197.
35. 9-bis (glutathionyl) aminopropylcadaverine (homotrypanothione) in Trypanosoma cruzi. Eur. J. Biochem. 226, 1019-1027.
36. Le Quesne, S.A. and Fairlamb, A.H. (1996) Regulation of a high-affinity diamine transport system in Trypanosoma cruzi epimastigotes. Biochem. J. 316, 481-486.
37. Arrick, B.A., Griffith, O.W. and Cerami, A. (1981) Inhibition of glutathione synthesis as a chemoratherapeutic strategy for trypanosomiasis. J. Exp. Med. 153, 720-725.
38. Meister, A. (1983) Selective modification of glutathione metabolism. Science 220, 445-447.