Glutathione and trypanothione in several strains of Trypanosoma cruzi: Effect of drugs

Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology

Volumn 115, Issue 2, 1996, Pages 281-285

  Repetto, Yolanda ^a   Opazo, Eduardo ^a   Maya, Juan Diego ^a   Agosin, Moises ^b   Morello, Antonio ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

benznidazole; buthionine sulfoximine; chemotherapy; cyclohexylamine; glutathione; nifurtimox; Trypan osoma; trypanthione

Indexed keywords

BENZNIDAZOLE; BUTHIONINE SULFOXIMINE; CYCLOHEXYLAMINE; GLUTATHIONE; GLUTATHIONYLSPERMIDINE; NIFURTIMOX; SPERMIDINE DERIVATIVE; TRYPANOTHIONE; UNCLASSIFIED DRUG;

ARTICLE; GENE EXPRESSION; PRIORITY JOURNAL; TAXONOMY; TRYPANOSOMA CRUZI;

TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0029961212     PISSN: 03050491     EISSN: None     Source Type: Journal    
DOI: 10.1016/0305-0491(96)00112-5     Document Type: Article

References (32)

1. Aguilar, E.G.; Koldosky, C.; Díaz de Toranzo, E.G.; Castro, J.A. Species and sex differences in the liver microsomal nitro-reductive biotransformation of nifurtimox and benznidazole. Arch. Int. Pharmacodyn. 287:181-187;1987.
2. Aldunate, J.; Morello, A. Free radicals in the mode of action of antiparasitic drugs. In: Aruoma, O.I., (ed). Free Radicals in Tropical Medicine. Switzerland: Harwood Press; 1993:137-165.
3. Arrick, B.A.; Griffith, O.W.; Cerami, A. Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis. J. Exp. Med. 153:720-725;1981.
4. Boveris, A.; Sies, H.; Martino, E.E.; Docampo, R.; Turrens, J.F.; Stoppani, A.O.M. Deficient metabolic utilization of hydrogen peroxide in Trypanosoma cruzi. Biochem. J. 188:643-648;1980.
5. Castro, J.A.; Díaz de Toranzo, E.G. Toxic effects of nifurtimox and benznidazole, two drugs used against American trypanosomiasis (Chagas disease). Biomed. Environ. Sci. 1:19-33;1988.
6. Díaz de Toranzo, E.A.; Castro, J.A.; Franke de Cazzulo, B.M.; Cazzulo, J.J. Interaction of benznidazole reactive metabolites with nuclear and kinetoplastic DNA, proteins and lipids from Trypanosoma cruzi. Experientia (Basel) 44:880-881;1988.
7. Docampo, R.; Stoppani, A.O.M. Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi. Arch. Biochem. Biophys. 197:317-321;1979.
8. Docampo, R.; Moreno, S.N.J. Free radical metabolites in the mode of action of chemotherapeutic agents and phagocytic cells on Trypanosoma cruzi. Rev. Infect. Dis. 6:223-238;1984.
9. Docampo, R.; Moreno, S.N.J. Free radical metabolism of antiparasitic agents. Fed. Proc. 45:2471-2476;1986.
10. Fairlamb, A.H.; Cerani, A. Identification of a novel containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids. Mol. Biochem. Parasitol. 14:187-198;1985.
11. Fairlamb, A.H.; Henderson, G.B.; Cerani, A. The biosynthesis of trypanothione and N-glutathionyl spermidine in Crithidia fasciculata. Mol. Biochem. Parasitol. 21:247-257;1986.
12. Fairlamb, A.H.; Henderson, G.B.; Bacchi, C.J.; Cerami, A. In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in blood stream forms of Trypanosome brucei. Mol. Biochem. Parasitol. 24:185-191;1987.
13. Fairlamb, A.H. Trypanothione metabolism and rational approaches to drug design in biochemistry of trypanosomes. Biochem. Soc. Trans. 18:717-720;1990.
14. Fairlamb, A.H.; Cerami, A. Metabolism and functions of trypanothione in the kinetoplastidia. Annu. Rev. Microbiol. 46: 695-729;1992.
15. Filardi, L.S.; Brener, Z. Susceptibility and natural resistance of Trypanosome cruzi strains to drugs used clinically in chagas disease. Trans. R. Soc. Trop. Med. Hyg. 81:755-759;1987.
16. Gorla, N.B.; Ledesma, O.S.; Barbieri, G.P.; Larripa, I.B. Thirteenfold increase of chromosomal aberrations non-randomly distributed in chagasic children treated with Nifurtimox. Mutat. Res. 224:263-267;1989.
17. Jockers-Scherübl, M.C.; Schirmer, R.H.; Krauth-Siegel, R.I. Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds. Eur. J. Biochem. 180:267-272;1989.
18. Kelly, J.M.; Taylor, M.C.; Smith, K.; Hunter, K.; Fairlamb, A.H. Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which over-express trypanothione reductase. Sensitivity toward agents that are thought to induce oxidative stress. Eur. J. Biochem. 218:29-37;1993.
19. Lowry, O.H.; Rosebrough, N.J.; Farr, A.L.; Randall, J.R. Protein measurement with Polin phenol reagent. J. Biol. Chem. 193:265-275;1951.
20. Masana, M.; Toranzo, E.G.D.; Castro, J.A. Reductive metabolism and activation of benznidazole. Biochem. Pharmacol. 33: 1041-1045;1984.
21. Meister, A. Selective modification of glutathione metabolism. Science 220:472-477;1983.
22. Moncada, C.; Repetto, Y.; Aldunate, J.; Letelier, M.E.; Morello, A. Role of glutathione in the susceptibility of Trypanosoma cruzi to drugs. Comp. Biochem. Physiol. 94C:87-91; 1989.
23. Morello, A. The biochemistry of the mode of action of drugs and the detoxication mechanisms in Trypanosoma cruzi. Comp. Biochem. Physiol. 90C:1-12;1988.
24. Morello, A.; Alduante, J.; Repetto, Y. Present status of Chagas' disease chemotherapy at the molecular level. In: Ehrlich, R.; Nieto, A. (eds). Biology of Parasitism. Montevideo, Uruguay: Ediciones Trilce; 1994:33-39.
25. Moreno, S.N.J.; Docampo, R.; Masson, R.P.; Leon, W.; Stoppani, A.O.M. Different behaviors of benznidazole as free radical generator with mammalian and Trypanosoma cruzi microsomal preparations. Arch. Biochem. Biophys. 218:585-591; 1982.
26. Repetto, Y.; Letelier, M.E.; Aldunate, J.; Morello, A. The gamma-glutamyltranspeptidase of Trypanosoma cruzi. Comp. Biochem. Physiol. 87B:73-78;1987.
27. Repetto, Y.; Opazo, E.; Aldunate, J.; Morello, A. Role of glutathione and trypanothione in parasites. In: Ehrlich, R.; Nieto, A. (eds). Biology of Parasitism. Montevideo, Uruguay: Ediciones Trilce; 1994:25-32.
28. Shames, S.L.; Fairlamb, A.H.; Cerami, A.; Walsh, C.T. Purification and characterization of trypanothione reductase from Crithidia fasciculata: a new member of the family of disulfide-containing flavoprotein reductases. Biochemistry 25:3519-3526;1986.
29. Shim, H.; Fairlamb, A.H. Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect Trypanosomatid Crithidia fasciculate. J. Gen. Microbiol. 134:807-817;1988.
30. Tsuhako, M.H.; Alves, M.J.M.; Colli, W.; Filardi, L.S.; Brener, Z.; Augusto, O. Comparative studies of nifurtimox uptake and metabolism by drug-resistant and susceptible strains of Trypanosoma cruzi. Comp. Biochem. Physiol. 99C:317-321;1991.
31. Vacchi, C.J.; McCann, P.P. Parasitic protozoa and polyamines. In: McCann, P.P.; Pegg, A.E.; Sjoerdsma, A. (eds). Inhibition of Polyamine Metabolism. New York: Academic Press; 1987:317-344.
32. Yawets, A.; Agosin, M. Glutathione S-transferase and drug metabolism in Trypanosoma cruzi: in vivo and in vitro formation of thioethers. Comp. Biochem. Physiol. 66C:265-267;1980.