메뉴 건너뛰기




Volumn 298, Issue 5, 2010, Pages

Cyclic AMP stimulates Mrp2 translocation by activating p38α MAPK in hepatic cells

Author keywords

Huh 7 cells; MAPK kinase; p38 MAPK isoforms; Phosphoinositide 3 kinase; Rat hepatocytes

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLIC AMP; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

EID: 77951463023     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00506.2009     Document Type: Article
Times cited : (13)

References (48)
  • 1
    • 0034624004 scopus 로고    scopus 로고
    • Growth regulation via p38 mitogen-activated protein kinase in developing liver
    • DOI 10.1074/jbc.M008040200
    • Awad MM, Enslen H, Boylan JM, Davis RJ, Gruppuso PA. Growth regulation via p38 mitogen-activated protein kinase in developing liver. J Biol Chem 275: 38716-38721, 2000. (Pubitemid 32009206)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.49 , pp. 38716-38721
    • Awad, M.M.1    Enslen, H.2    Boylan, J.M.3    Davis, R.J.4    Gruppuso, P.A.5
  • 2
    • 0035038177 scopus 로고    scopus 로고
    • Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver
    • Beuers U, Bilzer M, Chittattu A, Kullak-Ublick GA, Keppler D, Paumgartner G, Dombrowski F. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver. Hepatology 33: 1206-1216, 2001.
    • (2001) Hepatology , vol.33 , pp. 1206-1216
    • Beuers, U.1    Bilzer, M.2    Chittattu, A.3    Kullak-Ublick, G.A.4    Keppler, D.5    Paumgartner, G.6    Dombrowski, F.7
  • 3
    • 0038381474 scopus 로고    scopus 로고
    • Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol- 3 kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
    • Beuers U, Denk GU, Soroka CJ, Wimmer R, Rust C, Paumgartner G, Boyer JL. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol- 3 kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem 278: 17810-17818, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 17810-17818
    • Beuers, U.1    Denk, G.U.2    Soroka, C.J.3    Wimmer, R.4    Rust, C.5    Paumgartner, G.6    Boyer, J.L.7
  • 7
  • 8
    • 0031916832 scopus 로고    scopus 로고
    • Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
    • Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem 273: 1741-1748, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 1741-1748
    • Enslen, H.1    Raingeaud, J.2    Davis, R.J.3
  • 10
    • 15444367035 scopus 로고    scopus 로고
    • Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin
    • Geiger PC, Wright DC, Han DH, Holloszy JO. Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin. Am J Physiol Endocrinol Metab 288: E782-E788, 2005.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Geiger, P.C.1    Wright, D.C.2    Han, D.H.3    Holloszy, J.O.4
  • 11
    • 0036070539 scopus 로고    scopus 로고
    • Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition
    • Gerk PM, Vore M. Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J Pharmacol Exp Ther 302: 407-415, 2002.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 407-415
    • Gerk, P.M.1    Vore, M.2
  • 13
    • 0038172651 scopus 로고    scopus 로고
    • Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms
    • Graf D, Reinehr R, Kurz AK, Fischer R, Haussinger D. Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms. Arch Biochem Biophys 415: 34-42, 2003.
    • (2003) Arch Biochem Biophys , vol.415 , pp. 34-42
    • Graf, D.1    Reinehr, R.2    Kurz, A.K.3    Fischer, R.4    Haussinger, D.5
  • 14
    • 0038373452 scopus 로고    scopus 로고
    • cFLIP-L inhibits p38 MAPK activation: An additional anti-apoptotic mechanism in bile acid-mediated apoptosis
    • Grambihler A, Higuchi H, Bronk SF, Gores GJ. cFLIP-L inhibits p38 MAPK activation: an additional anti-apoptotic mechanism in bile acid-mediated apoptosis. J Biol Chem 278: 26831-26837, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 26831-26837
    • Grambihler, A.1    Higuchi, H.2    Bronk, S.F.3    Gores, G.J.4
  • 16
    • 0035834817 scopus 로고    scopus 로고
    • Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes
    • Heidkamp MC, Bayer AL, Martin JL, Samarel AM. Differential activation of mitogen-activated protein kinase cascades and apoptosis by protein kinase C epsilon and delta in neonatal rat ventricular myocytes. Circ Res 89: 882-890, 2001.
    • (2001) Circ Res , vol.89 , pp. 882-890
    • Heidkamp, M.C.1    Bayer, A.L.2    Martin, J.L.3    Samarel, A.M.4
  • 17
    • 0029982565 scopus 로고    scopus 로고
    • Characterization of the structure and function of a new mitogen- Activated protein kinase (p38beta)
    • DOI 10.1074/jbc.271.30.17920
    • Jiang Y, Chen C, Li Z, Guo W, Gegner JA, Lin S, Han J. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J Biol Chem 271: 17920-17926, 1996. (Pubitemid 26250772)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.30 , pp. 17920-17926
    • Jiang, Y.1    Chen, C.2    Li, Z.3    Guo, W.4    Gegner, J.A.5    Lin, S.6    Han, J.7
  • 18
    • 0030828701 scopus 로고    scopus 로고
    • Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta
    • Jiang Y, Gram H, Zhao M, New L, Gu J, Feng L, Di PF, Ulevitch RJ, Han J. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. J Biol Chem 272: 30122-30128, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 30122-30128
    • Jiang, Y.1    Gram, H.2    Zhao, M.3    New, L.4    Gu, J.5    Feng, L.6    Di, P.F.7    Ulevitch, R.J.8    Han, J.9
  • 19
    • 0842299393 scopus 로고    scopus 로고
    • Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase
    • Kubitz R, Sutfels G, Kuhlkamp T, Kolling R, Haussinger D. Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase. Gastroenterology 126: 541-553, 2004.
    • (2004) Gastroenterology , vol.126 , pp. 541-553
    • Kubitz, R.1    Sutfels, G.2    Kuhlkamp, T.3    Kolling, R.4    Haussinger, D.5
  • 20
    • 0030808984 scopus 로고    scopus 로고
    • Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase
    • Kummer JL, Rao PK, Heidenreich KA. Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J Biol Chem 272: 20490-20494, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 20490-20494
    • Kummer, J.L.1    Rao, P.K.2    Heidenreich, K.A.3
  • 21
    • 0034910937 scopus 로고    scopus 로고
    • Tauroursode-oxycholate- Induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats
    • Kurz AK, Graf D, Schmitt M, Dahl SV, Haussinger D. Tauroursode- oxycholate- induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. Gastroenterology 121: 407-419, 2001.
    • (2001) Gastroenterology , vol.121 , pp. 407-419
    • Kurz, A.K.1    Graf, D.2    Schmitt, M.3    Dahl, S.V.4    Haussinger, D.5
  • 23
    • 2442681520 scopus 로고    scopus 로고
    • Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes
    • McConkey M, Gillin H, Webster CR, Anwer MS. Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. J Biol Chem 279: 20882-20888, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 20882-20888
    • McConkey, M.1    Gillin, H.2    Webster, C.R.3    Anwer, M.S.4
  • 24
    • 0038102936 scopus 로고    scopus 로고
    • Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles
    • Misra S, Varticovski L, Arias IM. Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles. Am J Physiol Gastrointest Liver Physiol 285: G316-G324, 2003.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Misra, S.1    Varticovski, L.2    Arias, I.M.3
  • 25
    • 0036614376 scopus 로고    scopus 로고
    • Altered localization and activity of canalicular Mrp2 in estradiol-17beta- D-glucuronide-induced cholestasis
    • Mottino AD, Cao J, Veggi LM, Crocenzi F, Roma MG, Vore M. Altered localization and activity of canalicular Mrp2 in estradiol-17beta- D-glucuronide-induced cholestasis. Hepatology 35: 1409-1419, 2002.
    • (2002) Hepatology , vol.35 , pp. 1409-1419
    • Mottino, A.D.1    Cao, J.2    Veggi, L.M.3    Crocenzi, F.4    Roma, M.G.5    Vore, M.6
  • 26
    • 33846706434 scopus 로고    scopus 로고
    • The apical conjugate efflux pump ABCC2 (MRP2)
    • Nies AT, Keppler D. The apical conjugate efflux pump ABCC2 (MRP2). Pflügers Arch 453: 643-659, 2007.
    • (2007) Pflügers Arch , vol.453 , pp. 643-659
    • Nies, A.T.1    Keppler, D.2
  • 27
    • 11144269771 scopus 로고    scopus 로고
    • PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes
    • Pan J, Singh US, Takahashi T, Oka Y, Palm-Leis A, Herbelin BS, Baker KM. PKC mediates cyclic stretch-induced cardiac hypertrophy through Rho family GTPases and mitogen-activated protein kinases in cardiomyocytes. J Cell Physiol 202: 536-553, 2005.
    • (2005) J Cell Physiol , vol.202 , pp. 536-553
    • Pan, J.1    Singh, U.S.2    Takahashi, T.3    Oka, Y.4    Palm-Leis, A.5    Herbelin, B.S.6    Baker, K.M.7
  • 28
    • 0037405649 scopus 로고    scopus 로고
    • Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes
    • Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 23: 3052-3066, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 3052-3066
    • Qiao, L.1    Han, S.I.2    Fang, Y.3    Park, J.S.4    Gupta, S.5    Gilfor, D.6    Amorino, G.7    Valerie, K.8    Sealy, L.9    Engelhardt, J.F.10    Grant, S.11    Hylemon, P.B.12    Dent, P.13
  • 29
    • 0030051528 scopus 로고    scopus 로고
    • MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    • Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol 16: 1247-1255, 1996.
    • (1996) Mol Cell Biol , vol.16 , pp. 1247-1255
    • Raingeaud, J.1    Whitmarsh, A.J.2    Barrett, T.3    Derijard, B.4    Davis, R.J.5
  • 30
    • 0031573210 scopus 로고    scopus 로고
    • Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: Role in activation of reduced nicotinamide adenine dinucleotide oxidase
    • Rane MJ, Carrithers SL, Arthur JM, Klein JB, McLeish KR. Formyl peptide receptors are coupled to multiple mitogen-activated protein kinase cascades by distinct signal transduction pathways: role in activation of reduced nicotinamide adenine dinucleotide oxidase. J Immunol 159: 5070-5078, 1997.
    • (1997) J Immunol , vol.159 , pp. 5070-5078
    • Rane, M.J.1    Carrithers, S.L.2    Arthur, J.M.3    Klein, J.B.4    McLeish, K.R.5
  • 31
    • 0035793574 scopus 로고    scopus 로고
    • p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
    • Rane MJ, Coxon PY, Powell DW, Webster R, Klein JB, Pierce W, Ping P, McLeish KR. p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils. J Biol Chem 276: 3517-3523, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 3517-3523
    • Rane, M.J.1    Coxon, P.Y.2    Powell, D.W.3    Webster, R.4    Klein, J.B.5    Pierce, W.6    Ping, P.7    McLeish, K.R.8
  • 32
    • 20744441357 scopus 로고    scopus 로고
    • Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes
    • Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S. Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes. Mol Cell Biol 25: 5466-5479, 2005.
    • (2005) Mol Cell Biol , vol.25 , pp. 5466-5479
    • Robidoux, J.1    Cao, W.2    Quan, H.3    Daniel, K.W.4    Moukdar, F.5    Bai, X.6    Floering, L.M.7    Collins, S.8
  • 33
    • 0031979439 scopus 로고    scopus 로고
    • Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets
    • Roelofsen H, Soroka CJ, Keppler D, Boyer JL. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. J Cell Sci 111: 1137-1145, 1998.
    • (1998) J Cell Sci , vol.111 , pp. 1137-1145
    • Roelofsen, H.1    Soroka, C.J.2    Keppler, D.3    Boyer, J.L.4
  • 34
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
    • Roux PP, Blenis J. ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68: 320-344, 2004.
    • (2004) Microbiol Mol Biol Rev , vol.68 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 35
    • 0035877087 scopus 로고    scopus 로고
    • Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis
    • Saldeen J, Lee JC, Welsh N. Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. Biochem Pharmacol 61: 1561-1569, 2001.
    • (2001) Biochem Pharmacol , vol.61 , pp. 1561-1569
    • Saldeen, J.1    Lee, J.C.2    Welsh, N.3
  • 37
    • 42249111198 scopus 로고    scopus 로고
    • Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes
    • DOI 10.1002/hep.22162
    • Schonhoff CM, Gillin H, Webster CR, Anwer MS. Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. Hepatology 47: 1309-1316, 2008. (Pubitemid 351547917)
    • (2008) Hepatology , vol.47 , Issue.4 , pp. 1309-1316
    • Schonhoff, C.M.1    Gillin, H.2    Webster, C.R.L.3    Anwer, M.S.4
  • 39
    • 0033537853 scopus 로고    scopus 로고
    • An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes
    • Sweeney G, Somwar R, Ramlal T, Volchuk A, Ueyama A, Klip A. An inhibitor of p38 mitogen-activated protein kinase prevents insulin- stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes. J Biol Chem 274: 10071-10078, 1999. (Pubitemid 129518292)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.15 , pp. 10071-10078
    • Sweeney, G.1    Somwar, R.2    Ramlal, T.3    Volchuk, A.4    Ueyama, A.5    Klip, A.6
  • 40
    • 0141594871 scopus 로고    scopus 로고
    • Protein Kinase C Promotes Apoptosis in LNCaP Prostate Cancer Cells through Activation of p38 MAPK and Inhibition of the Akt Survival Pathway
    • DOI 10.1074/jbc.M303313200
    • Tanaka Y, Gavrielides MV, Mitsuuchi Y, Fujii T, Kazanietz MG. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. J Biol Chem 278: 33753-33762, 2003. (Pubitemid 37553209)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.36 , pp. 33753-33762
    • Tanaka, Y.1    Gavrielides, M.V.2    Mitsuuchi, Y.3    Fujii, T.4    Kazanietz, M.G.5
  • 42
    • 0031939753 scopus 로고    scopus 로고
    • Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
    • DOI 10.1074/jbc.273.4.2161
    • Wang Y, Huang S, Sah VP, Ross J Jr, Brown JH, Han J, Chien KR. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem 273: 2161-2168, 1998. (Pubitemid 28069266)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.4 , pp. 2161-2168
    • Wang, Y.1    Huang, S.2    Sah, V.P.3    Ross Jr., J.4    Brown, J.H.5    Han, J.6    Chien, K.R.7
  • 43
    • 0035123848 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes
    • Webster CR, Anwer MS. Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. Hepatology 33: 608-615, 2001.
    • (2001) Hepatology , vol.33 , pp. 608-615
    • Webster, C.R.1    Anwer, M.S.2
  • 45
    • 0033369266 scopus 로고    scopus 로고
    • Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp
    • Webster CRL, Anwer MS. Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp. Am J Physiol Gastrointest Liver Physiol 277: G1165-G1172, 1999.
    • (1999) Am J Physiol Gastrointest Liver Physiol , vol.277
    • Webster, C.R.L.1    Anwer, M.S.2
  • 46
    • 0034703036 scopus 로고    scopus 로고
    • +/ taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway
    • +/taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway. J Biol Chem 275: 29754-29760, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 29754-29760
    • Webster, C.R.L.1    Blanch, C.J.2    Philips, J.3    Anwer, M.S.4
  • 47
  • 48
    • 34548321724 scopus 로고    scopus 로고
    • Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): Hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression
    • DOI 10.1074/jbc.M611481200
    • Xu Z, Tavares-Sanchez OL, Li Q, Fernando J, Rodriguez CM, Studer EJ, Pandak WM, Hylemon PB, Gil G. Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression. J Biol Chem 282: 24607-24614, 2007. (Pubitemid 47347499)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.34 , pp. 24607-24614
    • Xu, Z.1    Tavares-Sanchez, O.L.2    Li, Q.3    Fernando, J.4    Rodriguez, C.M.5    Studer, E.J.6    Pandak, W.M.7    Hylemon, P.B.8    Gil, G.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.