Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): Hepatocyte nuclear factor-4α phosphorylation by the p38 MAPK is required for cholesterol 7α-hydroxylase expression

Journal of Biological Chemistry

Volumn 282, Issue 34, 2007, Pages 24607-24614

  Xu, Zhumei ^a   Tavares Sanchez, Olga L ^a   Li, Quanzhong ^a   Fernando, Josephine ^a   Rodriguez, Carmen M ^a   Studer, Elaine J ^a   Pandak, William M ^a   Hylemon, Phillip B ^a   Gil, Gregorio ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION; ACTIVATION ANALYSIS; BIOSYNTHESIS; CHOLESTEROL; ENZYME ACTIVITY;

BILE ACID; BILIARY SOLUBILIZATION; FUNCTIONAL LINKS; HYDROXYLASE EXPRESSION;

BODY FLUIDS;

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA FETOPROTEIN; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BILE ACID SYNTHESIS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; BILE ACIDS AND SALTS; CELLS, CULTURED; CHOLESTEROL 7-ALPHA-HYDROXYLASE; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTE NUCLEAR FACTOR 4; HEPATOCYTES; MODELS, BIOLOGICAL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 34548321724     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M611481200     Document Type: Article

References (36)

1. Stroup, D., and Chiang, J. Y. (2000) J. Lipid Res. 41, 1-11
2. Inoue, Y., Yu, A. M., Yim, S. H., Ma, X., Krausz, K. W., Inoue, J., Xiang, C. C., Brownstein, M. J., Eggertsen, G., Bjorkhem, I., and Gonzalez, F. J. (2006) J. Lipid Res. 47, 215-227
3. Del Castillo-Olivares, A., Campos, J. A., Pandak, W. M., and Gil, G. (2004) J. Biol. Chem. 279, 16813-16821
4. Aranda, A., and Pascual, A. (2001) Physiol. Rev. 81, 1269-1304
5. Hertz, R., Magenheim, J., Berman, I., and Bar-Tana, J. (1998) Nature 392, 512-516
6. Sladek, F. M., Zhong, W. M., Lai, E., and Darnell, J. E., Jr. (1990) Genes Dev. 4, 2353-2365
7. Bogan, A. A., Dallas-Yang, Q., Ruse, M. D., Jr., Maeda, Y., Jiang, G., Nepomuceno, L., Scanlan, T. S., Cohen, F. E., and Sladek, F. M. (2000) J. Mol. Biol. 302, 831-851
8. Datta, S., Wang, L., Moore, D. D., and Osborne, T. F. (2006) J. Biol. Chem. 281, 807-812
9. De Fabiani, E., Mitro, N., Gilardi, F., Caruso, D., Galli, G., and Crestani, M. (2003) J. Biol. Chem. 278, 39124-39132
10. Han, S. I., Studer, E., Gupta, S., Fang, Y., Qiao, L., Li, W., Grant, S., Hylemon, P. B., and Dent, P. (2004) Hepatology 39, 456-463
11. Gupta, S., Stravitz, R. T., Dent, P., and Hylemon, P. B. (2001) J. Biol. Chem. 276, 15816-15822
12. Qiao, L., Studer, E., Leach, K., McKinstry, R., Gupta, S., Decker, R., Kukreja, R., Valerie, K., Nagarkatti, P., Deiry, W. E., Molkentin, J., Schmidt-Ullrich, R., Fisher, P. B., Grant, S., Hylemon, P. B., and Dent, P. (2001) Mol. Biol. Cell 12, 2629-2645
13. Rao, Y. P., Studer, E. J., Stravitz, R. T., Gupta, S., Qiao, L., Dent, P., and Hylemon, P. B. (2002) Hepatology 35, 307-314
14. De Fabiani, E., Mitro, N., Anzulovich, A. C., Pinelli, A., Galli, G., and Crestani, M. (2001) J. Biol. Chem. 276, 30708-30716
15. Jahan, A., and Chiang, J. Y. (2005) Am. J. Physiol. 288, G685-G695
16. Shao, D., and Lazar, M. A. (1999) J. Clin. Investig. 103, 1617-1618
17. Viollet, B., Kahn, A., and Raymondjean, M. (1997) Mol. Cell. Biol. 17, 4208-4219
18. Jiang, G., Nepomuceno, L., Yang, Q., and Sladek, F. M. (1997) Arch. Biochem. Biophys. 340, 1-9
19. Guo, H., Gao, C., Mi, Z., Wai, P. Y., and Kuo, P. C. (2006) Biochem. J. 394, 379-387
20. Ktistaki, E., Ktistakis, N. T., Papadogeorgaki, E., and Talianidis, I. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 9876-9880
21. del Castillo-Olivares, A., and Gil, G. (2000) Nucleic Acids Res. 28, 3587-3593
22. Shin, D.-J., Campos, J. A., Gil, G., and Osborne, T. F. (2003) J. Biol. Chem. 278, 50047-50052
23. Folch, J., Lees, M., and Sloane-Stanley, G. H. (1957) J. Biol. Chem. 226, 497-509
24. Pandak, W. M., Ren, S., Marques, D., Hall, E., Redford, K., Mallonee, D., Bohdan, P., Heuman, D. M., Gil, G., and Hylemon, P. B. (2002) J. Biol. Chem. 277, 48158-48164
25. Sarkar, D., Su, Z. Z., Lebedeva, I. V., Sauane, M., Gopalkrishnan, R. V., Valerie, K., Dent, P., and Fisher, P. B. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 10054-10059
26. del Castillo-Olivares, A., and Gil, G. (2001) Nucleic Acids Res. 29, 4035-4042
27. Harrison, E. M., McNally, S. J., Devey, L., Garden, O. J., Ross, J. A., and Wigmore, S. J. (2006) FEBS J. 273, 2345-2356
28. Li, T., Kong, X., Owsley, E., Ellis, E., Strom, S., and Chiang, J. Y. (2006) J. Biol. Chem. 281, 28745-28754
29. Fang, Y., Han, S. I., Mitchell, C., Gupta, S., Studer, E., Grant, S., Hylemon, P. B., and Dent, P. (2004) Hepatology 40, 961-971
30. Kubitz, R., Sutfels, G., Kuhlkamp, T., Kolling, R., and Haussinger, D. (2004) Gastroenterology 126, 541-553
31. Stravitz, R. T., Vlahcevic, Z. R., Russell, T. L., Heizer, M. L., Avadhani, N. G., and Hylemon, P. B. (1996) J. Steroid Biochem. Mol. Biol. 57, 337-347
32. Guo, H., Gao, C., Mi, Z., Zhang, J., and Kuo, P. C. (2007) J. Biochem. (Tokyo) 141, 635-640
33. Hylemon, P. B., Gurley, E. C., Stravitz, R. T., Litz, J. S., Pandak, W. M., Chiang, J. Y. L., and Vlahcevic, Z. R. (1992) J. Biol. Chem. 267, 16866-16871
34. Andersen, E., Karlaganis, G., and Sjovall, J. (1988) Eur. J. Clin. Investig. 18, 166-172
35. Villanueva, G. R., Herreros, M., Perez-Barriocanal, F., Bolanos, J. P., Bravo, P., and Marin, J. J. (1990) J. Lab. Clin. Med. 115, 441-448
36. Puigserver, P., Rhee, J., Lin, J., Wu, Z., Yoon, J. C., Zhang, C. Y., Krauss, S., Mootha, V. K., Lowell, B. B., and Spiegelman, B. M. (2001) Mol. Cell 8, 971-982