-
1
-
-
1842478123
-
Current concepts in the pathogenesis of age-related macular degeneration
-
Zarbin MA. Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol 2004; 122:598-614.
-
(2004)
Arch Ophthalmol
, vol.122
, pp. 598-614
-
-
Zarbin, M.A.1
-
2
-
-
66249094217
-
Forecasting age-related macular degeneration through 2050
-
Klein BE, Klein R. Forecasting age-related macular degeneration through 2050. J Am Med Assoc 2009; 301:2152-2153.
-
(2009)
J Am Med Assoc
, vol.301
, pp. 2152-2153
-
-
Klein, B.E.1
Klein, R.2
-
3
-
-
67650705517
-
Emerging pharmacologic therapies for wet age-related macular degeneration
-
Ni Z, Hui P. Emerging pharmacologic therapies for wet age-related macular degeneration. Ophthalmologica 2009; 223:401-410.
-
(2009)
Ophthalmologica
, vol.223
, pp. 401-410
-
-
Ni, Z.1
Hui, P.2
-
5
-
-
0036741098
-
Arole for local inflammation in the formation of drusen in the aging eye
-
Anderson DH,Mullins RF,Hageman GS, et al.Arole for local inflammation in the formation of drusen in the aging eye. Am J Ophthalmol 2002; 134:411-431.
-
(2002)
Am J Ophthalmol
, vol.134
, pp. 411-431
-
-
Anderson, D.H.1
Mullins, R.F.2
Hageman, G.S.3
-
6
-
-
33144488589
-
Drusen complement components C3a and C5a promote choroidal neovascularization
-
Nozaki M, Raisler BJ, Sakurai E, et al. Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A 2006; 103:2328-2333.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 2328-2333
-
-
Nozaki, M.1
Raisler, B.J.2
Sakurai, E.3
-
7
-
-
0034832029
-
An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration
-
Hageman GS, Luthert PJ, Victor Chong NH, et al. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res 2001; 20:705-732.
-
(2001)
Prog Retin Eye Res
, vol.20
, pp. 705-732
-
-
Hageman, G.S.1
Luthert, P.J.2
Victor Chong, N.H.3
-
8
-
-
0034800655
-
A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no.8
-
AREDS
-
AREDS. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 2001; 119:1417-1436.
-
(2001)
Arch Ophthalmol
, vol.119
, pp. 1417-1436
-
-
-
9
-
-
70049083998
-
Laser treatment of drusen to prevent progression to advanced age-related macular degeneration
-
Parodi MB, Virgili G, Evans JR. Laser treatment of drusen to prevent progression to advanced age-related macular degeneration. Cochrane Database Syst Rev 2009; CD006537.
-
(2009)
Cochrane Database Syst Rev
-
-
Parodi, M.B.1
Virgili, G.2
Evans, J.R.3
-
10
-
-
77949468094
-
Sirolimus in the treatment of retinal diseases
-
Dugel P. Sirolimus in the treatment of retinal diseases. Retina Today2009; 2-5.
-
(2009)
Retina Today
, pp. 2-5
-
-
Dugel, P.1
-
11
-
-
0034804744
-
From beach to bedside: History of the development of sirolimus
-
Napoli KL, Taylor PJ. From beach to bedside: history of the development of sirolimus. Ther Drug Monit 2001; 23:559-586.
-
(2001)
Ther Drug Monit
, vol.23
, pp. 559-586
-
-
Napoli, K.L.1
Taylor, P.J.2
-
12
-
-
4644239244
-
Mammalian target of rapamycin inhibition
-
Dutcher JP. Mammalian target of rapamycin inhibition. Clin Cancer Res 2004; 10:6382S-6387S.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Dutcher, J.P.1
-
13
-
-
34547764305
-
Complement C3 variant and the risk of age-related macular degeneration
-
Yates JR, Sepp T, Matharu BK, et al. Complement C3 variant and the risk of age-related macular degeneration. N Engl J Med 2007; 357:553-561.
-
(2007)
N Engl J Med
, vol.357
, pp. 553-561
-
-
Yates, J.R.1
Sepp, T.2
Matharu, B.K.3
-
14
-
-
33947606580
-
Association of complement factor H Y402H gene polymorphism with different subtypes of exudative agerelated macular degeneration
-
Wegscheider BJ, Weger M, Renner W, et al. Association of complement factor H Y402H gene polymorphism with different subtypes of exudative agerelated macular degeneration. Ophthalmology 2007; 114:738-742.
-
(2007)
Ophthalmology
, vol.114
, pp. 738-742
-
-
Wegscheider, B.J.1
Weger, M.2
Renner, W.3
-
15
-
-
28344438168
-
Biomarkers of cardiovascular disease as risk factors for age-related macular degeneration
-
Vine AK, Stader J, Branham K, et al. Biomarkers of cardiovascular disease as risk factors for age-related macular degeneration. Ophthalmology 2005; 112:2076-2080.
-
(2005)
Ophthalmology
, vol.112
, pp. 2076-2080
-
-
Vine, A.K.1
Stader, J.2
Branham, K.3
-
16
-
-
33644872864
-
Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers
-
Sepp T, Khan JC, Thurlby DA, et al. Complement factor H variant Y402H is a major risk determinant for geographic atrophy and choroidal neovascularization in smokers and nonsmokers. Invest Ophthalmol Vis Sci 2006; 47:536-540.
-
(2006)
Invest Ophthalmol Vis Sci
, vol.47
, pp. 536-540
-
-
Sepp, T.1
Khan, J.C.2
Thurlby, D.A.3
-
17
-
-
0038708118
-
Age-related macular degeneration: Etiology, pathogenesis, and therapeutic strategies
-
Ambati J, Ambati BK, Yoo SH, et al. Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies. Surv Ophthalmol 2003; 48:257-293.
-
(2003)
Surv Ophthalmol
, vol.48
, pp. 257-293
-
-
Ambati, J.1
Ambati, B.K.2
Yoo, S.H.3
-
18
-
-
36549016602
-
Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab
-
Brantley MA Jr, Fang AM, King JM, et al. Association of complement factor H and LOC387715 genotypes with response of exudative age-related macular degeneration to intravitreal bevacizumab. Ophthalmology 2007; 114:2168-2173.
-
(2007)
Ophthalmology
, vol.114
, pp. 2168-2173
-
-
Brantley Jr., M.A.1
Fang, A.M.2
King, J.M.3
-
19
-
-
33746041795
-
Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration
-
Despriet DD, Klaver CC, Witteman JC, et al. Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration. J Am Med Assoc 2006; 296:301-309.
-
(2006)
J Am Med Assoc
, vol.296
, pp. 301-309
-
-
Despriet, D.D.1
Klaver, C.C.2
Witteman, J.C.3
-
20
-
-
20244380171
-
Complement factor H polymorphism in agerelated macular degeneration
-
Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in agerelated macular degeneration. Science 2005; 308:385-389.
-
(2005)
Science
, vol.308
, pp. 385-389
-
-
Klein, R.J.1
Zeiss, C.2
Chew, E.Y.3
-
21
-
-
20244388812
-
Complement factor H variant increases the risk of age-related macular degeneration
-
Haines JL, Hauser MA, Schmidt S, et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 2005; 308:419-421.
-
(2005)
Science
, vol.308
, pp. 419-421
-
-
Haines, J.L.1
Hauser, M.A.2
Schmidt, S.3
-
22
-
-
70350716559
-
CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD
-
Scholl HP, Fleckenstein M, Fritsche LG, et al. CFH, C3 and ARMS2 are significant risk loci for susceptibility but not for disease progression of geographic atrophy due to AMD. PLoS One 2009; 4:e7418.
-
(2009)
PLoS One
, vol.4
-
-
Scholl, H.P.1
Fleckenstein, M.2
Fritsche, L.G.3
-
23
-
-
52649116114
-
Compstatin: A complement inhibitor on its way to clinical application
-
Ricklin D, Lambris JD. Compstatin: a complement inhibitor on its way to clinical application. Adv Exp Med Biol 2008; 632:273-292.
-
(2008)
Adv Exp Med Biol
, vol.632
, pp. 273-292
-
-
Ricklin, D.1
Lambris, J.D.2
-
24
-
-
33748904355
-
The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria
-
Hillmen P, Young NS, Schubert J, et al. The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 2006; 355:1233-1243.
-
(2006)
N Engl J Med
, vol.355
, pp. 1233-1243
-
-
Hillmen, P.1
Young, N.S.2
Schubert, J.3
-
25
-
-
28444483571
-
Diagnosis and management of paroxysmal nocturnal hemoglobinuria
-
Parker C, Omine M, Richards S, et al. Diagnosis and management of paroxysmal nocturnal hemoglobinuria. Blood 2005; 106:3699-3709.
-
(2005)
Blood
, vol.106
, pp. 3699-3709
-
-
Parker, C.1
Omine, M.2
Richards, S.3
-
26
-
-
0036349623
-
Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation
-
Bok D, Yasumura D, Matthes MT, et al. Effects of adeno-associated virus-vectored ciliary neurotrophic factor on retinal structure and function in mice with a P216L rds/peripherin mutation. Exp Eye Res 2002; 74:719-735.
-
(2002)
Exp Eye Res
, vol.74
, pp. 719-735
-
-
Bok, D.1
Yasumura, D.2
Matthes, M.T.3
-
27
-
-
0032533962
-
Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse
-
Cayouette M, Behn D, Sendtner M, et al. Intraocular gene transfer of ciliary neurotrophic factor prevents death and increases responsiveness of rod photoreceptors in the retinal degeneration slow mouse. J Neurosci 1998; 18:9282-9293.
-
(1998)
J Neurosci
, vol.18
, pp. 9282-9293
-
-
Cayouette, M.1
Behn, D.2
Sendtner, M.3
-
28
-
-
0030997980
-
Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse
-
Cayouette M, Gravel C. Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse. Hum Gene Ther 1997; 8:423-430.
-
(1997)
Hum Gene Ther
, vol.8
, pp. 423-430
-
-
Cayouette, M.1
Gravel, C.2
-
29
-
-
0031937530
-
Protection of mouse photoreceptors by survival factors in retinal degenerations
-
LaVail MM, Yasumura D, Matthes MT, et al. Protection of mouse photoreceptors by survival factors in retinal degenerations. Invest Ophthalmol Vis Sci 1998; 39:592-602.
-
(1998)
Invest Ophthalmol Vis Sci
, vol.39
, pp. 592-602
-
-
La Vail, M.M.1
Yasumura, D.2
Matthes, M.T.3
-
30
-
-
0035179374
-
Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa
-
Liang FQ, Aleman TS, Dejneka NS, et al. Long-term protection of retinal structure but not function using RAAV.CNTF in animal models of retinitis pigmentosa. Mol Ther 2001; 4:461-472.
-
(2001)
Mol Ther
, vol.4
, pp. 461-472
-
-
Liang, F.Q.1
Aleman, T.S.2
Dejneka, N.S.3
-
31
-
-
0034980737
-
AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse
-
Liang FQ, Dejneka NS, Cohen DR, et al. AAV-mediated delivery of ciliary neurotrophic factor prolongs photoreceptor survival in the rhodopsin knockout mouse. Mol Ther 2001; 3:241-248.
-
(2001)
Mol Ther
, vol.3
, pp. 241-248
-
-
Liang, F.Q.1
Dejneka, N.S.2
Cohen, D.R.3
-
32
-
-
0036784819
-
Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa
-
Tao W, Wen R, Goddard MB, et al. Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa. Invest Ophthalmol Vis Sci 2002; 43:3292-3298.
-
(2002)
Invest Ophthalmol Vis Sci
, vol.43
, pp. 3292-3298
-
-
Tao, W.1
Wen, R.2
Goddard, M.B.3
-
33
-
-
0028968690
-
Treatment of amyotrophic lateral sclerosis using a gene therapy approach
-
Aebischer P, Kato AC. Treatment of amyotrophic lateral sclerosis using a gene therapy approach. Eur Neurol 1995; 35:65-68.
-
(1995)
Eur Neurol
, vol.35
, pp. 65-68
-
-
Aebischer, P.1
Kato, A.C.2
-
34
-
-
0029077018
-
Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse
-
Sagot Y, Tan SA, Baetge E, et al. Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse. Eur J Neurosci 1995; 7:1313-1322.
-
(1995)
Eur J Neurosci
, vol.7
, pp. 1313-1322
-
-
Sagot, Y.1
Tan, S.A.2
Baetge, E.3
-
35
-
-
0025895320
-
Neuropoietic cytokines in the hematopoietic fold
-
Bazan JF. Neuropoietic cytokines in the hematopoietic fold. Neuron 1991; 7:197-208.
-
(1991)
Neuron
, vol.7
, pp. 197-208
-
-
Bazan, J.F.1
-
36
-
-
0017161980
-
Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia
-
Helfand SL, Smith GA, Wessells NK. Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia. Dev Biol 1976; 50:541-547.
-
(1976)
Dev Biol
, vol.50
, pp. 541-547
-
-
Helfand, S.L.1
Smith, G.A.2
Wessells, N.K.3
-
37
-
-
0018691975
-
Cholinergic neuronotrophic factors: I. Survival, neurite outgrowth and choline acetyltransferase activity in monolayer cultures from chick embryo ciliary ganglia
-
Varon S, Manthorpe M, Adler R. Cholinergic neuronotrophic factors: I. Survival, neurite outgrowth and choline acetyltransferase activity in monolayer cultures from chick embryo ciliary ganglia. Brain Res 1979; 173:29-45.
-
(1979)
Brain Res
, vol.173
, pp. 29-45
-
-
Varon, S.1
Manthorpe, M.2
Adler, R.3
-
38
-
-
0028149838
-
The tripartite CNTF receptor complex: Activation and signaling involves components shared with other cytokines
-
Stahl N, Yancopoulos GD. The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines. J Neurobiol 1994; 25:1454-1466.
-
(1994)
J Neurobiol
, vol.25
, pp. 1454-1466
-
-
Stahl, N.1
Yancopoulos, G.D.2
-
39
-
-
0034212562
-
Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia
-
Peterson WM, Wang Q, Tzekova R, et al. Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J Neurosci 2000; 20:4081-4090.
-
(2000)
J Neurosci
, vol.20
, pp. 4081-4090
-
-
Peterson, W.M.1
Wang, Q.2
Tzekova, R.3
-
40
-
-
0001303249
-
Neurotrophic factors cause activation of intracellular signaling pathways in Muller cells and other cells of the inner retina, but not photoreceptors
-
Wahlin KJ, Campochiaro PA, Zack DJ, et al. Neurotrophic factors cause activation of intracellular signaling pathways in Muller cells and other cells of the inner retina, but not photoreceptors. Invest Ophthalmol Vis Sci 2000; 41:927-936.
-
(2000)
Invest Ophthalmol Vis Sci
, vol.41
, pp. 927-936
-
-
Wahlin, K.J.1
Campochiaro, P.A.2
Zack, D.J.3
-
41
-
-
0041842695
-
Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha)
-
Beltran WA, Zhang Q, Kijas JW, et al. Cloning, mapping, and retinal expression of the canine ciliary neurotrophic factor receptor alpha (CNTFRalpha). Invest Ophthalmol Vis Sci 2003; 44:3642-3649.
-
(2003)
Invest Ophthalmol Vis Sci
, vol.44
, pp. 3642-3649
-
-
Beltran, W.A.1
Zhang, Q.2
Kijas, J.W.3
-
42
-
-
0032547703
-
Differential regulation of ciliary neurotrophic factor receptor-alpha expression in all major neuronal cell classes during development of the chick retina
-
Fuhrmann S, Kirsch M, Heller S, et al. Differential regulation of ciliary neurotrophic factor receptor-alpha expression in all major neuronal cell classes during development of the chick retina. J Comp Neurol 1998; 400:244-254.
-
(1998)
J Comp Neurol
, vol.400
, pp. 244-254
-
-
Fuhrmann, S.1
Kirsch, M.2
Heller, S.3
-
43
-
-
0942287241
-
Expression of CNTF receptoralpha in chick violet-sensitive cones with unique morphologic properties
-
Seydewitz V, Rothermel A, Fuhrmann S, et al. Expression of CNTF receptoralpha in chick violet-sensitive cones with unique morphologic properties. Invest Ophthalmol Vis Sci 2004; 45:655-661.
-
(2004)
Invest Ophthalmol Vis Sci
, vol.45
, pp. 655-661
-
-
Seydewitz, V.1
Rothermel, A.2
Fuhrmann, S.3
-
44
-
-
0042379833
-
Location of CNTFRalpha on outer segments: Evidence of the site of action of CNTF in rat retina
-
Valter K, Bisti S, Stone J. Location of CNTFRalpha on outer segments: evidence of the site of action of CNTF in rat retina. Brain Res 2003; 985:169-175.
-
(2003)
Brain Res
, vol.985
, pp. 169-175
-
-
Valter, K.1
Bisti, S.2
Stone, J.3
-
45
-
-
34250615443
-
Preventing blindness in retinal disease: Ciliary neurotrophic factor intraocular implants
-
MacDonald IM, Sauve Y, Sieving PA. Preventing blindness in retinal disease: ciliary neurotrophic factor intraocular implants. Can J Ophthalmol 2007; 42:399-402.
-
(2007)
Can J Ophthalmol
, vol.42
, pp. 399-402
-
-
MacDonald, I.M.1
Sauve, Y.2
Sieving, P.A.3
-
47
-
-
3142514196
-
Oxidative stress in neurodegeneration: Cause or consequence?
-
Andersen JK. Oxidative stress in neurodegeneration: cause or consequence? Nat Med 2004; 10 (Suppl):S18-S25.
-
(2004)
Nat Med
, vol.10
, Issue.SUPPL.
-
-
Andersen, J.K.1
-
48
-
-
77049308856
-
Aging: A theory based on free radical and radiation chemistry
-
Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11:298-300.
-
(1956)
J Gerontol
, vol.11
, pp. 298-300
-
-
Harman, D.1
-
49
-
-
0033795036
-
The role of oxidative stress in the pathogenesis of age-related macular degeneration
-
Beatty S, Koh H, Phil M, et al. The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv Ophthalmol 2000; 45:115-134.
-
(2000)
Surv Ophthalmol
, vol.45
, pp. 115-134
-
-
Beatty, S.1
Koh, H.2
Phil, M.3
-
50
-
-
0041560975
-
Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane
-
Hahn P, Milam AH, Dunaief JL. Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. Arch Ophthalmol 2003; 121:1099-1105.
-
(2003)
Arch Ophthalmol
, vol.121
, pp. 1099-1105
-
-
Hahn, P.1
Milam, A.H.2
Dunaief, J.L.3
-
51
-
-
70350617849
-
Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration
-
Ni J, Yuan X, Gu J, et al. Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration. Mol Cell Proteomics 2009; 8:1921-1933.
-
(2009)
Mol Cell Proteomics
, vol.8
, pp. 1921-1933
-
-
Ni, J.1
Yuan, X.2
Gu, J.3
-
52
-
-
0038627633
-
Oxidatively truncated docosahexaenoate phospholipids: Total synthesis, generation, and peptide adduction chemistry
-
Gu X, Sun M, Gugiu B, et al. Oxidatively truncated docosahexaenoate phospholipids: total synthesis, generation, and peptide adduction chemistry. J Org Chem 2003; 68:3749-3761.
-
(2003)
J Org Chem
, vol.68
, pp. 3749-3761
-
-
Gu, X.1
Sun, M.2
Gugiu, B.3
-
53
-
-
0029862568
-
Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal
-
Sayre LM, Sha W, Xu G, et al. Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal. Chem Res Toxicol 1996; 9:1194-1201.
-
(1996)
Chem Res Toxicol
, vol.9
, pp. 1194-1201
-
-
Sayre, L.M.1
Sha, W.2
Xu, G.3
-
54
-
-
33748605874
-
Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for agerelated macular degeneration
-
Ebrahem Q, Renganathan K, Sears J, et al. Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: implications for agerelated macular degeneration. Proc Natl Acad Sci U S A 2006; 103: 13480-13484.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13480-13484
-
-
Ebrahem, Q.1
Renganathan, K.2
Sears, J.3
-
55
-
-
0036549782
-
Evidence that light modulates protein nitration in rat retina
-
Miyagi M, Sakaguchi H, Darrow RM, et al. Evidence that light modulates protein nitration in rat retina. Mol Cell Proteomics 2002; 1:293-303.
-
(2002)
Mol Cell Proteomics
, vol.1
, pp. 293-303
-
-
Miyagi, M.1
Sakaguchi, H.2
Darrow, R.M.3
-
56
-
-
34248334629
-
Protective effect of TEMPOL derivatives against light-induced retinal damage in rats
-
Tanito M, Li F, Elliott MH, et al. Protective effect of TEMPOL derivatives against light-induced retinal damage in rats. Invest Ophthalmol Vis Sci 2007; 48:1900-1905.
-
(2007)
Invest Ophthalmol Vis Sci
, vol.48
, pp. 1900-1905
-
-
Tanito, M.1
Li, F.2
Elliott, M.H.3
-
57
-
-
34547307366
-
Oxidative stress and the pathogenesis of neurodegenerative disorders
-
Reynolds A, Laurie C, Mosley RL, et al. Oxidative stress and the pathogenesis of neurodegenerative disorders. Int Rev Neurobiol 2007; 82:297-325.
-
(2007)
Int Rev Neurobiol
, vol.82
, pp. 297-325
-
-
Reynolds, A.1
Laurie, C.2
Mosley, R.L.3
-
58
-
-
0242352425
-
Tempol-H inhibits opacification of lenses in organ culture
-
Zigler JS Jr, Qin C, Kamiya T, et al. Tempol-H inhibits opacification of lenses in organ culture. Free Radic Biol Med 2003; 35:1194-1202.
-
(2003)
Free Radic Biol Med
, vol.35
, pp. 1194-1202
-
-
Zigler Jr., J.S.1
Qin, C.2
Kamiya, T.3
-
60
-
-
0036124957
-
What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lysosomal storage bodies
-
Katz ML, Robison WG Jr. What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lysosomal storage bodies. Arch Gerontol Geriatr 2002; 34:169-184.
-
(2002)
Arch Gerontol Geriatr
, vol.34
, pp. 169-184
-
-
Katz, M.L.1
Robison Jr., W.G.2
-
61
-
-
33745641375
-
Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD
-
Schmitz-Valckenberg S, Bindewald-Wittich A, Dolar-Szczasny J, et al. Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD. Invest Ophthalmol Vis Sci 2006; 47:2648-2654.
-
(2006)
Invest Ophthalmol Vis Sci
, vol.47
, pp. 2648-2654
-
-
Schmitz-Valckenberg, S.1
Bindewald-Wittich, A.2
Dolar-Szczasny, J.3
-
62
-
-
9444239272
-
Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration
-
Schmitz-Valckenberg S, Bultmann S, Dreyhaupt J, et al. Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Invest Ophthalmol Vis Sci 2004; 45:4470-4476.
-
(2004)
Invest Ophthalmol Vis Sci
, vol.45
, pp. 4470-4476
-
-
Schmitz-Valckenberg, S.1
Bultmann, S.2
Dreyhaupt, J.3
-
63
-
-
68349089202
-
In vivo imaging of foveal sparing in geographic atrophy secondary to age-related macular degeneration
-
Schmitz-Valckenberg S, Fleckenstein M, Helb HM, et al. In vivo imaging of foveal sparing in geographic atrophy secondary to age-related macular degeneration. Invest Ophthalmol Vis Sci 2009; 50:3915-3921.
-
(2009)
Invest Ophthalmol Vis Sci
, vol.50
, pp. 3915-3921
-
-
Schmitz-Valckenberg, S.1
Fleckenstein, M.2
Helb, H.M.3
-
64
-
-
33847073347
-
Progression of geographic atrophy and impact of fundus autofluorescence patterns in agerelated macular degeneration
-
Holz FG, Bindewald-Wittich A, Fleckenstein M, et al. Progression of geographic atrophy and impact of fundus autofluorescence patterns in agerelated macular degeneration. Am J Ophthalmol 2007; 143:463-472.
-
(2007)
Am J Ophthalmol
, vol.143
, pp. 463-472
-
-
Holz, F.G.1
Bindewald-Wittich, A.2
Fleckenstein, M.3
-
65
-
-
58449086657
-
Fundus autofluorescence and progression of age-related macular degeneration
-
Schmitz-Valckenberg S, Fleckenstein M, Scholl HP, et al. Fundus autofluorescence and progression of age-related macular degeneration. Surv Ophthalmol 2009; 54:96-117.
-
(2009)
Surv Ophthalmol
, vol.54
, pp. 96-117
-
-
Schmitz-Valckenberg, S.1
Fleckenstein, M.2
Scholl, H.P.3
-
66
-
-
18044366931
-
RPE lipofuscin and its role in retinal pathobiology
-
Sparrow JR, Boulton M. RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 2005; 80:595-606.
-
(2005)
Exp Eye Res
, vol.80
, pp. 595-606
-
-
Sparrow, J.R.1
Boulton, M.2
-
67
-
-
33747414464
-
A2E, a fluorophore of RPE lipofuscin, can destabilize membrane
-
Sparrow JR, Cai B, Jang YP, et al. A2E, a fluorophore of RPE lipofuscin, can destabilize membrane. Adv Exp Med Biol 2006; 572:63-68.
-
(2006)
Adv Exp Med Biol
, vol.572
, pp. 63-68
-
-
Sparrow, J.R.1
Cai, B.2
Jang, Y.P.3
-
68
-
-
33750814597
-
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium
-
Zhou J, Jang YP, Kim SR, et al. Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A 2006; 103:16182-16187.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 16182-16187
-
-
Zhou, J.1
Jang, Y.P.2
Kim, S.R.3
-
69
-
-
67649359896
-
A2E, a component of lipofuscin, is proangiogenic in vivo
-
Iriyama A, Inoue Y, Takahashi H, et al. A2E, a component of lipofuscin, is proangiogenic in vivo. J Cell Physiol 2009; 220:469-475.
-
(2009)
J Cell Physiol
, vol.220
, pp. 469-475
-
-
Iriyama, A.1
Inoue, Y.2
Takahashi, H.3
-
70
-
-
0034691089
-
Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration
-
Mata NL, Weng J, Travis GH. Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration. Proc Natl Acad Sci U S A 2000; 97:7154-7159.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7154-7159
-
-
Mata, N.L.1
Weng, J.2
Travis, G.H.3
-
71
-
-
0033538438
-
Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice
-
Weng J, Mata NL, Azarian SM, et al. Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice. Cell 1999; 98:13-23.
-
(1999)
Cell
, vol.98
, pp. 13-23
-
-
Weng, J.1
Mata, N.L.2
Azarian, S.M.3
-
72
-
-
0037447253
-
Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration
-
DOI 10.1073/pnas.0737855100
-
Radu RA, Mata NL, Nusinowitz S, et al. Treatment with isotretinoin inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Proc Natl Acad Sci U S A 2003; 100:4742-4747. (Pubitemid 36457800)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.8
, pp. 4742-4747
-
-
Radu, R.A.1
Mata, N.L.2
Nusinowitz, S.3
Liu, X.4
Sieving, P.A.5
Travis, G.H.6
-
73
-
-
33751566190
-
Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration
-
Radu RA, Mata NL, Nusinowitz S, et al. Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Novartis Found Symp 2004; 255:51-63. (Pubitemid 44844405)
-
(2003)
Novartis Foundation Symposium
, vol.255
, pp. 51-63
-
-
Radu, R.A.1
Mata, N.L.2
Nusinowitz, S.3
Liu, X.4
Travis, G.H.5
-
74
-
-
77951298446
-
-
ARVO. Ft. Lauderdale, Fl. Program # 5009
-
Kubota R, Birch D, David R. Phase 1, dose-escalating study of the safety, tolerability, and pharmacokinetics of ACU-4429 in healthy volunteers. 2009. ARVO. Ft. Lauderdale, Fl. Program # 5009.
-
(2009)
Phase 1, Dose-escalating Study of the Safety, Tolerability, and Pharmacokinetics of ACU-4429 in Healthy Volunteers
-
-
Kubota, R.1
Birch, D.2
David, R.3
-
76
-
-
33644795859
-
Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: A potential therapy for treatment of lipofuscin-based retinal diseases
-
Radu RA, Han Y, Bui TV, et al. Reductions in serum vitamin A arrest accumulation of toxic retinal fluorophores: a potential therapy for treatment of lipofuscin-based retinal diseases. Invest Ophthalmol Vis Sci 2005; 46:4393-4401.
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 4393-4401
-
-
Radu, R.A.1
Han, Y.2
Bui, T.V.3
-
78
-
-
77951297809
-
-
ARVO. Ft. Lauderdale, Fl. Program # 4918
-
Katz RS, Vogel R, McLeod K. A phase II multicenter, double-masked, placebo-controlled, dose-comparison study of the safety and efficacy of fenretinide in the treatment of geographic atrophy in subjects with age-related macular degeneration: preliminary demographic data and reasons for screen failure 2009. ARVO. Ft. Lauderdale, Fl. Program # 4918.
-
(2009)
A Phase II Multicenter, Double-masked, Placebo-controlled, Dose-comparison Study of the Safety and Efficacy of Fenretinide in the Treatment of Geographic Atrophy in Subjects with Age-related Macular Degeneration: Preliminary Demographic Data and Reasons for Screen Failure
-
-
Katz, R.S.1
Vogel, R.2
McLeod, K.3
-
79
-
-
77951298720
-
-
ARVO. Ft. Lauderdale, Fl. Program # 4919
-
Vogel R, Slakter J, McLeod K. A phase II, double-masked, placebo-controlled, dose-comparison study of the safety and efficacy of fenretinide in the treatment of geographic atrophy in subjects with age-related macular degeneration: baseline lesion size, characteristics, and preliminary progression data 2009. ARVO. Ft. Lauderdale, Fl. Program # 4919.
-
(2009)
A Phase II, Double-masked, Placebo-controlled, Dose-comparison Study of the Safety and Efficacy of Fenretinide in the Treatment of Geographic Atrophy in Subjects with Age-related Macular Degeneration: Baseline Lesion Size, Characteristics, and Preliminary Progression Data
-
-
Vogel, R.1
Slakter, J.2
McLeod, K.3
-
80
-
-
0028924106
-
Ocular blood flow velocity in age-related macular degeneration
-
Friedman E, Krupsky S, Lane A, et al. Ocular blood flow velocity in age-related macular degeneration. Ophthalmology 1995; 102:640-646.
-
(1995)
Ophthalmology
, vol.102
, pp. 640-646
-
-
Friedman, E.1
Krupsky, S.2
Lane, A.3
-
81
-
-
0031941450
-
Foveal choroidal blood flow in agerelated macular degeneration (AMD)
-
Grunwald J, Hariprasad S, DuPont J, et al. Foveal choroidal blood flow in agerelated macular degeneration (AMD). Invest Ophthalmol Vis Sci 1998; 39:385-390.
-
(1998)
Invest Ophthalmol Vis Sci
, vol.39
, pp. 385-390
-
-
Grunwald, J.1
Hariprasad, S.2
Du Pont, J.3
-
82
-
-
16244363706
-
Reduced foveolar choroidal blood flow in eyes with increasing AMD severity
-
Grunwald J, Metelitsina T, DuPont J, et al. Reduced foveolar choroidal blood flow in eyes with increasing AMD severity. Invest Ophthalmol Vis Sci 2005; 46:1033-1038.
-
(2005)
Invest Ophthalmol Vis Sci
, vol.46
, pp. 1033-1038
-
-
Grunwald, J.1
Metelitsina, T.2
Du Pont, J.3
-
83
-
-
33846507899
-
The long-term natural history of geographic atrophy from age-related macular degeneration
-
Sunness JS, Margalit E, Srikumaran D, et al. The long-term natural history of geographic atrophy from age-related macular degeneration. Ophthalmology 2007; 114:271-277.
-
(2007)
Ophthalmology
, vol.114
, pp. 271-277
-
-
Sunness, J.S.1
Margalit, E.2
Srikumaran, D.3
|